TWI733734B - 2-(4-氯苯基)-n-((2-(2,6-二氧六氫吡啶-3-基)-1-氧基異吲哚啉-5-基)甲基)-2,2-二氟乙醯胺之固體型式，及其醫藥組合物及用途 - Google Patents

2-(4-氯苯基)-n-((2-(2,6-二氧六氫吡啶-3-基)-1-氧基異吲哚啉-5-基)甲基)-2,2-二氟乙醯胺之固體型式，及其醫藥組合物及用途 Download PDF

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TWI733734B
TWI733734B TW106100541A TW106100541A TWI733734B TW I733734 B TWI733734 B TW I733734B TW 106100541 A TW106100541 A TW 106100541A TW 106100541 A TW106100541 A TW 106100541A TW I733734 B TWI733734 B TW I733734B
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compound
solid
solid form
leukemia
certain embodiments
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TW201726646A (zh
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保羅 F 法南德茲
安東尼歐 C 法瑞堤
摩希特 A 卡瑞爾
穎 李
漢華 文
張魏紅
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美商西建公司
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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TW106100541A 2016-01-08 2017-01-06 2-(4-氯苯基)-n-((2-(2,6-二氧六氫吡啶-3-基)-1-氧基異吲哚啉-5-基)甲基)-2,2-二氟乙醯胺之固體型式，及其醫藥組合物及用途 TWI733734B (zh)

Applications Claiming Priority (2)

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US201662276750P 2016-01-08 2016-01-08
US62/276,750 2016-01-08

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TW201726646A TW201726646A (zh) 2017-08-01
TWI733734B true TWI733734B (zh) 2021-07-21

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US (4) US10189808B2 (enExample)
EP (1) EP3399981B1 (enExample)
JP (1) JP7071922B2 (enExample)
CN (1) CN108712904B (enExample)
AR (1) AR107320A1 (enExample)
AU (1) AU2017206039B2 (enExample)
CA (1) CA3010794A1 (enExample)
ES (1) ES2959267T3 (enExample)
MX (2) MX385964B (enExample)
TW (1) TWI733734B (enExample)
WO (1) WO2017120415A1 (enExample)

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CA3010794A1 (en) 2016-01-08 2017-07-13 Celgene Corporation Solid forms of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses
EP3399980B1 (en) * 2016-01-08 2025-07-16 Celgene Corporation Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies
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BR112019028101A2 (pt) 2017-06-30 2020-07-28 Celgene Corporation composições e métodos para uso de (2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida)
US20210069356A1 (en) * 2018-01-02 2021-03-11 Celgene Corporation Isotopologues of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
BR112020024296A2 (pt) 2018-08-27 2021-03-09 Regeneron Pharmaceuticals, Inc. Métodos para produção de um intermediário de purificação de proteína concentrado, para monitoramento e controle dos atributos de qualidade críticos em um intermediário de purificação de proteína e para monitorar e controlar os níveis de excipientes no fluido de cultura de células colhido e/ou intermediário de purificação de proteína, e, intermediário de purificação de proteína
CN113597425A (zh) 2019-01-09 2021-11-02 细胞基因公司 包含(s)-4-(4-(4-(((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苯甲基)哌嗪-1-基)-3-氟苯甲腈及其盐的固体形式，以及包含它们的组合物和它们的使用方法
MX2022005371A (es) * 2019-11-05 2022-08-04 Celgene Corp Terapia de combinacion con 2-(4-clorofenil)-n-((2-(2,6-dioxopiperi din-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
MX2022006133A (es) 2019-12-06 2022-06-17 Celgene Corp Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.

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