TWI720946B - 包含改質套膜蛋白質ｅ３之類病毒粒子 - Google Patents
包含改質套膜蛋白質ｅ３之類病毒粒子 Download PDFInfo
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| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| KR102532832B1 (ko) | 2014-09-11 | 2023-05-16 | 브이엘피 테라퓨틱스 인코포레이티드 | 플라비바이러스 바이러스 유사 입자 |
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| US10166281B2 (en) | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
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| US11020473B2 (en) * | 2016-06-24 | 2021-06-01 | Institut Pasteur | Compositions and methods comprising measles virus defective interfering particles for the prevention of infectious diseases |
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| EP3600367A4 (en) * | 2017-03-28 | 2021-01-13 | Children's Hospital Medical Center | MONOVALENT VLP-BASED EBOLA VACCINES AND THEIR PREPARATION AND USE PROCEDURES |
| JP7346302B2 (ja) | 2017-03-28 | 2023-09-19 | オハイオ・ステイト・イノベーション・ファウンデーション | ヒトｐｄ－１ペプチドワクチン及びその使用法 |
| JP7412002B2 (ja) * | 2017-12-20 | 2024-01-12 | ブイエルピー・セラピューティクス・インコーポレイテッド | アルファウイルスレプリコン粒子 |
| JP2021512966A (ja) * | 2018-02-07 | 2021-05-20 | イミュジーン、リミテッドＩｍｕｇｅｎｅ Ｌｉｍｉｔｅｄ | ワクチン組成物およびその使用 |
| JP7359390B2 (ja) | 2018-02-09 | 2023-10-11 | 国立大学法人大阪大学 | チクングニアウイルスに対する抗体またはその抗原結合断片、およびその用途 |
| FR3078536A1 (fr) * | 2018-03-05 | 2019-09-06 | Peptinov Sas | Composition vaccinale anti-pd-1 |
| FR3078535B1 (fr) * | 2018-03-05 | 2024-02-09 | Peptinov Sas | Composition vaccinale anti-pd-l1 |
| CN109536464B (zh) * | 2018-12-10 | 2022-06-10 | 中国科学院武汉病毒研究所 | 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用 |
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| EP4143323A4 (en) | 2020-04-30 | 2025-01-08 | VLP Therapeutics, Inc. | CYTOKINE IMMUNOTHERAPY |
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| CN115466330B (zh) * | 2021-06-10 | 2023-10-20 | 清华大学 | 一种基于病毒样颗粒呈递冠状病毒受体结合区的冠状病毒亚单位疫苗 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8923123D0 (en) | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| AU2927892A (en) | 1991-11-16 | 1993-06-15 | Smithkline Beecham Biologicals (Sa) | Hybrid protein between cs from plasmodium and hbsag |
| US5580773A (en) | 1992-06-17 | 1996-12-03 | Korea Green Cross Corporation | Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV) |
| CA2143491C (en) | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
| AU716466B2 (en) | 1995-09-27 | 2000-02-24 | Medical Research Council | Recombinant viruses incorporating a protease cleavable protein |
| EP1054973A1 (en) | 1998-02-11 | 2000-11-29 | Maxygen, Inc. | Antigen library immunization |
| HU228477B1 (en) | 1999-08-23 | 2013-03-28 | Dana Farber Cancer Inst Inc | Pd-1, a receptor for b7-4, and uses therefor |
| AU2002344190B2 (en) | 2001-05-30 | 2007-10-18 | Transgene S.A. | Adenovirus protein IX, Its domains involved in capsid assembly, transcriptional activity and nuclear reorganization |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| EP1583500A4 (en) | 2002-11-13 | 2008-02-13 | Us Navy | METHODS AND COMPOSITIONS FOR INDUCING IMMUNE RESPONSES AND PROTEIN IMMUNITY BY PRIMARY IMMUNIZATION WITH ALPHAVIRUS REPLICON VACCINES |
| MXPA05012754A (es) * | 2003-05-29 | 2006-05-17 | Army Medical Res Inst For I | Vacunas virales atenuadas vivas para virus de encefalitis equina oriental. |
| BRPI0417159A (pt) | 2003-12-01 | 2007-03-06 | Dow Global Technologies Inc | produção de partìcula semelhante a vìrus icosaédrico recombinante em pseudomÈnades |
| RS52187B (sr) | 2004-10-14 | 2012-10-31 | Crucell Holland B.V. | Vakcine za indukciju i stimulaciju imunskog odgovora za malariju |
| US20090298955A1 (en) | 2005-02-16 | 2009-12-03 | Konica Minolta Holdings, Inc. | Altered virus capsid protein and use thereof |
| SG10201702670VA (en) | 2005-06-08 | 2017-06-29 | Dana Farber Cancer Inst Inc | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1) pathway |
| GB0513421D0 (en) | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
| CU23586A1 (es) | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus |
| US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
| AU2007291936B2 (en) | 2006-08-30 | 2012-09-27 | Artes Biotechnology Gmbh | Recombinant proteins and virus like particles comprising L and S polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same |
| AU2008338803B2 (en) | 2007-11-26 | 2015-02-05 | Glaxosmithkline Biologicals S.A. | Methods of generating alphavirus particles |
| CN102317308A (zh) * | 2008-11-26 | 2012-01-11 | 美国国有健康与人类服务部 | 类病毒组合物颗粒及其使用方法 |
| PT3067064T (pt) * | 2008-12-09 | 2020-06-16 | Novavax Inc | Proteínas f vsr modificadas e processos para a sua utilização |
| CN102695524B (zh) | 2009-09-18 | 2014-07-09 | 弗劳恩霍费尔美国股份有限公司 | 包含与植物病毒衣壳蛋白融合的靶蛋白的病毒样颗粒 |
| WO2012006180A1 (en) | 2010-06-29 | 2012-01-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv immunogens |
| WO2012023995A1 (en) | 2010-08-18 | 2012-02-23 | Takayuki Shiratsuchi | Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes |
| WO2012106356A2 (en) | 2011-01-31 | 2012-08-09 | GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | Virus-like particles and methods of use |
| JP6130307B2 (ja) | 2011-03-17 | 2017-05-17 | ザ ユニバーシティ オブ バーミンガム | 再指向性免疫療法 |
| BR112013032251B1 (pt) | 2011-06-17 | 2021-12-07 | Bharat Biotech International Limited | Composição estável da vacina da cepa do vírus chikungunya inativado com uma ou mais mutações, uso de isolados do vírus chikungunya, e composição combinada da vacina |
| CN102321639B (zh) | 2011-09-08 | 2013-06-26 | 中国疾病预防控制中心病毒病预防控制所 | 基孔肯雅病毒病毒样颗粒的制备方法和应用 |
| US20150265694A1 (en) | 2011-10-25 | 2015-09-24 | Florida Gulf Coast University Board Of Trustees | Vaccines and methods for creating a vaccine for inducing immunity to all dengue virus serotypes |
| BR112014024612A2 (pt) | 2012-04-02 | 2021-06-08 | Univ North Carolina Chapel Hill | ácido nucleico, polipeptídeo, glicoproteína e quimérica, epítopo de vírus da dengue, partícula semelhante a flavivírus quimérico (vlp), flavivírus quimérico, e métodos in vitro para identificar um anticorpo neutralizante e para identificar uma composição imunogênica contra um vírus da dengue |
| HUE039215T2 (hu) | 2012-05-16 | 2018-12-28 | Immune Design Corp | Vakcinák HSV-2-höz |
| KR102494564B1 (ko) | 2013-06-03 | 2023-01-31 | 브이엘피 테라퓨틱스 인코포레이티드 | 말라리아 백신 |
| US9637532B2 (en) | 2013-07-12 | 2017-05-02 | Vlp Therapeutics, Llc | Virus like particle comprising PD-1 antigen or PD-1 ligand antigen |
| EP3119801B1 (en) | 2014-03-18 | 2019-07-17 | Fraunhofer Gesellschaft zur Förderung der Angewand | Distinguishing flavivirus infection using a recombinant mutant envelope protein |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| EP3177720B1 (en) | 2014-08-08 | 2021-09-22 | VLP Therapeutics, Inc. | Virus like particle comprising modified envelope protein e3 |
| US9363353B1 (en) | 2014-12-04 | 2016-06-07 | Hon Man Ashley Chik | Mobile phone docks with multiple circulating phone connectors |
| WO2016109792A2 (en) | 2014-12-31 | 2016-07-07 | The Usa, As Represented By The Secretary, Detp. Of Health And Human Services | Novel multivalent nanoparticle-based vaccines |
| CN107849558A (zh) | 2015-06-12 | 2018-03-27 | 国立大学法人三重大学 | 2型人副流感病毒载体和疫苗 |
| US10799575B2 (en) | 2015-06-25 | 2020-10-13 | Technovax, Inc. | Flavivirus and alphavirus virus-like particles (VLPS) |
| KR20180036987A (ko) | 2015-07-16 | 2018-04-10 | 브하라트 바이오테크 인터내셔날 리미티드 | 백신 조성물 |
| EP4218805A1 (en) | 2015-07-21 | 2023-08-02 | ModernaTX, Inc. | Infectious disease vaccines |
| CN106085974B (zh) | 2016-06-07 | 2019-08-09 | 博奥生物集团有限公司 | 一种寨卡病毒假病毒颗粒及其制备方法 |
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