TWI710565B - 用於抑制精胺酸酶活性之組合物及方法 - Google Patents
用於抑制精胺酸酶活性之組合物及方法 Download PDFInfo
- Publication number
- TWI710565B TWI710565B TW105135189A TW105135189A TWI710565B TW I710565 B TWI710565 B TW I710565B TW 105135189 A TW105135189 A TW 105135189A TW 105135189 A TW105135189 A TW 105135189A TW I710565 B TWI710565 B TW I710565B
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- Prior art keywords
- cancer
- compound
- certain embodiments
- tumor
- acid
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- 0 C[C@@](C(N(C[C@@]1CCC*)C[C@]1(C(O)=O)N)=O)N Chemical compound C[C@@](C(N(C[C@@]1CCC*)C[C@]1(C(O)=O)N)=O)N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562248632P | 2015-10-30 | 2015-10-30 | |
| US62/248,632 | 2015-10-30 | ||
| US201662281964P | 2016-01-22 | 2016-01-22 | |
| US62/281,964 | 2016-01-22 | ||
| US201662323034P | 2016-04-15 | 2016-04-15 | |
| US62/323,034 | 2016-04-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201726692A TW201726692A (zh) | 2017-08-01 |
| TWI710565B true TWI710565B (zh) | 2020-11-21 |
Family
ID=58631120
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW105135189A TWI710565B (zh) | 2015-10-30 | 2016-10-28 | 用於抑制精胺酸酶活性之組合物及方法 |
| TW109135297A TWI734630B (zh) | 2015-10-30 | 2016-10-28 | 用於抑制精胺酸酶活性之組合物及方法 |
| TW110129153A TWI775556B (zh) | 2015-10-30 | 2016-10-28 | 用於抑制精胺酸酶活性之組合物及方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW109135297A TWI734630B (zh) | 2015-10-30 | 2016-10-28 | 用於抑制精胺酸酶活性之組合物及方法 |
| TW110129153A TWI775556B (zh) | 2015-10-30 | 2016-10-28 | 用於抑制精胺酸酶活性之組合物及方法 |
Country Status (36)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011242794B2 (en) | 2010-04-22 | 2016-11-24 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| ES2568680T3 (es) | 2010-10-26 | 2016-05-03 | Mars, Incorporated | Boratos como inhibidores de arginasa |
| TWI710565B (zh) | 2015-10-30 | 2020-11-21 | 美商卡利泰拉生物科技公司 | 用於抑制精胺酸酶活性之組合物及方法 |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| CA3042878A1 (en) | 2016-11-08 | 2018-05-17 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| MX378460B (es) * | 2016-12-22 | 2025-03-10 | Calithera Biosciences Inc | Composiciones y métodos para inhibir la actividad de la arginasa. |
| BR112019023582A2 (pt) | 2017-05-12 | 2020-06-02 | Calithera Biosciences Inc. | Método de preparar (3r,4s)-3-acetamido-4-alil-n-(terc-butil)pirrolidina-3-carboxamida |
| WO2019120296A1 (en) * | 2017-12-22 | 2019-06-27 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as arginase inhibitors |
| CA3091365A1 (en) | 2018-02-17 | 2019-08-22 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| EA202092086A1 (ru) | 2018-03-05 | 2021-02-09 | Аркус Байосайенсиз, Инк. | Ингибиторы аргиназы |
| WO2019177873A1 (en) | 2018-03-13 | 2019-09-19 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| PL3774843T3 (pl) | 2018-03-29 | 2022-11-14 | Molecure Sa | Dipeptydowe pochodne piperydyny |
| US11274111B2 (en) | 2018-06-20 | 2022-03-15 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| AU2019379808C1 (en) | 2018-11-16 | 2024-01-25 | Arcus Biosciences, Inc. | Inhibitors of ARG1 and/or ARG2 |
| CN109364252B (zh) * | 2018-11-21 | 2021-09-28 | 南京大学 | 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用 |
| WO2020131598A1 (en) | 2018-12-18 | 2020-06-25 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CN113614095B (zh) * | 2019-02-06 | 2024-08-23 | 广东新契生物医药科技有限公司 | 作为精氨酸酶抑制剂的烷基硼酸类化合物 |
| US11420966B2 (en) * | 2019-05-02 | 2022-08-23 | Aclaris Therapeutics, Inc. | Substituted pyrrolopyridines as JAK inhibitors |
| JP7579324B2 (ja) * | 2019-07-23 | 2024-11-07 | アストラゼネカ・アクチエボラーグ | アルギナーゼ阻害剤及びその使用方法 |
| CN110615753A (zh) * | 2019-09-02 | 2019-12-27 | 南京新酶合医药科技有限公司 | 一种(3r,4s)-1-取代-4-乙基吡咯-3-羧酸的合成方法 |
| CN110759843A (zh) * | 2019-09-30 | 2020-02-07 | 东北师范大学 | 一种氟叠氮取代的四元杂环化合物的制备和应用 |
| CN110734456A (zh) * | 2019-11-06 | 2020-01-31 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和医药上的应用 |
| CN115135385B (zh) | 2019-11-12 | 2024-05-10 | 纳米医疗有限公司 | 用于治疗癌症的含有ido拮抗剂前药的调配的和/或共同调配的脂质体组合物及其方法 |
| US20230140132A1 (en) * | 2020-01-07 | 2023-05-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| SI4175719T1 (sl) | 2020-07-02 | 2025-07-31 | Incyte Corporation | Triciklične sečninske spojine kot zaviralci jak2 v617f |
| TW202216662A (zh) * | 2020-07-17 | 2022-05-01 | 美商英塞特公司 | 製備精胺酸酶抑制劑及其合成中間物之方法 |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| TW202228720A (zh) * | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
| US11958861B2 (en) | 2021-02-25 | 2024-04-16 | Incyte Corporation | Spirocyclic lactams as JAK2 V617F inhibitors |
| US12084430B2 (en) | 2022-03-17 | 2024-09-10 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| TW202416968A (zh) | 2022-10-21 | 2024-05-01 | 美商英塞特公司 | 作為ｊａｋ２ ｖ６１７ｆ抑制劑之三環脲化合物 |
| CN121079299A (zh) | 2023-03-13 | 2025-12-05 | 因赛特公司 | 作为激酶抑制剂的双环脲 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058065A1 (en) * | 2010-10-26 | 2012-05-03 | Mars Incorporated | Boronates as arginase inhibitors |
| WO2015061752A1 (en) * | 2013-10-25 | 2015-04-30 | Pharmacyclics, Inc. | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
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| US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
| GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
| GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| US6403609B1 (en) | 1997-07-29 | 2002-06-11 | Alcon Manufacturing, Ltd. | Ophthalmic compositions containing galactomannan polymers and borate |
| EP1049660A1 (en) | 1997-10-10 | 2000-11-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting arginase activity |
| CA2318920A1 (en) | 1998-01-29 | 1999-08-05 | James W. Young | Pharmaceutical uses of optically pure (-)-bupropion |
| US20040063666A1 (en) | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
| US8889112B2 (en) | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
| WO2002004465A1 (en) | 2000-07-06 | 2002-01-17 | Fal Diagnostics | Methods and kits for the detection of arginine compounds |
| CA2431080A1 (en) | 2003-06-02 | 2004-12-02 | Catherine Adele O'brien | Enhancement of anticancer immunity through inhibition of arginase |
| US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
| DE602004023516D1 (de) | 2003-08-07 | 2009-11-19 | Allergan Inc | Zusammensetzungen zur abgabe von therapeutika in die augen und verfahren zu ihrer herstellung und verwendung |
| US20050059744A1 (en) | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| US20090298912A1 (en) | 2005-07-01 | 2009-12-03 | The Johns Hopkins University | Arginase II: A Target treatment of aging heart and heart failure |
| CN101755130B (zh) | 2007-07-12 | 2012-10-17 | 山洋电气株式会社 | 双重反转式轴流鼓风机 |
| KR20100080798A (ko) * | 2007-10-12 | 2010-07-12 | 레솔빅스 파마슈티칼즈, 인코퍼레이티드 | 안과 질환의 치료를 위한 옥실리핀 화합물 |
| CA2722992A1 (en) * | 2008-05-05 | 2009-11-12 | Schering Corporation | Sequential administration of chemotherapeutic agents for treatment of cancer |
| HUE046932T2 (hu) * | 2009-01-26 | 2020-04-28 | Univ Pennsylvania | Argináz inhibitorok és felhasználási eljárások |
| AU2011242794B2 (en) | 2010-04-22 | 2016-11-24 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| US8894970B2 (en) | 2010-12-31 | 2014-11-25 | Corridor Pharmaceuticals, Inc. | Arginase inhibitors and methods of use thereof |
| US9266908B2 (en) | 2011-10-19 | 2016-02-23 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| BR112014009531A8 (pt) | 2011-10-20 | 2018-01-16 | Glaxosmithkline Llc | aza-heterociclos bicíclicos substituídos e análogos como moduladores de sirtuína |
| WO2013158262A1 (en) | 2012-04-18 | 2013-10-24 | Mars, Incorporated | Ring constrained analogs as arginase inhibitors |
| CN111329989A (zh) * | 2012-11-02 | 2020-06-26 | 药品循环有限责任公司 | Tec家族激酶抑制剂辅助疗法 |
| CN105879030A (zh) * | 2014-09-30 | 2016-08-24 | 复旦大学 | 治疗肿瘤的增效药物复合物及其制备方法 |
| EP3270907A1 (en) * | 2015-03-20 | 2018-01-24 | Sammy Oyoo OPIYO | Use of suramin and arginase inhibitors in malignant neoplasia |
| MX385315B (es) * | 2015-06-23 | 2025-03-14 | Calithera Biosciences Inc | Composiciones y metodos para inhibir actividad de arginasa. |
| TWI710565B (zh) | 2015-10-30 | 2020-11-21 | 美商卡利泰拉生物科技公司 | 用於抑制精胺酸酶活性之組合物及方法 |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
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2016
- 2016-10-28 TW TW105135189A patent/TWI710565B/zh not_active IP Right Cessation
- 2016-10-28 BR BR112018008746-7A patent/BR112018008746B1/pt not_active IP Right Cessation
- 2016-10-28 PT PT168608834T patent/PT3368541T/pt unknown
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- 2016-10-28 SG SG10201911402YA patent/SG10201911402YA/en unknown
- 2016-10-28 ES ES22150809T patent/ES2991555T3/es active Active
- 2016-10-28 KR KR1020187015208A patent/KR102434308B1/ko active Active
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- 2016-10-28 CN CN202110097870.5A patent/CN113150015A/zh active Pending
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- 2016-10-28 MD MDE20180870T patent/MD3368541T2/ro unknown
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2018
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2019
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2020
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|---|---|---|---|---|
| WO2012058065A1 (en) * | 2010-10-26 | 2012-05-03 | Mars Incorporated | Boronates as arginase inhibitors |
| WO2015061752A1 (en) * | 2013-10-25 | 2015-04-30 | Pharmacyclics, Inc. | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
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