TWI680774B - 緩釋藥物配方 - Google Patents

緩釋藥物配方 Download PDF

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Publication number
TWI680774B
TWI680774B TW103137471A TW103137471A TWI680774B TW I680774 B TWI680774 B TW I680774B TW 103137471 A TW103137471 A TW 103137471A TW 103137471 A TW103137471 A TW 103137471A TW I680774 B TWI680774 B TW I680774B
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TW
Taiwan
Prior art keywords
item
layer
patent application
polymer material
drug
Prior art date
Application number
TW103137471A
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English (en)
Chinese (zh)
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TW201542243A (zh
Inventor
費雷普 何塞 奧力維拉 瓦倫
岡薩雷茲 羅伯托 卡洛斯 布拉
湯瑪士 布塞
Original Assignee
迪洛特醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US14/066,054 external-priority patent/US9814681B2/en
Application filed by 迪洛特醫藥有限公司 filed Critical 迪洛特醫藥有限公司
Publication of TW201542243A publication Critical patent/TW201542243A/zh
Application granted granted Critical
Publication of TWI680774B publication Critical patent/TWI680774B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005Coating of tablets or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/606Salicylic acid; Derivatives thereof having amino groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW103137471A 2013-10-29 2014-10-29 緩釋藥物配方 TWI680774B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14/066,054 US9814681B2 (en) 2012-04-30 2013-10-29 Delayed release drug formulation
PCT/EP2013/072648 WO2015062640A1 (en) 2013-10-29 2013-10-29 A delayed release drug formulation
US14/066054 2013-10-29
WOPCT/EP2013/072648 2013-10-29

Publications (2)

Publication Number Publication Date
TW201542243A TW201542243A (zh) 2015-11-16
TWI680774B true TWI680774B (zh) 2020-01-01

Family

ID=49515360

Family Applications (3)

Application Number Title Priority Date Filing Date
TW103137471A TWI680774B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108142795A TWI736031B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108122234A TWI725458B (zh) 2013-10-29 2014-10-29 緩釋藥物配方

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW108142795A TWI736031B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108122234A TWI725458B (zh) 2013-10-29 2014-10-29 緩釋藥物配方

Country Status (25)

Country Link
US (1) US10799515B2 (https=)
EP (2) EP3542791A1 (https=)
JP (1) JP6273356B2 (https=)
KR (2) KR102174942B1 (https=)
CN (2) CN105555260B (https=)
AU (2) AU2013404367B2 (https=)
BR (2) BR122020013726B1 (https=)
CA (1) CA2923063C (https=)
CR (1) CR20160192A (https=)
CU (1) CU20160055A7 (https=)
EA (1) EA032504B1 (https=)
HK (1) HK1222547A1 (https=)
IL (2) IL244260B (https=)
MA (1) MA38847B2 (https=)
MX (2) MX382146B (https=)
MY (1) MY189394A (https=)
NZ (2) NZ717159A (https=)
PH (2) PH12020551522A1 (https=)
SA (2) SA116370660B1 (https=)
SG (1) SG11201600501UA (https=)
TN (1) TN2016000119A1 (https=)
TW (3) TWI680774B (https=)
UA (1) UA117260C2 (https=)
WO (1) WO2015062640A1 (https=)
ZA (1) ZA201600630B (https=)

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EP3187171B1 (en) 2012-04-30 2024-09-25 Tillotts Pharma AG A delayed release drug formulation
CA2999367C (en) 2015-09-23 2023-09-26 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
EP3162362A1 (de) * 2015-10-30 2017-05-03 Dr. Falk Pharma Gmbh Optimierte mesalazinhaltige hochdosistablette
EP3257501A1 (en) 2016-06-14 2017-12-20 Tillotts Pharma AG Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating
EP3728061A4 (en) * 2017-12-21 2021-09-08 Pepsico Inc MULTI-INGREDIENT POP-UP DRINK CAPSULE FOR PREPARING A DRINK
EP3662900A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Colonic drug delivery formulation
EP3662898A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG Solid composition comprising mesalazine
ES2994844T3 (en) * 2018-12-07 2025-02-03 Tillotts Pharma Ag Colonic drug delivery formulation
EP3662895A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG A process for manufacturing reducing sugar-free 5-asa tablet cores
EP3662901B1 (en) 2018-12-07 2025-01-01 Tillotts Pharma AG Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing
GB201906917D0 (en) * 2019-05-16 2019-07-03 Intract Pharma Ltd Novel compositions
CA3160869C (en) * 2019-12-11 2024-06-25 Priyanka HAKSAR Dosage form for use in treating or preventing of a disease

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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1233170A (zh) * 1996-10-11 1999-10-27 普罗克特和甘保尔公司 具有多重肠溶聚合物包衣的供结肠释放的药物剂型
CN102319218A (zh) * 2011-09-22 2012-01-18 贝沃特医药技术(上海)有限公司 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法

Also Published As

Publication number Publication date
BR112016004863A8 (pt) 2020-02-11
EP3542791A1 (en) 2019-09-25
CN105555260B (zh) 2021-04-23
IL244260B (en) 2021-08-31
KR102174942B1 (ko) 2020-11-06
CA2923063A1 (en) 2015-05-07
US20160250232A1 (en) 2016-09-01
WO2015062640A1 (en) 2015-05-07
ZA201600630B (en) 2017-05-31
KR20160077040A (ko) 2016-07-01
BR112016004863B1 (pt) 2022-09-20
EA032504B1 (ru) 2019-06-28
MA38847A1 (fr) 2017-08-31
PH12016500307A1 (en) 2016-05-16
BR122020013726B1 (pt) 2022-11-01
NZ747731A (en) 2020-02-28
TW202011945A (zh) 2020-04-01
EP3062776A1 (en) 2016-09-07
MX382146B (es) 2025-03-13
US10799515B2 (en) 2020-10-13
IL265381A (en) 2019-05-30
TWI725458B (zh) 2021-04-21
PH12020551522A1 (en) 2022-11-14
CN110279669A (zh) 2019-09-27
AU2013404367B2 (en) 2020-02-27
CA2923063C (en) 2021-09-07
SG11201600501UA (en) 2016-02-26
TWI736031B (zh) 2021-08-11
CN110279669B (zh) 2022-02-15
AU2020201365B2 (en) 2021-09-16
MX2019002162A (es) 2019-06-17
TW201944984A (zh) 2019-12-01
UA117260C2 (uk) 2018-07-10
HK1222547A1 (zh) 2017-07-07
JP2016535030A (ja) 2016-11-10
MX388063B (es) 2025-03-19
MX2016001840A (es) 2016-08-11
TN2016000119A1 (en) 2017-10-06
MY189394A (en) 2022-02-09
AU2013404367A1 (en) 2016-02-18
IL265381B (en) 2022-05-01
JP6273356B2 (ja) 2018-01-31
SA114360006B1 (ar) 2016-11-09
AU2020201365A1 (en) 2020-03-12
EA201690596A1 (ru) 2016-08-31
MA38847B2 (fr) 2021-02-26
CR20160192A (es) 2016-07-13
SA116370660B1 (ar) 2019-02-24
TW201542243A (zh) 2015-11-16
KR102237356B1 (ko) 2021-04-08
PH12016500307B1 (en) 2022-02-11
CU20160055A7 (es) 2016-10-28
CN105555260A (zh) 2016-05-04
KR20200075041A (ko) 2020-06-25
IL244260A0 (en) 2016-04-21
NZ717159A (en) 2019-06-28

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