TWI666219B - 使用免疫球蛋白片段之位點專一性ｇｌｐ－２接合物 - Google Patents
使用免疫球蛋白片段之位點專一性ｇｌｐ－２接合物 Download PDFInfo
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- TWI666219B TWI666219B TW101150930A TW101150930A TWI666219B TW I666219 B TWI666219 B TW I666219B TW 101150930 A TW101150930 A TW 101150930A TW 101150930 A TW101150930 A TW 101150930A TW I666219 B TWI666219 B TW I666219B
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
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- Peptides Or Proteins (AREA)
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| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| US9949927B2 (en) | 2012-04-10 | 2018-04-24 | The Regents Of The University Of California | Bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| EP3046586B1 (en) * | 2013-09-19 | 2021-07-07 | The Regents of The University of California | Methods of treatment using bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| US9994616B2 (en) | 2013-10-15 | 2018-06-12 | The University Of Tokyo | c-Met protein agonist |
| KR102455171B1 (ko) * | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| MX387560B (es) * | 2014-03-31 | 2025-03-18 | Hanmi Pharmaceutical Co Ltd | Procedimiento para mejorar la solubilidad de proteínas y péptidos usando un enlace del fragmento fc de inmunoglobulina. |
| KR101825048B1 (ko) * | 2014-12-31 | 2018-02-05 | 주식회사 제넥신 | GLP 및 면역글로불린 하이브리드 Fc 융합 폴리펩타이드 및 이의 용도 |
| MY206271A (en) | 2016-07-11 | 2024-12-06 | Opko Biologics Ltd | Long-acting coagulation factor vii and methods of producing same |
| CN107987170B (zh) * | 2016-10-27 | 2018-12-18 | 浙江道尔生物科技有限公司 | 一种用于治疗肠道疾病的融合蛋白 |
| AU2018223811B2 (en) | 2017-02-27 | 2021-05-27 | Urigen N.A. | Treatment of lower urinary tract epithelium with glucagon like peptide 2 |
| KR102174436B1 (ko) * | 2017-08-17 | 2020-11-04 | 주식회사 엘지화학 | 불용성 안료 화합물의 정성분석방법 |
| BR112020003736A2 (pt) | 2017-08-22 | 2020-09-08 | Shire-Nps Pharmaceuticals, Inc. | polipeptídeos de fusão de glp-2 e usos para tratar e prevenir condições gastrointestinais |
| EA202090571A1 (ru) * | 2017-09-28 | 2020-07-30 | Ханми Фарм. Ко., Лтд. | Конъюгаты производных glp-2 пролонгированного действия |
| WO2019090209A1 (en) * | 2017-11-06 | 2019-05-09 | Shire-Nps Pharmaceuticals, Inc. | Glp-2 analogs and peptibodies for administration before during, or after surgery |
| JP2022512688A (ja) * | 2018-10-24 | 2022-02-07 | シャイア－エヌピーエス ファーマシューティカルズ インコーポレイテッド | Ｇｌｐ－２融合ポリペプチドならびに消化管の状態の処置および予防のための使用 |
| CA3129576A1 (en) * | 2019-02-11 | 2020-08-20 | Opko Biologics Ltd. | Long-acting glp-2 analogs |
| WO2020198604A1 (en) * | 2019-03-28 | 2020-10-01 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods of treating and preventing systemic complications of acute illness |
| MX2022006861A (es) | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| JP7846622B2 (ja) * | 2019-12-24 | 2026-04-15 | ハンミ ファーマシューティカル カンパニー リミテッド | Ｇｌｐ－２又はその結合体を含む、代謝性骨疾患の予防又は治療用薬学的組成物 |
| WO2021201654A1 (ko) * | 2020-04-03 | 2021-10-07 | 한미약품 주식회사 | Glp-2 유도체 또는 이의 지속형 결합체를 포함하는 방사선요법, 화학요법, 또는 이들의 조합으로 유발된 점막염의 예방 또는 치료용 약학적 조성물 |
| MX2022014671A (es) * | 2020-05-22 | 2023-02-13 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de conjugado de glp-2 de accion prolongada. |
| CN111560062A (zh) * | 2020-05-26 | 2020-08-21 | 成都圣诺生物制药有限公司 | 一种Elisiglutide的制备方法 |
| WO2022159555A1 (en) * | 2021-01-20 | 2022-07-28 | The Trustees Of Columbia University In The City Of New York | Methods for treating graft-versus-host disease using glp-2 agonists and analogues thereof |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
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| WO2010107256A2 (en) * | 2009-03-20 | 2010-09-23 | Hanmi Pharm. Co., Ltd. | Method for preparing a site-specific physiologically active polypeptide conjugate |
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| EP2797621A4 (en) | 2015-09-02 |
| KR101895047B1 (ko) | 2018-09-06 |
| CN109810198A (zh) | 2019-05-28 |
| JP2015503554A (ja) | 2015-02-02 |
| WO2013100704A1 (en) | 2013-07-04 |
| CN109810198B (zh) | 2023-06-06 |
| ES2725805T3 (es) | 2019-09-27 |
| US9504757B2 (en) | 2016-11-29 |
| EP2797621B1 (en) | 2019-03-06 |
| TW201333032A (zh) | 2013-08-16 |
| US20140377290A1 (en) | 2014-12-25 |
| JP6131490B2 (ja) | 2017-05-24 |
| KR20130078634A (ko) | 2013-07-10 |
| CN104144697A (zh) | 2014-11-12 |
| EP2797621A1 (en) | 2014-11-05 |
| AR089506A1 (es) | 2014-08-27 |
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