TWI659952B - Ｐｌｋ－４抑制劑之鹽和結晶形式 - Google Patents
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- TWI659952B TWI659952B TW103135953A TW103135953A TWI659952B TW I659952 B TWI659952 B TW I659952B TW 103135953 A TW103135953 A TW 103135953A TW 103135953 A TW103135953 A TW 103135953A TW I659952 B TWI659952 B TW I659952B
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| PT2556071T (pt) | 2010-04-06 | 2016-11-22 | Univ Health Network | Inibidores de quinase e seus usos no tratamento de cancro |
| PT3057965T (pt) | 2013-10-18 | 2019-04-23 | Univ Health Network | Formas de sal e cristal de inibidor de plk-4 |
| TWI845482B (zh) | 2017-09-08 | 2024-06-21 | 加拿大健康網路大學 | 用於抑制類polo激酶4之組合療法 |
| BR112021021106A2 (pt) * | 2019-04-24 | 2021-12-14 | Univ Health Network | Forma cristalina s4 do inibidor plk4 fumarato (ir,2s)-(e)-2-(3-(4-((cis-2,6-dimetilmorfolino)metil)estiril)-1h-imidazol-6-il)-5'-metoxiespiro[ciclopropano-1,3'-indolin]-2'ona |
| CN115397429A (zh) * | 2019-12-06 | 2022-11-25 | 大学健康网络 | 急性髓性白血病或骨髓增生异常综合征治疗 |
| IL308346A (en) | 2021-05-11 | 2024-01-01 | Oric Pharmaceuticals Inc | Polo like kinase 4 inhibitors |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481525B2 (en) * | 2009-04-06 | 2013-07-09 | University Of Health Network | Kinase inhibitors and method of treating cancer with same |
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