ES2718603T3 - Sal y formas cristalinas de inhibidor de PLK-4 - Google Patents
Sal y formas cristalinas de inhibidor de PLK-4 Download PDFInfo
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- ES2718603T3 ES2718603T3 ES14854037T ES14854037T ES2718603T3 ES 2718603 T3 ES2718603 T3 ES 2718603T3 ES 14854037 T ES14854037 T ES 14854037T ES 14854037 T ES14854037 T ES 14854037T ES 2718603 T3 ES2718603 T3 ES 2718603T3
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- salt
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- fumarate
- cancer
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201361892564P | 2013-10-18 | 2013-10-18 | |
| PCT/CA2014/051001 WO2015054793A1 (en) | 2013-10-18 | 2014-10-17 | Salt and crystal forms of plk-4 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2718603T3 true ES2718603T3 (es) | 2019-07-03 |
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| PT2556071T (pt) | 2010-04-06 | 2016-11-22 | Univ Health Network | Inibidores de quinase e seus usos no tratamento de cancro |
| PT3057965T (pt) | 2013-10-18 | 2019-04-23 | Univ Health Network | Formas de sal e cristal de inibidor de plk-4 |
| TWI845482B (zh) | 2017-09-08 | 2024-06-21 | 加拿大健康網路大學 | 用於抑制類polo激酶4之組合療法 |
| BR112021021106A2 (pt) * | 2019-04-24 | 2021-12-14 | Univ Health Network | Forma cristalina s4 do inibidor plk4 fumarato (ir,2s)-(e)-2-(3-(4-((cis-2,6-dimetilmorfolino)metil)estiril)-1h-imidazol-6-il)-5'-metoxiespiro[ciclopropano-1,3'-indolin]-2'ona |
| CN115397429A (zh) * | 2019-12-06 | 2022-11-25 | 大学健康网络 | 急性髓性白血病或骨髓增生异常综合征治疗 |
| IL308346A (en) | 2021-05-11 | 2024-01-01 | Oric Pharmaceuticals Inc | Polo like kinase 4 inhibitors |
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| US2483323A (en) * | 1945-08-01 | 1949-09-27 | Kay Fries Chemicals Inc | Method of preparing phenyl ethyl alcohol |
| US7205328B2 (en) | 2002-10-21 | 2007-04-17 | Irm Llc | Oxindoles with anti-HIV activity |
| DE102005005395A1 (de) * | 2005-02-03 | 2006-08-10 | Schering Aktiengesellschaft | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
| GB0606234D0 (en) * | 2006-03-29 | 2006-05-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutically acceptable salts and polymorphic forms |
| US8227640B2 (en) * | 2007-03-23 | 2012-07-24 | Institute Of Bioengineering And Nanotechnology | Palladium catalysts |
| NZ584760A (en) * | 2007-09-25 | 2012-03-30 | Takeda Pharmaceutical | Polo-like kinase inhibitors |
| JP2011506494A (ja) * | 2007-12-21 | 2011-03-03 | ユニバーシティ・ヘルス・ネットワーク | 癌の治療に有用なキナーゼ阻害剤としてのインダゾリル、ベンズイミダゾリル、ベンゾトリアゾリル置換インドルモン誘導体 |
| CA2756568C (en) | 2009-04-06 | 2018-02-13 | University Health Network | Kinase inhibitors and method of treating cancer with same |
| CN102428086B (zh) * | 2009-04-29 | 2014-08-20 | 内尔维阿诺医学科学有限公司 | Cdk抑制剂的盐类 |
| PT2556071T (pt) | 2010-04-06 | 2016-11-22 | Univ Health Network | Inibidores de quinase e seus usos no tratamento de cancro |
| US8933070B2 (en) | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| WO2012048411A1 (en) * | 2010-10-13 | 2012-04-19 | University Health Network | Plk-4 inhibitors and method of treating cancer with same |
| WO2012121764A1 (en) * | 2010-11-25 | 2012-09-13 | Ratiopharm Gmbh | Novel salts and polymorphic forms of afatinib |
| CA2850394C (en) * | 2011-10-12 | 2019-05-21 | University Health Network | Indazole compounds as kinase inhibitors and method of treating cancer with same |
| JP6525983B2 (ja) | 2013-10-18 | 2019-06-05 | ユニバーシティー ヘルス ネットワーク | 膵癌の治療法 |
| PT3057965T (pt) | 2013-10-18 | 2019-04-23 | Univ Health Network | Formas de sal e cristal de inibidor de plk-4 |
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