TWI649098B - （ｓ）-（１-（（４-（３-（５-氯-２-氟-３-（甲基磺醯胺基）苯基-１-異丙基-１ｈ-吡唑-４-基）嘧啶-２-基）胺基）丙-２-基)胺基甲酸甲酯之固體醫藥調配物 - Google Patents
（ｓ）-（１-（（４-（３-（５-氯-２-氟-３-（甲基磺醯胺基）苯基-１-異丙基-１ｈ-吡唑-４-基）嘧啶-２-基）胺基）丙-２-基)胺基甲酸甲酯之固體醫藥調配物 Download PDFInfo
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- TWI649098B TWI649098B TW101143808A TW101143808A TWI649098B TW I649098 B TWI649098 B TW I649098B TW 101143808 A TW101143808 A TW 101143808A TW 101143808 A TW101143808 A TW 101143808A TW I649098 B TWI649098 B TW I649098B
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- Taiwan
- Prior art keywords
- formulation
- amino
- solid oral
- oral pharmaceutical
- phenyl
- Prior art date
Links
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- -1 pyrimidine-2-yl Chemical group 0.000 title claims abstract description 14
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 title claims abstract description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims abstract description 9
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 title claims 5
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Classifications
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| US11007194B2 (en) | 2011-11-11 | 2021-05-18 | Array Biopharma Inc. | Method of treating a proliferative disease |
| WO2013078264A1 (en) | 2011-11-23 | 2013-05-30 | Novartis Ag | Pharmaceutical formulations |
| BR112017025398A2 (pt) | 2015-06-04 | 2018-08-07 | Pfizer Inc. | formas de dosagem sólidas de palbociclib |
| RU2615986C1 (ru) * | 2016-02-25 | 2017-04-12 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | Замещенные метил (2-{ 4-[3-(3-метансульфониламино-2-фтор-5-хлор-фенил)-1Н-пиразол-4-ил]пиримидин-2-иламино} -этил)карбаматы, способ их получения и применения |
| CN109078006B (zh) | 2016-03-29 | 2021-04-20 | 深圳市药欣生物科技有限公司 | 一种帕布昔利布的药物制剂及其制备方法 |
| BR112018074941A2 (pt) | 2016-06-03 | 2019-03-12 | Caponigro Giordano | combinações farmacêuticas |
| CN106000220A (zh) * | 2016-06-30 | 2016-10-12 | 东华大学 | 一种含化学试剂的有机溶剂崩解片的制备方法与应用 |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
| EP4225307A1 (en) | 2020-10-05 | 2023-08-16 | Pierre Fabre Medicament | Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma |
| CN114557977A (zh) * | 2022-02-16 | 2022-05-31 | 北京康立生医药技术开发有限公司 | 一种治疗肠癌的药物的制备方法、制剂及纯度分析方法 |
| TR2022009483A2 (tr) * | 2022-06-08 | 2023-12-21 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Palbosiklib içeren bir farmasötik bileşim. |
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| WO2025262137A1 (en) * | 2024-06-21 | 2025-12-26 | Nanoform Finland Oyj | Formulations comprising crystalline nanosized encorafenib |
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| WO2009050291A2 (en) * | 2007-10-19 | 2009-04-23 | Abbott Gmbh & Co. Kg | Solid dispersion product of n-aryl urea-based drugs |
| US20100311751A1 (en) * | 2009-06-08 | 2010-12-09 | Abbott Laboratories | Solid dispersions containing an apoptosis-promoting agent |
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