TWI644663B - 二丁基羥基甲苯的穩定化方法,及含二丁基羥基甲苯之製品(一) - Google Patents

二丁基羥基甲苯的穩定化方法,及含二丁基羥基甲苯之製品(一) Download PDF

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Publication number
TWI644663B
TWI644663B TW104107429A TW104107429A TWI644663B TW I644663 B TWI644663 B TW I644663B TW 104107429 A TW104107429 A TW 104107429A TW 104107429 A TW104107429 A TW 104107429A TW I644663 B TWI644663 B TW I644663B
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TW
Taiwan
Prior art keywords
dibutylhydroxytoluene
container
liquid agent
aforementioned
liquid
Prior art date
Application number
TW104107429A
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English (en)
Chinese (zh)
Other versions
TW201617056A (zh
Inventor
根本夫規子
中瀨駿佐
Original Assignee
日商千壽製藥股份有限公司
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Publication of TW201617056A publication Critical patent/TW201617056A/zh
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Publication of TWI644663B publication Critical patent/TWI644663B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1412Containers with closing means, e.g. caps
    • A61J1/1418Threaded type

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
TW104107429A 2014-03-10 2015-03-09 二丁基羥基甲苯的穩定化方法,及含二丁基羥基甲苯之製品(一) TWI644663B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014046903 2014-03-10
JP2014-046903 2014-03-10

Publications (2)

Publication Number Publication Date
TW201617056A TW201617056A (zh) 2016-05-16
TWI644663B true TWI644663B (zh) 2018-12-21

Family

ID=54071770

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104107429A TWI644663B (zh) 2014-03-10 2015-03-09 二丁基羥基甲苯的穩定化方法,及含二丁基羥基甲苯之製品(一)

Country Status (5)

Country Link
JP (2) JP6509811B2 (fr)
CN (1) CN106068122B (fr)
RU (1) RU2690490C2 (fr)
TW (1) TWI644663B (fr)
WO (1) WO2015137326A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI644663B (zh) * 2014-03-10 2018-12-21 日商千壽製藥股份有限公司 二丁基羥基甲苯的穩定化方法,及含二丁基羥基甲苯之製品(一)
JPWO2015190483A1 (ja) * 2014-06-10 2017-04-20 ロート製薬株式会社 眼科用水性組成物
JP2017105752A (ja) * 2015-08-31 2017-06-15 ロート製薬株式会社 眼科組成物
JPWO2017043488A1 (ja) * 2015-09-08 2018-06-28 ロート製薬株式会社 眼科組成物
JPWO2019230971A1 (ja) * 2018-05-31 2021-07-08 千寿製薬株式会社 ジブチルヒドロキシトルエンの含量低下が抑制された眼科用液剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006232823A (ja) * 2005-01-26 2006-09-07 Rohto Pharmaceut Co Ltd プラノプロフェン含有組成物
WO2013099861A1 (fr) * 2011-12-27 2013-07-04 千寿製薬株式会社 Préparation contenant du dibutylhydroxytoluène et procédé destiné à la stabilisation du dibutylhydroxytoluène

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69534258T2 (de) * 1994-03-15 2006-05-04 Mitsubishi Pharma Corp. Verfahren zur Stabilisierung von Pranoprofen und stabile flüssige Zubereitung von Pranoprofen
JP4831944B2 (ja) * 2004-04-28 2011-12-07 ロート製薬株式会社 プラノプロフェン含有組成物
JP2007099697A (ja) * 2005-10-05 2007-04-19 Rohto Pharmaceut Co Ltd プラノプロフェン及びクロモグリク酸塩含有点眼剤
JP6009141B2 (ja) * 2009-10-09 2016-10-19 ロート製薬株式会社 水性組成物
CN102085395A (zh) * 2009-12-02 2011-06-08 日本乐敦制药株式会社 硅酮水凝胶隐形眼镜用眼科组合物
WO2013009961A1 (fr) * 2011-07-12 2013-01-17 University Of Houston Conception de nanocapteurs ultra rapides en graphène suspendu qui conviennent pour une production à grande échelle
TWI644663B (zh) * 2014-03-10 2018-12-21 日商千壽製藥股份有限公司 二丁基羥基甲苯的穩定化方法,及含二丁基羥基甲苯之製品(一)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006232823A (ja) * 2005-01-26 2006-09-07 Rohto Pharmaceut Co Ltd プラノプロフェン含有組成物
WO2013099861A1 (fr) * 2011-12-27 2013-07-04 千寿製薬株式会社 Préparation contenant du dibutylhydroxytoluène et procédé destiné à la stabilisation du dibutylhydroxytoluène

Also Published As

Publication number Publication date
WO2015137326A1 (fr) 2015-09-17
JP2019147802A (ja) 2019-09-05
JP6509811B2 (ja) 2019-05-08
RU2016139409A (ru) 2018-04-10
CN106068122A (zh) 2016-11-02
JPWO2015137326A1 (ja) 2017-04-06
CN106068122B (zh) 2019-04-19
JP6800264B2 (ja) 2020-12-16
RU2016139409A3 (fr) 2018-09-26
TW201617056A (zh) 2016-05-16
RU2690490C2 (ru) 2019-06-04

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