TWI639429B - 基於阿拉莫林的藥物療法 - Google Patents

基於阿拉莫林的藥物療法 Download PDF

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Publication number
TWI639429B
TWI639429B TW104128838A TW104128838A TWI639429B TW I639429 B TWI639429 B TW I639429B TW 104128838 A TW104128838 A TW 104128838A TW 104128838 A TW104128838 A TW 104128838A TW I639429 B TWI639429 B TW I639429B
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TW
Taiwan
Prior art keywords
alamorin
patient
patients
item
patent application
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TW104128838A
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English (en)
Chinese (zh)
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TW201613587A (en
Inventor
曼恩威廉
William Mann
佛瑞德約翰
John Friend
呂明啓
Ming Lu
杜斯伊莉莎白
Elizabeth DUUS
波維諾威廉
William Polvino
艾倫蘇珊
Suzan ALLEN
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和欣保健Ｓａ有限公司
Helsinn Healthcare, S. A.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55436476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI639429(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 和欣保健Ｓａ有限公司, Helsinn Healthcare, S. A. filed Critical 和欣保健Ｓａ有限公司
Publication of TW201613587A publication Critical patent/TW201613587A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
TW104128838A 2014-09-04 2015-09-01 基於阿拉莫林的藥物療法 TWI639429B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462045976P 2014-09-04 2014-09-04
US62/045,976 2014-09-04

Publications (2)

Publication Number Publication Date
TW201613587A TW201613587A (en) 2016-04-16
TWI639429B true TWI639429B (zh) 2018-11-01

Family

ID=55436476

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TW104128838A TWI639429B (zh) 2014-09-04 2015-09-01 基於阿拉莫林的藥物療法

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US (5) US9675600B2 (https=)
EP (2) EP3590338A3 (https=)
JP (3) JP6356907B2 (https=)
KR (3) KR102307275B1 (https=)
CN (5) CN113577073A (https=)
AP (1) AP2017009772A0 (https=)
AR (1) AR103118A1 (https=)
AU (1) AU2015312231B2 (https=)
BR (1) BR112017003552A2 (https=)
CA (1) CA2959158A1 (https=)
CL (1) CL2017000494A1 (https=)
CO (1) CO2017003263A2 (https=)
CR (1) CR20170121A (https=)
CY (1) CY1122746T1 (https=)
DK (1) DK3188599T3 (https=)
DO (1) DOP2017000055A (https=)
EA (1) EA035578B1 (https=)
EC (1) ECSP17019893A (https=)
ES (1) ES2761777T3 (https=)
GE (2) GEAP201814459A (https=)
HR (1) HRP20192345T1 (https=)
HU (1) HUE046894T2 (https=)
IL (1) IL250692B (https=)
JO (1) JO3541B1 (https=)
LT (1) LT3188599T (https=)
MA (1) MA40607B1 (https=)
MD (1) MD4710C1 (https=)
ME (1) ME03597B (https=)
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MY (1) MY187167A (https=)
NI (1) NI201700024A (https=)
PE (1) PE20171109A1 (https=)
PH (1) PH12017500392B1 (https=)
PL (1) PL3188599T3 (https=)
PT (1) PT3188599T (https=)
RS (1) RS59751B1 (https=)
SG (1) SG11201701567UA (https=)
SI (1) SI3188599T1 (https=)
SV (1) SV2017005400A (https=)
TN (1) TN2017000040A1 (https=)
TW (1) TWI639429B (https=)
UA (1) UA120765C2 (https=)
UY (1) UY36286A (https=)
WO (1) WO2016036598A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014159609A1 (en) 2013-03-14 2014-10-02 Allergen Research Corporation Peanut formulations and uses thereof
GEAP201814459A (en) 2014-09-04 2018-09-10 Helsinn Healthcare Sa Medical treatments based on anamorelin
US12433945B2 (en) 2018-08-16 2025-10-07 Société des Produits Nestlé S.A. Peanut oral immunotherapy with maintenance dose
US12226448B2 (en) 2018-12-20 2025-02-18 Société des Produits Nestlé S.A. Peanut oral immunotherapy dosing schedule for missed doses
CA3137295A1 (en) 2019-05-10 2020-11-19 Aimmune Therapeutics, Inc. Methods for improving the quality of life of a patient with a peanut allergy
CN115569120A (zh) 2019-08-30 2023-01-06 赫尔森保健股份公司 具有改善稳定性的阿拉莫林片剂的生产方法
KR20220087427A (ko) 2019-10-24 2022-06-24 도레이 카부시키가이샤 악액질의 치료제 또는 예방제
JP2024534464A (ja) * 2021-09-17 2024-09-20 小野薬品工業株式会社 食欲不振／悪液質患者における患者報告アウトカムに関する臨床的に意味のある改善を判定し、提供する方法
WO2025004650A1 (ja) * 2023-06-28 2025-01-02 日清オイリオグループ株式会社 中高年者の疲労感を軽減するための剤及び組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100448A2 (en) * 2007-02-13 2008-08-21 Helsinn Therapeutics (U.S.), Inc. Method of treating cell proliferative disorders using growth hormone secretagogues
US20080300194A1 (en) * 2007-04-10 2008-12-04 Sapphire Therapeutics, Inc. Methods of treating emesis using growth hormone secretagogues

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303620B1 (en) 1998-05-11 2001-10-16 Novo Nordisk A/S Compounds with growth hormone releasing properties
ECSP993020A (es) 1999-06-16 1999-08-12 Terapia de combinacion para la fragilidad musculoesqueletica
ECSP993021A (es) 1999-06-16 1999-08-12 Combinaciones terapeuticas para la fragilidad musculoesqueletica
US20010020012A1 (en) 2000-02-01 2001-09-06 Andersen Maibritt Bansholm Use of compounds for the regulation of food intake
EP1660117A2 (en) 2003-08-06 2006-05-31 Gastrotech Pharma A/S Use of secretagogues like ghrelin in cancer cachexia and for stimulating appetite
CN1863550A (zh) * 2003-08-06 2006-11-15 加斯特罗泰克药物公司 促分泌素样生长素释放肽在癌症恶病质中以及在刺激食欲方面的应用
KR20070010151A (ko) 2004-03-30 2007-01-22 사파이어 세라퓨틱스, 인크. 성장 호르몬 분비촉진제를 이용하여 ｃ-반응성 단백질을감소시키는 방법
US7825138B2 (en) * 2004-06-29 2010-11-02 Helsinn Therapeutics (U.S.), Inc. Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
JO3353B1 (ar) * 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي
KR20150020602A (ko) * 2012-05-25 2015-02-26 라퀄리아 파마 인코포레이티드 무산증 치료를 위한 그렐린 수용체 효능물질
GEAP201814459A (en) 2014-09-04 2018-09-10 Helsinn Healthcare Sa Medical treatments based on anamorelin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100448A2 (en) * 2007-02-13 2008-08-21 Helsinn Therapeutics (U.S.), Inc. Method of treating cell proliferative disorders using growth hormone secretagogues
US20080300194A1 (en) * 2007-04-10 2008-12-04 Sapphire Therapeutics, Inc. Methods of treating emesis using growth hormone secretagogues

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOSE M GARCIA ET AL, "Effects of the ghrelin receptor agonist anamorelin on lean body mass in cancer patients with cachexia; results from a Phase II randomized, double blind, multicenter study", CANCER & METABOLISM, BIOMED CENTRAL LTD, LONDON, UK, (20140528), vol. 2, no. Suppl 1
OSE M GARCIA ET AL, "Effects of the ghrelin receptor agonist anamorelin on lean body mass in cancer patients with cachexia; results from a Phase II randomized, double blind, multicenter study", CANCER & METABOLISM, BIOMED CENTRAL LTD, LONDON, UK, (20140528), vol. 2, no. Suppl 1 *
SUMBUL ALI ET AL, "Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment", CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE, (20131101), vol. 7, no. 4
SUMBUL ALI ET AL, "Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment", CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE, (20131101), vol. 7, no. 4 J *

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ME03597B (me) 2020-07-20
AU2015312231B2 (en) 2017-10-19
US20210093627A1 (en) 2021-04-01
US20160067236A1 (en) 2016-03-10
CN107205389A (zh) 2017-09-26
DOP2017000055A (es) 2017-08-15
SV2017005400A (es) 2017-04-20
EP3188599A4 (en) 2017-10-11
CN113577073A (zh) 2021-11-02
UA120765C2 (uk) 2020-02-10
MD4710C1 (ro) 2021-04-30
TN2017000040A1 (en) 2018-07-04
JP2018154655A (ja) 2018-10-04
JP2017526695A (ja) 2017-09-14
SG11201701567UA (en) 2017-03-30
JP2021080281A (ja) 2021-05-27
JP6356907B2 (ja) 2018-07-11
MY187167A (en) 2021-09-07
CA2959158A1 (en) 2016-03-10
EA035578B1 (ru) 2020-07-09
GEP20186939B (en) 2018-12-25
MX361741B (es) 2018-12-14
PE20171109A1 (es) 2017-08-07
AR103118A1 (es) 2017-04-19
CO2017003263A2 (es) 2017-07-28
MA40607B1 (fr) 2019-11-29
MD20170025A2 (ro) 2017-07-31
NZ729673A (en) 2023-09-29
PL3188599T3 (pl) 2020-06-01
UY36286A (es) 2016-02-29
EP3188599A1 (en) 2017-07-12
KR20210035923A (ko) 2021-04-01
EP3590338A2 (en) 2020-01-08
BR112017003552A2 (pt) 2017-12-05
PH12017500392A1 (en) 2017-07-17
LT3188599T (lt) 2019-12-10
NI201700024A (es) 2017-07-18
KR102234319B1 (ko) 2021-04-01
CN107375285A (zh) 2017-11-24
MX2017002825A (es) 2017-09-28
AP2017009772A0 (en) 2017-02-28
CR20170121A (es) 2017-07-17
ES2761777T3 (es) 2020-05-21
GEAP201814459A (en) 2018-09-10
DK3188599T3 (da) 2019-11-25
EA201790352A1 (ru) 2017-07-31
US20240024303A1 (en) 2024-01-25
CN109172575A (zh) 2019-01-11
RS59751B1 (sr) 2020-02-28
KR20180085047A (ko) 2018-07-25
ECSP17019893A (es) 2017-05-31
KR102307275B1 (ko) 2021-09-30
US10278964B2 (en) 2019-05-07
EP3590338A3 (en) 2020-03-18
KR101881264B1 (ko) 2018-07-23
IL250692B (en) 2019-05-30
JP7044918B2 (ja) 2022-03-30
US9675600B2 (en) 2017-06-13
PT3188599T (pt) 2020-01-15
JO3541B1 (ar) 2020-07-05
PH12017500392B1 (en) 2018-08-31
US10894041B2 (en) 2021-01-19
EP3188599B1 (en) 2019-10-02
JP6923486B2 (ja) 2021-08-18
WO2016036598A1 (en) 2016-03-10
CL2017000494A1 (es) 2017-09-15
US11723902B2 (en) 2023-08-15
CY1122746T1 (el) 2021-03-12
CN113577074A (zh) 2021-11-02
HRP20192345T1 (hr) 2020-03-20
IL250692A0 (en) 2017-04-30
MD4710B1 (ro) 2020-09-30
KR20170047372A (ko) 2017-05-04
US20170296526A1 (en) 2017-10-19
HUE046894T2 (hu) 2020-04-28
TW201613587A (en) 2016-04-16
AU2015312231A1 (en) 2017-03-23
US20190175574A1 (en) 2019-06-13
SI3188599T1 (sl) 2020-02-28

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