TWI623528B - 金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途 - Google Patents

金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途 Download PDF

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Publication number
TWI623528B
TWI623528B TW105144241A TW105144241A TWI623528B TW I623528 B TWI623528 B TW I623528B TW 105144241 A TW105144241 A TW 105144241A TW 105144241 A TW105144241 A TW 105144241A TW I623528 B TWI623528 B TW I623528B
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TW
Taiwan
Prior art keywords
phenyl
pyridin
difluoro
piperazin
hydroxy
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TW105144241A
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English (en)
Chinese (zh)
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TW201734000A (zh
Inventor
克里斯多夫Ｍ 耶茨
聖米Ｒ 雪佛
威廉Ｊ 荷科斯特
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維愛美製藥公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
TW105144241A 2015-12-30 2016-12-30 金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途 TWI623528B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562273167P 2015-12-30 2015-12-30
US62/273,167 2015-12-30

Publications (2)

Publication Number Publication Date
TW201734000A TW201734000A (zh) 2017-10-01
TWI623528B true TWI623528B (zh) 2018-05-11

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TW105144241A TWI623528B (zh) 2015-12-30 2016-12-30 金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途

Country Status (12)

Country Link
US (1) US10464922B2 (https=)
EP (1) EP3397629B1 (https=)
JP (1) JP6803923B2 (https=)
KR (1) KR102240920B1 (https=)
CN (1) CN108779094B (https=)
AU (1) AU2016380349B2 (https=)
BR (1) BR112018013522A2 (https=)
CA (1) CA3006469C (https=)
EA (1) EA038421B1 (https=)
MX (1) MX376201B (https=)
TW (1) TWI623528B (https=)
WO (1) WO2017117393A1 (https=)

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JP6606508B2 (ja) 2014-03-19 2019-11-13 マイコヴィア ファーマシューティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
KR102441243B1 (ko) 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-디플루오르페닐)-1,1-디플루오르-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법
CN109970629B (zh) 2014-03-19 2023-04-11 迈科维亚医药公司 抗真菌化合物的制备方法
AU2015231275B2 (en) 2014-03-19 2019-03-07 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP2017509646A (ja) 2014-03-19 2017-04-06 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
AU2015231216B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CN108289457B (zh) 2015-09-18 2021-08-06 迈科维亚医药公司 抗真菌化合物制备方法
WO2019182743A1 (en) * 2018-03-20 2019-09-26 Innocrin Pharmaceuticals, Inc. Compositions for the treatment of brain tumors
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CN113444131B (zh) * 2021-06-24 2022-10-21 鲁东大学 N-乙酰氨基葡萄糖类化合物及其制备方法和应用
US20250270193A1 (en) * 2021-10-20 2025-08-28 Ohio State Innovation Foundation Arylimidamides for use in treatment of cancers
CN115466227B (zh) * 2022-06-30 2024-07-19 杭州国瑞生物科技有限公司 一种3-(氯甲基)-1-甲基-1h-1,2,4-三唑盐酸盐的制备方法

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Also Published As

Publication number Publication date
CA3006469C (en) 2023-01-10
EP3397629B1 (en) 2023-04-19
TW201734000A (zh) 2017-10-01
MX2018008105A (es) 2018-11-12
CN108779094B (zh) 2021-11-16
JP6803923B2 (ja) 2020-12-23
EA201891539A1 (ru) 2018-12-28
BR112018013522A2 (pt) 2018-12-11
KR20180099845A (ko) 2018-09-05
AU2016380349A1 (en) 2018-06-14
EP3397629A4 (en) 2019-06-05
MX376201B (es) 2025-03-07
CN108779094A (zh) 2018-11-09
JP2019502755A (ja) 2019-01-31
US20190016700A1 (en) 2019-01-17
WO2017117393A1 (en) 2017-07-06
EP3397629A1 (en) 2018-11-07
US10464922B2 (en) 2019-11-05
AU2016380349B2 (en) 2020-10-29
KR102240920B1 (ko) 2021-04-16
CA3006469A1 (en) 2017-07-06
EA038421B1 (ru) 2021-08-26

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