TWI613193B - 包含磺醯亞胺基團之5-氟-n-(吡啶-2-基)吡啶-2-胺衍生物 - Google Patents

包含磺醯亞胺基團之5-氟-n-(吡啶-2-基)吡啶-2-胺衍生物 Download PDF

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Publication number
TWI613193B
TWI613193B TW102141761A TW102141761A TWI613193B TW I613193 B TWI613193 B TW I613193B TW 102141761 A TW102141761 A TW 102141761A TW 102141761 A TW102141761 A TW 102141761A TW I613193 B TWI613193 B TW I613193B
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Taiwan
Prior art keywords
fluoro
group
methyl
pyridin
formula
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TW102141761A
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English (en)
Chinese (zh)
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TW201420569A (zh
Inventor
尤利奇 盧津
尼爾斯 波恩克
阿恩 舒爾茨
飛利浦 里恩那
傑爾哈德 希梅斯特
沃夫 波默
德克 科斯蒙德
羅夫 鮑爾曼
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拜耳製藥公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW102141761A 2012-11-15 2013-11-15 包含磺醯亞胺基團之5-氟-n-(吡啶-2-基)吡啶-2-胺衍生物 TWI613193B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12192852 2012-11-15
??12192852.7 2012-11-15

Publications (2)

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TW201420569A TW201420569A (zh) 2014-06-01
TWI613193B true TWI613193B (zh) 2018-02-01

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WO2022078309A1 (zh) * 2020-10-12 2022-04-21 上海海雁医药科技有限公司 取代的二(吡啶-2-基)胺衍生物、其组合物及医药上的用途
WO2023179597A1 (zh) * 2022-03-25 2023-09-28 成都苑东生物制药股份有限公司 一种氨基吡啶类衍生物、其制备方法及用途
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CN105102444B (zh) 2017-08-01
BR112015010707A8 (pt) 2019-10-01
EA027226B1 (ru) 2017-07-31
NZ707084A (en) 2019-09-27
UY35141A (es) 2014-06-30
JO3332B1 (ar) 2019-03-13
ME02880B (me) 2018-04-20
AU2013346939B2 (en) 2017-06-08
CR20150256A (es) 2015-07-01
ECSP15019323A (es) 2016-01-29
DK2928878T3 (en) 2016-12-19
PE20151071A1 (es) 2015-08-19
AU2013346939A1 (en) 2015-05-14
TW201420569A (zh) 2014-06-01
IL238322A (en) 2017-08-31
US9877954B2 (en) 2018-01-30
BR112015010707A2 (pt) 2017-07-11
DOP2015000118A (es) 2015-06-15
SV2015004979A (es) 2017-01-30
SI2928878T1 (sl) 2016-12-30
JP2015537015A (ja) 2015-12-24
BR112015010707B1 (pt) 2022-05-17
KR102242871B1 (ko) 2021-04-20
MY170609A (en) 2019-08-20
CL2015001304A1 (es) 2015-07-17
MA38090B1 (fr) 2018-09-28
SG11201503079PA (en) 2015-06-29
RS55580B1 (sr) 2017-06-30
CA2891358A1 (en) 2014-05-22
PT2928878T (pt) 2017-02-08
PH12015501003B1 (en) 2017-10-20
AP3872A (en) 2016-10-31
CA2891358C (en) 2021-05-18
WO2014076091A1 (en) 2014-05-22
AP2015008432A0 (en) 2015-05-31
UA115254C2 (uk) 2017-10-10
CN105102444A (zh) 2015-11-25
CY1118441T1 (el) 2017-06-28
PL2928878T3 (pl) 2017-04-28
LT2928878T (lt) 2016-11-25
US20150291528A1 (en) 2015-10-15
AR093505A1 (es) 2015-06-10
HK1213255A1 (zh) 2016-06-30
HRP20161547T1 (hr) 2016-12-30
EP2928878A1 (en) 2015-10-14
MA38090A1 (fr) 2018-02-28
TN2015000185A1 (en) 2016-10-03
EP2928878B1 (en) 2016-11-02
IL238322A0 (en) 2015-06-30
PH12015501003A1 (en) 2015-07-27
KR20150084968A (ko) 2015-07-22
US20170202815A1 (en) 2017-07-20
EA201590890A1 (ru) 2015-11-30
ES2612978T3 (es) 2017-05-19
US9650340B2 (en) 2017-05-16
MX374333B (es) 2025-03-06
MX2015006169A (es) 2015-08-10
HUE032868T2 (en) 2017-11-28
CU20150052A7 (es) 2015-09-29
JP6263193B2 (ja) 2018-01-17

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