TWI606094B - 含有所需水含量及透氧性之聚矽氧水凝膠 - Google Patents
含有所需水含量及透氧性之聚矽氧水凝膠 Download PDFInfo
- Publication number
- TWI606094B TWI606094B TW101149233A TW101149233A TWI606094B TW I606094 B TWI606094 B TW I606094B TW 101149233 A TW101149233 A TW 101149233A TW 101149233 A TW101149233 A TW 101149233A TW I606094 B TWI606094 B TW I606094B
- Authority
- TW
- Taiwan
- Prior art keywords
- group
- methyl
- meth
- monomer
- slow
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 45
- 229910052760 oxygen Inorganic materials 0.000 title claims description 38
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims description 30
- 239000000017 hydrogel Substances 0.000 title claims description 30
- 239000001301 oxygen Substances 0.000 title claims description 30
- 230000035699 permeability Effects 0.000 title claims description 18
- 229920001296 polysiloxane Polymers 0.000 title description 2
- 239000000178 monomer Substances 0.000 claims description 112
- 239000000203 mixture Substances 0.000 claims description 86
- -1 3-methacryloxypropyl Chemical group 0.000 claims description 79
- 239000011541 reaction mixture Substances 0.000 claims description 57
- 239000003085 diluting agent Substances 0.000 claims description 56
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 36
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 31
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 31
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 31
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 27
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 24
- 238000006243 chemical reaction Methods 0.000 claims description 21
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 20
- 239000003431 cross linking reagent Substances 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 11
- 229920001223 polyethylene glycol Polymers 0.000 claims description 11
- 239000004971 Cross linker Substances 0.000 claims description 9
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 9
- 239000007983 Tris buffer Substances 0.000 claims description 9
- 229920006324 polyoxymethylene Polymers 0.000 claims description 9
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims description 6
- 101150065749 Churc1 gene Proteins 0.000 claims description 6
- 239000005977 Ethylene Substances 0.000 claims description 6
- 102100038239 Protein Churchill Human genes 0.000 claims description 6
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 claims description 6
- 125000000524 functional group Chemical group 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- AFXKUUDFKHVAGI-UHFFFAOYSA-N 1-methyl-3-methylidenepyrrolidin-2-one Chemical compound CN1CCC(=C)C1=O AFXKUUDFKHVAGI-UHFFFAOYSA-N 0.000 claims description 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 4
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 claims description 4
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims description 4
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- ZZDBHIVVDUTWJC-UHFFFAOYSA-N 1-methyl-5-methylidenepyrrolidin-2-one Chemical compound CN1C(=C)CCC1=O ZZDBHIVVDUTWJC-UHFFFAOYSA-N 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000001033 ether group Chemical group 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 3
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 3
- RBACIKXCRWGCBB-UHFFFAOYSA-N 1,2-Epoxybutane Chemical compound CCC1CO1 RBACIKXCRWGCBB-UHFFFAOYSA-N 0.000 claims description 2
- PBGPBHYPCGDFEZ-UHFFFAOYSA-N 1-ethenylpiperidin-2-one Chemical compound C=CN1CCCCC1=O PBGPBHYPCGDFEZ-UHFFFAOYSA-N 0.000 claims description 2
- ACOUENYDWAONBH-UHFFFAOYSA-N 3-methylidene-1-propan-2-ylpyrrolidin-2-one Chemical compound CC(C)N1CCC(=C)C1=O ACOUENYDWAONBH-UHFFFAOYSA-N 0.000 claims description 2
- XVUWMCJNMDQXKX-UHFFFAOYSA-N 5-ethyl-3-methylidenepyrrolidin-2-one Chemical compound CCC1CC(=C)C(=O)N1 XVUWMCJNMDQXKX-UHFFFAOYSA-N 0.000 claims description 2
- VDORPYPVQAFLTR-UHFFFAOYSA-N 5-methyl-3-methylidenepyrrolidin-2-one Chemical compound CC1CC(=C)C(=O)N1 VDORPYPVQAFLTR-UHFFFAOYSA-N 0.000 claims description 2
- YNQNQJPLBDEVRW-UHFFFAOYSA-N 5-methylidene-1-propan-2-ylpyrrolidin-2-one Chemical compound CC(C)N1C(=C)CCC1=O YNQNQJPLBDEVRW-UHFFFAOYSA-N 0.000 claims description 2
- RRUNPGIXAGEPSW-UHFFFAOYSA-N 5-methylidene-1-propylpyrrolidin-2-one Chemical compound CCCN1C(=C)CCC1=O RRUNPGIXAGEPSW-UHFFFAOYSA-N 0.000 claims description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 4
- 241000208340 Araliaceae Species 0.000 claims 3
- KDWQGVIRHOTQHB-UHFFFAOYSA-N CC(CCCCCCCCCOCCCCCCCCCC)(C)C Chemical compound CC(CCCCCCCCCOCCCCCCCCCC)(C)C KDWQGVIRHOTQHB-UHFFFAOYSA-N 0.000 claims 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 3
- 235000008434 ginseng Nutrition 0.000 claims 3
- MRIKSZXJKCQQFT-UHFFFAOYSA-N (3-hydroxy-2,2-dimethylpropyl) prop-2-enoate Chemical compound OCC(C)(C)COC(=O)C=C MRIKSZXJKCQQFT-UHFFFAOYSA-N 0.000 claims 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- CXNYYQBHNJHBNH-UHFFFAOYSA-N 1-ethyl-5-methylidenepyrrolidin-2-one Chemical compound CCN1C(=C)CCC1=O CXNYYQBHNJHBNH-UHFFFAOYSA-N 0.000 claims 1
- JNSHJDXBICHABV-UHFFFAOYSA-N 11-oxatetracyclo[7.5.0.02,7.010,12]tetradeca-1(9),2,4,6,13-pentaene Chemical compound C12C(C=CC=3C4=CC=CC=C4CC13)O2 JNSHJDXBICHABV-UHFFFAOYSA-N 0.000 claims 1
- UJTICEIMISHYHJ-UHFFFAOYSA-N 3-(2-carboxyethenylamino)propanoic acid Chemical compound OC(=O)CCNC=CC(O)=O UJTICEIMISHYHJ-UHFFFAOYSA-N 0.000 claims 1
- SXIFAEWFOJETOA-UHFFFAOYSA-N 4-hydroxy-butyl Chemical group [CH2]CCCO SXIFAEWFOJETOA-UHFFFAOYSA-N 0.000 claims 1
- 229910052684 Cerium Inorganic materials 0.000 claims 1
- NSMPFGWDOGVQDR-UHFFFAOYSA-N N-carboxy-beta-alanine Chemical compound OC(=O)CCNC(O)=O NSMPFGWDOGVQDR-UHFFFAOYSA-N 0.000 claims 1
- NGPHCCBDMPHGMX-UHFFFAOYSA-N N1C(=CC2=CC=CC=C12)N.C=CC Chemical compound N1C(=CC2=CC=CC=C12)N.C=CC NGPHCCBDMPHGMX-UHFFFAOYSA-N 0.000 claims 1
- 241000947853 Vibrionales Species 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- GWXLDORMOJMVQZ-UHFFFAOYSA-N cerium Chemical compound [Ce] GWXLDORMOJMVQZ-UHFFFAOYSA-N 0.000 claims 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 1
- JJVJPJWQXDQCEI-UHFFFAOYSA-N ethenylhydrazine Chemical compound NNC=C JJVJPJWQXDQCEI-UHFFFAOYSA-N 0.000 claims 1
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims 1
- 229920001281 polyalkylene Polymers 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229920001567 vinyl ester resin Polymers 0.000 claims 1
- 239000000243 solution Substances 0.000 description 51
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 22
- 239000002953 phosphate buffered saline Substances 0.000 description 22
- 239000000523 sample Substances 0.000 description 22
- 229920000642 polymer Polymers 0.000 description 21
- 239000007864 aqueous solution Substances 0.000 description 19
- 102100026735 Coagulation factor VIII Human genes 0.000 description 18
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 17
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical group CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- 102000016943 Muramidase Human genes 0.000 description 14
- 108010014251 Muramidase Proteins 0.000 description 14
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 14
- 239000004325 lysozyme Substances 0.000 description 14
- 235000010335 lysozyme Nutrition 0.000 description 14
- 229960000274 lysozyme Drugs 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 229920002675 Polyoxyl Polymers 0.000 description 11
- 238000009472 formulation Methods 0.000 description 11
- 230000003287 optical effect Effects 0.000 description 11
- 102000007592 Apolipoproteins Human genes 0.000 description 10
- 108010071619 Apolipoproteins Proteins 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- FRDAATYAJDYRNW-UHFFFAOYSA-N 3-methyl-3-pentanol Chemical compound CCC(C)(O)CC FRDAATYAJDYRNW-UHFFFAOYSA-N 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000001723 curing Methods 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 238000004806 packaging method and process Methods 0.000 description 8
- 238000006116 polymerization reaction Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 238000002791 soaking Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- VUIWJRYTWUGOOF-UHFFFAOYSA-N 2-ethenoxyethanol Chemical compound OCCOC=C VUIWJRYTWUGOOF-UHFFFAOYSA-N 0.000 description 6
- IEVADDDOVGMCSI-UHFFFAOYSA-N 2-hydroxybutyl 2-methylprop-2-enoate Chemical compound CCC(O)COC(=O)C(C)=C IEVADDDOVGMCSI-UHFFFAOYSA-N 0.000 description 6
- DLHQZZUEERVIGQ-UHFFFAOYSA-N 3,7-dimethyl-3-octanol Chemical compound CCC(C)(O)CCCC(C)C DLHQZZUEERVIGQ-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000003618 borate buffered saline Substances 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000003480 eluent Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- UUORTJUPDJJXST-UHFFFAOYSA-N n-(2-hydroxyethyl)prop-2-enamide Chemical compound OCCNC(=O)C=C UUORTJUPDJJXST-UHFFFAOYSA-N 0.000 description 6
- 229920005862 polyol Polymers 0.000 description 6
- 150000003077 polyols Chemical class 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 150000003333 secondary alcohols Chemical class 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- 150000003509 tertiary alcohols Chemical class 0.000 description 6
- 229920001169 thermoplastic Polymers 0.000 description 6
- 229920002554 vinyl polymer Polymers 0.000 description 6
- 239000004743 Polypropylene Substances 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 238000004364 calculation method Methods 0.000 description 5
- 235000019439 ethyl acetate Nutrition 0.000 description 5
- 229920002098 polyfluorene Polymers 0.000 description 5
- 229920001155 polypropylene Polymers 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- BJELTSYBAHKXRW-UHFFFAOYSA-N 2,4,6-triallyloxy-1,3,5-triazine Chemical compound C=CCOC1=NC(OCC=C)=NC(OCC=C)=N1 BJELTSYBAHKXRW-UHFFFAOYSA-N 0.000 description 4
- NGDNVOAEIVQRFH-UHFFFAOYSA-N 2-nonanol Chemical compound CCCCCCCC(C)O NGDNVOAEIVQRFH-UHFFFAOYSA-N 0.000 description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
- 238000000889 atomisation Methods 0.000 description 4
- 150000001735 carboxylic acids Chemical class 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 4
- 238000007872 degassing Methods 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical group CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 4
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 4
- ZOCHHNOQQHDWHG-UHFFFAOYSA-N hexan-3-ol Chemical compound CCCC(O)CC ZOCHHNOQQHDWHG-UHFFFAOYSA-N 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 239000003999 initiator Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 3
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 3
- 239000006096 absorbing agent Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- AFYNADDZULBEJA-UHFFFAOYSA-N bicinchoninic acid Chemical compound C1=CC=CC2=NC(C=3C=C(C4=CC=CC=C4N=3)C(=O)O)=CC(C(O)=O)=C21 AFYNADDZULBEJA-UHFFFAOYSA-N 0.000 description 3
- 238000005266 casting Methods 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- CDMADVZSLOHIFP-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane;decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 CDMADVZSLOHIFP-UHFFFAOYSA-N 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 238000000424 optical density measurement Methods 0.000 description 3
- JYVLIDXNZAXMDK-UHFFFAOYSA-N pentan-2-ol Chemical compound CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 description 3
- 229920000768 polyamine Polymers 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- ONMLAAZEQUPQSE-UHFFFAOYSA-N (3-hydroxy-2,2-dimethylpropyl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C)(C)CO ONMLAAZEQUPQSE-UHFFFAOYSA-N 0.000 description 2
- VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- LPCWIFPJLFCXRS-UHFFFAOYSA-N 1-ethylcyclopentan-1-ol Chemical compound CCC1(O)CCCC1 LPCWIFPJLFCXRS-UHFFFAOYSA-N 0.000 description 2
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 2
- IKECULIHBUCAKR-UHFFFAOYSA-N 2,3-dimethylbutan-2-ol Chemical compound CC(C)C(C)(C)O IKECULIHBUCAKR-UHFFFAOYSA-N 0.000 description 2
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
- WULAHPYSGCVQHM-UHFFFAOYSA-N 2-(2-ethenoxyethoxy)ethanol Chemical compound OCCOCCOC=C WULAHPYSGCVQHM-UHFFFAOYSA-N 0.000 description 2
- CETWDUZRCINIHU-UHFFFAOYSA-N 2-heptanol Chemical compound CCCCCC(C)O CETWDUZRCINIHU-UHFFFAOYSA-N 0.000 description 2
- RIWRBSMFKVOJMN-UHFFFAOYSA-N 2-methyl-1-phenylpropan-2-ol Chemical compound CC(C)(O)CC1=CC=CC=C1 RIWRBSMFKVOJMN-UHFFFAOYSA-N 0.000 description 2
- WFRBDWRZVBPBDO-UHFFFAOYSA-N 2-methyl-2-pentanol Chemical group CCCC(C)(C)O WFRBDWRZVBPBDO-UHFFFAOYSA-N 0.000 description 2
- XKIRHOWVQWCYBT-UHFFFAOYSA-N 3-ethylpentan-3-ol Chemical compound CCC(O)(CC)CC XKIRHOWVQWCYBT-UHFFFAOYSA-N 0.000 description 2
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical compound CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 description 2
- PQOSNJHBSNZITJ-UHFFFAOYSA-N 3-methyl-3-heptanol Chemical compound CCCCC(C)(O)CC PQOSNJHBSNZITJ-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- AFYJIPGNQDXCDQ-UHFFFAOYSA-N C(C)CCCCCCCCNC=C Chemical compound C(C)CCCCCCCCNC=C AFYJIPGNQDXCDQ-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 241001274216 Naso Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 2
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 description 2
- CGQCWMIAEPEHNQ-UHFFFAOYSA-N Vanillylmandelic acid Chemical compound COC1=CC(C(O)C(O)=O)=CC=C1O CGQCWMIAEPEHNQ-UHFFFAOYSA-N 0.000 description 2
- 150000003926 acrylamides Chemical class 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- 229940000635 beta-alanine Drugs 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- PEEKVIHQOHJITP-UHFFFAOYSA-N boric acid;propane-1,2,3-triol Chemical compound OB(O)O.OCC(O)CO PEEKVIHQOHJITP-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- FXPHJTKVWZVEGA-UHFFFAOYSA-N ethenyl hydrogen carbonate Chemical compound OC(=O)OC=C FXPHJTKVWZVEGA-UHFFFAOYSA-N 0.000 description 2
- 150000002170 ethers Chemical group 0.000 description 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 2
- 229940116333 ethyl lactate Drugs 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- QNVRIHYSUZMSGM-UHFFFAOYSA-N hexan-2-ol Chemical compound CCCCC(C)O QNVRIHYSUZMSGM-UHFFFAOYSA-N 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 2
- SJWFXCIHNDVPSH-UHFFFAOYSA-N octan-2-ol Chemical compound CCCCCCC(C)O SJWFXCIHNDVPSH-UHFFFAOYSA-N 0.000 description 2
- NMRPBPVERJPACX-UHFFFAOYSA-N octan-3-ol Chemical compound CCCCCC(O)CC NMRPBPVERJPACX-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 150000002923 oximes Chemical class 0.000 description 2
- AQIXEPGDORPWBJ-UHFFFAOYSA-N pentan-3-ol Chemical compound CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920001515 polyalkylene glycol Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- NLAIHECABDOZBR-UHFFFAOYSA-M sodium 2,2-bis(2-methylprop-2-enoyloxymethyl)butyl 2-methylprop-2-enoate 2-hydroxyethyl 2-methylprop-2-enoate 2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O.CC(=C)C(=O)OCCO.CCC(COC(=O)C(C)=C)(COC(=O)C(C)=C)COC(=O)C(C)=C NLAIHECABDOZBR-UHFFFAOYSA-M 0.000 description 2
- 125000005504 styryl group Chemical group 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- ZQTYQMYDIHMKQB-RRKCRQDMSA-N (1s,3r,4r)-bicyclo[2.2.1]heptan-3-ol Chemical compound C1C[C@H]2[C@H](O)C[C@@H]1C2 ZQTYQMYDIHMKQB-RRKCRQDMSA-N 0.000 description 1
- PNWODCMQYWCKBF-UHFFFAOYSA-N (2-hydroxy-2-methylpropyl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C)(C)O PNWODCMQYWCKBF-UHFFFAOYSA-N 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- DPZNOMCNRMUKPS-UHFFFAOYSA-N 1,3-Dimethoxybenzene Chemical compound COC1=CC=CC(OC)=C1 DPZNOMCNRMUKPS-UHFFFAOYSA-N 0.000 description 1
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 description 1
- OTIXUSNHAKOJBX-UHFFFAOYSA-N 1-(aziridin-1-yl)ethanone Chemical compound CC(=O)N1CC1 OTIXUSNHAKOJBX-UHFFFAOYSA-N 0.000 description 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- VTBOTOBFGSVRMA-UHFFFAOYSA-N 1-Methylcyclohexanol Chemical compound CC1(O)CCCCC1 VTBOTOBFGSVRMA-UHFFFAOYSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 description 1
- JNOZGFXJZQXOSU-UHFFFAOYSA-N 1-chloro-2-methylpropan-2-ol Chemical compound CC(C)(O)CCl JNOZGFXJZQXOSU-UHFFFAOYSA-N 0.000 description 1
- XOQRLXHLTSYZBF-UHFFFAOYSA-N 1-decylphosphonoyldecane Chemical compound CCCCCCCCCCP(=O)CCCCCCCCCC XOQRLXHLTSYZBF-UHFFFAOYSA-N 0.000 description 1
- LLLWMXQKXWIRDZ-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one Chemical compound C=CN1CCCC1=O.C=CN1CCCC1=O LLLWMXQKXWIRDZ-UHFFFAOYSA-N 0.000 description 1
- JOLQKTGDSGKSKJ-UHFFFAOYSA-N 1-ethoxypropan-2-ol Chemical compound CCOCC(C)O JOLQKTGDSGKSKJ-UHFFFAOYSA-N 0.000 description 1
- 239000012956 1-hydroxycyclohexylphenyl-ketone Substances 0.000 description 1
- ZMARGGQEAJXRFP-UHFFFAOYSA-N 1-hydroxypropan-2-yl 2-methylprop-2-enoate Chemical compound OCC(C)OC(=O)C(C)=C ZMARGGQEAJXRFP-UHFFFAOYSA-N 0.000 description 1
- CAKWRXVKWGUISE-UHFFFAOYSA-N 1-methylcyclopentan-1-ol Chemical compound CC1(O)CCCC1 CAKWRXVKWGUISE-UHFFFAOYSA-N 0.000 description 1
- QIGOESOMEANKQI-UHFFFAOYSA-N 1-methylcyclopentane-1,3-diol Chemical compound CC1(O)CCC(O)C1 QIGOESOMEANKQI-UHFFFAOYSA-N 0.000 description 1
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical class C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 description 1
- GELKGHVAFRCJNA-UHFFFAOYSA-N 2,2-Dimethyloxirane Chemical group CC1(C)CO1 GELKGHVAFRCJNA-UHFFFAOYSA-N 0.000 description 1
- PLSMHHUFDLYURK-UHFFFAOYSA-N 2,3,4-trimethyl-3-pentanol Chemical compound CC(C)C(C)(O)C(C)C PLSMHHUFDLYURK-UHFFFAOYSA-N 0.000 description 1
- NEBBLNDVSSWJLL-UHFFFAOYSA-N 2,3-bis(2-methylprop-2-enoyloxy)propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(OC(=O)C(C)=C)COC(=O)C(C)=C NEBBLNDVSSWJLL-UHFFFAOYSA-N 0.000 description 1
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 description 1
- FMLSQAUAAGVTJO-UHFFFAOYSA-N 2,4-dimethylpentan-2-ol Chemical compound CC(C)CC(C)(C)O FMLSQAUAAGVTJO-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- CUDYYMUUJHLCGZ-UHFFFAOYSA-N 2-(2-methoxypropoxy)propan-1-ol Chemical group COC(C)COC(C)CO CUDYYMUUJHLCGZ-UHFFFAOYSA-N 0.000 description 1
- FJGQBLRYBUAASW-UHFFFAOYSA-N 2-(benzotriazol-2-yl)phenol Chemical compound OC1=CC=CC=C1N1N=C2C=CC=CC2=N1 FJGQBLRYBUAASW-UHFFFAOYSA-N 0.000 description 1
- LESMLVDJJCWZAJ-UHFFFAOYSA-N 2-(diphenylphosphorylmethyl)-1,3,5-trimethylbenzene Chemical compound CC1=CC(C)=CC(C)=C1CP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 LESMLVDJJCWZAJ-UHFFFAOYSA-N 0.000 description 1
- HTTGVORJOBRXRJ-UHFFFAOYSA-N 2-(triazin-4-yl)phenol Chemical compound OC1=CC=CC=C1C1=CC=NN=N1 HTTGVORJOBRXRJ-UHFFFAOYSA-N 0.000 description 1
- QNVRIHYSUZMSGM-LURJTMIESA-N 2-Hexanol Natural products CCCC[C@H](C)O QNVRIHYSUZMSGM-LURJTMIESA-N 0.000 description 1
- GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 description 1
- WAEVWDZKMBQDEJ-UHFFFAOYSA-N 2-[2-(2-methoxypropoxy)propoxy]propan-1-ol Chemical group COC(C)COC(C)COC(C)CO WAEVWDZKMBQDEJ-UHFFFAOYSA-N 0.000 description 1
- LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 description 1
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical compound CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- BQZJOQXSCSZQPS-UHFFFAOYSA-N 2-methoxy-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(OC)C(=O)C1=CC=CC=C1 BQZJOQXSCSZQPS-UHFFFAOYSA-N 0.000 description 1
- ACBMYYVZWKYLIP-UHFFFAOYSA-N 2-methylheptan-2-ol Chemical compound CCCCCC(C)(C)O ACBMYYVZWKYLIP-UHFFFAOYSA-N 0.000 description 1
- KRIMXCDMVRMCTC-UHFFFAOYSA-N 2-methylhexan-2-ol Chemical compound CCCCC(C)(C)O KRIMXCDMVRMCTC-UHFFFAOYSA-N 0.000 description 1
- VREDNSVJXRJXRI-UHFFFAOYSA-N 2-methylnonan-2-ol Chemical compound CCCCCCCC(C)(C)O VREDNSVJXRJXRI-UHFFFAOYSA-N 0.000 description 1
- KBCNUEXDHWDIFX-UHFFFAOYSA-N 2-methyloctan-2-ol Chemical compound CCCCCCC(C)(C)O KBCNUEXDHWDIFX-UHFFFAOYSA-N 0.000 description 1
- XGLHYBVJPSZXIF-UHFFFAOYSA-N 2-phenylbutan-2-ol Chemical compound CCC(C)(O)C1=CC=CC=C1 XGLHYBVJPSZXIF-UHFFFAOYSA-N 0.000 description 1
- BDCFWIDZNLCTMF-UHFFFAOYSA-N 2-phenylpropan-2-ol Chemical compound CC(C)(O)C1=CC=CC=C1 BDCFWIDZNLCTMF-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- UURVHRGPGCBHIC-UHFFFAOYSA-N 3-(ethenoxycarbonylamino)propanoic acid 4-[[[[[[[[[[[[[[[[[[[[[[[[[[[4-ethenoxycarbonyloxybutyl(dimethyl)silyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]butyl ethenyl carbonate 1-ethenylpyrrolidin-2-one ethenyl N-[3-tris(trimethylsilyloxy)silylpropyl]carbamate Chemical compound C=CN1CCCC1=O.OC(=O)CCNC(=O)OC=C.C[Si](C)(C)O[Si](CCCNC(=O)OC=C)(O[Si](C)(C)C)O[Si](C)(C)C.C[Si](C)(CCCCOC(=O)OC=C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CCCCOC(=O)OC=C UURVHRGPGCBHIC-UHFFFAOYSA-N 0.000 description 1
- NMRPBPVERJPACX-QMMMGPOBSA-N 3-Octanol Natural products CCCCC[C@@H](O)CC NMRPBPVERJPACX-QMMMGPOBSA-N 0.000 description 1
- HNVRRHSXBLFLIG-UHFFFAOYSA-N 3-hydroxy-3-methylbut-1-ene Chemical compound CC(C)(O)C=C HNVRRHSXBLFLIG-UHFFFAOYSA-N 0.000 description 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
- JEWXYDDSLPIBBO-UHFFFAOYSA-N 3-methyl-3-octanol Chemical compound CCCCCC(C)(O)CC JEWXYDDSLPIBBO-UHFFFAOYSA-N 0.000 description 1
- KYWJZCSJMOILIZ-UHFFFAOYSA-N 3-methylhexan-3-ol Chemical compound CCCC(C)(O)CC KYWJZCSJMOILIZ-UHFFFAOYSA-N 0.000 description 1
- XVGZUJYMDCFKIZ-UHFFFAOYSA-N 3-methylidene-1-propylpyrrolidin-2-one Chemical compound CCCN1CCC(=C)C1=O XVGZUJYMDCFKIZ-UHFFFAOYSA-N 0.000 description 1
- VZBFPIMCUSPDLS-UHFFFAOYSA-N 3-methylnonan-3-ol Chemical compound CCCCCCC(C)(O)CC VZBFPIMCUSPDLS-UHFFFAOYSA-N 0.000 description 1
- BESKSSIEODQWBP-UHFFFAOYSA-N 3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C BESKSSIEODQWBP-UHFFFAOYSA-N 0.000 description 1
- LEBRCVXHIFZXEM-UHFFFAOYSA-N 4-(benzotriazol-2-yl)benzene-1,3-diol Chemical compound OC1=CC(O)=CC=C1N1N=C2C=CC=CC2=N1 LEBRCVXHIFZXEM-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- GNROHGFUVTWFNG-UHFFFAOYSA-N 4-ethylheptan-4-ol Chemical compound CCCC(O)(CC)CCC GNROHGFUVTWFNG-UHFFFAOYSA-N 0.000 description 1
- SBVKVAIECGDBTC-UHFFFAOYSA-N 4-hydroxy-2-methylidenebutanamide Chemical compound NC(=O)C(=C)CCO SBVKVAIECGDBTC-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- YKXAYLPDMSGWEV-UHFFFAOYSA-N 4-hydroxybutyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCO YKXAYLPDMSGWEV-UHFFFAOYSA-N 0.000 description 1
- IQXKGRKRIRMQCQ-UHFFFAOYSA-N 4-methylheptan-4-ol Chemical compound CCCC(C)(O)CCC IQXKGRKRIRMQCQ-UHFFFAOYSA-N 0.000 description 1
- GDCOAKPWVJCNGI-UHFFFAOYSA-N 4-methylnonan-4-ol Chemical compound CCCCCC(C)(O)CCC GDCOAKPWVJCNGI-UHFFFAOYSA-N 0.000 description 1
- RXSIKQJQLQRQQY-UHFFFAOYSA-N 4-methyloctan-4-ol Chemical compound CCCCC(C)(O)CCC RXSIKQJQLQRQQY-UHFFFAOYSA-N 0.000 description 1
- OHSMKBPEDBXYDU-UHFFFAOYSA-N 4-propan-2-ylheptan-4-ol Chemical compound CCCC(O)(C(C)C)CCC OHSMKBPEDBXYDU-UHFFFAOYSA-N 0.000 description 1
- SJTPBRMACCDJPZ-UHFFFAOYSA-N 4-propylheptan-4-ol Chemical compound CCCC(O)(CCC)CCC SJTPBRMACCDJPZ-UHFFFAOYSA-N 0.000 description 1
- FPQZBCKFBQMBHG-UHFFFAOYSA-N 5,5-dimethyltetradecane Chemical compound CCCCCCCCCC(C)(C)CCCC FPQZBCKFBQMBHG-UHFFFAOYSA-N 0.000 description 1
- LPEKGGXMPWTOCB-UHFFFAOYSA-N 8beta-(2,3-epoxy-2-methylbutyryloxy)-14-acetoxytithifolin Chemical group COC(=O)C(C)O LPEKGGXMPWTOCB-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 102100035526 B melanoma antigen 1 Human genes 0.000 description 1
- LNRIBIFTBJLRPN-UHFFFAOYSA-N C(CCCCCCCCC)[PH2]=O Chemical compound C(CCCCCCCCC)[PH2]=O LNRIBIFTBJLRPN-UHFFFAOYSA-N 0.000 description 1
- BESOMKAUSZZROD-UHFFFAOYSA-N CC(=C)C(=O)OCC(COCCCC(OCCCCCCCCCC(C)(C)C)OCCCCCCCCCC(C)(C)C)O Chemical compound CC(=C)C(=O)OCC(COCCCC(OCCCCCCCCCC(C)(C)C)OCCCCCCCCCC(C)(C)C)O BESOMKAUSZZROD-UHFFFAOYSA-N 0.000 description 1
- PXZJWNDTTKXTGP-UHFFFAOYSA-N CC1CC(C(N1)=O)=C.CN1C(CCC1=C)=O Chemical compound CC1CC(C(N1)=O)=C.CN1C(CCC1=C)=O PXZJWNDTTKXTGP-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000008192 Lactoglobulins Human genes 0.000 description 1
- 108010060630 Lactoglobulins Proteins 0.000 description 1
- 102000019298 Lipocalin Human genes 0.000 description 1
- 108050006654 Lipocalin Proteins 0.000 description 1
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical group COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- UFHDWXDNIYWQRZ-UHFFFAOYSA-N OC(=COCCC1=C(C=C(C=C1)C)N1N=C2C(=N1)C=CC=C2)C Chemical compound OC(=COCCC1=C(C=C(C=C1)C)N1N=C2C(=N1)C=CC=C2)C UFHDWXDNIYWQRZ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- LFOXEOLGJPJZAA-UHFFFAOYSA-N [(2,6-dimethoxybenzoyl)-(2,4,4-trimethylpentyl)phosphoryl]-(2,6-dimethoxyphenyl)methanone Chemical compound COC1=CC=CC(OC)=C1C(=O)P(=O)(CC(C)CC(C)(C)C)C(=O)C1=C(OC)C=CC=C1OC LFOXEOLGJPJZAA-UHFFFAOYSA-N 0.000 description 1
- GUCYFKSBFREPBC-UHFFFAOYSA-N [phenyl-(2,4,6-trimethylbenzoyl)phosphoryl]-(2,4,6-trimethylphenyl)methanone Chemical compound CC1=CC(C)=CC(C)=C1C(=O)P(=O)(C=1C=CC=CC=1)C(=O)C1=C(C)C=C(C)C=C1C GUCYFKSBFREPBC-UHFFFAOYSA-N 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 1
- 125000000746 allylic group Chemical group 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- ZJRXSAYFZMGQFP-UHFFFAOYSA-N barium peroxide Chemical compound [Ba+2].[O-][O-] ZJRXSAYFZMGQFP-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- UKXSKSHDVLQNKG-UHFFFAOYSA-N benzilic acid Chemical compound C=1C=CC=CC=1C(O)(C(=O)O)C1=CC=CC=C1 UKXSKSHDVLQNKG-UHFFFAOYSA-N 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- MQDJYUACMFCOFT-UHFFFAOYSA-N bis[2-(1-hydroxycyclohexyl)phenyl]methanone Chemical compound C=1C=CC=C(C(=O)C=2C(=CC=CC=2)C2(O)CCCCC2)C=1C1(O)CCCCC1 MQDJYUACMFCOFT-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229930006711 bornane-2,3-dione Natural products 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 238000010538 cationic polymerization reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 125000006165 cyclic alkyl group Chemical group 0.000 description 1
- XCIXKGXIYUWCLL-UHFFFAOYSA-N cyclopentanol Chemical compound OC1CCCC1 XCIXKGXIYUWCLL-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- PODOEQVNFJSWIK-UHFFFAOYSA-N diphenylphosphoryl-(2,4,6-trimethoxyphenyl)methanone Chemical compound COC1=CC(OC)=CC(OC)=C1C(=O)P(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 PODOEQVNFJSWIK-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical group C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- OCLXJTCGWSSVOE-UHFFFAOYSA-N ethanol etoh Chemical compound CCO.CCO OCLXJTCGWSSVOE-UHFFFAOYSA-N 0.000 description 1
- PQLFROTZSIMBKR-UHFFFAOYSA-N ethenyl carbonochloridate Chemical compound ClC(=O)OC=C PQLFROTZSIMBKR-UHFFFAOYSA-N 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- OJCSPXHYDFONPU-UHFFFAOYSA-N etoac etoac Chemical compound CCOC(C)=O.CCOC(C)=O OJCSPXHYDFONPU-UHFFFAOYSA-N 0.000 description 1
- ZQTYQMYDIHMKQB-UHFFFAOYSA-N exo-norborneol Chemical compound C1CC2C(O)CC1C2 ZQTYQMYDIHMKQB-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- SYJRVVFAAIUVDH-UHFFFAOYSA-N ipa isopropanol Chemical compound CC(C)O.CC(C)O SYJRVVFAAIUVDH-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- DIDDVZFHORVZMG-UHFFFAOYSA-N methyl 2-methylprop-2-eneperoxoate Chemical class COOC(=O)C(C)=C DIDDVZFHORVZMG-UHFFFAOYSA-N 0.000 description 1
- 229940057867 methyl lactate Drugs 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- FTWUXYZHDFCGSV-UHFFFAOYSA-N n,n'-diphenyloxamide Chemical compound C=1C=CC=CC=1NC(=O)C(=O)NC1=CC=CC=C1 FTWUXYZHDFCGSV-UHFFFAOYSA-N 0.000 description 1
- YWWNNLPSZSEZNZ-UHFFFAOYSA-N n,n-dimethyldecan-1-amine Chemical compound CCCCCCCCCCN(C)C YWWNNLPSZSEZNZ-UHFFFAOYSA-N 0.000 description 1
- MBHINSULENHCMF-UHFFFAOYSA-N n,n-dimethylpropanamide Chemical group CCC(=O)N(C)C MBHINSULENHCMF-UHFFFAOYSA-N 0.000 description 1
- QQZOPKMRPOGIEB-UHFFFAOYSA-N n-butyl methyl ketone Natural products CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 description 1
- 239000002077 nanosphere Substances 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 125000005429 oxyalkyl group Chemical group 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- OJNNAJJFLWBPRS-UHFFFAOYSA-N phenyl-[(2,4,6-trimethylphenyl)methyl]-[(2,4,6-trimethylphenyl)methylidene]phosphanium Chemical compound CC1=C(C=P(C2=CC=CC=C2)=CC2=C(C=C(C=C2C)C)C)C(=CC(=C1)C)C OJNNAJJFLWBPRS-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000000016 photochemical curing Methods 0.000 description 1
- XIPFMBOWZXULIA-UHFFFAOYSA-N pivalamide Chemical group CC(C)(C)C(N)=O XIPFMBOWZXULIA-UHFFFAOYSA-N 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920000962 poly(amidoamine) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- AMLFJZRZIOZGPW-UHFFFAOYSA-N prop-1-en-1-amine Chemical compound CC=CN AMLFJZRZIOZGPW-UHFFFAOYSA-N 0.000 description 1
- KIWATKANDHUUOB-UHFFFAOYSA-N propan-2-yl 2-hydroxypropanoate Chemical group CC(C)OC(=O)C(C)O KIWATKANDHUUOB-UHFFFAOYSA-N 0.000 description 1
- BWJUFXUULUEGMA-UHFFFAOYSA-N propan-2-yl propan-2-yloxycarbonyloxy carbonate Chemical compound CC(C)OC(=O)OOC(=O)OC(C)C BWJUFXUULUEGMA-UHFFFAOYSA-N 0.000 description 1
- XUWVIABDWDTJRZ-UHFFFAOYSA-N propan-2-ylazanide Chemical compound CC(C)[NH-] XUWVIABDWDTJRZ-UHFFFAOYSA-N 0.000 description 1
- NHARPDSAXCBDDR-UHFFFAOYSA-N propyl 2-methylprop-2-enoate Chemical compound CCCOC(=O)C(C)=C NHARPDSAXCBDDR-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/12—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes
- C08F283/124—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes on to polysiloxanes having carbon-to-carbon double bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
- C08F283/12—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/068—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/442—Block-or graft-polymers containing polysiloxane sequences containing vinyl polymer sequences
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Eyeglasses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Silicon Polymers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579693P | 2011-12-23 | 2011-12-23 | |
| US201161579683P | 2011-12-23 | 2011-12-23 | |
| US13/720,277 US8937111B2 (en) | 2011-12-23 | 2012-12-19 | Silicone hydrogels comprising desirable water content and oxygen permeability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201343793A TW201343793A (zh) | 2013-11-01 |
| TWI606094B true TWI606094B (zh) | 2017-11-21 |
Family
ID=48669491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101149233A TWI606094B (zh) | 2011-12-23 | 2012-12-22 | 含有所需水含量及透氧性之聚矽氧水凝膠 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8937111B2 (enExample) |
| EP (3) | EP2794726B1 (enExample) |
| JP (1) | JP6227552B2 (enExample) |
| KR (1) | KR102056039B1 (enExample) |
| CN (1) | CN104114612B (enExample) |
| AR (1) | AR089469A1 (enExample) |
| AU (1) | AU2012358819B2 (enExample) |
| BR (1) | BR112014015366A2 (enExample) |
| CA (1) | CA2860221A1 (enExample) |
| RU (1) | RU2632202C2 (enExample) |
| SG (2) | SG10201700248SA (enExample) |
| TW (1) | TWI606094B (enExample) |
| WO (1) | WO2013096600A1 (enExample) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877103B2 (en) | 2010-04-13 | 2014-11-04 | Johnson & Johnson Vision Care, Inc. | Process for manufacture of a thermochromic contact lens material |
| US8697770B2 (en) | 2010-04-13 | 2014-04-15 | Johnson & Johnson Vision Care, Inc. | Pupil-only photochromic contact lenses displaying desirable optics and comfort |
| US8937111B2 (en) | 2011-12-23 | 2015-01-20 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising desirable water content and oxygen permeability |
| US9156934B2 (en) | 2011-12-23 | 2015-10-13 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising n-vinyl amides and hydroxyalkyl (meth)acrylates or (meth)acrylamides |
| US8937110B2 (en) | 2011-12-23 | 2015-01-20 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels having a structure formed via controlled reaction kinetics |
| US9140825B2 (en) | 2011-12-23 | 2015-09-22 | Johnson & Johnson Vision Care, Inc. | Ionic silicone hydrogels |
| US9588258B2 (en) * | 2011-12-23 | 2017-03-07 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels formed from zero diluent reactive mixtures |
| US10209534B2 (en) * | 2012-03-27 | 2019-02-19 | Johnson & Johnson Vision Care, Inc. | Increased stiffness center optic in soft contact lenses for astigmatism correction |
| WO2016145204A1 (en) | 2015-03-11 | 2016-09-15 | University Of Florida Research Foundation, Inc. | Mesh size control of lubrication in gemini hydrogels |
| US10081142B2 (en) | 2015-12-15 | 2018-09-25 | Novartis Ag | Method for producing contact lenses with a lubricious surface |
| US10371865B2 (en) | 2016-07-06 | 2019-08-06 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising polyamides |
| CN109416414B (zh) | 2016-07-06 | 2023-03-10 | 庄臣及庄臣视力保护公司 | 用于散光矫正的软性接触镜片中的增加硬度的中心视区 |
| US11125916B2 (en) * | 2016-07-06 | 2021-09-21 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising N-alkyl methacrylamides and contact lenses made thereof |
| US10370476B2 (en) | 2016-07-06 | 2019-08-06 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising high levels of polyamides |
| US11021558B2 (en) | 2016-08-05 | 2021-06-01 | Johnson & Johnson Vision Care, Inc. | Polymer compositions containing grafted polymeric networks and processes for their preparation and use |
| US10676575B2 (en) | 2016-10-06 | 2020-06-09 | Johnson & Johnson Vision Care, Inc. | Tri-block prepolymers and their use in silicone hydrogels |
| ES2678773B1 (es) * | 2017-01-16 | 2019-06-12 | Consejo Superior Investigacion | Recubrimientos tipo hidrogel en base vinil-lactamas |
| RU2766412C2 (ru) | 2017-06-07 | 2022-03-15 | Алькон Инк. | Силикон-гидрогелевые контактные линзы |
| CN110740855B (zh) | 2017-06-07 | 2021-10-22 | 爱尔康公司 | 用于生产硅氧烷水凝胶隐形眼镜的方法 |
| KR20250012724A (ko) | 2017-06-07 | 2025-01-24 | 알콘 인코포레이티드 | 실리콘 하이드로겔 콘택트 렌즈 |
| US10752720B2 (en) | 2017-06-26 | 2020-08-25 | Johnson & Johnson Vision Care, Inc. | Polymerizable blockers of high energy light |
| US10723732B2 (en) | 2017-06-30 | 2020-07-28 | Johnson & Johnson Vision Care, Inc. | Hydroxyphenyl phenanthrolines as polymerizable blockers of high energy light |
| US10526296B2 (en) | 2017-06-30 | 2020-01-07 | Johnson & Johnson Vision Care, Inc. | Hydroxyphenyl naphthotriazoles as polymerizable blockers of high energy light |
| US10809181B2 (en) | 2017-08-24 | 2020-10-20 | Alcon Inc. | Method and apparatus for determining a coefficient of friction at a test site on a surface of a contact lens |
| SG11202003457WA (en) | 2017-12-13 | 2020-07-29 | Alcon Inc | Method for producing mps-compatible water gradient contact lenses |
| US10961341B2 (en) | 2018-01-30 | 2021-03-30 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices derived from grafted polymeric networks and processes for their preparation and use |
| US11034789B2 (en) | 2018-01-30 | 2021-06-15 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices containing localized grafted networks and processes for their preparation and use |
| US10935695B2 (en) | 2018-03-02 | 2021-03-02 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| US12486348B2 (en) | 2019-08-30 | 2025-12-02 | Johnson & Johnson Vision Care, Inc. | Contact lens displaying improved vision attributes |
| US11543683B2 (en) | 2019-08-30 | 2023-01-03 | Johnson & Johnson Vision Care, Inc. | Multifocal contact lens displaying improved vision attributes |
| US12486403B2 (en) | 2018-03-02 | 2025-12-02 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| US11993037B1 (en) | 2018-03-02 | 2024-05-28 | Johnson & Johnson Vision Care, Inc. | Contact lens displaying improved vision attributes |
| US10996491B2 (en) | 2018-03-23 | 2021-05-04 | Johnson & Johnson Vision Care, Inc. | Ink composition for cosmetic contact lenses |
| EP3794388A1 (en) | 2018-05-15 | 2021-03-24 | Bausch & Lomb Incorporated | Water extractable ophthalmic devices |
| TWI682158B (zh) * | 2018-05-23 | 2020-01-11 | 財團法人國家實驗硏究院 | 檢測眼膜透鏡之含水量與透氧率的方法及用於檢驗眼膜透鏡的光學檢測系統 |
| US11046636B2 (en) | 2018-06-29 | 2021-06-29 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| WO2020009747A1 (en) * | 2018-07-03 | 2020-01-09 | Bausch & Lomb Incorporated | Water extractable ophthalmic devices |
| US10932902B2 (en) | 2018-08-03 | 2021-03-02 | Johnson & Johnson Vision Care, Inc. | Dynamically tunable apodized multiple-focus opthalmic devices and methods |
| US12174465B2 (en) | 2018-08-03 | 2024-12-24 | Johnson & Johnson Vision Care, Inc. | Dynamically tunable apodized multiple-focus opthalmic devices and methods |
| US20200073145A1 (en) | 2018-09-05 | 2020-03-05 | Johnson & Johnson Vision Care, Inc. | Vision care kit |
| US11493668B2 (en) | 2018-09-26 | 2022-11-08 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| MY208061A (en) | 2018-12-03 | 2025-04-11 | Alcon Inc | Method for making coated silicone hydrogel contact lenses |
| US11099300B2 (en) | 2018-12-03 | 2021-08-24 | Alcon Inc. | Method for producing coated silicone hydrogel contact lenses |
| CN112703213A (zh) * | 2019-02-26 | 2021-04-23 | 株式会社目立康 | 聚合物材料 |
| US11724471B2 (en) | 2019-03-28 | 2023-08-15 | Johnson & Johnson Vision Care, Inc. | Methods for the manufacture of photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby |
| EP3953744B1 (en) | 2019-04-10 | 2025-08-13 | Alcon Inc. | Method for producing coated contact lenses |
| US11578176B2 (en) | 2019-06-24 | 2023-02-14 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogel contact lenses having non-uniform morphology |
| CN114096911A (zh) * | 2019-06-27 | 2022-02-25 | 株式会社目立康 | 包含光致变色聚合物的眼用医疗器械和其制造方法 |
| US11958824B2 (en) | 2019-06-28 | 2024-04-16 | Johnson & Johnson Vision Care, Inc. | Photostable mimics of macular pigment |
| US20200407324A1 (en) | 2019-06-28 | 2020-12-31 | Johnson & Johnson Vision Care, Inc. | Polymerizable fused tricyclic compounds as absorbers of uv and visible light |
| US20210003754A1 (en) | 2019-07-02 | 2021-01-07 | Johnson & Johnson Vision Care, Inc. | Core-shell particles and methods of making and using thereof |
| US11891526B2 (en) | 2019-09-12 | 2024-02-06 | Johnson & Johnson Vision Care, Inc. | Ink composition for cosmetic contact lenses |
| EP4369081B1 (en) | 2019-12-16 | 2025-06-25 | Alcon Inc. | Method for producing an ophthalmic product |
| US11360240B2 (en) | 2019-12-19 | 2022-06-14 | Johnson & Johnson Vision Care, Inc. | Contact lens containing photosensitive chromophore and package therefor |
| US20210301088A1 (en) | 2020-03-18 | 2021-09-30 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices containing transition metal complexes as high energy visible light filters |
| US11853013B2 (en) | 2020-06-15 | 2023-12-26 | Johnson & Johnson Vision Care, Inc. | Systems and methods for indicating the time elapsed since the occurrence of a triggering event |
| US12116443B2 (en) | 2020-06-16 | 2024-10-15 | Johnson & Johnson Vision Care, Inc. | Amino acid-based polymerizable compounds and ophthalmic devices prepared therefrom |
| US12180318B2 (en) | 2020-06-16 | 2024-12-31 | Johnson & Johnson Vision Care, Inc. | Imidazolium zwitterion polymerizable compounds and ophthalmic devices incorporating them |
| TW202231215A (zh) | 2020-09-14 | 2022-08-16 | 美商壯生和壯生視覺關懷公司 | 單一觸碰式隱形眼鏡盒 |
| TW202225787A (zh) | 2020-09-14 | 2022-07-01 | 美商壯生和壯生視覺關懷公司 | 單指觸動隱形眼鏡包裝 |
| US20220113558A1 (en) | 2020-10-13 | 2022-04-14 | Johnson & Johnson Vision Care, Inc. | Contact lens position and rotation control using the pressure of the eyelid margin |
| TW202237001A (zh) | 2020-12-13 | 2022-10-01 | 美商壯生和壯生視覺關懷公司 | 隱形眼鏡包裝盒及其打開方法 |
| US20220194944A1 (en) | 2020-12-18 | 2022-06-23 | Johnson & Johnson Vision Care, Inc. | Photostable mimics of macular pigment |
| US12049606B2 (en) | 2021-01-12 | 2024-07-30 | Johnson & Johnson Vision Care, Inc. | Compositions for ophthalmologic devices |
| US12054499B2 (en) | 2021-06-30 | 2024-08-06 | Johnson & Johnson Vision Care, Inc. | Transition metal complexes as visible light absorbers |
| US20230096315A1 (en) | 2021-08-31 | 2023-03-30 | Bausch + Lomb Ireland Limited | Ophthalmic devices |
| US11873361B2 (en) | 2021-08-31 | 2024-01-16 | Bausch + Lomb Ireland Limited | Ophthalmic devices |
| US12405488B2 (en) | 2021-08-31 | 2025-09-02 | Bausch + Lomb Ireland Limited | Ophthalmic devices |
| CA3173598A1 (en) | 2021-09-13 | 2023-03-13 | Johnson & Johnson Vision Care, Inc. | Contact lens packages and methods of handling and manufacture |
| WO2023052889A1 (en) | 2021-09-29 | 2023-04-06 | Johnson & Johnson Vision Care, Inc. | Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses |
| WO2023052890A1 (en) | 2021-09-29 | 2023-04-06 | Johnson & Johnson Vision Care, Inc. | Anthraquinone-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses |
| US20230176251A1 (en) | 2021-09-29 | 2023-06-08 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lenses and their manufacture by in-mold modification |
| US11912800B2 (en) | 2021-09-29 | 2024-02-27 | Johnson & Johnson Vision Care, Inc. | Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses |
| US12396534B2 (en) | 2021-10-08 | 2025-08-26 | Johnson & Johnson Vision Care, Inc. | Multi-material lens package |
| US11708209B2 (en) | 2021-11-05 | 2023-07-25 | Johnson & Johnson Vision Care, Inc. | Touchless contact lens packages and methods of handling |
| TW202335928A (zh) | 2021-12-08 | 2023-09-16 | 美商壯生和壯生視覺關懷公司 | 具鏡片升高臂的隱形眼鏡包裝及拿取方法 |
| TW202415312A (zh) | 2021-12-08 | 2024-04-16 | 美商壯生和壯生視覺關懷公司 | 開槽式隱形眼鏡包裝盒及處理方法 |
| TW202340053A (zh) | 2021-12-13 | 2023-10-16 | 美商壯生和壯生視覺關懷公司 | 使鏡片滑動或傾斜轉移的隱形眼鏡包裝盒及處理方法 |
| EP4448405A1 (en) | 2021-12-14 | 2024-10-23 | Johnson & Johnson Vision Care, Inc. | Contact lens packages having twisting or thimble levers and methods of handling |
| WO2023111851A1 (en) | 2021-12-15 | 2023-06-22 | Johnson & Johnson Vision Care, Inc. | Solutionless contact lens packages and methods of manufacture |
| WO2023111852A1 (en) | 2021-12-15 | 2023-06-22 | Johnson & Johnson Vision Care, Inc. | No-touch contact lens packages and methods of handling |
| US20250058951A1 (en) | 2021-12-16 | 2025-02-20 | Johnson & Johnson Vision Care, Inc. | Pressurized or vacuum-sealed contact lens packages |
| WO2023111941A1 (en) | 2021-12-16 | 2023-06-22 | Johnson & Johnson Vision Care, Inc. | No-touch contact lens packages and methods of handling |
| KR20240127377A (ko) | 2021-12-17 | 2024-08-22 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 선회 메커니즘을 가지는 콘택트 렌즈 패키지 및 취급 방법 |
| CN118742238A (zh) | 2021-12-17 | 2024-10-01 | 强生视力健公司 | 接触镜片分配器 |
| US20230296807A1 (en) | 2021-12-20 | 2023-09-21 | Johnson & Johnson Vision Care, Inc. | Contact lenses containing light absorbing regions and methods for their preparation |
| US20230244000A1 (en) | 2022-02-02 | 2023-08-03 | Bausch + Lomb Ireland Limited | Multifunctional crosslinking agents and ophthalmic devices formed therefrom |
| US20230350228A1 (en) * | 2022-04-28 | 2023-11-02 | Coopervision International Limited | Contact lens |
| US11733440B1 (en) | 2022-04-28 | 2023-08-22 | Johnson & Johnson Vision Care, Inc. | Thermally stable nanoparticles and methods thereof |
| US20230348717A1 (en) | 2022-04-28 | 2023-11-02 | Johnson & Johnson Vision Care, Inc. | Particle surface modification to increase compatibility and stability in hydrogels |
| US20230348718A1 (en) | 2022-04-28 | 2023-11-02 | Johnson & Johnson Vision Care, Inc. | Light-filtering materials for biomaterial integration and methods thereof |
| JP2025516196A (ja) | 2022-04-28 | 2025-05-27 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | 光フィルタリングのための粒子の使用 |
| US11971518B2 (en) | 2022-04-28 | 2024-04-30 | Johnson & Johnson Vision Care, Inc. | Shape engineering of particles to create a narrow spectral filter against a specific portion of the light spectrum |
| TW202419898A (zh) | 2022-06-16 | 2024-05-16 | 美商壯生和壯生視覺關懷公司 | 含有光穩定黃斑色素模擬物及其他可見光濾波物之眼用裝置 |
| USD1062223S1 (en) | 2022-06-21 | 2025-02-18 | Johnson & Johnson Vision Care, Inc. | Contact lens package |
| USD1061023S1 (en) | 2022-06-21 | 2025-02-11 | Johnson & Johnson Vision Care, Inc. | Contact lens package |
| US12064018B2 (en) | 2022-09-27 | 2024-08-20 | Johnson & Johnson Vision Care, Inc. | Contact lens package with draining port |
| US20240099435A1 (en) | 2022-09-27 | 2024-03-28 | Johnson & Johnson Vision Care, Inc. | Flat contact lens packages and methods of handling |
| US20240122321A1 (en) | 2022-10-18 | 2024-04-18 | Johnson & Johnson Vision Care, Inc. | Contact lens packages having an absorbent member |
| US20240165019A1 (en) | 2022-11-21 | 2024-05-23 | Bausch + Lomb Ireland Limited | Methods for Treating Eyetear Film Deficiency |
| US20240228466A1 (en) | 2022-12-15 | 2024-07-11 | Johnson & Johnson Vision Care, Inc. | Transition metal complexes as visible light absorbers |
| TW202430231A (zh) | 2022-12-21 | 2024-08-01 | 美商壯生和壯生視覺關懷公司 | 眼用裝置之組成物 |
| WO2024134381A1 (en) | 2022-12-21 | 2024-06-27 | Johnson & Johnson Vision Care, Inc. | Compositions for ophthalmologic devices |
| WO2024134382A1 (en) | 2022-12-21 | 2024-06-27 | Johnson & Johnson Vision Care, Inc. | Compositions for ophthalmologic devices |
| WO2024134383A1 (en) | 2022-12-21 | 2024-06-27 | Johnson & Johnson Vision Care, Inc. | Compositions for ophthalmologic devices |
| US12187522B2 (en) | 2023-01-13 | 2025-01-07 | Johnson & Johnson Vision Care, Inc. | Contact lens packages having an absorbent member |
| US20240302569A1 (en) | 2023-03-08 | 2024-09-12 | Bausch + Lomb Ireland Limited | Contact lens containing deprotected ultraviolet blockers |
| CN119173379A (zh) | 2023-03-20 | 2024-12-20 | 强生视力健公司 | 眼科镜片及其通过模内修改的制造 |
| US20240317943A1 (en) | 2023-03-22 | 2024-09-26 | Bausch + Lomb Ireland Limited | Silicone hydrogels |
| US20240317988A1 (en) | 2023-03-22 | 2024-09-26 | Bausch + Lomb Ireland Limited | Monofunctional silicone monomers and silicone hydrogels formed therefrom |
| WO2024201156A1 (en) | 2023-03-28 | 2024-10-03 | Johnson & Johnson Vision Care, Inc. | Grafted opthalmic devices containing deactivated regions and processes for their preparation and use |
| US20240352170A1 (en) | 2023-04-21 | 2024-10-24 | Bausch + Lomb Ireland Limited | Rigid gas permeable prepolymer and rigid gas permeable contact lens formed therefrom |
| WO2025024631A1 (en) | 2023-07-27 | 2025-01-30 | Johnson & Johnson Vision Care, Inc. | Supervised machine learning curing systems |
| US20250040673A1 (en) | 2023-07-28 | 2025-02-06 | Bausch + Lomb Ireland Limited | Packaging solutions |
| WO2025104612A1 (en) | 2023-11-16 | 2025-05-22 | Johnson & Johnson Vision Care, Inc. | Cosmetic contact lens having an elliptical dot pattern suitable for forming an apparent limbal ring |
| WO2025125986A1 (en) | 2023-12-12 | 2025-06-19 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices containing photostable mimics of macular pigment and other visible light filters |
| WO2025215096A1 (en) | 2024-04-11 | 2025-10-16 | Bausch + Lomb Ireland Limited | Silicone contact lens-forming prepolymer and silicone contact lens formed therefrom |
| US20250334718A1 (en) | 2024-04-30 | 2025-10-30 | Bausch + Lomb Ireland Limited | Surface modified silicone ophthalmic device |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS108895A (enExample) | 1961-12-27 | |||
| NL128305C (enExample) | 1963-09-11 | |||
| US4113224A (en) | 1975-04-08 | 1978-09-12 | Bausch & Lomb Incorporated | Apparatus for forming optical lenses |
| US4197266A (en) | 1974-05-06 | 1980-04-08 | Bausch & Lomb Incorporated | Method for forming optical lenses |
| US4136250A (en) * | 1977-07-20 | 1979-01-23 | Ciba-Geigy Corporation | Polysiloxane hydrogels |
| US4153641A (en) | 1977-07-25 | 1979-05-08 | Bausch & Lomb Incorporated | Polysiloxane composition and contact lens |
| JPS5466853A (en) | 1977-11-08 | 1979-05-29 | Toyo Contact Lens Co Ltd | Soft contact lens |
| US4246389A (en) | 1979-06-25 | 1981-01-20 | American Optical Corporation | Contact lens composition having increased oxygen permeability |
| US4260725A (en) * | 1979-12-10 | 1981-04-07 | Bausch & Lomb Incorporated | Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hydrophilic sidechains |
| US4495313A (en) | 1981-04-30 | 1985-01-22 | Mia Lens Production A/S | Preparation of hydrogel for soft contact lens with water displaceable boric acid ester |
| US5712327A (en) | 1987-01-07 | 1998-01-27 | Chang; Sing-Hsiung | Soft gas permeable contact lens having improved clinical performance |
| US4837289A (en) | 1987-04-30 | 1989-06-06 | Ciba-Geigy Corporation | UV- and heat curable terminal polyvinyl functional macromers and polymers thereof |
| US4810764A (en) | 1988-02-09 | 1989-03-07 | Bausch & Lomb Incorporated | Polymeric materials with high oxygen permeability and low protein substantivity |
| US5314961A (en) | 1990-10-11 | 1994-05-24 | Permeable Technologies, Inc. | Silicone-containing polymers, compositions and improved oxygen permeable hydrophilic contact lenses |
| BR9206889A (pt) | 1991-11-05 | 1995-05-02 | Bausch & Lomb | Método para melhorar a molhabilidade de hidrogéis, composição de hidrogel, dispositivo biomédico e lente de contato |
| US5358995A (en) * | 1992-05-15 | 1994-10-25 | Bausch & Lomb Incorporated | Surface wettable silicone hydrogels |
| US5321108A (en) | 1993-02-12 | 1994-06-14 | Bausch & Lomb Incorporated | Fluorosilicone hydrogels |
| US5760100B1 (en) | 1994-09-06 | 2000-11-14 | Ciba Vision Corp | Extended wear ophthalmic lens |
| US6020445A (en) | 1997-10-09 | 2000-02-01 | Johnson & Johnson Vision Products, Inc. | Silicone hydrogel polymers |
| US6943203B2 (en) * | 1998-03-02 | 2005-09-13 | Johnson & Johnson Vision Care, Inc. | Soft contact lenses |
| US5998498A (en) * | 1998-03-02 | 1999-12-07 | Johnson & Johnson Vision Products, Inc. | Soft contact lenses |
| US7052131B2 (en) | 2001-09-10 | 2006-05-30 | J&J Vision Care, Inc. | Biomedical devices containing internal wetting agents |
| US6849671B2 (en) * | 1998-03-02 | 2005-02-01 | Johnson & Johnson Vision Care, Inc. | Contact lenses |
| US6367929B1 (en) | 1998-03-02 | 2002-04-09 | Johnson & Johnson Vision Care, Inc. | Hydrogel with internal wetting agent |
| WO2000002937A1 (en) | 1998-07-08 | 2000-01-20 | Sunsoft Corporation | Interpenetrating polymer network hydrophilic hydrogels for contact lens |
| US6630243B2 (en) | 1999-05-20 | 2003-10-07 | Bausch & Lomb Incorporated | Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating |
| ES2206270T3 (es) | 1999-07-27 | 2004-05-16 | BAUSCH & LOMB INCORPORATED | Material para lentes de contacto. |
| KR100719796B1 (ko) | 1999-10-07 | 2007-05-21 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 실리콘 하이드로겔의 제조에 유용한 마크로머 |
| WO2001044861A1 (en) | 1999-12-16 | 2001-06-21 | Asahikasei Aime Co., Ltd. | Soft contact lens capable of being worn for a long period |
| JP3929014B2 (ja) | 2000-02-24 | 2007-06-13 | Hoyaヘルスケア株式会社 | 側鎖にポリシロキサン構造を有するマクロマーからなるコンタクトレンズ材料 |
| WO2001071415A1 (en) | 2000-03-22 | 2001-09-27 | Menicon Co., Ltd. | Material for ocular lens |
| US20070138692A1 (en) | 2002-09-06 | 2007-06-21 | Ford James D | Process for forming clear, wettable silicone hydrogel articles |
| US8158695B2 (en) | 2002-09-06 | 2012-04-17 | Johnson & Johnson Vision Care, Inc. | Forming clear, wettable silicone hydrogel articles without surface treatments |
| TWI336720B (en) | 2003-03-07 | 2011-02-01 | Johnson & Johnson Vision Care | Diluents for forming clear, wettable silicone hydrogel articles |
| DE602004021248D1 (de) | 2003-04-03 | 2009-07-09 | Seed Co Ltd | Kontaktlinsen mit der fähigkeit einer andauernden medikamentenfreigabe und schutzlösungen dafür |
| US7722808B2 (en) * | 2003-09-12 | 2010-05-25 | Novartis Ag | Method and kits for sterilizing and storing soft contact lenses |
| CN101163991A (zh) * | 2004-08-27 | 2008-04-16 | 旭化成爱目股份有限公司 | 硅水凝胶隐形眼镜 |
| KR101367538B1 (ko) * | 2004-08-27 | 2014-02-26 | 쿠퍼비젼 인터내셔날 홀딩 캄파니, 엘피 | 실리콘 히드로겔 콘택트 렌즈 |
| US7249848B2 (en) * | 2004-09-30 | 2007-07-31 | Johnson & Johnson Vision Care, Inc. | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents |
| US20060142525A1 (en) * | 2004-12-29 | 2006-06-29 | Bausch & Lomb Incorporated | Hydrogel copolymers for biomedical devices |
| WO2006102050A2 (en) | 2005-03-17 | 2006-09-28 | Johnson & Johnson Vision Care, Inc. | Process for the production of monodisperse and narrow disperse monofunctional silicones |
| US8414804B2 (en) * | 2006-03-23 | 2013-04-09 | Johnson & Johnson Vision Care, Inc. | Process for making ophthalmic lenses |
| US8231218B2 (en) | 2006-06-15 | 2012-07-31 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
| TWI443116B (zh) | 2006-06-15 | 2014-07-01 | Coopervision Int Holding Co Lp | 可溼性矽氧水凝膠隱形眼鏡及相關組合物及方法 |
| GB0623299D0 (en) * | 2006-11-22 | 2007-01-03 | Sauflon Cl Ltd | Contact lens |
| CA2671740C (en) | 2006-12-13 | 2015-08-11 | Novartis Ag | Actinically curable silicone hydrogel copolymers and uses thereof |
| CN101641206B (zh) | 2007-03-22 | 2013-03-20 | 诺瓦提斯公司 | 具有含悬挂的聚硅氧烷的聚合物链的预聚物 |
| RU2009138703A (ru) | 2007-03-22 | 2011-04-27 | Новартис АГ (CH) | Силиконсодержащие форполимеры с висящими гидрофильными полимерными цепями |
| WO2008144427A1 (en) | 2007-05-18 | 2008-11-27 | Coopervision International Holding Company, Lp | Thermal curing methods and systems for forming contact lenses |
| US8075909B2 (en) | 2007-09-04 | 2011-12-13 | University Of Florida Research Foundation, Incorporated | Contact lens based bioactive agent delivery system |
| DE102007050988A1 (de) | 2007-10-25 | 2009-04-30 | Robert Bosch Gmbh | Sensor, insbesondere zur Drehzahlerfassung, und Verfahren zur Herstellung desselben |
| US20090111905A1 (en) | 2007-10-31 | 2009-04-30 | Ture Kindt-Larsen | Process for forming random (meth)acrylate containing prepolymers |
| US7934830B2 (en) | 2007-12-03 | 2011-05-03 | Bausch & Lomb Incorporated | High water content silicone hydrogels |
| CN101932632B (zh) | 2008-02-08 | 2015-06-24 | 库柏维景国际控股公司 | 亲水性聚硅氧烷大单体、其制造及用途 |
| DE102008002375A1 (de) | 2008-06-12 | 2009-12-17 | Evonik Röhm Gmbh | Hydrogel basierend auf silikonhaltigen Copolymeren |
| JP5896404B2 (ja) | 2008-07-21 | 2016-03-30 | ノバルティス アーゲー | 加水分解性基を有するシリコーン含有ポリマー材料 |
| US8470906B2 (en) * | 2008-09-30 | 2013-06-25 | Johnson & Johnson Vision Care, Inc. | Ionic silicone hydrogels having improved hydrolytic stability |
| US8534031B2 (en) | 2008-12-30 | 2013-09-17 | Bausch & Lomb Incorporated | Packaging solutions |
| RU2424478C2 (ru) * | 2009-02-02 | 2011-07-20 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ГАРАНТ-Экологические Технологии Энергосбережения" | Устройство для разделения биогаза на метан и двуокись углерода |
| US20100249273A1 (en) * | 2009-03-31 | 2010-09-30 | Scales Charles W | Polymeric articles comprising oxygen permeability enhancing particles |
| US20100315588A1 (en) | 2009-06-16 | 2010-12-16 | Bausch & Lomb Incorporated | Biomedical devices |
| WO2011005937A2 (en) * | 2009-07-09 | 2011-01-13 | Bausch & Lomb Incorporated | Mono ethylenically unsaturated polymerizable group containing polycarbosiloxane monomers |
| US8672475B2 (en) | 2009-10-01 | 2014-03-18 | Coopervision International Holding Company, LLC | Silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses |
| GB0917806D0 (en) | 2009-10-12 | 2009-11-25 | Sauflon Cl Ltd | Fluorinated silicone hydrogels |
| JP5720103B2 (ja) * | 2010-03-18 | 2015-05-20 | 東レ株式会社 | シリコーンハイドロゲル、眼用レンズおよびコンタクトレンズ |
| US9522980B2 (en) | 2010-05-06 | 2016-12-20 | Johnson & Johnson Vision Care, Inc. | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same |
| TWI432486B (zh) | 2011-02-21 | 2014-04-01 | Far Eastern New Century Corp | 製造具有高含水率之聚矽氧水膠的方法 |
| WO2012118677A1 (en) | 2011-02-28 | 2012-09-07 | Coopervison International Holding Company, Lp | Low modulus silicon hydrogel contact lenses |
| MY161370A (en) | 2011-02-28 | 2017-04-14 | Coopervision Int Holding Co Lp | Wettable silicon hydrogel contact lenses |
| WO2012118682A2 (en) | 2011-02-28 | 2012-09-07 | Coopervision International Holding Company, Lp | Silicone hydrogel contact lenses with high freezable water content |
| US9217813B2 (en) | 2011-02-28 | 2015-12-22 | Coopervision International Holding Company, Lp | Silicone hydrogel contact lenses |
| SG192187A1 (en) | 2011-02-28 | 2013-08-30 | Coopervision Int Holding Co Lp | Phosphine-containing hydrogel contact lenses |
| MY151110A (en) | 2011-02-28 | 2014-04-15 | Coopervision Int Holding Co Lp | Dimensionally stable silicone hydrogel contact lenses |
| TWI512048B (zh) | 2011-02-28 | 2015-12-11 | Coopervision Int Holding Co Lp | 聚矽氧水凝膠隱形眼鏡 |
| CN103403608B (zh) | 2011-02-28 | 2015-11-25 | 库柏维景国际控股公司 | 硅酮水凝胶隐形眼镜 |
| MX367173B (es) | 2011-02-28 | 2019-08-07 | Coopervision Int Holding Co Lp | Lentes de contacto de hidrogel de silicona y composiciones y metodos relacionados. |
| SG192245A1 (en) | 2011-02-28 | 2013-09-30 | Coopervision Int Holding Co Lp | Silicone hydrogel contact lenses |
| CN102558458B (zh) | 2011-11-18 | 2013-12-11 | 明基材料有限公司 | 隐形眼镜材料、隐形眼镜及隐形眼镜的制造方法 |
| US9156934B2 (en) | 2011-12-23 | 2015-10-13 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising n-vinyl amides and hydroxyalkyl (meth)acrylates or (meth)acrylamides |
| US8937111B2 (en) | 2011-12-23 | 2015-01-20 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels comprising desirable water content and oxygen permeability |
| US9140825B2 (en) | 2011-12-23 | 2015-09-22 | Johnson & Johnson Vision Care, Inc. | Ionic silicone hydrogels |
| US9588258B2 (en) | 2011-12-23 | 2017-03-07 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels formed from zero diluent reactive mixtures |
| US8937110B2 (en) | 2011-12-23 | 2015-01-20 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogels having a structure formed via controlled reaction kinetics |
| US9125808B2 (en) | 2011-12-23 | 2015-09-08 | Johnson & Johnson Vision Care, Inc. | Ionic silicone hydrogels |
| CN102786641B (zh) | 2012-06-19 | 2014-09-03 | 明基材料有限公司 | 形成隐形眼镜的方法及隐形眼镜 |
-
2012
- 2012-12-19 US US13/720,277 patent/US8937111B2/en active Active
- 2012-12-20 JP JP2014548883A patent/JP6227552B2/ja active Active
- 2012-12-20 RU RU2014130260A patent/RU2632202C2/ru active
- 2012-12-20 EP EP12815933.2A patent/EP2794726B1/en not_active Revoked
- 2012-12-20 EP EP21210220.6A patent/EP4011940A1/en not_active Withdrawn
- 2012-12-20 KR KR1020147020495A patent/KR102056039B1/ko active Active
- 2012-12-20 EP EP16195164.5A patent/EP3181614B9/en not_active Revoked
- 2012-12-20 CN CN201280070501.6A patent/CN104114612B/zh active Active
- 2012-12-20 WO PCT/US2012/070899 patent/WO2013096600A1/en not_active Ceased
- 2012-12-20 SG SG10201700248SA patent/SG10201700248SA/en unknown
- 2012-12-20 BR BR112014015366A patent/BR112014015366A2/pt not_active Application Discontinuation
- 2012-12-20 CA CA2860221A patent/CA2860221A1/en not_active Abandoned
- 2012-12-20 SG SG11201403472XA patent/SG11201403472XA/en unknown
- 2012-12-20 AU AU2012358819A patent/AU2012358819B2/en not_active Ceased
- 2012-12-22 TW TW101149233A patent/TWI606094B/zh active
- 2012-12-26 AR ARP120104987A patent/AR089469A1/es not_active Application Discontinuation
-
2014
- 2014-12-09 US US14/564,667 patent/US9244197B2/en active Active
-
2015
- 2015-12-15 US US14/969,292 patent/US9612365B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9612365B2 (en) | 2017-04-04 |
| AU2012358819A1 (en) | 2014-07-10 |
| KR20140116881A (ko) | 2014-10-06 |
| SG11201403472XA (en) | 2014-10-30 |
| AU2012358819B2 (en) | 2016-02-11 |
| EP3181614B9 (en) | 2022-10-05 |
| RU2014130260A (ru) | 2016-02-20 |
| BR112014015366A8 (pt) | 2017-06-13 |
| EP4011940A1 (en) | 2022-06-15 |
| CN104114612B (zh) | 2017-09-26 |
| SG10201700248SA (en) | 2017-02-27 |
| EP2794726B1 (en) | 2016-10-26 |
| US8937111B2 (en) | 2015-01-20 |
| KR102056039B1 (ko) | 2019-12-16 |
| TW201343793A (zh) | 2013-11-01 |
| JP2015503632A (ja) | 2015-02-02 |
| US20130172440A1 (en) | 2013-07-04 |
| WO2013096600A1 (en) | 2013-06-27 |
| US20150094395A1 (en) | 2015-04-02 |
| AR089469A1 (es) | 2014-08-27 |
| HK1203532A1 (en) | 2015-10-30 |
| CA2860221A1 (en) | 2013-06-27 |
| CN104114612A (zh) | 2014-10-22 |
| JP6227552B2 (ja) | 2017-11-08 |
| US9244197B2 (en) | 2016-01-26 |
| EP3181614A1 (en) | 2017-06-21 |
| BR112014015366A2 (pt) | 2017-06-13 |
| EP3181614B1 (en) | 2022-03-30 |
| RU2632202C2 (ru) | 2017-10-03 |
| HK1201548A1 (en) | 2015-09-04 |
| US20160103248A1 (en) | 2016-04-14 |
| EP2794726A1 (en) | 2014-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI606094B (zh) | 含有所需水含量及透氧性之聚矽氧水凝膠 | |
| TWI564313B (zh) | 包含n-乙烯基醯胺及(甲基)丙烯酸羥基烷酯或羥基烷基(甲基)丙烯醯胺之聚矽氧水凝膠 | |
| TWI585126B (zh) | 離子性聚矽氧水凝膠 | |
| KR102056040B1 (ko) | 제어된 반응 동역학을 통해 형성되는 구조를 갖는 실리콘 하이드로겔 | |
| HK1237806A1 (en) | Silicone hydrogels comprising desirable water content and oxygen permeability | |
| HK1237806B (en) | Silicone hydrogels comprising desirable water content and oxygen permeability | |
| HK40072577A (en) | Silicone hydrogels comprising desirable water content and oxygen permeability | |
| HK1203532B (en) | Silicone hydrogels comprising desirable water content and oxygen permeability | |
| HK1201548B (en) | Silicone hydrogels comprising desirable water content and oxygen permeability |