TWI591174B - 非接觸式即時微型聚合酶連鎖反應之系統及其方法 - Google Patents
非接觸式即時微型聚合酶連鎖反應之系統及其方法 Download PDFInfo
- Publication number
- TWI591174B TWI591174B TW100115011A TW100115011A TWI591174B TW I591174 B TWI591174 B TW I591174B TW 100115011 A TW100115011 A TW 100115011A TW 100115011 A TW100115011 A TW 100115011A TW I591174 B TWI591174 B TW I591174B
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- Prior art keywords
- wafer
- heater
- sample
- embedded metal
- pcr
- Prior art date
Links
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1816—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1215CH2010 | 2010-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201144432A TW201144432A (en) | 2011-12-16 |
| TWI591174B true TWI591174B (zh) | 2017-07-11 |
Family
ID=44860952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW100115011A TWI591174B (zh) | 2010-04-30 | 2011-04-29 | 非接觸式即時微型聚合酶連鎖反應之系統及其方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9404151B2 (enExample) |
| EP (1) | EP2563513A4 (enExample) |
| JP (1) | JP6026996B2 (enExample) |
| KR (1) | KR20130092391A (enExample) |
| CN (1) | CN102939161B (enExample) |
| AR (1) | AR081288A1 (enExample) |
| BR (1) | BR112012027876A2 (enExample) |
| EA (1) | EA201291008A1 (enExample) |
| SG (1) | SG185045A1 (enExample) |
| TW (1) | TWI591174B (enExample) |
| WO (1) | WO2011135535A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618027B2 (en) | 2019-12-10 | 2023-04-04 | Wistron Corp. | Molecular diagnostics apparatus |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102604827B (zh) * | 2012-03-31 | 2014-01-29 | 中国科学院上海微系统与信息技术研究所 | 非接触式电导法实现pcr反应过程的实时检测系统和方法 |
| NZ719726A (en) * | 2013-10-15 | 2021-07-30 | Bio Molecular Systems Pty Ltd | Improved thermocycler |
| CN103645167A (zh) * | 2013-12-13 | 2014-03-19 | 苏州东胜兴业科学仪器有限公司 | 一种聚合酶链反应检测仪 |
| GB201520193D0 (en) * | 2015-11-16 | 2015-12-30 | Mast Group Ltd | Apparatus for conducting an assay |
| CN205874440U (zh) * | 2016-04-08 | 2017-01-11 | 周辉 | 核糖核酸链式聚合扩增反应检测装置 |
| DK3287190T3 (da) * | 2016-08-26 | 2020-08-10 | aquila biolabs GmbH | Fremgangsmåde til at overvåge en målprocesparameter |
| WO2018093913A1 (en) * | 2016-11-15 | 2018-05-24 | Quidel Coroporation | Device, instrument, and method for inductive heating of a sample for analyte detection |
| GB2556626A (en) * | 2016-11-16 | 2018-06-06 | Dublin Institute Of Tech | A microfluidic device |
| US10207241B2 (en) * | 2016-11-29 | 2019-02-19 | Kontak LLC | Inductively heated microchannel reactor |
| CN107051598B (zh) * | 2017-03-20 | 2019-12-06 | 上海交通大学 | Pcr微流控芯片和其制备与使用方法以及pcr设备 |
| TWI656211B (zh) * | 2017-12-22 | 2019-04-11 | 新加坡商元昌生技醫療私人股份有限公司 | 一種熱對流式聚合酶鏈式反應裝置 |
| CN109957506B (zh) | 2017-12-22 | 2022-04-01 | 克雷多生物医学私人有限公司 | 通过试剂容器以热对流进行定量聚合酶链式反应的装置 |
| CN108315252B (zh) * | 2018-03-30 | 2023-09-05 | 中国科学院天津工业生物技术研究所 | 一种光控芯片反应系统及方法 |
| US11638331B2 (en) | 2018-05-29 | 2023-04-25 | Kontak LLC | Multi-frequency controllers for inductive heating and associated systems and methods |
| US11555473B2 (en) | 2018-05-29 | 2023-01-17 | Kontak LLC | Dual bladder fuel tank |
| CN108998371A (zh) * | 2018-09-28 | 2018-12-14 | 北京金豪制药股份有限公司 | 一种低压磁感应加热的pcr控温装置 |
| CN111286459B (zh) * | 2020-02-28 | 2023-05-30 | 宁波胤瑞生物医学仪器有限责任公司 | 一种用于数字pcr芯片的油封装置 |
| CN112858864B (zh) * | 2021-01-18 | 2022-02-18 | 厦门大学 | 一种对led芯片进行非接触式光电检测的装置及方法 |
| CN114381363B (zh) * | 2021-12-28 | 2024-04-30 | 深圳市思坦科技有限公司 | Pcr快速检测系统制备方法及pcr快速检测系统 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6017990B2 (ja) * | 1978-08-03 | 1985-05-08 | 三菱電機株式会社 | 焼成炉 |
| JPH0235053A (ja) * | 1988-07-25 | 1990-02-05 | Shigeo Tani | 大豆の不快臭発生防止方法及びその装置 |
| JPH074037B2 (ja) * | 1989-07-12 | 1995-01-18 | 巖 橋本 | マイクロホンヘッドの風防網組立治具および方法ならびに溶着装置 |
| US6833536B2 (en) * | 2002-05-22 | 2004-12-21 | Applera Corporation | Non-contact radiant heating and temperature sensing device for a chemical reaction chamber |
| GB0212764D0 (en) * | 2002-05-31 | 2002-07-10 | Deltadot Ltd | Direct PCR quantification |
| US20050158725A1 (en) * | 2002-09-24 | 2005-07-21 | Tetsuo Yukimasa | Method of amplifying nucleic acid by electromagnetic induction heating and reaction container and reaction device to be used therein |
| JP4705035B2 (ja) * | 2003-05-23 | 2011-06-22 | バイオ−ラッド ラボラトリーズ，インコーポレイティド | 反応培地の空間配列に対し局部化した温度制御 |
| US20060082768A1 (en) * | 2004-08-31 | 2006-04-20 | Wilson Denise M | Miniaturized fluorescence analysis system |
| US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
| CL2008003008A1 (es) * | 2007-10-12 | 2009-10-02 | Bigtec Private Ltd | Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo. |
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2011
- 2011-04-28 EP EP11774523.2A patent/EP2563513A4/en not_active Withdrawn
- 2011-04-28 WO PCT/IB2011/051872 patent/WO2011135535A1/en not_active Ceased
- 2011-04-28 CN CN201180021966.8A patent/CN102939161B/zh not_active Expired - Fee Related
- 2011-04-28 KR KR1020127029020A patent/KR20130092391A/ko not_active Ceased
- 2011-04-28 EA EA201291008A patent/EA201291008A1/ru unknown
- 2011-04-28 US US13/695,254 patent/US9404151B2/en active Active
- 2011-04-28 JP JP2013506801A patent/JP6026996B2/ja not_active Expired - Fee Related
- 2011-04-28 SG SG2012079307A patent/SG185045A1/en unknown
- 2011-04-28 BR BR112012027876A patent/BR112012027876A2/pt not_active IP Right Cessation
- 2011-04-29 TW TW100115011A patent/TWI591174B/zh not_active IP Right Cessation
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618027B2 (en) | 2019-12-10 | 2023-04-04 | Wistron Corp. | Molecular diagnostics apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130092391A (ko) | 2013-08-20 |
| WO2011135535A1 (en) | 2011-11-03 |
| EP2563513A4 (en) | 2013-12-04 |
| SG185045A1 (en) | 2012-11-29 |
| AR081288A1 (es) | 2012-08-01 |
| JP6026996B2 (ja) | 2016-11-16 |
| US9404151B2 (en) | 2016-08-02 |
| EP2563513A1 (en) | 2013-03-06 |
| EA201291008A1 (ru) | 2013-05-30 |
| CN102939161A (zh) | 2013-02-20 |
| US20130101983A1 (en) | 2013-04-25 |
| JP2013524832A (ja) | 2013-06-20 |
| CN102939161B (zh) | 2016-01-20 |
| TW201144432A (en) | 2011-12-16 |
| BR112012027876A2 (pt) | 2017-03-21 |
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