TWI554522B - 新穎環孢靈ａ晶形、其製備方法及其使用方法 - Google Patents

新穎環孢靈ａ晶形、其製備方法及其使用方法 Download PDF

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Publication number
TWI554522B
TWI554522B TW101119051A TW101119051A TWI554522B TW I554522 B TWI554522 B TW I554522B TW 101119051 A TW101119051 A TW 101119051A TW 101119051 A TW101119051 A TW 101119051A TW I554522 B TWI554522 B TW I554522B
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TW
Taiwan
Prior art keywords
eye
crystal form
cyclosporin
csa
crystal
Prior art date
Application number
TW101119051A
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English (en)
Chinese (zh)
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TW201311730A (zh
Inventor
奇歐瑪斯 卡拉米
理查Ｓ 葛拉漢
安奴拉達Ｖ 高爾
史考特Ｗ 史密斯
吳凱
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歐樂根公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46178866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI554522(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 歐樂根公司 filed Critical 歐樂根公司
Publication of TW201311730A publication Critical patent/TW201311730A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
TW101119051A 2011-05-27 2012-05-28 新穎環孢靈ａ晶形、其製備方法及其使用方法 TWI554522B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161490887P 2011-05-27 2011-05-27

Publications (2)

Publication Number Publication Date
TW201311730A TW201311730A (zh) 2013-03-16
TWI554522B true TWI554522B (zh) 2016-10-21

Family

ID=46178866

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101119051A TWI554522B (zh) 2011-05-27 2012-05-28 新穎環孢靈ａ晶形、其製備方法及其使用方法

Country Status (19)

Country Link
US (4) US8772245B2 (cg-RX-API-DMAC7.html)
EP (2) EP3521302A1 (cg-RX-API-DMAC7.html)
JP (1) JP6163482B2 (cg-RX-API-DMAC7.html)
KR (1) KR102079402B1 (cg-RX-API-DMAC7.html)
CN (1) CN103649108B (cg-RX-API-DMAC7.html)
AR (1) AR086586A1 (cg-RX-API-DMAC7.html)
AU (4) AU2012262513B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013030554B1 (cg-RX-API-DMAC7.html)
CA (1) CA2836946C (cg-RX-API-DMAC7.html)
CL (1) CL2013003400A1 (cg-RX-API-DMAC7.html)
IL (2) IL229475A0 (cg-RX-API-DMAC7.html)
MX (1) MX362271B (cg-RX-API-DMAC7.html)
MY (1) MY180581A (cg-RX-API-DMAC7.html)
RU (1) RU2602062C2 (cg-RX-API-DMAC7.html)
SG (1) SG10201607344UA (cg-RX-API-DMAC7.html)
TW (1) TWI554522B (cg-RX-API-DMAC7.html)
UA (1) UA113627C2 (cg-RX-API-DMAC7.html)
WO (1) WO2012166610A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201308665B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2779994T3 (da) * 2011-11-15 2020-05-18 Allergan Inc Suspensioner af cyclosporin a form 2
AU2012339695B2 (en) * 2011-11-15 2017-10-05 Allergan, Inc. Sustained action formulation of cyclosporin Form 2
RU2635547C2 (ru) 2011-11-15 2017-11-14 Аллерган, Инк. Форма 2 циклоспорина а и способ ее получения
WO2013074616A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Autoclavable suspensions of cyclosporin a form 2
CN104487449A (zh) 2012-06-01 2015-04-01 阿勒根公司 环孢菌素a类似物
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US10524661B2 (en) * 2013-06-12 2020-01-07 Proactive Live, Inc. Sleep monitoring and stimulation
AU2015289387B2 (en) 2014-07-18 2020-10-22 Allergan, Inc. Suspension compositions of cyclosporin A for subconjunctival and periocular injection
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
US10443292B2 (en) * 2016-04-25 2019-10-15 Magna Closures, Inc. Non-contact obstacle detection system for motor vehicles
RU2766160C2 (ru) 2017-05-17 2022-02-08 Юю Фарма, Инк. Новый пептид и фармацевтический состав для лечения глазного заболевания, содержащий пептид в качестве активного фармацевтического ингредиента
US11613558B2 (en) 2018-11-14 2023-03-28 Yuyu Pharma, Inc. Peptides and pharmaceutical compositions for treating eye diseases
KR20250088544A (ko) 2022-10-20 2025-06-17 추가이 세이야쿠 가부시키가이샤 고리형 펩티드 결정을 제조하는 방법
JPWO2024195801A1 (cg-RX-API-DMAC7.html) 2023-03-20 2024-09-26

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途
BRPI0822221A2 (pt) * 2008-01-04 2015-06-23 Alcon Pharmaceuticals Ltd Composições aquosas e estáveis de ciclosporina

Also Published As

Publication number Publication date
US20140315827A1 (en) 2014-10-23
JP2014515372A (ja) 2014-06-30
RU2602062C2 (ru) 2016-11-10
CL2013003400A1 (es) 2014-08-18
CN103649108B (zh) 2017-03-29
US8772245B2 (en) 2014-07-08
SG10201607344UA (en) 2016-10-28
MY180581A (en) 2020-12-02
BR112013030554A2 (pt) 2016-09-06
IL229475A0 (en) 2014-01-30
KR20140047054A (ko) 2014-04-21
AR086586A1 (es) 2014-01-08
KR102079402B1 (ko) 2020-02-19
WO2012166610A1 (en) 2012-12-06
IL290158A (en) 2022-03-01
EP2714720A1 (en) 2014-04-09
US20210269484A1 (en) 2021-09-02
NZ719272A (en) 2017-10-27
EP2714720B1 (en) 2018-12-26
UA113627C2 (xx) 2017-02-27
NZ618213A (en) 2016-05-27
AU2012262513B2 (en) 2016-03-17
AU2012262513A1 (en) 2013-12-12
CA2836946C (en) 2017-08-01
TW201311730A (zh) 2013-03-16
CN103649108A (zh) 2014-03-19
AU2019204192A1 (en) 2019-07-04
MX2013013855A (es) 2014-02-17
BR112013030554B1 (pt) 2020-12-15
AU2019204192B2 (en) 2021-02-04
US20160083432A1 (en) 2016-03-24
MX362271B (es) 2019-01-10
EP3521302A1 (en) 2019-08-07
CA2836946A1 (en) 2012-12-06
ZA201308665B (en) 2014-07-30
US9206228B2 (en) 2015-12-08
US20130023482A1 (en) 2013-01-24
AU2017265008A1 (en) 2017-12-07
RU2013155033A (ru) 2015-07-20
JP6163482B2 (ja) 2017-07-12
AU2016203990A1 (en) 2016-06-30

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