TWI535733B - 抗cd37抗體 - Google Patents
抗cd37抗體 Download PDFInfo
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- TWI535733B TWI535733B TW097130378A TW97130378A TWI535733B TW I535733 B TWI535733 B TW I535733B TW 097130378 A TW097130378 A TW 097130378A TW 97130378 A TW97130378 A TW 97130378A TW I535733 B TWI535733 B TW I535733B
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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EP07114128 | 2007-08-09 |
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TW097130378A TWI535733B (zh) | 2007-08-09 | 2008-08-08 | 抗cd37抗體 |
TW103121994A TW201512220A (zh) | 2007-08-09 | 2008-08-08 | 抗cd37抗體 |
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TW103121994A TW201512220A (zh) | 2007-08-09 | 2008-08-08 | 抗cd37抗體 |
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US (7) | US20100189722A1 (fr) |
EP (3) | EP2241577A1 (fr) |
JP (3) | JP5325216B2 (fr) |
KR (1) | KR101593403B1 (fr) |
CN (4) | CN105273086A (fr) |
AR (2) | AR071242A1 (fr) |
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BR (2) | BRPI0815369A2 (fr) |
CA (1) | CA2693464C (fr) |
CL (3) | CL2008002349A1 (fr) |
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DK (1) | DK2178915T3 (fr) |
EA (2) | EA027499B1 (fr) |
EC (2) | ECSP109946A (fr) |
ES (1) | ES2555202T3 (fr) |
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IL (1) | IL202645A (fr) |
MA (1) | MA32665B1 (fr) |
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PE (3) | PE20140196A1 (fr) |
PH (1) | PH12014501812A1 (fr) |
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PT (1) | PT2178915E (fr) |
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SG (1) | SG190657A1 (fr) |
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Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
CA2654317A1 (fr) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Proteines de liaison monocatenaires polyvalentes dotees d'une fonction d'effecteur |
PE20140196A1 (es) * | 2007-08-09 | 2014-03-19 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
CA2700673A1 (fr) * | 2007-09-24 | 2009-04-02 | Tragara Pharmaceuticals, Inc. | Therapies pour traiter le cancer en utilisant des combinaisons d'inhibiteurs de cox-2 et des anticorps anti-her2(erbb2) ou des combinaisons d'inhibiteurs de cox-2 et des inhibiteurs du recepteur her2(erbb2) de la tyrosine kinase |
PT2132228E (pt) | 2008-04-11 | 2011-10-11 | Emergent Product Dev Seattle | Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional |
JP5944831B2 (ja) * | 2009-12-23 | 2016-07-05 | シュニムネ ゲーエムベーハーSYNIMMUNE GmbH | 抗flt3抗体及びその使用方法 |
NO331080B1 (no) * | 2010-01-29 | 2011-09-26 | Nordic Nanovector As | Radioimmunkonjugater, farmasøytiske sammensetninger og kit omfattende det samme og anvendelse derav |
RU2610662C9 (ru) | 2010-03-12 | 2017-07-24 | Иммьюноджен, Инк. | Cd37-связывающие молекулы и их иммуноконъюгаты |
US20120189618A1 (en) * | 2010-07-16 | 2012-07-26 | Boehringer Ingelheim International Gmbh | Superior efficacy of cd37 antibodies in cll blood samples |
UA112062C2 (uk) | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
US20120107317A1 (en) * | 2010-10-27 | 2012-05-03 | The University Of Hong Kong | Use of cytoplasmic c-myc for regulating immune responses |
JP6018622B2 (ja) * | 2011-04-01 | 2016-11-02 | イミュノジェン, インコーポレイテッド | Cd37結合性分子及びその免疫複合体 |
EP2710042A2 (fr) | 2011-05-16 | 2014-03-26 | Fabion Pharmaceuticals, Inc. | Protéines de fusion contenant un fab multi-spécifique et procédé d'utilisation |
RU2658438C2 (ru) * | 2011-12-13 | 2018-06-21 | Нордик Нановектор Аса | Химерное терапевтическое антитело нн1 против cd-37 |
MX2014011745A (es) * | 2012-03-30 | 2015-01-22 | Immunogen Inc | Metodos para aumentar la eficacia de terapia basada en cd37. |
US20130287797A1 (en) * | 2012-04-26 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Combination of cd37 antibodies with bendamustine |
JP2015517511A (ja) * | 2012-05-16 | 2015-06-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cd37抗体とice(イフォスファミド、カルボプラチン、エトポシド)の併用 |
JP2015517512A (ja) * | 2012-05-16 | 2015-06-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cd37抗体の更なる薬剤との併用 |
WO2014151438A1 (fr) * | 2013-03-15 | 2014-09-25 | Emergent Product Development Seattle, Llc | Anticorps anti-cd37 multispécifiques, compositions et méthodes s'y rapportant |
US20160106837A1 (en) * | 2013-06-14 | 2016-04-21 | Boehringer Ingelheim International Gmbh | Combination of cd37 antibodies with chlorambucil |
JP6510518B2 (ja) | 2013-08-01 | 2019-05-08 | アジェンシス,インコーポレイテッド | Cd37タンパク質に結合する抗体薬物結合体(adc) |
US9291244B2 (en) | 2014-01-17 | 2016-03-22 | Ford Global Technologies, Llc | Nine speed automatic transmission |
EP2966085A1 (fr) | 2014-07-11 | 2016-01-13 | Boehringer Ingelheim International GmbH | Anticorps de type IgG1 ayant une chaîne constante lourde modifiée |
MA53355A (fr) | 2015-05-29 | 2022-03-16 | Agenus Inc | Anticorps anti-ctla-4 et leurs procédés d'utilisation |
MA44391A (fr) | 2015-06-08 | 2019-01-23 | Debiopharm Int Sa | Combinaisons d'immunoconjugués anti-cd37 et d'anticorps anti-cd20 |
LT3124976T (lt) | 2015-07-28 | 2018-12-27 | F. Hoffmann-La Roche Ag | Patobulintas bakterinio endotoksino testas, skirtas endotoksinų aptikimui |
JP6890581B2 (ja) | 2015-08-28 | 2021-06-18 | デビオファーム インターナショナル, エス. アー. | Cd37の検出のための抗体およびアッセイ |
EP3352760A4 (fr) | 2015-09-21 | 2019-03-06 | Aptevo Research and Development LLC | Polypeptides de liaison à cd3 |
US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
US11278629B2 (en) | 2016-11-02 | 2022-03-22 | Debiopharm International, S.A. | Methods for improving anti-CD37 immunoconjugate therapy |
PT3551660T (pt) * | 2016-12-07 | 2023-11-30 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-ctla-4 e métodos de uso dos mesmos |
US11578115B2 (en) | 2017-01-10 | 2023-02-14 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
WO2018170458A1 (fr) | 2017-03-16 | 2018-09-20 | The General Hospital Corporation | Récepteurs d'antigènes chimériques ciblant cd37 |
NZ757603A (en) | 2017-03-31 | 2024-05-31 | Genmab Holding B V | Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof |
SG11201911886PA (en) * | 2017-06-27 | 2020-01-30 | Regeneron Pharma | Non-human animals comprising a humanized asgr1 locus |
WO2019243636A1 (fr) | 2018-06-22 | 2019-12-26 | Genmab Holding B.V. | Anticorps anti-cd37 et anticorps anti-cd20, compositions et méthodes d'utilisation de ceux-ci |
CA3099928A1 (fr) * | 2018-06-22 | 2019-12-26 | The General Hospital Corporation | Recepteurs antigeniques chimeriques ciblant cd37 et cd19 |
WO2020004337A1 (fr) * | 2018-06-27 | 2020-01-02 | 国立大学法人名古屋大学 | Récepteur antigénique chimérique spécifique à cd37 |
US20240252635A1 (en) | 2018-10-04 | 2024-08-01 | Genmab Holding B.V. | Pharmaceutical compositions comprising bispecific anti-cd37 antibodies |
WO2021041678A1 (fr) * | 2019-08-30 | 2021-03-04 | Qilu Puget Sound Biotherapeutics Corporation | Anticorps anti-cd20, anticorps anti-cd37 et leurs mélanges |
EP4412715A1 (fr) | 2021-10-06 | 2024-08-14 | Nordic Nanovector ASA | Hh1 humanisée |
WO2023057595A1 (fr) | 2021-10-06 | 2023-04-13 | Nordic Nanovector Asa | Hh1 rew humanisé |
TW202330041A (zh) * | 2021-10-18 | 2023-08-01 | 日商第一三共股份有限公司 | 抗cd37抗體-藥物結合物 |
WO2024118480A1 (fr) * | 2022-11-28 | 2024-06-06 | Epiphany Biosciences | Utilisation d'agents antiviraux, composition de matière, préparations/agents de combinaison pour traiter des maladies chroniques associées au virus d'epstein-barr et à d'autres virus de l'herpès humain |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
AU606320B2 (en) | 1985-11-01 | 1991-02-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
WO1988007089A1 (fr) | 1987-03-18 | 1988-09-22 | Medical Research Council | Anticorps alteres |
GB8800077D0 (en) * | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel chimeric antibodies |
DE68908175T2 (de) | 1988-05-27 | 1994-03-03 | Centocor Inc | Gefriergetrocknete formulierung für antikörperprodukte. |
ATE190355T1 (de) * | 1988-09-06 | 2000-03-15 | Xoma Corp | Genexpressions-elemente und herstellung von chimären maus-mensch-antikörpern |
DE59010941D1 (de) | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
ES2193136T3 (es) | 1991-08-14 | 2003-11-01 | Genentech Inc | Variantes de inmunoglubina para receptores especificos de fc epsilon. |
EP0563475B1 (fr) | 1992-03-25 | 2000-05-31 | Immunogen Inc | Conjugués d'agents ciblés et de dérivés du CC-1065 |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
ES2108460T3 (es) | 1993-06-03 | 1997-12-16 | Therapeutic Antibodies Inc | Fragmentos de anticuerpos en terapeutica. |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
EP0904107B1 (fr) | 1996-03-18 | 2004-10-20 | Board Of Regents, The University Of Texas System | Domaines analogues a l'immunoglobuline a demi-vies prolongees |
US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
DE69738522T2 (de) | 1996-08-02 | 2009-04-02 | Bristol-Myers Squibb Co. | Ein verfahren zur inhibierung immunglobulininduzierter toxizität aufgrund von der verwendung von immunoglobinen in therapie und in vivo diagnostik |
US6991790B1 (en) | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
HUP0100813A3 (en) | 1998-02-25 | 2003-08-28 | Lexigen Pharmaceuticals Corp L | Enhancing the circulating half-life of antibody-based fusion proteins |
DE19911329A1 (de) | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
DE69937291T2 (de) | 1998-04-02 | 2008-07-10 | Genentech, Inc., South San Francisco | Antikörpervarianten und fragmente davon |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
ATE349438T1 (de) | 1999-11-24 | 2007-01-15 | Immunogen Inc | Cytotoxische wirkstoffe enthaltend taxane und deren therapeutische anwendung |
DE60031793T2 (de) | 1999-12-29 | 2007-08-23 | Immunogen Inc., Cambridge | Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung |
ATE489395T1 (de) | 2000-12-12 | 2010-12-15 | Medimmune Llc | Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung |
US20030133939A1 (en) * | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
CA2476166C (fr) * | 2002-02-14 | 2011-11-15 | Immunomedics, Inc. | Anticorps anti-cd20 et proteines hybrides desdits anticorps, et methodes d'utilisation |
US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
US20040110226A1 (en) | 2002-03-01 | 2004-06-10 | Xencor | Antibody optimization |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
US6596757B1 (en) | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
AU2003259835A1 (en) | 2002-08-15 | 2004-03-03 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
EP3502133A1 (fr) | 2002-09-27 | 2019-06-26 | Xencor, Inc. | Variantes fc optimisées et leurs procédés de génération |
AU2003286467B2 (en) | 2002-10-15 | 2009-10-01 | Abbvie Biotherapeutics Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
EP2368578A1 (fr) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification et ingénierie d'anticorps avec régions FC de variante et procédés d'utilisation associés |
EP2281577B1 (fr) | 2003-05-14 | 2016-11-16 | ImmunoGen, Inc. | Composition constituee de conjuges de medicaments |
US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
US20050249723A1 (en) | 2003-12-22 | 2005-11-10 | Xencor, Inc. | Fc polypeptides with novel Fc ligand binding sites |
EP1737890A2 (fr) | 2004-03-24 | 2007-01-03 | Xencor, Inc. | Variantes d'immunoglobuline a l'exterieur de la region fc |
EP2471813B1 (fr) | 2004-07-15 | 2014-12-31 | Xencor, Inc. | Variantes optimisées de Fc |
WO2006031994A2 (fr) | 2004-09-14 | 2006-03-23 | Xencor, Inc. | Domaines fc monomeres des immunoglobulines |
WO2006047350A2 (fr) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | Variants d'immunoglobuline igg a fonction effectrice optimisee |
EP2845865A1 (fr) | 2004-11-12 | 2015-03-11 | Xencor Inc. | Variantes Fc avec liaison altérée en FcRn |
US20080279850A1 (en) | 2005-07-25 | 2008-11-13 | Trubion Pharmaceuticals, Inc. | B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules |
SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
CA2624189A1 (fr) | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Variants de fc dotes de proprietes de liaison aux recepteurs fc optimisees |
EP1945671A2 (fr) | 2005-10-12 | 2008-07-23 | MorphoSys AG | Generation et profilage d'anticorps therapeutiques derives de hucal gold entierement humains, specifiques de cd38 humain |
EP1806365A1 (fr) | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Anticorps spécifiques pour la protéine alpha d'activation de fibroblastes et leurs immunoconjugués |
AU2008287195A1 (en) | 2007-07-06 | 2009-02-19 | Emergent Product Development Seattle, Llc | Binding peptides having a C-terminally disposed specific binding domain |
PE20140196A1 (es) | 2007-08-09 | 2014-03-19 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
PT2132228E (pt) | 2008-04-11 | 2011-10-11 | Emergent Product Dev Seattle | Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional |
NZ590330A (en) | 2008-07-21 | 2012-08-31 | Immunomedics Inc | Structural variants of anti-cd20 antibodies for improved therapeutic characteristics |
JP2012508774A (ja) | 2008-11-13 | 2012-04-12 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | Cd37免疫治療薬併用療法およびその使用 |
US20120189618A1 (en) * | 2010-07-16 | 2012-07-26 | Boehringer Ingelheim International Gmbh | Superior efficacy of cd37 antibodies in cll blood samples |
US20130287797A1 (en) * | 2012-04-26 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Combination of cd37 antibodies with bendamustine |
JP2015517511A (ja) * | 2012-05-16 | 2015-06-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cd37抗体とice(イフォスファミド、カルボプラチン、エトポシド)の併用 |
JP2015517512A (ja) * | 2012-05-16 | 2015-06-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cd37抗体の更なる薬剤との併用 |
US20160106837A1 (en) | 2013-06-14 | 2016-04-21 | Boehringer Ingelheim International Gmbh | Combination of cd37 antibodies with chlorambucil |
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