TWI526209B - 包括酶可切割的羥考酮前驅藥之組合物 - Google Patents
包括酶可切割的羥考酮前驅藥之組合物 Download PDFInfo
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- TWI526209B TWI526209B TW101100923A TW101100923A TWI526209B TW I526209 B TWI526209 B TW I526209B TW 101100923 A TW101100923 A TW 101100923A TW 101100923 A TW101100923 A TW 101100923A TW I526209 B TWI526209 B TW I526209B
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- Prior art keywords
- compound
- prodrug
- oxycodone
- trypsin
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- 229940002612 prodrug Drugs 0.000 title claims description 266
- 239000000651 prodrug Substances 0.000 title claims description 266
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- 229960002085 oxycodone Drugs 0.000 title claims description 136
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- 239000002753 trypsin inhibitor Substances 0.000 claims description 167
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- 101710162629 Trypsin inhibitor Proteins 0.000 claims description 148
- 239000003112 inhibitor Substances 0.000 claims description 129
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- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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| WO2012096887A3 (en) | 2012-10-04 |
| AU2012205733A1 (en) | 2013-05-09 |
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| CA2814763C (en) | 2019-05-28 |
| US9499581B2 (en) | 2016-11-22 |
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