TWI488659B - Containing tegafur, gemcitabine, and otiracazide - Google Patents
Containing tegafur, gemcitabine, and otiracazide Download PDFInfo
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- TWI488659B TWI488659B TW101118538A TW101118538A TWI488659B TW I488659 B TWI488659 B TW I488659B TW 101118538 A TW101118538 A TW 101118538A TW 101118538 A TW101118538 A TW 101118538A TW I488659 B TWI488659 B TW I488659B
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- 229960001674 tegafur Drugs 0.000 title claims description 40
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 title claims description 40
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title claims description 35
- 229960005277 gemcitabine Drugs 0.000 title claims description 35
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Classifications
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011116884 | 2011-05-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201300141A TW201300141A (zh) | 2013-01-01 |
| TWI488659B true TWI488659B (zh) | 2015-06-21 |
Family
ID=47217314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| TW101118538A TWI488659B (zh) | 2011-05-25 | 2012-05-24 | Containing tegafur, gemcitabine, and otiracazide |
| TW104113084A TWI566787B (zh) | 2011-05-25 | 2012-05-24 | Contains tegafur, gemcopyrimidine, otiorasilide potassium tablets (b) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104113084A TWI566787B (zh) | 2011-05-25 | 2012-05-24 | Contains tegafur, gemcopyrimidine, otiorasilide potassium tablets (b) |
Country Status (16)
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| US (1) | US20140335174A1 (https=) |
| EP (1) | EP2716290B1 (https=) |
| JP (2) | JP5689173B2 (https=) |
| KR (2) | KR101869127B1 (https=) |
| AU (1) | AU2012259803B2 (https=) |
| BR (1) | BR112013030093B1 (https=) |
| CA (1) | CA2836865C (https=) |
| ES (1) | ES2671926T3 (https=) |
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| MX (1) | MX353289B (https=) |
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| PH (1) | PH12013502323A1 (https=) |
| RU (1) | RU2601620C2 (https=) |
| SG (2) | SG10201505503WA (https=) |
| TW (2) | TWI488659B (https=) |
| WO (1) | WO2012161240A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX353289B (es) * | 2011-05-25 | 2018-01-05 | Taiho Pharmaceutical Co Ltd | Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico. |
| CN107837273A (zh) * | 2016-09-18 | 2018-03-27 | 江苏金甙生物技术有限公司 | 一种肠溶替吉奥缓释制剂及其制备方法 |
| CN107865871B (zh) * | 2016-09-23 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种替吉奥组合物及其制备方法 |
| CN106619689B (zh) * | 2016-12-30 | 2018-05-01 | 陈晓华 | 一种用于治疗癌症的药物组合物、试剂盒及其应用 |
| AU2020347662A1 (en) * | 2019-09-13 | 2022-03-31 | Meiji Co., Ltd. | Solid food and solid milk |
| KR20250022143A (ko) * | 2022-06-10 | 2025-02-14 | 다이호야쿠힌고교 가부시키가이샤 | 피미테스핍을 함유하는 의약 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020015728A1 (en) * | 2000-05-18 | 2002-02-07 | Payumo Francis C. | Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form |
| CN1558753A (zh) * | 2001-09-28 | 2004-12-29 | ��ʽ�������ͻ�ѧ�о��� | 有核型速溶崩解性成型品 |
| CN101711765A (zh) * | 2009-10-31 | 2010-05-26 | 山东新时代药业有限公司 | 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0543015B1 (en) * | 1991-05-27 | 1998-11-11 | Taiho Pharmaceutical Co., Ltd. | Composition, method and kit for potentiating antitumor activity and for curing tumor |
| JP2002505269A (ja) * | 1998-03-06 | 2002-02-19 | エウランド インターナショナル ソシエタ ペル アチオニ | 急速崩壊錠剤 |
| JP2005512997A (ja) * | 2001-11-07 | 2005-05-12 | シントン・ベスローテン・フェンノートシャップ | タムスロシン錠 |
| US6723348B2 (en) * | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
| WO2003080023A2 (en) * | 2002-03-20 | 2003-10-02 | Elan Pharma International Limited | Fast dissolving dosage forms having reduced friability |
| CN1761665A (zh) * | 2003-03-14 | 2006-04-19 | 大鹏药品工业株式会社 | 抗肿瘤效果增强剂和抗肿瘤剂 |
| AU2004275569B2 (en) * | 2003-09-29 | 2011-04-21 | Cipla Limited | Pharmaceutical formulation with improved stability |
| CN100333726C (zh) | 2004-12-23 | 2007-08-29 | 鲁南制药集团股份有限公司 | 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片 |
| CN101155600B (zh) * | 2005-04-01 | 2011-05-04 | 大鹏药品工业株式会社 | 放射线治疗增强剂 |
| JP4994618B2 (ja) * | 2005-08-11 | 2012-08-08 | 学校法人北里研究所 | Ｔｓ−１／カンプトテシン類による化学放射線療法 |
| WO2009084216A1 (ja) * | 2007-12-27 | 2009-07-09 | Taiho Pharmaceutical Co., Ltd. | 経口粉粒状抗腫瘍剤 |
| TWI468188B (zh) * | 2008-01-30 | 2015-01-11 | Univ Tokushima | Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation |
| KR100934876B1 (ko) | 2008-01-31 | 2010-01-06 | 성균관대학교산학협력단 | Ｌｉｇａ공정의 도금방법 |
| CN101380327B (zh) * | 2008-10-09 | 2011-01-26 | 北京恒瑞康达医药科技发展有限公司 | 抗癌复合缓释组合物及制备 |
| JP5553522B2 (ja) | 2009-03-31 | 2014-07-16 | 大鵬薬品工業株式会社 | 経口投与用医薬組成物 |
| CA2761243A1 (en) * | 2009-05-12 | 2010-11-18 | Taiho Pharmaceutical Co., Ltd. | Anti-tumor agent containing tegafur-gimeracil-oteracil potassium combination drug and oxaliplatin |
| MX353289B (es) * | 2011-05-25 | 2018-01-05 | Taiho Pharmaceutical Co Ltd | Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico. |
| CN102614183B (zh) * | 2012-03-05 | 2013-10-30 | 齐鲁制药(海南)有限公司 | 一种替吉奥的口服制剂 |
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2012
- 2012-05-24 MX MX2013013563A patent/MX353289B/es active IP Right Grant
- 2012-05-24 MY MYPI2013702158A patent/MY167883A/en unknown
- 2012-05-24 PH PH1/2013/502323A patent/PH12013502323A1/en unknown
- 2012-05-24 SG SG10201505503WA patent/SG10201505503WA/en unknown
- 2012-05-24 WO PCT/JP2012/063260 patent/WO2012161240A1/ja not_active Ceased
- 2012-05-24 AU AU2012259803A patent/AU2012259803B2/en not_active Ceased
- 2012-05-24 JP JP2013516428A patent/JP5689173B2/ja active Active
- 2012-05-24 SG SG2013083829A patent/SG194922A1/en unknown
- 2012-05-24 BR BR112013030093A patent/BR112013030093B1/pt not_active IP Right Cessation
- 2012-05-24 US US14/118,952 patent/US20140335174A1/en not_active Abandoned
- 2012-05-24 KR KR1020137033946A patent/KR101869127B1/ko not_active Expired - Fee Related
- 2012-05-24 TW TW101118538A patent/TWI488659B/zh not_active IP Right Cessation
- 2012-05-24 TW TW104113084A patent/TWI566787B/zh not_active IP Right Cessation
- 2012-05-24 KR KR1020177016653A patent/KR20170072959A/ko not_active Ceased
- 2012-05-24 EP EP12789023.4A patent/EP2716290B1/en not_active Not-in-force
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020015728A1 (en) * | 2000-05-18 | 2002-02-07 | Payumo Francis C. | Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form |
| CN1558753A (zh) * | 2001-09-28 | 2004-12-29 | ��ʽ�������ͻ�ѧ�о��� | 有核型速溶崩解性成型品 |
| CN101711765A (zh) * | 2009-10-31 | 2010-05-26 | 山东新时代药业有限公司 | 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片 |
Also Published As
| Publication number | Publication date |
|---|---|
| MY167883A (en) | 2018-09-26 |
| KR101869127B1 (ko) | 2018-06-19 |
| JP5689173B2 (ja) | 2015-03-25 |
| CA2836865A1 (en) | 2012-11-29 |
| BR112013030093B1 (pt) | 2019-12-10 |
| TWI566787B (zh) | 2017-01-21 |
| TW201529100A (zh) | 2015-08-01 |
| RU2601620C2 (ru) | 2016-11-10 |
| JP5769853B2 (ja) | 2015-08-26 |
| IL229372A0 (en) | 2014-01-30 |
| MX2013013563A (es) | 2013-12-16 |
| EP2716290A1 (en) | 2014-04-09 |
| IL229372B (en) | 2018-12-31 |
| SG10201505503WA (en) | 2015-09-29 |
| JP2014218523A (ja) | 2014-11-20 |
| SG194922A1 (en) | 2013-12-30 |
| KR20140037879A (ko) | 2014-03-27 |
| TW201300141A (zh) | 2013-01-01 |
| MX353289B (es) | 2018-01-05 |
| EP2716290A4 (en) | 2014-11-26 |
| US20140335174A1 (en) | 2014-11-13 |
| CA2836865C (en) | 2018-02-27 |
| KR20170072959A (ko) | 2017-06-27 |
| EP2716290B1 (en) | 2018-03-14 |
| RU2013157528A (ru) | 2015-06-27 |
| AU2012259803B2 (en) | 2016-03-17 |
| NZ617625A (en) | 2015-10-30 |
| WO2012161240A1 (ja) | 2012-11-29 |
| JPWO2012161240A1 (ja) | 2014-07-31 |
| BR112013030093A2 (pt) | 2016-09-20 |
| PH12013502323A1 (en) | 2014-01-06 |
| ES2671926T3 (es) | 2018-06-11 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |