MX2013013563A - Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico. - Google Patents

Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico.

Info

Publication number
MX2013013563A
MX2013013563A MX2013013563A MX2013013563A MX2013013563A MX 2013013563 A MX2013013563 A MX 2013013563A MX 2013013563 A MX2013013563 A MX 2013013563A MX 2013013563 A MX2013013563 A MX 2013013563A MX 2013013563 A MX2013013563 A MX 2013013563A
Authority
MX
Mexico
Prior art keywords
gimeracil
dry
coated tablet
oteracil potassium
tablet containing
Prior art date
Application number
MX2013013563A
Other languages
English (en)
Other versions
MX353289B (es
Inventor
Takumi Okamoto
Takashi Yoshizawa
Yoshito Ohnishi
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of MX2013013563A publication Critical patent/MX2013013563A/es
Publication of MX353289B publication Critical patent/MX353289B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención presente proporciona una tableta revestida en seco que comprende: un centro interior que contiene, como ingredientes activos, (a) tegafur, (b) gimeracil, y (c) oteracil potásico; y un forro exterior.
MX2013013563A 2011-05-25 2012-05-24 Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico. MX353289B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011116884 2011-05-25
PCT/JP2012/063260 WO2012161240A1 (ja) 2011-05-25 2012-05-24 テガフール、ギメラシル、オテラシルカリウム含有有核錠

Publications (2)

Publication Number Publication Date
MX2013013563A true MX2013013563A (es) 2013-12-16
MX353289B MX353289B (es) 2018-01-05

Family

ID=47217314

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013563A MX353289B (es) 2011-05-25 2012-05-24 Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico.

Country Status (15)

Country Link
US (1) US20140335174A1 (es)
EP (1) EP2716290B1 (es)
JP (2) JP5689173B2 (es)
KR (2) KR101869127B1 (es)
AU (1) AU2012259803B2 (es)
BR (1) BR112013030093B1 (es)
CA (1) CA2836865C (es)
ES (1) ES2671926T3 (es)
IL (1) IL229372B (es)
MX (1) MX353289B (es)
MY (1) MY167883A (es)
RU (1) RU2601620C2 (es)
SG (2) SG194922A1 (es)
TW (2) TWI488659B (es)
WO (1) WO2012161240A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI488659B (zh) * 2011-05-25 2015-06-21 Taiho Pharmaceutical Co Ltd Containing tegafur, gemcitabine, and otiracazide
CN107837273A (zh) * 2016-09-18 2018-03-27 江苏金甙生物技术有限公司 一种肠溶替吉奥缓释制剂及其制备方法
CN107865871B (zh) * 2016-09-23 2021-09-03 江苏恒瑞医药股份有限公司 一种替吉奥组合物及其制备方法
CN106619689B (zh) * 2016-12-30 2018-05-01 陈晓华 一种用于治疗癌症的药物组合物、试剂盒及其应用
TW202404585A (zh) * 2022-06-10 2024-02-01 日商大鵬藥品工業股份有限公司 含有匹密特匹（Pimitespib）之醫藥組合物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148589B1 (ko) * 1991-05-27 1998-11-02 고바야시 유끼오 항종양 효과의 상승 및 종양의 치료를 위한 조성물 및 키트
ES2178876T5 (es) * 1998-03-06 2012-10-01 Aptalis Pharma S.R.L. Pastilla de desintegración rápida
US7276252B2 (en) * 2000-05-18 2007-10-02 Massachusetts Institute Of Technology Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
KR20040037138A (ko) * 2001-09-28 2004-05-04 가부시키가이샤산와카가쿠켄큐쇼 유핵형 속용붕괴성 성형품
NZ532589A (en) * 2001-11-07 2005-02-25 Synthon Bv Tamsulosin tablets
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
US20030215502A1 (en) * 2002-03-20 2003-11-20 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
ATE408408T1 (de) * 2003-03-14 2008-10-15 Taiho Pharmaceutical Co Ltd Eine die antitumorwirkung verstärkende verbindung und antitumormittel
US20070117781A1 (en) * 2003-09-29 2007-05-24 Koninklijke Philips Electronics, N.V. Pharmaceutical formulation with improved stability
CN100333726C (zh) 2004-12-23 2007-08-29 鲁南制药集团股份有限公司 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片
KR101065932B1 (ko) * 2005-04-01 2011-09-19 다이호야쿠힌고교 가부시키가이샤 방사선 치료 증강제
JP4994618B2 (ja) * 2005-08-11 2012-08-08 学校法人北里研究所 Ｔｓ−１／カンプトテシン類による化学放射線療法
US20100266706A1 (en) * 2007-12-27 2010-10-21 Taiho Pharmaceutical Co., Ltd. Oral particulate antitumor preparation
TWI468188B (zh) * 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
KR100934876B1 (ko) 2008-01-31 2010-01-06 성균관대학교산학협력단 Ｌｉｇａ공정의 도금방법
CN101380327B (zh) * 2008-10-09 2011-01-26 北京恒瑞康达医药科技发展有限公司 抗癌复合缓释组合物及制备
JP5553522B2 (ja) 2009-03-31 2014-07-16 大鵬薬品工業株式会社 経口投与用医薬組成物
WO2010131460A1 (ja) * 2009-05-12 2010-11-18 大鵬薬品工業株式会社 テガフール・ギメラシル・オテラシルカリウム配合剤及びオキサリプラチンを含有する抗腫瘍剤
CN101711765B (zh) * 2009-10-31 2011-03-23 山东新时代药业有限公司 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片
TWI488659B (zh) * 2011-05-25 2015-06-21 Taiho Pharmaceutical Co Ltd Containing tegafur, gemcitabine, and otiracazide
CN102614183B (zh) * 2012-03-05 2013-10-30 齐鲁制药(海南)有限公司 一种替吉奥的口服制剂

Also Published As

Publication number Publication date
ES2671926T3 (es) 2018-06-11
EP2716290A4 (en) 2014-11-26
AU2012259803B2 (en) 2016-03-17
JPWO2012161240A1 (ja) 2014-07-31
TWI488659B (zh) 2015-06-21
EP2716290B1 (en) 2018-03-14
JP2014218523A (ja) 2014-11-20
IL229372A0 (en) 2014-01-30
KR101869127B1 (ko) 2018-06-19
CA2836865A1 (en) 2012-11-29
NZ617625A (en) 2015-10-30
US20140335174A1 (en) 2014-11-13
KR20170072959A (ko) 2017-06-27
BR112013030093A2 (pt) 2016-09-20
SG10201505503WA (en) 2015-09-29
IL229372B (en) 2018-12-31
TW201529100A (zh) 2015-08-01
BR112013030093B1 (pt) 2019-12-10
RU2013157528A (ru) 2015-06-27
KR20140037879A (ko) 2014-03-27
MX353289B (es) 2018-01-05
JP5769853B2 (ja) 2015-08-26
TW201300141A (zh) 2013-01-01
MY167883A (en) 2018-09-26
SG194922A1 (en) 2013-12-30
CA2836865C (en) 2018-02-27
WO2012161240A1 (ja) 2012-11-29
RU2601620C2 (ru) 2016-11-10
JP5689173B2 (ja) 2015-03-25
TWI566787B (zh) 2017-01-21
EP2716290A1 (en) 2014-04-09

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