TWI486161B - 含那若松（ｎａｌｏｘｏｎｅ）的鼻內藥物劑型 - Google Patents

含那若松（ｎａｌｏｘｏｎｅ）的鼻內藥物劑型 Download PDF

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Publication number
TWI486161B
TWI486161B TW101116857A TW101116857A TWI486161B TW I486161 B TWI486161 B TW I486161B TW 101116857 A TW101116857 A TW 101116857A TW 101116857 A TW101116857 A TW 101116857A TW I486161 B TWI486161 B TW I486161B
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Taiwan
Prior art keywords
dosage form
hydrochloride
administration
microliters
amount
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TW101116857A
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English (en)
Chinese (zh)
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TW201311244A (zh
Inventor
約翰 史崔
亞歷山大 歐克沙
史帝芬 哈瑞斯
凱文 史密斯
露西 珍莫帝爾
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歐 賽提克股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dispersion Chemistry (AREA)
  • Addiction (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW101116857A 2011-05-13 2012-05-11 含那若松（ｎａｌｏｘｏｎｅ）的鼻內藥物劑型 TWI486161B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11166076 2011-05-13

Publications (2)

Publication Number Publication Date
TW201311244A TW201311244A (zh) 2013-03-16
TWI486161B true TWI486161B (zh) 2015-06-01

Family

ID=44658496

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101116857A TWI486161B (zh) 2011-05-13 2012-05-11 含那若松（ｎａｌｏｘｏｎｅ）的鼻內藥物劑型

Country Status (37)

Country Link
US (7) US20150018379A1 (enExample)
EP (2) EP3320893A1 (enExample)
JP (3) JP6110367B2 (enExample)
KR (2) KR101873174B1 (enExample)
CN (2) CN107260672A (enExample)
AR (1) AR086391A1 (enExample)
AT (1) AT16553U1 (enExample)
AU (2) AU2012257785B2 (enExample)
BR (1) BR112013029126A2 (enExample)
CA (1) CA2835940C (enExample)
CO (1) CO6821959A2 (enExample)
CY (1) CY1120399T1 (enExample)
DE (1) DE202012013606U1 (enExample)
DK (2) DK2706982T4 (enExample)
ES (1) ES2661838T5 (enExample)
HK (1) HK1255428A1 (enExample)
HR (1) HRP20180233T1 (enExample)
HU (1) HUE036465T2 (enExample)
IL (1) IL229409B (enExample)
LT (1) LT2706982T (enExample)
ME (1) ME02958B (enExample)
MX (1) MX354249B (enExample)
MY (1) MY194947A (enExample)
NO (1) NO2706982T3 (enExample)
PH (2) PH12013502313A1 (enExample)
PL (1) PL2706982T3 (enExample)
PT (1) PT2706982T (enExample)
RS (1) RS57054B1 (enExample)
RU (2) RU2657441C1 (enExample)
SG (1) SG194927A1 (enExample)
SI (1) SI2706982T1 (enExample)
SM (1) SMT201800105T1 (enExample)
TR (1) TR201802716T4 (enExample)
TW (1) TWI486161B (enExample)
UA (1) UA110974C2 (enExample)
WO (1) WO2012156317A2 (enExample)
ZA (1) ZA201308280B (enExample)

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US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
NO2706982T3 (enExample) * 2011-05-13 2018-06-02
WO2015095644A1 (en) 2013-12-20 2015-06-25 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US10085937B2 (en) 2014-03-14 2018-10-02 Adapt Pharma Limited Nasal drug products and methods of their use
EP3777838A1 (en) * 2014-03-14 2021-02-17 Opiant Pharmaceuticals, Inc. Nasal drug products and methods of their use
US9561177B2 (en) 2014-03-14 2017-02-07 Adapt Pharma Limited Nasal drug products and methods of their use
US9480644B2 (en) 2014-03-14 2016-11-01 Opiant Pharmaceuticals, Inc. Nasal drug products and methods of their use
US11135155B2 (en) 2014-07-08 2021-10-05 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
US10722510B2 (en) 2014-07-08 2020-07-28 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
CA2954637A1 (en) * 2014-07-09 2016-01-14 Opiant Pharmaceuticals, Inc. Co-packaged drug products
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US11559483B2 (en) * 2015-07-10 2023-01-24 Sanjay Gupta Nasal foam via cribriform plate for medication delivery to the brain and/or body and for nasal moisturization and hygiene
EP3349756A4 (en) * 2015-09-17 2019-05-15 Adapt Pharma Limited NASAL MEDICAMENT PRODUCTS AND METHOD FOR USE THEREOF
US20190209464A1 (en) * 2016-06-24 2019-07-11 Opiant Pharmaceuticals, Inc. Compositions, devices and methods for the treatment of alcohol use disorder
WO2018034920A1 (en) * 2016-08-17 2018-02-22 Insys Development Company, Inc. Liquid naloxone spray
WO2020198327A1 (en) * 2019-03-26 2020-10-01 Pocket Naloxone Corp. Devices and methods for delivering pharmaceutical compositions
EP3946547A4 (en) 2019-03-26 2023-01-18 Pocket Naloxone Corp. DEVICES AND METHODS FOR DELIVERING PHARMACEUTICAL COMPOSITIONS
US10653690B1 (en) * 2019-07-09 2020-05-19 Orexo Ab Pharmaceutical composition for nasal delivery
US10729687B1 (en) 2019-07-09 2020-08-04 Orexo Ab Pharmaceutical composition for nasal delivery
WO2021222545A1 (en) * 2020-04-29 2021-11-04 The Texas A&M University System Naloxone nanoparticle compositions and methods thereof
HRP20221361T1 (hr) 2020-05-18 2023-01-06 Orexo Ab Novi farmaceutski sastav za davanje lijeka
US11278709B1 (en) 2021-03-12 2022-03-22 Pocket Naloxone Corp. Drug delivery device and methods for using same
WO2023014906A1 (en) 2021-08-04 2023-02-09 Opiant Pharmaceuticals, Inc. Compositions and methods for the treatment of opioid overdose
GB202117016D0 (en) 2021-11-25 2022-01-12 Orexo Ab New pharmaceutical device
WO2023094826A1 (en) 2021-11-25 2023-06-01 Orexo Ab Pharmaceutical composition comprising adrenaline

Citations (3)

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WO2000062757A1 (en) * 1999-04-19 2000-10-26 Britannia Pharmaceuticals Limited Composition containing opioid antagonists and spray dispenser
CN1575795A (zh) * 2003-06-25 2005-02-09 中国人民解放军军事医学科学院毒物药物研究所 盐酸纳洛酮鼻腔喷雾剂

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EP3777838A1 (en) 2014-03-14 2021-02-17 Opiant Pharmaceuticals, Inc. Nasal drug products and methods of their use
US9561177B2 (en) 2014-03-14 2017-02-07 Adapt Pharma Limited Nasal drug products and methods of their use
US10085937B2 (en) 2014-03-14 2018-10-02 Adapt Pharma Limited Nasal drug products and methods of their use
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Publication number Priority date Publication date Assignee Title
US4464378A (en) * 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
WO2000062757A1 (en) * 1999-04-19 2000-10-26 Britannia Pharmaceuticals Limited Composition containing opioid antagonists and spray dispenser
CN1575795A (zh) * 2003-06-25 2005-02-09 中国人民解放军军事医学科学院毒物药物研究所 盐酸纳洛酮鼻腔喷雾剂

Also Published As

Publication number Publication date
EP3320893A1 (en) 2018-05-16
KR20140007482A (ko) 2014-01-17
AU2016204880A1 (en) 2016-07-28
US20190374464A1 (en) 2019-12-12
NO2706982T3 (enExample) 2018-06-02
PL2706982T3 (pl) 2018-07-31
KR101873174B1 (ko) 2018-06-29
EP2706982B2 (en) 2021-03-10
AU2016204880B2 (en) 2017-11-23
EP2706982B1 (en) 2018-01-03
JP2016128453A (ja) 2016-07-14
CN103764119A (zh) 2014-04-30
DE202012013606U1 (de) 2018-04-18
RS57054B1 (sr) 2018-05-31
PH12016501342B1 (en) 2018-06-11
US20240082149A1 (en) 2024-03-14
RU2657441C1 (ru) 2018-06-13
CN107260672A (zh) 2017-10-20
CY1120399T1 (el) 2019-07-10
TR201802716T4 (tr) 2018-03-21
US20170231904A1 (en) 2017-08-17
DK2706982T4 (da) 2021-05-10
LT2706982T (lt) 2018-05-25
ES2661838T5 (es) 2021-11-18
JP2018150336A (ja) 2018-09-27
IL229409B (en) 2020-10-29
DK2706982T3 (en) 2018-03-12
US20150126540A1 (en) 2015-05-07
EP2706982A2 (en) 2014-03-19
UA110974C2 (uk) 2016-03-10
RU2587051C2 (ru) 2016-06-10
MX354249B (es) 2018-02-20
DK201800034U1 (da) 2018-05-25
JP6110367B2 (ja) 2017-04-05
US20170304192A1 (en) 2017-10-26
ME02958B (me) 2018-07-20
HK1255428A1 (en) 2019-08-16
KR20170010078A (ko) 2017-01-25
ZA201308280B (en) 2014-07-30
CA2835940A1 (en) 2012-11-22
RU2013155479A (ru) 2015-06-20
WO2012156317A2 (en) 2012-11-22
AU2012257785B2 (en) 2016-04-14
SMT201800105T1 (it) 2018-05-02
HRP20180233T1 (hr) 2018-06-01
BR112013029126A2 (pt) 2017-02-07
AU2012257785A1 (en) 2013-11-28
US11806428B2 (en) 2023-11-07
US20210338574A1 (en) 2021-11-04
PT2706982T (pt) 2018-03-08
MX2013013276A (es) 2014-08-07
WO2012156317A3 (en) 2013-05-10
TW201311244A (zh) 2013-03-16
US20150018379A1 (en) 2015-01-15
AT16553U1 (de) 2020-01-15
CA2835940C (en) 2020-08-04
HUE036465T2 (hu) 2018-07-30
NZ705933A (en) 2016-07-29
CO6821959A2 (es) 2013-12-31
NZ617442A (en) 2015-03-27
AR086391A1 (es) 2013-12-11
JP2014513683A (ja) 2014-06-05
ES2661838T3 (es) 2018-04-04
MY194947A (en) 2022-12-27
SI2706982T1 (en) 2018-05-31
US12458591B2 (en) 2025-11-04
SG194927A1 (en) 2013-12-30
PH12016501342A1 (en) 2018-06-11
US11020343B2 (en) 2021-06-01
PH12013502313A1 (en) 2022-04-08
KR101698182B1 (ko) 2017-01-19
IL229409A0 (en) 2014-01-30

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