TWI483938B - 以內皮素受體抑制劑處理星狀腫瘤細胞 - Google Patents

以內皮素受體抑制劑處理星狀腫瘤細胞 Download PDF

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TWI483938B
TWI483938B TW099126507A TW99126507A TWI483938B TW I483938 B TWI483938 B TW I483938B TW 099126507 A TW099126507 A TW 099126507A TW 99126507 A TW99126507 A TW 99126507A TW I483938 B TWI483938 B TW I483938B
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cells
brain
cell
stellate
paclitaxel
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TW099126507A
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TW201109315A (en
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Isaiah J Fidler
Sun-Jin Kim
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Univ Texas
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61P35/00Antineoplastic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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TW099126507A 2009-08-10 2010-08-09 以內皮素受體抑制劑處理星狀腫瘤細胞 TWI483938B (zh)

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US23268709P 2009-08-10 2009-08-10

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TW201109315A TW201109315A (en) 2011-03-16
TWI483938B true TWI483938B (zh) 2015-05-11

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US (2) US8999934B2 (show.php)
EP (1) EP2464218B1 (show.php)
JP (1) JP2013501791A (show.php)
KR (1) KR20120088665A (show.php)
CN (1) CN102510719B (show.php)
AU (1) AU2010282744B2 (show.php)
BR (1) BR112012003103A2 (show.php)
CA (1) CA2770397A1 (show.php)
CL (1) CL2012000333A1 (show.php)
DK (1) DK2464218T3 (show.php)
EA (1) EA023864B1 (show.php)
ES (1) ES2543280T3 (show.php)
HR (1) HRP20150890T1 (show.php)
HU (1) HUE026005T2 (show.php)
IL (1) IL217915A0 (show.php)
IN (1) IN2012DN01261A (show.php)
MA (1) MA33571B1 (show.php)
MX (1) MX2012001562A (show.php)
NZ (1) NZ598078A (show.php)
PL (1) PL2464218T3 (show.php)
PT (1) PT2464218E (show.php)
SG (1) SG178828A1 (show.php)
SI (1) SI2464218T1 (show.php)
TN (1) TN2012000054A1 (show.php)
TW (1) TWI483938B (show.php)
WO (1) WO2011019630A2 (show.php)
ZA (1) ZA201200980B (show.php)

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AU2012213036A1 (en) * 2011-02-04 2013-09-19 Actelion Pharmaceuticals Ltd Combinations comprising macitentan for the treatment of glioblastoma multiforme
CA2840170A1 (en) * 2011-06-21 2012-12-27 The Johns Hopkins University Focused radiation for augmenting immune-based therapies against neoplasms
US10076518B2 (en) * 2015-03-06 2018-09-18 Beyondspring Pharmaceuticals, Inc. Method of treating a brain tumor
US10238650B2 (en) 2015-03-06 2019-03-26 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
JP6969848B2 (ja) 2015-07-13 2021-11-24 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド プリナブリン組成物
MX2018001507A (es) 2015-08-03 2018-09-18 Enb Therapeutics Llc Composiciones y metodos para tratar cánceres asociados con la activacion del etbr.
JP6996728B2 (ja) * 2016-01-07 2022-01-17 学校法人自治医科大学 グルコーストランスポーター1発現用アデノ随伴ウイルスベクター
JP2019511565A (ja) 2016-02-08 2019-04-25 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド ツカレゾールまたはそのアナログを含む組成物
WO2017209272A1 (ja) * 2016-06-03 2017-12-07 国立大学法人東京大学 がん転移阻害剤
EP3463337A4 (en) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド チューブリン結合化合物およびその治療的使用
CN110381938A (zh) 2017-02-01 2019-10-25 大连万春布林医药有限公司 减少中性粒细胞缺乏症的方法
AU2018221745A1 (en) 2017-02-15 2019-10-03 The Regents Of The University Of California Compositions and methods for activating NK cells
JP7539151B2 (ja) 2018-01-12 2024-08-23 イーエヌビー・セラピューティクス・インク Etbr活性化に関連する癌を処置するための重水素化化合物、組成物、および方法
BR112020014960A2 (pt) 2018-01-24 2020-12-22 Beyondspring Pharmaceuticals, Inc. Composição e método para redução de trombocitopenia
CN109232546B (zh) 2018-09-25 2020-09-04 中国人民解放军总医院 一种嘧啶磺酰胺类衍生物的医药用途
ES2988900T3 (es) 2019-05-22 2024-11-22 Wuxi Biocity Biopharmaceutics Co Ltd Forma cristalina del compuesto de pirimidina sulfonamida y método de preparación de la misma
CN112062857B (zh) * 2019-06-10 2024-08-09 鸿运华宁(杭州)生物医药有限公司 Eta抗体与bnp的融合蛋白质,及其药物组合物和应用
CA3156004A1 (en) * 2019-09-25 2021-04-01 The Board Of Trustees Of The Leland Stanford Junior University Thalamic input to orbitofrontal cortex drives brain-wide, frequency-dependent inhibition mediated by gaba and zona incerta
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors

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HRP20140215T1 (hr) 2008-02-20 2014-04-11 Actelion Pharmaceuticals Ltd. Kombinacija koja sadrži paklitaksel za lijeäśenje raka jajnika
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Publication number Publication date
JP2013501791A (ja) 2013-01-17
IL217915A0 (en) 2012-03-29
AU2010282744B2 (en) 2014-08-28
HK1171336A1 (en) 2013-03-28
BR112012003103A2 (pt) 2016-04-19
TN2012000054A1 (en) 2013-09-19
HUE026005T2 (en) 2016-04-28
WO2011019630A2 (en) 2011-02-17
US20150352113A1 (en) 2015-12-10
AU2010282744A1 (en) 2012-03-22
TW201109315A (en) 2011-03-16
SG178828A1 (en) 2012-04-27
WO2011019630A3 (en) 2011-06-03
ZA201200980B (en) 2012-10-31
KR20120088665A (ko) 2012-08-08
DK2464218T3 (en) 2015-07-20
EA201270264A1 (ru) 2013-02-28
MX2012001562A (es) 2013-01-29
CL2012000333A1 (es) 2013-01-25
HRP20150890T1 (hr) 2015-09-25
EA023864B1 (ru) 2016-07-29
CN102510719B (zh) 2015-07-22
CA2770397A1 (en) 2011-02-17
US8999934B2 (en) 2015-04-07
IN2012DN01261A (show.php) 2015-05-15
EP2464218A2 (en) 2012-06-20
CN102510719A (zh) 2012-06-20
US20120144510A1 (en) 2012-06-07
NZ598078A (en) 2013-07-26
PT2464218E (pt) 2015-09-16
SI2464218T1 (sl) 2015-10-30
PL2464218T3 (pl) 2015-12-31
ES2543280T3 (es) 2015-08-17
EP2464218B1 (en) 2015-05-27
MA33571B1 (fr) 2012-09-01

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