TWI483938B - 以內皮素受體抑制劑處理星狀腫瘤細胞 - Google Patents

以內皮素受體抑制劑處理星狀腫瘤細胞 Download PDF

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TWI483938B
TWI483938B TW099126507A TW99126507A TWI483938B TW I483938 B TWI483938 B TW I483938B TW 099126507 A TW099126507 A TW 099126507A TW 99126507 A TW99126507 A TW 99126507A TW I483938 B TWI483938 B TW I483938B
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cells
brain
cell
stellate
paclitaxel
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TW099126507A
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TW201109315A (en
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Isaiah J Fidler
Sun-Jin Kim
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Univ Texas
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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TW099126507A 2009-08-10 2010-08-09 以內皮素受體抑制劑處理星狀腫瘤細胞 TWI483938B (zh)

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US23268709P 2009-08-10 2009-08-10

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TW201109315A TW201109315A (en) 2011-03-16
TWI483938B true TWI483938B (zh) 2015-05-11

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US (2) US8999934B2 (cg-RX-API-DMAC7.html)
EP (1) EP2464218B1 (cg-RX-API-DMAC7.html)
JP (1) JP2013501791A (cg-RX-API-DMAC7.html)
KR (1) KR20120088665A (cg-RX-API-DMAC7.html)
CN (1) CN102510719B (cg-RX-API-DMAC7.html)
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BR (1) BR112012003103A2 (cg-RX-API-DMAC7.html)
CA (1) CA2770397A1 (cg-RX-API-DMAC7.html)
CL (1) CL2012000333A1 (cg-RX-API-DMAC7.html)
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EA (1) EA023864B1 (cg-RX-API-DMAC7.html)
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HR (1) HRP20150890T1 (cg-RX-API-DMAC7.html)
HU (1) HUE026005T2 (cg-RX-API-DMAC7.html)
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EP2670405B1 (en) * 2011-02-04 2015-09-02 Actelion Pharmaceuticals Ltd. Combinations comprising macitentan for the treatment of glioblastoma multiforme
AU2012273182A1 (en) * 2011-06-21 2014-01-16 The Johns Hopkins University Focused radiation for augmenting immune-based therapies against neoplasms
EP3265091A4 (en) * 2015-03-06 2018-08-01 Beyondspring Pharmaceuticals Inc. Method of treating a brain tumor
JP6769982B2 (ja) 2015-03-06 2020-10-14 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド Ras変異と関連するがんの治療方法
CN108026075B (zh) 2015-07-13 2021-06-29 大连万春布林医药有限公司 普那布林组合物
CA2994544C (en) 2015-08-03 2021-03-30 Enb Therapeutics, Llc Compositions and methods for treating cancers associated with etbr activation
JP6996728B2 (ja) * 2016-01-07 2022-01-17 学校法人自治医科大学 グルコーストランスポーター1発現用アデノ随伴ウイルスベクター
RU2753543C1 (ru) 2016-02-08 2021-08-17 Бейондспринг Фармасьютикалс, Инк. Композиции, содержащие тукаресол или его аналоги
WO2017209272A1 (ja) * 2016-06-03 2017-12-07 国立大学法人東京大学 がん転移阻害剤
EP3463337A4 (en) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
SG11201907023UA (en) 2017-02-01 2019-08-27 Beyondspring Pharmaceuticals Inc Method of reducing neutropenia
CA3059058A1 (en) 2017-02-15 2018-08-23 The Regents Of The University Of California Compositions and methods for activating nk cells
EA202091630A1 (ru) 2018-01-12 2020-12-04 Инб Терапьютикс, Инк. Дейтерированные соединения, композиции и способы для лечения раков, связанных с активацией etbr
BR112020014960A2 (pt) 2018-01-24 2020-12-22 Beyondspring Pharmaceuticals, Inc. Composição e método para redução de trombocitopenia
CN109232546B (zh) 2018-09-25 2020-09-04 中国人民解放军总医院 一种嘧啶磺酰胺类衍生物的医药用途
HUE068647T2 (hu) 2019-05-22 2025-01-28 Wuxi Biocity Biopharmaceutics Co Ltd Pirimidin-szulfonamid vegyület kristályos formája és annak elõállítási módszere
CN112062857B (zh) * 2019-06-10 2024-08-09 鸿运华宁(杭州)生物医药有限公司 Eta抗体与bnp的融合蛋白质,及其药物组合物和应用
KR20220070267A (ko) * 2019-09-25 2022-05-30 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 안와전두 피질에 대한 시상 입력은 gaba 및 불확대에 의해 매개된 광범한 뇌, 주파수-의존적 억제를 유도한다
JP2024513505A (ja) 2021-04-09 2024-03-25 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド 腫瘍を治療するための組成物及び方法

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HUE026005T2 (en) 2016-04-28
CA2770397A1 (en) 2011-02-17
HK1171336A1 (en) 2013-03-28
KR20120088665A (ko) 2012-08-08
HRP20150890T1 (hr) 2015-09-25
EA201270264A1 (ru) 2013-02-28
US8999934B2 (en) 2015-04-07
CN102510719B (zh) 2015-07-22
WO2011019630A2 (en) 2011-02-17
EA023864B1 (ru) 2016-07-29
AU2010282744A1 (en) 2012-03-22
WO2011019630A3 (en) 2011-06-03
ES2543280T3 (es) 2015-08-17
EP2464218B1 (en) 2015-05-27
DK2464218T3 (en) 2015-07-20
NZ598078A (en) 2013-07-26
PT2464218E (pt) 2015-09-16
US20120144510A1 (en) 2012-06-07
SG178828A1 (en) 2012-04-27
TW201109315A (en) 2011-03-16
JP2013501791A (ja) 2013-01-17
MX2012001562A (es) 2013-01-29
IL217915A0 (en) 2012-03-29
AU2010282744B2 (en) 2014-08-28
MA33571B1 (fr) 2012-09-01
TN2012000054A1 (en) 2013-09-19
SI2464218T1 (sl) 2015-10-30
PL2464218T3 (pl) 2015-12-31
US20150352113A1 (en) 2015-12-10
IN2012DN01261A (cg-RX-API-DMAC7.html) 2015-05-15
BR112012003103A2 (pt) 2016-04-19
CN102510719A (zh) 2012-06-20
ZA201200980B (en) 2012-10-31
EP2464218A2 (en) 2012-06-20
CL2012000333A1 (es) 2013-01-25

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