TWI436986B - 新穎之２環性雜環化合物 - Google Patents
新穎之２環性雜環化合物 Download PDFInfo
- Publication number
- TWI436986B TWI436986B TW098144921A TW98144921A TWI436986B TW I436986 B TWI436986 B TW I436986B TW 098144921 A TW098144921 A TW 098144921A TW 98144921 A TW98144921 A TW 98144921A TW I436986 B TWI436986 B TW I436986B
- Authority
- TW
- Taiwan
- Prior art keywords
- group
- substituted
- compound
- unsubstituted
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008332796 | 2008-12-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201028386A TW201028386A (en) | 2010-08-01 |
| TWI436986B true TWI436986B (zh) | 2014-05-11 |
Family
ID=42287798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098144921A TWI436986B (zh) | 2008-12-26 | 2009-12-25 | 新穎之２環性雜環化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8471038B2 (de) |
| EP (1) | EP2380881B1 (de) |
| JP (1) | JP5143916B2 (de) |
| KR (1) | KR101663336B1 (de) |
| CN (1) | CN102264707B (de) |
| AU (1) | AU2009331179B2 (de) |
| BR (1) | BRPI0924126B1 (de) |
| CA (1) | CA2748251C (de) |
| CY (1) | CY1118862T1 (de) |
| DK (1) | DK2380881T3 (de) |
| ES (1) | ES2620446T3 (de) |
| HK (1) | HK1163676A1 (de) |
| IL (1) | IL213690A0 (de) |
| LT (1) | LT2380881T (de) |
| MX (1) | MX2011006904A (de) |
| PL (1) | PL2380881T3 (de) |
| PT (1) | PT2380881T (de) |
| RU (1) | RU2518073C2 (de) |
| SI (1) | SI2380881T1 (de) |
| TW (1) | TWI436986B (de) |
| WO (1) | WO2010074193A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2518073C2 (ru) * | 2008-12-26 | 2014-06-10 | ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. | Новое бициклическое гетероциклическое соединение |
| JP5667934B2 (ja) * | 2010-06-28 | 2015-02-12 | 大日本住友製薬株式会社 | 新規２環性複素環化合物からなる医薬 |
| CN101985453B (zh) * | 2010-10-18 | 2012-10-31 | 国家海洋局第三海洋研究所 | 一种4-氨基吡啶衍生物及其制备方法与应用 |
| EP2681200A4 (de) * | 2011-03-03 | 2015-05-27 | Zalicus Pharmaceuticals Ltd | Benzimidazolhemmer des natriumkanals |
| KR101952981B1 (ko) * | 2011-07-07 | 2019-02-27 | 구미아이 가가쿠 고교 가부시키가이샤 | 니트로벤젠 화합물의 제조방법 |
| US20130172342A1 (en) * | 2011-12-28 | 2013-07-04 | Allergan, Inc. | Benzimidazole derivatives as selective blockers of persistent sodium current |
| CA2887887C (en) | 2012-10-31 | 2020-08-25 | Raqualia Pharma Inc. | Pyrazolopyridine derivatives as ttx-s blockers |
| JP2016169161A (ja) * | 2013-07-19 | 2016-09-23 | 大日本住友製薬株式会社 | 新規イミダゾピリジン化合物 |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| SI3080134T1 (sl) | 2013-12-13 | 2018-11-30 | Vertex Pharmaceuticals Incorporated | Predzdravila piridon amidov uporabna kot modulatorji natrijevih kanalov |
| JP2016079168A (ja) * | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | ９員縮合環誘導体 |
| US11242332B2 (en) | 2017-03-15 | 2022-02-08 | Sumitomo Dainippon Pharma Co., Ltd. | Method for producing benzimidazole derivative |
| WO2018168898A1 (ja) * | 2017-03-15 | 2018-09-20 | 大日本住友製薬株式会社 | 新規ベンズイミダゾロン化合物およびその医薬用途 |
| CA3063901A1 (en) | 2017-05-16 | 2018-11-22 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| MA49566A (fr) | 2017-07-11 | 2020-05-20 | Vertex Pharma | Carboxamides utilisés en tant qu'inhibiteurs des canaux sodiques |
| TW202002971A (zh) | 2018-02-12 | 2020-01-16 | 美商維泰克斯製藥公司 | 治療疼痛的方法 |
| IL280118B1 (en) * | 2018-07-19 | 2024-09-01 | Sumitomo Pharma Co Ltd | Medical preparation for external use |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| AR120680A1 (es) | 2019-12-06 | 2022-03-09 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| EP4268816A1 (de) | 2020-12-23 | 2023-11-01 | Sumitomo Pharma Co., Ltd. | Orale feste zubereitung |
| WO2022256679A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| WO2022256676A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| AU2022283934A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| WO2022256842A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| AR126073A1 (es) | 2021-06-04 | 2023-09-06 | Vertex Pharma | N-(hidroxialquil(hetero)aril)tetrahidrofuran carboxamidas como moduladores de canales de sodio |
| BR112023025264A2 (pt) | 2021-06-04 | 2024-02-20 | Vertex Pharma | Formas farmacêuticas sólidas e regimes posológicos compreendendo (2r,3s,4s,5r)-4-[[3- (3,4-difluoro-2-metóxi-fenil)-4,5-dimetil-5-(trifluorometil) tetra-hidrofuran-2-carbonil]amino ]piridina-2-carboxamida |
| WO2023205468A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023205465A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| US20230373925A1 (en) | 2022-04-22 | 2023-11-23 | Vertex Pharma | Heteroaryl compounds for the treatment of pain |
| AR129116A1 (es) | 2022-04-22 | 2024-07-17 | Vertex Pharma | Compuestos de heteroarilo para el tratamiento del dolor |
| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19705450A1 (de) * | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
| CA2425185A1 (en) * | 2000-10-06 | 2002-04-11 | Stephane De Lombaert | Benzimidazole and indole derivatives as crf receptor modulators |
| WO2002042278A2 (en) * | 2000-11-21 | 2002-05-30 | Vertex Pharmaceuticals Incorporated | Imidazole and benzimidazole caspase inhibitors and uses thereof |
| CN1902181A (zh) * | 2003-10-28 | 2007-01-24 | 沃泰克斯药物股份有限公司 | 可用作离子通道调控剂的苯并咪唑 |
| WO2008033739A2 (en) * | 2006-09-12 | 2008-03-20 | Neurogen Corporation | Benzimidazole carboxamide derivatives |
| EP2234487A4 (de) | 2007-12-19 | 2011-09-07 | Scripps Research Inst | Anilide und analoge als rho-kinasehemmer |
| RU2518073C2 (ru) * | 2008-12-26 | 2014-06-10 | ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. | Новое бициклическое гетероциклическое соединение |
| IL280118B1 (en) * | 2018-07-19 | 2024-09-01 | Sumitomo Pharma Co Ltd | Medical preparation for external use |
-
2009
- 2009-12-25 RU RU2011131048/04A patent/RU2518073C2/ru active
- 2009-12-25 LT LTEP09834989.7T patent/LT2380881T/lt unknown
- 2009-12-25 KR KR1020117017450A patent/KR101663336B1/ko active IP Right Grant
- 2009-12-25 CA CA2748251A patent/CA2748251C/en active Active
- 2009-12-25 JP JP2010544140A patent/JP5143916B2/ja active Active
- 2009-12-25 DK DK09834989.7T patent/DK2380881T3/en active
- 2009-12-25 CN CN200980152533.9A patent/CN102264707B/zh active Active
- 2009-12-25 MX MX2011006904A patent/MX2011006904A/es active IP Right Grant
- 2009-12-25 ES ES09834989.7T patent/ES2620446T3/es active Active
- 2009-12-25 PT PT98349897T patent/PT2380881T/pt unknown
- 2009-12-25 TW TW098144921A patent/TWI436986B/zh active
- 2009-12-25 WO PCT/JP2009/071529 patent/WO2010074193A1/ja active Application Filing
- 2009-12-25 PL PL09834989T patent/PL2380881T3/pl unknown
- 2009-12-25 AU AU2009331179A patent/AU2009331179B2/en active Active
- 2009-12-25 EP EP09834989.7A patent/EP2380881B1/de active Active
- 2009-12-25 BR BRPI0924126-4A patent/BRPI0924126B1/pt active IP Right Grant
- 2009-12-25 SI SI200931642A patent/SI2380881T1/sl unknown
- 2009-12-25 US US13/141,301 patent/US8471038B2/en active Active
-
2011
- 2011-06-21 IL IL213690A patent/IL213690A0/en active IP Right Grant
-
2012
- 2012-05-02 HK HK12104295.0A patent/HK1163676A1/xx not_active IP Right Cessation
-
2013
- 2013-05-15 US US13/895,089 patent/US20130303535A1/en active Pending
-
2017
- 2017-03-16 CY CY20171100330T patent/CY1118862T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010074193A1 (ja) | 2010-07-01 |
| HK1163676A1 (en) | 2012-09-14 |
| KR20110098971A (ko) | 2011-09-02 |
| US8471038B2 (en) | 2013-06-25 |
| SI2380881T1 (sl) | 2017-05-31 |
| AU2009331179A1 (en) | 2011-08-11 |
| AU2009331179A2 (en) | 2011-08-11 |
| CA2748251A1 (en) | 2010-07-01 |
| EP2380881A4 (de) | 2013-01-09 |
| DK2380881T3 (en) | 2017-05-08 |
| TW201028386A (en) | 2010-08-01 |
| CA2748251C (en) | 2016-08-02 |
| BRPI0924126A2 (pt) | 2020-08-11 |
| CN102264707B (zh) | 2014-09-03 |
| PL2380881T3 (pl) | 2017-07-31 |
| RU2518073C2 (ru) | 2014-06-10 |
| EP2380881B1 (de) | 2017-01-25 |
| RU2011131048A (ru) | 2013-02-10 |
| US20130303535A1 (en) | 2013-11-14 |
| PT2380881T (pt) | 2017-04-18 |
| ES2620446T3 (es) | 2017-06-28 |
| CY1118862T1 (el) | 2018-01-10 |
| JP5143916B2 (ja) | 2013-02-13 |
| JPWO2010074193A1 (ja) | 2012-06-21 |
| BRPI0924126B1 (pt) | 2021-07-27 |
| LT2380881T (lt) | 2017-04-10 |
| KR101663336B1 (ko) | 2016-10-06 |
| MX2011006904A (es) | 2011-07-20 |
| AU2009331179B2 (en) | 2014-09-18 |
| IL213690A0 (en) | 2011-07-31 |
| CN102264707A (zh) | 2011-11-30 |
| EP2380881A1 (de) | 2011-10-26 |
| US20110294804A1 (en) | 2011-12-01 |
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