TWI436774B

TWI436774B - Skin enhancers and their use

Skin enhancers and their use Download PDF

Info

Publication number: TWI436774B
Authority: TW; Taiwan
Prior art keywords: skin; camellia; lipoic acid; acid; resveratrol
Prior art date: 2011-04-28

Application number

TW101115224A

Other languages

English (en)

Chinese (zh)

Other versions

TW201300136A (zh

Inventor

Tsutomu Nozaki

Keno Ishihara

Original Assignee

Bhn Co Ltd

Priority date

2011-04-28

Filing date

2012-04-27

Publication date

2014-05-11

2012-04-27 Application filed by Bhn Co Ltd filed Critical Bhn Co Ltd

2013-01-01 Publication of TW201300136A publication Critical patent/TW201300136A/zh

2014-05-11 Application granted granted Critical

2014-05-11 Publication of TWI436774B publication Critical patent/TWI436774B/zh

Links

239000003623 enhancer Substances 0.000 title 1
235000019136 lipoic acid Nutrition 0.000 claims description 82
229960002663 thioctic acid Drugs 0.000 claims description 82
239000000284 extract Substances 0.000 claims description 67
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 50
102000008186 Collagen Human genes 0.000 claims description 47
108010035532 Collagen Proteins 0.000 claims description 47
229920001436 collagen Polymers 0.000 claims description 47
LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 45
230000017531 blood circulation Effects 0.000 claims description 45
QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 43
235000021283 resveratrol Nutrition 0.000 claims description 43
229940016667 resveratrol Drugs 0.000 claims description 43
240000001548 Camellia japonica Species 0.000 claims description 42
235000018597 common camellia Nutrition 0.000 claims description 37
150000002632 lipids Chemical class 0.000 claims description 37
239000000203 mixture Substances 0.000 claims description 37
239000002269 analeptic agent Substances 0.000 claims description 36
108090000765 processed proteins & peptides Proteins 0.000 claims description 36
239000003795 chemical substances by application Substances 0.000 claims description 33
239000000843 powder Substances 0.000 claims description 31
239000000126 substance Substances 0.000 claims description 30
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238000000034 method Methods 0.000 claims description 22
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235000011852 gelatine desserts Nutrition 0.000 claims description 16
239000002245 particle Substances 0.000 claims description 15
239000004480 active ingredient Substances 0.000 claims description 14
239000013078 crystal Substances 0.000 claims description 14
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241000196324 Embryophyta Species 0.000 claims description 12
239000000419 plant extract Substances 0.000 claims description 12
230000001737 promoting effect Effects 0.000 claims description 12
238000002844 melting Methods 0.000 claims description 11
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HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 10
YDGQDJXYFVWQDO-UHFFFAOYSA-N camelliasaponin B1 Natural products CC=C(/C)C(=O)OC1CC(C)(C)CC2C3=CCC4C5(C)CCC(OC6OC(CO)C(O)C(OC7OCC(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C6OC9OC(CO)C(O)C(O)C9O)C(C)(C=O)C5CCC4(C)C3(C)CC(O)C12CO YDGQDJXYFVWQDO-UHFFFAOYSA-N 0.000 claims description 9
MGTOPLIWMNGFCQ-UHFFFAOYSA-N camelliasaponin B2 Natural products O=CC1(C)C2CCC3(C)C4(C)CC(O)C5(CO)C(OC(=O)C(C)=CC)CC(C)(C)CC5C4=CCC3C2(C)CCC1OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(C(O)=O)C(O)C1OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O MGTOPLIWMNGFCQ-UHFFFAOYSA-N 0.000 claims description 9
RWTCSOPMUDGZQL-UHFFFAOYSA-N Camelliasaponin C2 Natural products CC=C(/C)C(=O)OC1CC(C)(C)CC2C3=CCC4C5(C)CCC(OC6OC(CO)C(O)C(OC7OCC(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C6OC9OC(CO)C(O)C(O)C9O)C(C)(CO)C5CCC4(C)C3(C)CC(O)C12CO RWTCSOPMUDGZQL-UHFFFAOYSA-N 0.000 claims description 8
230000037406 food intake Effects 0.000 claims description 8
KTCJGPRMIOCILW-UXZWGIKGSA-N Camelliasaponin A1 Natural products CC=C(C)C(=O)O[C@H]1CC(C)(C)C[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@@H]([C@@H](O)[C@H](O[C@@H]7OC[C@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]6O[C@@H]9O[C@H](CO)[C@H](O)[C@H](O)[C@H]9O)C(=O)O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)C[C@@H](O)[C@@]12CO KTCJGPRMIOCILW-UXZWGIKGSA-N 0.000 claims description 7
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150000001875 compounds Chemical class 0.000 claims description 6
239000003925 fat Substances 0.000 claims description 6
239000001397 quillaja saponaria molina bark Substances 0.000 claims description 6
MGTOPLIWMNGFCQ-PGGKNCGUSA-N camelliasaponin b2 Chemical compound O=CC1(C)C2CCC3(C)C4(C)CC(O)C5(CO)C(OC(=O)C(/C)=C/C)CC(C)(C)CC5C4=CCC3C2(C)CCC1OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(C(O)=O)C(O)C1OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O MGTOPLIWMNGFCQ-PGGKNCGUSA-N 0.000 claims description 5
239000002537 cosmetic Substances 0.000 claims description 5
KRGSIOSNSSCAMH-IHGNYCBKSA-N (2r,3s,6r)-6-[[(4r,4ar,6as,6bs,8ar,12as,14ar,14br)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-9-[(e)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-[(2s,3s,4r,5s)-4,5-dihydroxy-3-[(2s,3s,4r) Chemical compound O([C@H]1[C@H](O)[C@@H](O)CO[C@H]1OC1[C@H](O)[C@@H](O[C@H](C1O[C@H]1C(C(O)C(O)C(CO)O1)O)OC1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC([C@@]5(C(O)C[C@@]4(C)[C@@]3(C)CC[C@H]2[C@@]1(CO)C)CO)OC(=O)C(/C)=C/C)C(O)=O)[C@@H]1OC(CO)C(O)[C@@H](O)[C@@H]1O KRGSIOSNSSCAMH-IHGNYCBKSA-N 0.000 claims description 4
MGTOPLIWMNGFCQ-UOPXLPJJSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,9s,12as,14ar,14br)-4-formyl-8-hydroxy-8a-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-9-[(z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-[(2s,3r,4s,5s)-4,5-dihy Chemical compound O([C@@H]1[C@@H](O)[C@@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)C[C@@H]([C@@]5([C@H](O)C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)CO)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O MGTOPLIWMNGFCQ-UOPXLPJJSA-N 0.000 claims description 4
KTCJGPRMIOCILW-PHROOHHUSA-N Camelliasaponin A2 Natural products O=C(O[C@@H]1[C@]2(CO)[C@H](O)C[C@@]3(C)[C@@]4(C)[C@@H]([C@]5(C)[C@H](C(C)(C)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O7)[C@@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H](O)[C@@H](O)CO7)[C@H](O)[C@@H](C(=O)O)O6)CC5)CC4)CC=C3[C@@H]2CC(C)(C)C1)/C(=C\C)/C KTCJGPRMIOCILW-PHROOHHUSA-N 0.000 claims description 4
KRGSIOSNSSCAMH-QPAGQQEASA-N Camelliasaponin C1 Natural products O([C@@H]1[C@@H](O)[C@@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)C[C@@H]([C@@]5([C@H](O)C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(CO)C)CO)OC(=O)C(/C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O KRGSIOSNSSCAMH-QPAGQQEASA-N 0.000 claims description 4
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239000002253 acid Substances 0.000 claims description 4
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