TWI422368B - 治療慢性阻塞性肺疾之組成物 - Google Patents
治療慢性阻塞性肺疾之組成物 Download PDFInfo
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- TWI422368B TWI422368B TW096106639A TW96106639A TWI422368B TW I422368 B TWI422368 B TW I422368B TW 096106639 A TW096106639 A TW 096106639A TW 96106639 A TW96106639 A TW 96106639A TW I422368 B TWI422368 B TW I422368B
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- 238000003905 indoor air pollution Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000005980 lung dysfunction Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 1
- XMYQHJDBLRZMLW-UHFFFAOYSA-N methanolamine Chemical compound NCO XMYQHJDBLRZMLW-UHFFFAOYSA-N 0.000 description 1
- NSPJNIDYTSSIIY-UHFFFAOYSA-N methoxy(methoxymethoxy)methane Chemical compound COCOCOC NSPJNIDYTSSIIY-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 150000003956 methylamines Chemical class 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- UFFQZCPLBHYOFV-UHFFFAOYSA-N n,n-diethyldecan-1-amine Chemical compound CCCCCCCCCCN(CC)CC UFFQZCPLBHYOFV-UHFFFAOYSA-N 0.000 description 1
- YWWNNLPSZSEZNZ-UHFFFAOYSA-N n,n-dimethyldecan-1-amine Chemical compound CCCCCCCCCCN(C)C YWWNNLPSZSEZNZ-UHFFFAOYSA-N 0.000 description 1
- AIAKLPAJNLBVEA-UHFFFAOYSA-N n-[2-(2-benzamidophenoxy)phenyl]benzamide Chemical compound C=1C=CC=CC=1C(=O)NC1=CC=CC=C1OC1=CC=CC=C1NC(=O)C1=CC=CC=C1 AIAKLPAJNLBVEA-UHFFFAOYSA-N 0.000 description 1
- RDXBZXWKSIEKKS-UHFFFAOYSA-N n-ethyldecan-1-amine Chemical compound CCCCCCCCCCNCC RDXBZXWKSIEKKS-UHFFFAOYSA-N 0.000 description 1
- IKVDMBQGHZVMRN-UHFFFAOYSA-N n-methyldecan-1-amine Chemical compound CCCCCCCCCCNC IKVDMBQGHZVMRN-UHFFFAOYSA-N 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000003822 preparative gas chromatography Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009325 pulmonary function Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 238000011125 single therapy Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000003419 tautomerization reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- LMYRWZFENFIFIT-UHFFFAOYSA-N toluene-4-sulfonamide Chemical compound CC1=CC=C(S(N)(=O)=O)C=C1 LMYRWZFENFIFIT-UHFFFAOYSA-N 0.000 description 1
- 150000004992 toluidines Chemical class 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77694306P | 2006-02-28 | 2006-02-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200800161A TW200800161A (en) | 2008-01-01 |
| TWI422368B true TWI422368B (zh) | 2014-01-11 |
Family
ID=38462529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096106639A TWI422368B (zh) | 2006-02-28 | 2007-02-27 | 治療慢性阻塞性肺疾之組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070203228A1 (enExample) |
| EP (1) | EP1988905B1 (enExample) |
| JP (2) | JP5377970B2 (enExample) |
| KR (1) | KR101409706B1 (enExample) |
| CN (1) | CN101432002B (enExample) |
| AR (1) | AR059636A1 (enExample) |
| AU (1) | AU2007223469B2 (enExample) |
| BR (1) | BRPI0708362A2 (enExample) |
| CA (1) | CA2642744C (enExample) |
| MX (1) | MX2008011148A (enExample) |
| NZ (1) | NZ571092A (enExample) |
| TW (1) | TWI422368B (enExample) |
| WO (1) | WO2007102446A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0708362A2 (pt) * | 2006-02-28 | 2011-05-24 | Sucampo Ag | método e composição para o tratamento de doença pulmonar obstrutiva crÈnica |
| WO2011072383A1 (en) * | 2009-12-18 | 2011-06-23 | Apotex Pharmachem Inc. | Processes for the purification of lubiprostone |
| BR112013026644A2 (pt) * | 2011-04-19 | 2016-12-27 | Sucampo Ag | método para a modulação da atividade de citocina |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0978284A1 (en) * | 1997-11-28 | 2000-02-09 | R-Tech Ueno, Ltd. | Endothelin antagonist |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2597649B2 (ja) * | 1988-05-11 | 1997-04-09 | 株式会社上野製薬応用研究所 | 気管・気管支拡張剤 |
| US5362751A (en) * | 1988-05-11 | 1994-11-08 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Tracheobronchodilator using 16-substituted PGEs |
| US5254588A (en) * | 1989-11-22 | 1993-10-19 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds |
| JPH0791192B2 (ja) * | 1989-11-22 | 1995-10-04 | 株式会社上野製薬応用研究所 | ガス交換機能不全処置剤 |
| CA2030344C (en) * | 1989-11-22 | 2000-04-18 | Ryuji Ueno | Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds |
| CA2150287C (en) * | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| ATE433754T1 (de) * | 2000-04-06 | 2009-07-15 | Sucampo Ag | Gallensäurefördernde zusammensetzung für lebertransplantation welche ein 15-keto prostaglandin enthält |
| CA2458471C (en) * | 2001-08-31 | 2012-07-31 | Sucampo Ag | Prostaglandin analogs as chloride channel opener |
| JP5294559B2 (ja) * | 2003-07-03 | 2013-09-18 | スキャンポ・アーゲー | クロライドチャンネルオープナーとしてプロスタグランジンアナログを含む腸溶性組成物 |
| BRPI0708362A2 (pt) * | 2006-02-28 | 2011-05-24 | Sucampo Ag | método e composição para o tratamento de doença pulmonar obstrutiva crÈnica |
| BR112013026644A2 (pt) * | 2011-04-19 | 2016-12-27 | Sucampo Ag | método para a modulação da atividade de citocina |
-
2007
- 2007-02-27 BR BRPI0708362-9A patent/BRPI0708362A2/pt not_active IP Right Cessation
- 2007-02-27 EP EP07737738.0A patent/EP1988905B1/en not_active Not-in-force
- 2007-02-27 WO PCT/JP2007/054127 patent/WO2007102446A2/en not_active Ceased
- 2007-02-27 KR KR1020087023221A patent/KR101409706B1/ko not_active Expired - Fee Related
- 2007-02-27 AU AU2007223469A patent/AU2007223469B2/en not_active Ceased
- 2007-02-27 JP JP2008541517A patent/JP5377970B2/ja not_active Expired - Fee Related
- 2007-02-27 NZ NZ571092A patent/NZ571092A/en not_active IP Right Cessation
- 2007-02-27 AR ARP070100795A patent/AR059636A1/es unknown
- 2007-02-27 CA CA2642744A patent/CA2642744C/en not_active Expired - Fee Related
- 2007-02-27 US US11/711,097 patent/US20070203228A1/en not_active Abandoned
- 2007-02-27 CN CN2007800071240A patent/CN101432002B/zh not_active Expired - Fee Related
- 2007-02-27 TW TW096106639A patent/TWI422368B/zh not_active IP Right Cessation
- 2007-02-27 MX MX2008011148A patent/MX2008011148A/es active IP Right Grant
-
2013
- 2013-06-21 JP JP2013130784A patent/JP2013209429A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0978284A1 (en) * | 1997-11-28 | 2000-02-09 | R-Tech Ueno, Ltd. | Endothelin antagonist |
Non-Patent Citations (1)
| Title |
|---|
| E. Weitzenblum et al, "Medical treatment of pulmonary hypertension in chronic lung disease", European Respiratory Journal, 7:148-152, 1994. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101432002B (zh) | 2012-04-04 |
| EP1988905B1 (en) | 2014-06-04 |
| TW200800161A (en) | 2008-01-01 |
| NZ571092A (en) | 2010-11-26 |
| JP2013209429A (ja) | 2013-10-10 |
| JP2009528259A (ja) | 2009-08-06 |
| EP1988905A2 (en) | 2008-11-12 |
| AU2007223469B2 (en) | 2012-06-07 |
| KR20080104024A (ko) | 2008-11-28 |
| CA2642744A1 (en) | 2007-09-13 |
| MX2008011148A (es) | 2008-09-08 |
| BRPI0708362A2 (pt) | 2011-05-24 |
| CN101432002A (zh) | 2009-05-13 |
| WO2007102446A3 (en) | 2008-04-03 |
| AR059636A1 (es) | 2008-04-16 |
| AU2007223469A1 (en) | 2007-09-13 |
| JP5377970B2 (ja) | 2013-12-25 |
| US20070203228A1 (en) | 2007-08-30 |
| CA2642744C (en) | 2015-02-24 |
| WO2007102446A2 (en) | 2007-09-13 |
| KR101409706B1 (ko) | 2014-06-20 |
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| Date | Code | Title | Description |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |