TWI409070B - 用於調節trpv3功能之化合物 - Google Patents
用於調節trpv3功能之化合物 Download PDFInfo
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- TWI409070B TWI409070B TW095140730A TW95140730A TWI409070B TW I409070 B TWI409070 B TW I409070B TW 095140730 A TW095140730 A TW 095140730A TW 95140730 A TW95140730 A TW 95140730A TW I409070 B TWI409070 B TW I409070B
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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| US79921206P | 2006-05-09 | 2006-05-09 | |
| US83860906P | 2006-08-18 | 2006-08-18 |
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| JP (1) | JP2009514954A (https=) |
| CN (1) | CN101355946B (https=) |
| AU (1) | AU2006311883A1 (https=) |
| CA (1) | CA2628441A1 (https=) |
| TW (1) | TWI409070B (https=) |
| WO (1) | WO2007056124A2 (https=) |
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| US8916550B2 (en) * | 2005-05-09 | 2014-12-23 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| EP1948161B1 (en) * | 2005-06-27 | 2012-01-04 | Newtree Co., Ltd. | Method for preventing and treating conditions mediated by ppar using macelignan |
| US7893260B2 (en) * | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| CA2660957C (en) | 2006-08-23 | 2016-10-11 | Neurogen Corporation | 2-phenoxy pyrimidinone analogues |
| US7998980B2 (en) | 2006-09-15 | 2011-08-16 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| KR100933559B1 (ko) | 2007-10-01 | 2009-12-23 | 재단법인서울대학교산학협력재단 | 3H-퀴나졸린-4-온 유도체를 함유하는 Hsp90 억제제및 이를 이용한 항암제 |
| WO2009084034A2 (en) * | 2007-12-18 | 2009-07-09 | Glenmark Pharmaceuticals, S. A. | Chromane derivatives as trpv3 modulators |
| CA2724008A1 (en) * | 2008-01-11 | 2009-09-11 | Glenmark Pharmaceuticals, S.A. | Fused pyrimidine derivatives as trpv3 modulators |
| US8119647B2 (en) * | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
| MX2010011762A (es) * | 2008-06-17 | 2011-02-03 | Glenmark Pharmaceuticals Sa | Derivados de cromano como moduladores del trpv3. |
| WO2010055384A1 (en) * | 2008-11-17 | 2010-05-20 | Glenmark Pharmaceuticals S.A. | Chromenone derivatives as trpv3 antagonists |
| KR101034300B1 (ko) * | 2008-12-02 | 2011-05-16 | 고려대학교 산학협력단 | Trpv3 활성 억제 약물 및 이의 활용 |
| KR101034299B1 (ko) * | 2008-12-02 | 2011-05-16 | 고려대학교 산학협력단 | Trpv3 활성 조절 약물 및 이의 활용 |
| US8318928B2 (en) * | 2008-12-15 | 2012-11-27 | Glenmark Pharmaceuticals, S.A. | Fused imidazole carboxamides as TRPV3 modulators |
| JP2012514577A (ja) | 2008-12-26 | 2012-06-28 | グレンマーク ファーマシューティカルズ, エセ.アー. | Trpv3アンタゴニストとしての縮合イミダゾール誘導体 |
| US20110319416A1 (en) * | 2009-01-28 | 2011-12-29 | Emory University | Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions |
| EP2521548A2 (en) * | 2009-11-27 | 2012-11-14 | Proteologics, Ltd | Quinazolin-4(3a)-one derivatives and methods of use thereof |
| MX2013001612A (es) | 2010-08-10 | 2013-07-05 | Abbvie Inc | Moduladores de trpv3 novedosos. |
| US9216177B2 (en) | 2011-02-28 | 2015-12-22 | Drexel University | Small molecular inhibitors of RAD51 recombinase and methods thereof |
| US9012651B2 (en) | 2011-03-24 | 2015-04-21 | Abbvie Inc. | TRPV3 modulators |
| CN102994508B (zh) * | 2011-09-14 | 2015-04-01 | 深圳华大基因科技有限公司 | Olmsted综合征相关基因的鉴别以及与其相关的产品、方法及用途 |
| WO2013062964A2 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Novel trpv3 modulators |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9452973B2 (en) | 2012-05-04 | 2016-09-27 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| JP2016510749A (ja) * | 2013-03-05 | 2016-04-11 | ユニヴァーシティー オブ ノートル ダム デュ ラック | キナゾリノン抗生物質 |
| PT3052485T (pt) | 2013-10-04 | 2021-10-22 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos e suas utilizações |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX382033B (es) | 2014-03-19 | 2025-03-13 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN104744379B (zh) * | 2015-03-13 | 2017-10-27 | 三峡大学 | 一种喹唑啉酮类化合物及其合成方法 |
| WO2016160938A1 (en) | 2015-04-02 | 2016-10-06 | Abbvie Inc. | N-(1,3-thiazol-2-yl)pyrimidine-5-carboxamides as trpv3 modulators |
| WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN107056715B (zh) * | 2017-04-07 | 2019-07-30 | 江南大学 | 一种增强TRPV4-KCa2.3复合体耦联度的化合物及其在抗高血压中的应用 |
| CN110339360B (zh) * | 2018-04-02 | 2024-04-19 | 苏中药业集团股份有限公司 | 瞬时受体电位阳离子通道trpv3在研制预防或治疗银屑病药物中的应用 |
| FR3088823B1 (fr) * | 2018-11-28 | 2020-12-11 | Commissariat Energie Atomique | Nouvelles dihydroquinazolinones ayant une activite protectrice vis-a-vis de toxines au mode d’action intracellulaire, de virus et de bacteries |
| CN113396149B (zh) * | 2018-12-06 | 2024-07-02 | 星座制药公司 | Trex1的调节剂 |
| KR20210129677A (ko) | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 안구 표면 통증의 치료 방법 |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤 |
| MX2021015605A (es) * | 2019-06-27 | 2022-02-16 | Glaxosmithkline Ip Dev Ltd | Compuestos 2,3-dihidroquinazolin como inhibidores nav1.8. |
| EP4003985A1 (en) * | 2019-07-23 | 2022-06-01 | Constellation Pharmaceuticals, Inc. | Modulators of trex1 |
| WO2021154966A1 (en) | 2020-01-29 | 2021-08-05 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
| CN113197900B (zh) * | 2021-01-27 | 2022-07-29 | 徐州医科大学 | Trpml1特异性小分子抑制剂ml-si3的应用 |
| CN116270670A (zh) * | 2023-04-26 | 2023-06-23 | 南通大学 | 化合物2-apb在制备治疗帕金森病药物制剂中的应用 |
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-
2006
- 2006-11-03 US US11/592,783 patent/US7893260B2/en active Active
- 2006-11-03 TW TW095140730A patent/TWI409070B/zh not_active IP Right Cessation
- 2006-11-03 WO PCT/US2006/042930 patent/WO2007056124A2/en not_active Ceased
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- 2006-11-03 EP EP06836869A patent/EP1954283A2/en not_active Withdrawn
- 2006-11-03 CN CN2006800496369A patent/CN101355946B/zh not_active Expired - Fee Related
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2013
- 2013-08-30 US US14/014,636 patent/US20140155417A1/en not_active Abandoned
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| US5196427A (en) * | 1990-09-13 | 1993-03-23 | Eli Lilly And Company | 3-aryl-4(3H) quinazolinone CCK antagonists and pharmaceutical formulations thereof |
| WO1997043276A1 (en) * | 1996-05-15 | 1997-11-20 | Pfizer Inc. | Novel 2,3 disubstituted-4(3h)-quinazolinones |
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Also Published As
| Publication number | Publication date |
|---|---|
| US7893260B2 (en) | 2011-02-22 |
| US20070179164A1 (en) | 2007-08-02 |
| TW200803862A (en) | 2008-01-16 |
| US8552009B2 (en) | 2013-10-08 |
| CN101355946A (zh) | 2009-01-28 |
| CN101355946B (zh) | 2013-05-08 |
| WO2007056124A3 (en) | 2007-07-26 |
| WO2007056124A2 (en) | 2007-05-18 |
| US20110144135A1 (en) | 2011-06-16 |
| EP1954283A2 (en) | 2008-08-13 |
| JP2009514954A (ja) | 2009-04-09 |
| CA2628441A1 (en) | 2007-05-18 |
| AU2006311883A1 (en) | 2007-05-18 |
| US20100152209A1 (en) | 2010-06-17 |
| US20140155417A1 (en) | 2014-06-05 |
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