AU2006311883A1 - Compounds for modulating TRPV3 function - Google Patents
Compounds for modulating TRPV3 function Download PDFInfo
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- AU2006311883A1 AU2006311883A1 AU2006311883A AU2006311883A AU2006311883A1 AU 2006311883 A1 AU2006311883 A1 AU 2006311883A1 AU 2006311883 A AU2006311883 A AU 2006311883A AU 2006311883 A AU2006311883 A AU 2006311883A AU 2006311883 A1 AU2006311883 A1 AU 2006311883A1
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- Prior art keywords
- trpv3
- substituted
- compound
- pain
- nhso
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- Rheumatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
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|---|---|---|---|
| AU2013204105A AU2013204105A1 (en) | 2005-11-04 | 2013-04-11 | Compounds for modulating TRPV3 function |
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| US83860906P | 2006-08-18 | 2006-08-18 | |
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| PCT/US2006/042930 WO2007056124A2 (en) | 2005-11-04 | 2006-11-03 | Compounds for modulating trpv3 function |
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| JP (1) | JP2009514954A (https=) |
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| CA (1) | CA2628441A1 (https=) |
| TW (1) | TWI409070B (https=) |
| WO (1) | WO2007056124A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2392328A1 (en) * | 2005-05-09 | 2011-12-07 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 Function |
| US8916550B2 (en) * | 2005-05-09 | 2014-12-23 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| EP1948161B1 (en) * | 2005-06-27 | 2012-01-04 | Newtree Co., Ltd. | Method for preventing and treating conditions mediated by ppar using macelignan |
| US7893260B2 (en) * | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| CA2660957C (en) | 2006-08-23 | 2016-10-11 | Neurogen Corporation | 2-phenoxy pyrimidinone analogues |
| US7998980B2 (en) | 2006-09-15 | 2011-08-16 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| KR100933559B1 (ko) | 2007-10-01 | 2009-12-23 | 재단법인서울대학교산학협력재단 | 3H-퀴나졸린-4-온 유도체를 함유하는 Hsp90 억제제및 이를 이용한 항암제 |
| WO2009084034A2 (en) * | 2007-12-18 | 2009-07-09 | Glenmark Pharmaceuticals, S. A. | Chromane derivatives as trpv3 modulators |
| CA2724008A1 (en) * | 2008-01-11 | 2009-09-11 | Glenmark Pharmaceuticals, S.A. | Fused pyrimidine derivatives as trpv3 modulators |
| US8119647B2 (en) * | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
| MX2010011762A (es) * | 2008-06-17 | 2011-02-03 | Glenmark Pharmaceuticals Sa | Derivados de cromano como moduladores del trpv3. |
| WO2010055384A1 (en) * | 2008-11-17 | 2010-05-20 | Glenmark Pharmaceuticals S.A. | Chromenone derivatives as trpv3 antagonists |
| KR101034300B1 (ko) * | 2008-12-02 | 2011-05-16 | 고려대학교 산학협력단 | Trpv3 활성 억제 약물 및 이의 활용 |
| KR101034299B1 (ko) * | 2008-12-02 | 2011-05-16 | 고려대학교 산학협력단 | Trpv3 활성 조절 약물 및 이의 활용 |
| US8318928B2 (en) * | 2008-12-15 | 2012-11-27 | Glenmark Pharmaceuticals, S.A. | Fused imidazole carboxamides as TRPV3 modulators |
| JP2012514577A (ja) | 2008-12-26 | 2012-06-28 | グレンマーク ファーマシューティカルズ, エセ.アー. | Trpv3アンタゴニストとしての縮合イミダゾール誘導体 |
| US20110319416A1 (en) * | 2009-01-28 | 2011-12-29 | Emory University | Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions |
| EP2521548A2 (en) * | 2009-11-27 | 2012-11-14 | Proteologics, Ltd | Quinazolin-4(3a)-one derivatives and methods of use thereof |
| MX2013001612A (es) | 2010-08-10 | 2013-07-05 | Abbvie Inc | Moduladores de trpv3 novedosos. |
| US9216177B2 (en) | 2011-02-28 | 2015-12-22 | Drexel University | Small molecular inhibitors of RAD51 recombinase and methods thereof |
| US9012651B2 (en) | 2011-03-24 | 2015-04-21 | Abbvie Inc. | TRPV3 modulators |
| CN102994508B (zh) * | 2011-09-14 | 2015-04-01 | 深圳华大基因科技有限公司 | Olmsted综合征相关基因的鉴别以及与其相关的产品、方法及用途 |
| WO2013062964A2 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Novel trpv3 modulators |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9452973B2 (en) | 2012-05-04 | 2016-09-27 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| JP2016510749A (ja) * | 2013-03-05 | 2016-04-11 | ユニヴァーシティー オブ ノートル ダム デュ ラック | キナゾリノン抗生物質 |
| PT3052485T (pt) | 2013-10-04 | 2021-10-22 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos e suas utilizações |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX382033B (es) | 2014-03-19 | 2025-03-13 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN104744379B (zh) * | 2015-03-13 | 2017-10-27 | 三峡大学 | 一种喹唑啉酮类化合物及其合成方法 |
| WO2016160938A1 (en) | 2015-04-02 | 2016-10-06 | Abbvie Inc. | N-(1,3-thiazol-2-yl)pyrimidine-5-carboxamides as trpv3 modulators |
| WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN107056715B (zh) * | 2017-04-07 | 2019-07-30 | 江南大学 | 一种增强TRPV4-KCa2.3复合体耦联度的化合物及其在抗高血压中的应用 |
| CN110339360B (zh) * | 2018-04-02 | 2024-04-19 | 苏中药业集团股份有限公司 | 瞬时受体电位阳离子通道trpv3在研制预防或治疗银屑病药物中的应用 |
| FR3088823B1 (fr) * | 2018-11-28 | 2020-12-11 | Commissariat Energie Atomique | Nouvelles dihydroquinazolinones ayant une activite protectrice vis-a-vis de toxines au mode d’action intracellulaire, de virus et de bacteries |
| CN113396149B (zh) * | 2018-12-06 | 2024-07-02 | 星座制药公司 | Trex1的调节剂 |
| KR20210129677A (ko) | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 안구 표면 통증의 치료 방법 |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤 |
| MX2021015605A (es) * | 2019-06-27 | 2022-02-16 | Glaxosmithkline Ip Dev Ltd | Compuestos 2,3-dihidroquinazolin como inhibidores nav1.8. |
| EP4003985A1 (en) * | 2019-07-23 | 2022-06-01 | Constellation Pharmaceuticals, Inc. | Modulators of trex1 |
| WO2021154966A1 (en) | 2020-01-29 | 2021-08-05 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
| CN113197900B (zh) * | 2021-01-27 | 2022-07-29 | 徐州医科大学 | Trpml1特异性小分子抑制剂ml-si3的应用 |
| CN116270670A (zh) * | 2023-04-26 | 2023-06-23 | 南通大学 | 化合物2-apb在制备治疗帕金森病药物制剂中的应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| US5075313A (en) * | 1990-09-13 | 1991-12-24 | Eli Lilly And Company | 3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof |
| US5196427A (en) * | 1990-09-13 | 1993-03-23 | Eli Lilly And Company | 3-aryl-4(3H) quinazolinone CCK antagonists and pharmaceutical formulations thereof |
| US5756502A (en) | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| DE19615262A1 (de) | 1996-04-18 | 1997-10-23 | Bayer Ag | Heteroverknüpfte Phenylglycinolamide |
| CN1103772C (zh) | 1996-05-15 | 2003-03-26 | 辉瑞大药厂 | 新的2,3-二取代-4(3h)-喹唑啉酮类化合物 |
| EP0807633B1 (en) * | 1996-05-15 | 2002-11-06 | Pfizer Inc. | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones |
| TR199902094T2 (xx) | 1997-02-28 | 1999-12-21 | Prizer Products Inc. | 3-Heteroareil-4(3H)-kinazolinonlar�n atropizomerleri. |
| SK113299A3 (en) | 1997-02-28 | 2001-05-10 | Pfizer Prod Inc | Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists |
| US6627755B1 (en) * | 1997-06-09 | 2003-09-30 | Pfizer Inc | Quinazolin-4-one AMPA antagonists |
| US6060479A (en) | 1997-06-09 | 2000-05-09 | Pfizer Inc | Quinazoline-4-one AMPA antagonists |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
| US6223208B1 (en) * | 1997-10-03 | 2001-04-24 | International Business Machines Corporation | Moving data in and out of processor units using idle register/storage functional units |
| JPH11279158A (ja) | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―4―オン誘導体の製造方法 |
| JP4994552B2 (ja) | 1999-09-16 | 2012-08-08 | キュリス,インコーポレイテッド | ヘッジホッグシグナル伝達経路のメディエーター、組成物及びそれらと関連する利用 |
| US20030219806A1 (en) * | 2000-02-22 | 2003-11-27 | Millennium Pharmaceuticals, Inc. | Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor |
| AU2001270240A1 (en) * | 2000-06-26 | 2002-01-08 | Millennium Pharmaceuticals, Inc. | Human calcium channels (48000; 52920) and uses thereof |
| GB2372993A (en) | 2000-11-03 | 2002-09-11 | Smithkline Beecham Plc | Vanilloid Receptor 6 |
| US20030027164A1 (en) | 2000-12-01 | 2003-02-06 | Gaughan Glen T. | Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain |
| EP1399558A2 (en) * | 2001-06-13 | 2004-03-24 | Novartis AG | Vanilloid receptor-related nucleic acids and polypeptides |
| US7053216B2 (en) * | 2001-11-19 | 2006-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of Rho C activity |
| US20040110777A1 (en) * | 2001-12-03 | 2004-06-10 | Annis Gary David | Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests |
| US20040009537A1 (en) * | 2002-01-11 | 2004-01-15 | Jack Roos | Methods of modulating and of identifying agents that modulate intracellular calcium |
| TW200401770A (en) | 2002-06-18 | 2004-02-01 | Sankyo Co | Fused-ring pyrimidin-4(3H)-one derivatives, processes for the preparation and uses thereof |
| MXPA05004328A (es) * | 2002-11-04 | 2005-08-02 | Nps Pharma Inc | Compuestos de quinazolinona como calciliticos. |
| CA2545725A1 (en) * | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| EP1722783A4 (en) | 2004-03-08 | 2009-08-12 | Wyeth Corp | MODULATORS OF THE ION CHANNEL FUNCTION |
| EP1750715A1 (en) | 2004-06-04 | 2007-02-14 | Icos Corporation | Methods for treating mast cell disorders |
| AR051596A1 (es) | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
| EP2392328A1 (en) | 2005-05-09 | 2011-12-07 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 Function |
| US8916550B2 (en) | 2005-05-09 | 2014-12-23 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| GB0509573D0 (en) | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| US20090298856A1 (en) | 2005-05-11 | 2009-12-03 | Rebecca Elizabeth Brown | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) |
| US7893260B2 (en) * | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| US7998980B2 (en) | 2006-09-15 | 2011-08-16 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
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- 2006-11-03 TW TW095140730A patent/TWI409070B/zh not_active IP Right Cessation
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|---|---|
| US7893260B2 (en) | 2011-02-22 |
| US20070179164A1 (en) | 2007-08-02 |
| TW200803862A (en) | 2008-01-16 |
| US8552009B2 (en) | 2013-10-08 |
| CN101355946A (zh) | 2009-01-28 |
| CN101355946B (zh) | 2013-05-08 |
| WO2007056124A3 (en) | 2007-07-26 |
| WO2007056124A2 (en) | 2007-05-18 |
| US20110144135A1 (en) | 2011-06-16 |
| EP1954283A2 (en) | 2008-08-13 |
| JP2009514954A (ja) | 2009-04-09 |
| CA2628441A1 (en) | 2007-05-18 |
| US20100152209A1 (en) | 2010-06-17 |
| US20140155417A1 (en) | 2014-06-05 |
| TWI409070B (zh) | 2013-09-21 |
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