TWI392674B - 噻托溴銨之新穎結晶型 - Google Patents

噻托溴銨之新穎結晶型 Download PDF

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Publication number
TWI392674B
TWI392674B TW095115408A TW95115408A TWI392674B TW I392674 B TWI392674 B TW I392674B TW 095115408 A TW095115408 A TW 095115408A TW 95115408 A TW95115408 A TW 95115408A TW I392674 B TWI392674 B TW I392674B
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TW
Taiwan
Prior art keywords
tiotropium bromide
solvate
minutes
crystals
tiotropium
Prior art date
Application number
TW095115408A
Other languages
English (en)
Chinese (zh)
Other versions
TW200708513A (en
Inventor
Mihaela Pop
Mulder Stephanie Houdayer
Mimoun Lamkadmi
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36693210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI392674(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TW200708513A publication Critical patent/TW200708513A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
TW095115408A 2005-05-02 2006-04-28 噻托溴銨之新穎結晶型 TWI392674B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67680705P 2005-05-02 2005-05-02

Publications (2)

Publication Number Publication Date
TW200708513A TW200708513A (en) 2007-03-01
TWI392674B true TWI392674B (zh) 2013-04-11

Family

ID=36693210

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095115408A TWI392674B (zh) 2005-05-02 2006-04-28 噻托溴銨之新穎結晶型

Country Status (23)

Country Link
US (1) US7879871B2 (https=)
EP (2) EP2085396A3 (https=)
JP (1) JP5227790B2 (https=)
KR (1) KR20080012932A (https=)
CN (1) CN101166738B (https=)
AR (1) AR053599A1 (https=)
AU (1) AU2006243238B2 (https=)
BR (1) BRPI0609295A2 (https=)
CA (1) CA2606549A1 (https=)
DK (1) DK1881980T3 (https=)
ES (1) ES2393794T3 (https=)
IL (1) IL187055A (https=)
MX (1) MX2007013142A (https=)
NZ (1) NZ563596A (https=)
PE (1) PE20061438A1 (https=)
PL (1) PL1881980T3 (https=)
PT (1) PT1881980E (https=)
RU (1) RU2417224C2 (https=)
SI (1) SI1881980T1 (https=)
TW (1) TWI392674B (https=)
UY (1) UY29506A1 (https=)
WO (1) WO2006117299A2 (https=)
ZA (1) ZA200708048B (https=)

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US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
DK2240477T3 (en) * 2008-01-10 2014-12-08 Generics Uk Ltd New process for the preparation of skopinestre
JP2012507574A (ja) * 2008-11-04 2012-03-29 シプラ・リミテッド 医薬エアロゾル組成物
WO2010052450A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Tiotropium bromide having a low degree of crystallinity
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
UA115888C2 (uk) * 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
JP6473738B2 (ja) 2013-04-01 2019-02-20 パルマトリックス，インコーポレイテッド チオトロピウム乾燥粉末
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) * 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos

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CN1520294A (zh) * 2001-06-22 2004-08-11 ���ָ��Ӣ��ķ�������Ϲ�˾ 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途

Also Published As

Publication number Publication date
NZ563596A (en) 2011-01-28
EP2085396A3 (en) 2009-11-25
CN101166738A (zh) 2008-04-23
JP5227790B2 (ja) 2013-07-03
MX2007013142A (es) 2008-03-18
IL187055A0 (en) 2008-02-09
KR20080012932A (ko) 2008-02-12
WO2006117299A9 (en) 2006-12-28
JP2008540366A (ja) 2008-11-20
AU2006243238B2 (en) 2012-05-24
EP2085396A2 (en) 2009-08-05
HK1114856A1 (en) 2008-11-14
ZA200708048B (en) 2008-10-29
EP1881980B1 (en) 2012-08-22
RU2007144521A (ru) 2009-06-10
PL1881980T3 (pl) 2013-01-31
AR053599A1 (es) 2007-05-09
BRPI0609295A2 (pt) 2010-03-23
US20070092453A1 (en) 2007-04-26
US7879871B2 (en) 2011-02-01
PT1881980E (pt) 2012-12-06
CN101166738B (zh) 2011-06-01
AU2006243238A1 (en) 2006-11-09
EP1881980A2 (en) 2008-01-30
DK1881980T3 (da) 2012-10-01
UY29506A1 (es) 2006-11-30
WO2006117299A3 (en) 2007-02-22
RU2417224C2 (ru) 2011-04-27
CA2606549A1 (en) 2006-11-09
WO2006117299A2 (en) 2006-11-09
IL187055A (en) 2012-09-24
SI1881980T1 (sl) 2012-12-31
TW200708513A (en) 2007-03-01
ES2393794T3 (es) 2012-12-28
PE20061438A1 (es) 2007-01-12

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