CN101166738B - 噻托溴铵的新晶型 - Google Patents

噻托溴铵的新晶型 Download PDF

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Publication number
CN101166738B
CN101166738B CN2006800142275A CN200680014227A CN101166738B CN 101166738 B CN101166738 B CN 101166738B CN 2006800142275 A CN2006800142275 A CN 2006800142275A CN 200680014227 A CN200680014227 A CN 200680014227A CN 101166738 B CN101166738 B CN 101166738B
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China
Prior art keywords
tiotropium bromide
solvate
present
preparation
crystallization
Prior art date
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Expired - Lifetime
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CN2006800142275A
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English (en)
Chinese (zh)
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CN101166738A (zh
Inventor
迈黑拉·M·波普
斯蒂法妮·马尔德霍戴尔
米芒·拉姆卡德米
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CN2006800142275A 2005-05-02 2006-04-21 噻托溴铵的新晶型 Expired - Lifetime CN101166738B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67680705P 2005-05-02 2005-05-02
US60/676,807 2005-05-02
PCT/EP2006/061763 WO2006117299A2 (en) 2005-05-02 2006-04-21 Novel crystalline forms of tiotropium bromide

Publications (2)

Publication Number Publication Date
CN101166738A CN101166738A (zh) 2008-04-23
CN101166738B true CN101166738B (zh) 2011-06-01

Family

ID=36693210

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800142275A Expired - Lifetime CN101166738B (zh) 2005-05-02 2006-04-21 噻托溴铵的新晶型

Country Status (23)

Country Link
US (1) US7879871B2 (https=)
EP (2) EP2085396A3 (https=)
JP (1) JP5227790B2 (https=)
KR (1) KR20080012932A (https=)
CN (1) CN101166738B (https=)
AR (1) AR053599A1 (https=)
AU (1) AU2006243238B2 (https=)
BR (1) BRPI0609295A2 (https=)
CA (1) CA2606549A1 (https=)
DK (1) DK1881980T3 (https=)
ES (1) ES2393794T3 (https=)
IL (1) IL187055A (https=)
MX (1) MX2007013142A (https=)
NZ (1) NZ563596A (https=)
PE (1) PE20061438A1 (https=)
PL (1) PL1881980T3 (https=)
PT (1) PT1881980E (https=)
RU (1) RU2417224C2 (https=)
SI (1) SI1881980T1 (https=)
TW (1) TWI392674B (https=)
UY (1) UY29506A1 (https=)
WO (1) WO2006117299A2 (https=)
ZA (1) ZA200708048B (https=)

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RS52663B2 (sr) * 2005-12-19 2018-05-31 Sicor Inc Nova kristalna forma tiotropijum bromida i proces njene pripreme
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US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
DK2240477T3 (en) * 2008-01-10 2014-12-08 Generics Uk Ltd New process for the preparation of skopinestre
JP2012507574A (ja) * 2008-11-04 2012-03-29 シプラ・リミテッド 医薬エアロゾル組成物
WO2010052450A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Tiotropium bromide having a low degree of crystallinity
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
UA115888C2 (uk) * 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
JP6473738B2 (ja) 2013-04-01 2019-02-20 パルマトリックス，インコーポレイテッド チオトロピウム乾燥粉末
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) * 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1392795A (zh) * 2000-10-12 2003-01-22 贝林格尔英格海姆法玛公司 含噻托品鎓的新颖可吸入粉末
CN1520294A (zh) * 2001-06-22 2004-08-11 ���ָ��Ӣ��ķ�������Ϲ�˾ 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途

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CN1520294A (zh) * 2001-06-22 2004-08-11 ���ָ��Ӣ��ķ�������Ϲ�˾ 结晶性抗胆碱能药,其制备方法及其在药物制备中的用途

Also Published As

Publication number Publication date
NZ563596A (en) 2011-01-28
EP2085396A3 (en) 2009-11-25
CN101166738A (zh) 2008-04-23
JP5227790B2 (ja) 2013-07-03
MX2007013142A (es) 2008-03-18
IL187055A0 (en) 2008-02-09
KR20080012932A (ko) 2008-02-12
WO2006117299A9 (en) 2006-12-28
JP2008540366A (ja) 2008-11-20
AU2006243238B2 (en) 2012-05-24
EP2085396A2 (en) 2009-08-05
HK1114856A1 (en) 2008-11-14
ZA200708048B (en) 2008-10-29
EP1881980B1 (en) 2012-08-22
RU2007144521A (ru) 2009-06-10
PL1881980T3 (pl) 2013-01-31
AR053599A1 (es) 2007-05-09
TWI392674B (zh) 2013-04-11
BRPI0609295A2 (pt) 2010-03-23
US20070092453A1 (en) 2007-04-26
US7879871B2 (en) 2011-02-01
PT1881980E (pt) 2012-12-06
AU2006243238A1 (en) 2006-11-09
EP1881980A2 (en) 2008-01-30
DK1881980T3 (da) 2012-10-01
UY29506A1 (es) 2006-11-30
WO2006117299A3 (en) 2007-02-22
RU2417224C2 (ru) 2011-04-27
CA2606549A1 (en) 2006-11-09
WO2006117299A2 (en) 2006-11-09
IL187055A (en) 2012-09-24
SI1881980T1 (sl) 2012-12-31
TW200708513A (en) 2007-03-01
ES2393794T3 (es) 2012-12-28
PE20061438A1 (es) 2007-01-12

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