TWI362945B - Controlled surface gelling of mucoadhesive polymers on oral mucosa - Google Patents

Controlled surface gelling of mucoadhesive polymers on oral mucosa Download PDF

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Publication number
TWI362945B
TWI362945B TW097133997A TW97133997A TWI362945B TW I362945 B TWI362945 B TW I362945B TW 097133997 A TW097133997 A TW 097133997A TW 97133997 A TW97133997 A TW 97133997A TW I362945 B TWI362945 B TW I362945B
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Taiwan
Prior art keywords
oral composition
cation
releasing compound
rupturable capsule
oral
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Application number
TW097133997A
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English (en)
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TW200916119A (en
Inventor
Shira Pilch
James Gerard Masters
Rensl Dillon
David Benedict Viscio
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Colgate Palmolive Co
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Publication of TW200916119A publication Critical patent/TW200916119A/zh
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Publication of TWI362945B publication Critical patent/TWI362945B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

70%之聚氧乙烯。界面活性劑協 t於整個口腔中，並使得組成物 具有侧之分子量且包括70%之3 助成分達錢底且完全分散於整個 接雙。非離子界面活性劑亦藉由溶解調味油 而幫助調味劑保持在溶液中。可包括以重量計約至 約3%之界面活性劑量。 、者[〇 〇 2 6 ]有用於製備根據本發明之牙粉之界面活性劑 ，包括〶碳脂肪自复單甘油g旨單硫酸鹽之水溶性鹽類， 諸如氫化之椰油脂肪酸的單硫酸化單甘油 酯之納鹽、椰油 -胺丙基甜木驗、尚碳烧基硫酸鹽，諸如月桂基硫酸鈉、 烷基芳基石頁酸鹽，諸如十二烷基苯磺酸鈉、高碳烷基磺乙 酸鹽’諸如月桂基續基乙酸鈉、1，2_二絲丙糾酸鹽之高 ，脂肪酸酯及低碳脂肪族胺基羧酸化合物的實質飽和之高 奴脂肪族gi基g!胺’諸如該等在脂肪酸、烧基或醯基及類 及Ν-月桂醯基、Ν_肉豆蔻醯基或 ‘鉀及乙醇胺鹽類。可根據本發明 似物中具有12至16個碳原子者。最後述及之酿胺的實例 為N-月桂酿基肌胺酸，艿入了 B认μ u 、τ
1362945、 劑量。 [0028] 有用於製備根據本發明之牙粉之保濕劑的實 例包括三曱基甘胺酸、甘油、山梨醇、聚乙二醇、聚丙二 醇、甘露醇、木糖醇或其混合物，可包括以重量計大於約 5 20%及較佳地以重量計約3%至約70%之保濕劑量。 [0029] 有用於製備根據本發明之漱口水或喷霧劑之 甜味劑的實例包括糖精、蔗糖素或其混合物，可包括以重 量計約0.01%至約1%之甜味劑量。 [0030] 有用於製備根據本發明之牙齡之甜味劑的實 ίο 例包括阿斯巴甜、糖精、嚴糖素或其混合物，可包括以重 量計約0.1%至約2%之甜味劑量。 [0031] 有用於製備根據本發明之漱口水或喷霧劑之 保存劑的實例包括苯曱酸、苯曱酸鈉、氯化鯨蠟基吡錠、 對羥苯甲酸酯或其混合物，可包括以重量計約0.1%至約2 15 %之保存劑量。 [0032] 有用於製備根據本發明之組成物的額外成分 包括唾液刺激化合物，諸如檸檬酸、抗壞血酸或木糖醇， 可包括以重量計約0.25至約10%之該成分量。亦可包括在 本技藝中已知的其他成分，諸如漂白劑、植物化合物、抗 20 細菌劑及著色劑。 [0033] 有用於製備根據本發明之牙粉之增稠劑的實 例包括瓜爾膠、羧甲基纖維素及聚氧乙烯聚氧丙烯嵌段共 聚物及黃原膠。可根據本發明使用之其他增稠劑的實例包 括刺槐豆膠、羥甲基纖維素及羥丙基纖維素。可包括以重 π

Claims (1)

1362945 ·
、申請專利範圍： 七 專利申請案第97133997號 ROC Patent Application. No. 97133997 修正後之申請專利範圍替換本-附件(四） Amended Claims in Chinese - Encl.dV) (民國100年11月16日送呈） (Submitted on November 16, 2011) 種口腔組成物，其包含： 修立| 陽離子-敏感性黏膜黏著性聚合物if 陽離子-釋放化合物； 其中將陽離子釋放化合物囊封在可破裂膠囊中。 2·根據請求項i之口腔組成物，其中該黏膜黏著性聚合物 包含結蘭膠(gellan gum)。 3.根據請求項丨之口腔組成物，其中該黏膜黏著性聚合物 包含鹿角菜膠。 1〇 4.根據請求項1之口腔組成物，其中該陽離子-釋放化合物 包含可溶性二價鹽。 5.根據請求項1之口腔組成物’其中該陽離子_釋放化合物 包含約鹽。 6·根據請求項5之口腔組成物，其中該陽離子-釋放化合物 包含CaCl2。 7.根據請求項1之口腔組成物，其中該可破裂膠囊包含聚 石夕氧。 8·根據請求項1之口腔組成物，其中該可破裂膠囊包含 PLGA。 20 9.根據請求項1之口腔組成物，其中該可破裂膠囊包含白 明膠。 10.根據請求項1之口腔組成物’其中該可破裂膠囊包含烷 基纖維素聚合物。 14 1362945 ‘ 11. 一種漱口水、口腔喷霧劑或牙膏，其包含請求項i之口 腔組成物。 12. —種根據請求項1之口腔組成物於製造用於減輕及/或預 防口乾之口腔保健產品之用途。 5 13. —種口腔絚成物，其包含： 陽離子-敏感性黏膜黏著性聚合物 ，其選自由結蘭膠 及鹿角菜膠所組成之群組； CaCl2鹽；及 可破裂膠囊，其句.冬理
、PLGA、白明膠 15
TW097133997A 2007-09-06 2008-09-05 Controlled surface gelling of mucoadhesive polymers on oral mucosa TWI362945B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/850,886 US10512597B2 (en) 2007-09-06 2007-09-06 Controlled surface gelling of mucoadhesive polymers on oral mucosa

Publications (2)

Publication Number Publication Date
TW200916119A TW200916119A (en) 2009-04-16
TWI362945B true TWI362945B (en) 2012-05-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW097133997A TWI362945B (en) 2007-09-06 2008-09-05 Controlled surface gelling of mucoadhesive polymers on oral mucosa

Country Status (21)

Country Link
US (1) US10512597B2 (zh)
EP (1) EP2197554B1 (zh)
JP (1) JP2010538073A (zh)
CN (1) CN101795730B (zh)
AR (1) AR068378A1 (zh)
AT (1) ATE494929T1 (zh)
AU (1) AU2008296755B2 (zh)
BR (1) BRPI0814463B1 (zh)
CA (1) CA2689443C (zh)
CO (1) CO6251296A2 (zh)
DE (1) DE602008004569D1 (zh)
DK (1) DK2197554T3 (zh)
ES (1) ES2358475T3 (zh)
HK (1) HK1144402A1 (zh)
MX (1) MX2009012774A (zh)
MY (1) MY146260A (zh)
PL (1) PL2197554T3 (zh)
RU (1) RU2440809C2 (zh)
TW (1) TWI362945B (zh)
WO (1) WO2009032404A1 (zh)
ZA (1) ZA200908560B (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080267891A1 (en) * 2007-04-30 2008-10-30 Colgate-Palmolive Company Oral Care Composition To Reduce Or Eliminate Dental Sensitivity
US20090053267A1 (en) * 2007-08-20 2009-02-26 Depierro Karen Dentifrice composition containing silicone oil beads
JP5782429B2 (ja) 2009-05-18 2015-09-24 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ ポリグアニジニウム化合物を含有する口腔用組成物及び製造の方法並びにその使用
TWI499430B (zh) 2009-12-17 2015-09-11 Colgate Palmolive Co 抗侵蝕的牙膏組成物
CN103200994B (zh) 2010-01-29 2016-02-10 高露洁-棕榄公司 用于敏感釉质护理的口腔护理产品
AU2010365779B2 (en) 2010-12-23 2015-07-23 Colgate-Palmolive Company Fluid compositions comprising a structuring agent
EP2654706B1 (en) 2010-12-23 2017-10-25 Colgate-Palmolive Company Aqueous oral care composition comprising xanthan gum, cellulose gum and carbomer
WO2012095774A1 (en) 2011-01-12 2012-07-19 Indian Institute Of Technology Bombay Self assembled nanostructured saliva substitutes
EP2925791B1 (en) 2012-12-03 2017-03-22 Colgate-Palmolive Company Manufacturing processes for gellan gum-based fluid gels
US20150044136A1 (en) * 2013-08-12 2015-02-12 George H. Scherr Ophthalmological treatment for michobial infections
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US11291613B2 (en) 2017-05-16 2022-04-05 Johnson & Johnson Consumer Inc. Coated particles and their uses

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Also Published As

Publication number Publication date
ZA200908560B (en) 2012-11-28
ATE494929T1 (de) 2011-01-15
RU2010112986A (ru) 2011-10-20
TW200916119A (en) 2009-04-16
US20090068259A1 (en) 2009-03-12
EP2197554A1 (en) 2010-06-23
ES2358475T3 (es) 2011-05-11
US10512597B2 (en) 2019-12-24
BRPI0814463B1 (pt) 2016-07-12
CO6251296A2 (es) 2011-02-21
JP2010538073A (ja) 2010-12-09
HK1144402A1 (en) 2011-02-18
RU2440809C2 (ru) 2012-01-27
AU2008296755B2 (en) 2011-08-11
BRPI0814463A2 (pt) 2015-01-20
CN101795730B (zh) 2015-09-02
MX2009012774A (es) 2009-12-10
PL2197554T3 (pl) 2011-06-30
AR068378A1 (es) 2009-11-11
EP2197554B1 (en) 2011-01-12
WO2009032404A1 (en) 2009-03-12
DK2197554T3 (da) 2011-05-09
CA2689443A1 (en) 2009-03-12
DE602008004569D1 (de) 2011-02-24
MY146260A (en) 2012-07-31
CN101795730A (zh) 2010-08-04
AU2008296755A1 (en) 2009-03-12
CA2689443C (en) 2012-09-18

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