JP2005526120A - 口腔咽頭の空洞障害の局所治療用ジクロフェナク系組成物 - Google Patents
口腔咽頭の空洞障害の局所治療用ジクロフェナク系組成物 Download PDFInfo
- Publication number
- JP2005526120A JP2005526120A JP2004502991A JP2004502991A JP2005526120A JP 2005526120 A JP2005526120 A JP 2005526120A JP 2004502991 A JP2004502991 A JP 2004502991A JP 2004502991 A JP2004502991 A JP 2004502991A JP 2005526120 A JP2005526120 A JP 2005526120A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- salt
- diclofenac
- tromethamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
実施例1
マウスウオッシュA
100gのマウスウオッシュAは、
トロメタミンとのジクロフェナク塩* 0.104 g
キシリトール 10.000 g
ポロキシマー(商標登録)407 0.500 g
安息香酸ナトリウム 0.500 g
天然ミント香味料 0.500 ml
E131の水溶液(1mg/ml) 0.200 ml
pH7.8 リン酸緩衝液** qs 100 g
pH 7.6
* 0.074gの酸性のジクロフェナク塩と等量
** 精製した水の1リットルの溶液は、無水第二リン酸ナトリウム(5.803g)、無水リン酸2水素カリウム(3.522g)、及び1N水酸化ナトリウム(18.70ml)を含む。
マウスウオッシュB
100gのマウスウオッシュBは、以下を除き、マウスウオッシュAと同じ組成物を有する。すなわち、それは、天然果実香味料(0.04ml)及び天然ザクロ果実シロップ香味料(0.02ml)、及び、0.2mlのE131(1mg/ml)水溶液の代わりに、0.25mlのE124(10mg/ml)の水溶液を含む。
マウスウオッシュC
pH7.8リン酸緩衝液の代わりに、精製した水を含むことを除き、マウスウオッシュAと同様の組成物を有するマウスウオッシュを調整した。
マウスウオッシュD
pH7.8リン酸緩衝液の代わりに、精製した水を含むことを除き、マウスウオッシュBと同様の組成物を有するマウスウオッシュを調整した。
マウスウオッシュA及びBは、安定であることが判明した。
Claims (8)
- トロメタミンとのジクロフェナク塩の水溶液からなり、前記塩の量が0.1%から0.2%(W/W) であり、pHが7〜8の間に調整されることを特徴とする口腔咽頭の空洞障害の局所治療用組成物。
- 前記組成物が、0.10%(W/W)のトロメタミンとのジクロフェナク塩を含むことを特徴とする請求項1記載の組成物。
- さらに、前記組成物が、サッカリン酸ナトリウム、ソルビトール、アセスルファム、及びキシリトールからなる群から選択される甘味料を含むことを特徴とする請求項1又は2記載の組成物。
- さらに、前記組成物が、安息香酸ナトリウム、メチルp−ヒドロキシ安息香酸、及びプロピルp−ヒドロキシ安息香酸からなる群から選択される保存料を含むことを特徴とする先行する請求項1〜3項のいずれか1項に記載の組成物。
- さらに、前記組成物が、ポリエチレングリコール、及びポリプロピレングリコールのブロック共重合体からなるゲル化剤を含むことを特徴とする先行する請求項1〜4項のいずれか1項に記載の組成物。
- さらに、前記組成物が、薬剤的に許容可能な香味料を含むことを特徴とする先行する請求項1〜5のいずれか1項に記載の組成物。
- さらに、前記組成物が、薬剤的に許容可能な着色料を含むことを特徴とする先行する請求項1〜6項のいずれか1項に記載の組成物。
- 歯肉炎、舌炎、口内炎、アフター性口内炎、パラデントシス(paradentosis)、歯根炎(paradentitis)、喉頭炎、咽頭炎、放射線治療及び化学治療によって引起される口頭空洞の粘膜炎、及び歯科及び/又は一般外科の後遺症の治療用に使用されることを特徴とする先行する請求項1〜7項のいずれか1項に記載の組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI000986A ITMI20020986A1 (it) | 2002-05-10 | 2002-05-10 | Composizione a base di diclofenac per il trattamento topico di affezioni del cavo orofaringeo |
PCT/EP2003/004044 WO2003094905A1 (en) | 2002-05-10 | 2003-04-16 | Diclofenac-based composition for the topical treatment of oropharyngeal cavity disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005526120A true JP2005526120A (ja) | 2005-09-02 |
Family
ID=11449862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004502991A Pending JP2005526120A (ja) | 2002-05-10 | 2003-04-16 | 口腔咽頭の空洞障害の局所治療用ジクロフェナク系組成物 |
Country Status (22)
Country | Link |
---|---|
US (1) | US20050100597A1 (ja) |
EP (1) | EP1503747B1 (ja) |
JP (1) | JP2005526120A (ja) |
KR (1) | KR20040111415A (ja) |
CN (1) | CN1303992C (ja) |
AR (1) | AR039977A1 (ja) |
AT (1) | ATE333872T1 (ja) |
AU (1) | AU2003232480B2 (ja) |
CA (1) | CA2477773C (ja) |
DE (1) | DE60307086T2 (ja) |
DK (1) | DK1503747T3 (ja) |
EA (1) | EA006165B1 (ja) |
ES (1) | ES2268402T3 (ja) |
GE (1) | GEP20063822B (ja) |
HK (1) | HK1071312A1 (ja) |
IL (2) | IL163871A0 (ja) |
IT (1) | ITMI20020986A1 (ja) |
MX (1) | MXPA04010401A (ja) |
PL (1) | PL215221B1 (ja) |
PT (1) | PT1503747E (ja) |
UA (1) | UA79110C2 (ja) |
WO (1) | WO2003094905A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20032523A1 (it) * | 2003-12-19 | 2005-06-20 | Acraf | Forma di dosaggio per uso orale comprendente un farmaco |
ITMI20040235A1 (it) * | 2004-02-13 | 2004-05-13 | Therapicon Srl | Preparazione farmaceutica per il cavo orale |
CN101138544B (zh) * | 2006-09-06 | 2010-09-29 | 上海医药工业研究院 | 双氯芬酸或其盐局部成膜凝胶组合物及其应用 |
AU2007311019B2 (en) | 2006-10-17 | 2013-05-16 | Nuvo Pharmaceuticals, Inc | Diclofenac gel |
US8546450B1 (en) | 2009-03-31 | 2013-10-01 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
US8618164B2 (en) | 2009-03-31 | 2013-12-31 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
US20120003162A1 (en) * | 2010-06-30 | 2012-01-05 | Mcneil-Ppc, Inc. | Methods of Preparing Non-Alcohol Bioactive Esential Oil Mouth Rinses |
KR101936192B1 (ko) | 2010-12-29 | 2019-01-08 | 엘지전자 주식회사 | 공기조화기의 실외기 |
DE102011111944A1 (de) * | 2011-08-29 | 2013-02-28 | Richard A. Huthmacher | Verwendung von Diclofenac zur Verhinderung und Behandlung grippaler Infekte sowie durch grippale Infekte bewirkter Krankheitssymtome |
JP2017526638A (ja) * | 2014-06-30 | 2017-09-14 | ミトコンドリアル サブストレート インベンション リミテッドMitochondrial Substrate Invention Limited | 認知機能向上のための栄養素溶液 |
CN104546527A (zh) * | 2014-12-29 | 2015-04-29 | 福建省闽东力捷迅药业有限公司 | 一种含七叶皂苷钠的漱口液及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT370721B (de) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der |
ES2054089T3 (es) * | 1988-11-10 | 1994-08-01 | Ciba Geigy Ag | Formulaciones orales liquidas. |
CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
US5028413A (en) * | 1990-03-21 | 1991-07-02 | Bausch & Lomb Incorporated | Novel fluoride-containing dentifrice |
IT1243342B (it) * | 1990-07-13 | 1994-06-10 | Farcon Ag | Composizioni farmaceutiche orali liquide ad attivita' antiinfiammatoria |
US5972906A (en) * | 1991-07-03 | 1999-10-26 | Hyal Pharmaceutical Corporation | Treatment of mucous membrane disease, trauma or condition and for the relief of pain thereof |
IT1250636B (it) * | 1991-07-04 | 1995-04-21 | Ricerche Di Schiena Del Dr Mic | Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono. |
US5626838A (en) * | 1995-03-13 | 1997-05-06 | The Procter & Gamble Company | Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx |
CN1059797C (zh) * | 1995-11-22 | 2000-12-27 | 王树力 | 双氯芬酸钠喷雾剂 |
-
2002
- 2002-05-10 IT IT2002MI000986A patent/ITMI20020986A1/it unknown
-
2003
- 2003-04-16 IL IL16387103A patent/IL163871A0/xx active IP Right Grant
- 2003-04-16 CN CNB038105764A patent/CN1303992C/zh not_active Expired - Fee Related
- 2003-04-16 WO PCT/EP2003/004044 patent/WO2003094905A1/en active IP Right Grant
- 2003-04-16 PL PL371426A patent/PL215221B1/pl unknown
- 2003-04-16 AU AU2003232480A patent/AU2003232480B2/en not_active Ceased
- 2003-04-16 CA CA2477773A patent/CA2477773C/en not_active Expired - Fee Related
- 2003-04-16 US US10/505,178 patent/US20050100597A1/en not_active Abandoned
- 2003-04-16 ES ES03749856T patent/ES2268402T3/es not_active Expired - Lifetime
- 2003-04-16 MX MXPA04010401A patent/MXPA04010401A/es unknown
- 2003-04-16 DE DE60307086T patent/DE60307086T2/de not_active Expired - Lifetime
- 2003-04-16 UA UA20040907893A patent/UA79110C2/uk unknown
- 2003-04-16 KR KR10-2004-7014564A patent/KR20040111415A/ko active IP Right Grant
- 2003-04-16 JP JP2004502991A patent/JP2005526120A/ja active Pending
- 2003-04-16 DK DK03749856T patent/DK1503747T3/da active
- 2003-04-16 AT AT03749856T patent/ATE333872T1/de active
- 2003-04-16 EA EA200401090A patent/EA006165B1/ru not_active IP Right Cessation
- 2003-04-16 PT PT03749856T patent/PT1503747E/pt unknown
- 2003-04-16 GE GE5669A patent/GEP20063822B/en unknown
- 2003-04-16 EP EP03749856A patent/EP1503747B1/en not_active Expired - Lifetime
- 2003-05-08 AR ARP030101608A patent/AR039977A1/es not_active Application Discontinuation
-
2004
- 2004-09-01 IL IL163871A patent/IL163871A/en unknown
-
2005
- 2005-05-24 HK HK05104340A patent/HK1071312A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2003094905A8 (en) | 2004-04-01 |
MXPA04010401A (es) | 2005-02-17 |
CN1652763A (zh) | 2005-08-10 |
IL163871A (en) | 2007-10-31 |
ITMI20020986A0 (it) | 2002-05-10 |
CN1303992C (zh) | 2007-03-14 |
AU2003232480B2 (en) | 2008-07-31 |
PT1503747E (pt) | 2006-11-30 |
CA2477773C (en) | 2011-01-18 |
AU2003232480A1 (en) | 2003-11-11 |
DE60307086D1 (de) | 2006-09-07 |
KR20040111415A (ko) | 2004-12-31 |
EA006165B1 (ru) | 2005-10-27 |
EA200401090A1 (ru) | 2005-02-24 |
PL215221B1 (pl) | 2013-11-29 |
US20050100597A1 (en) | 2005-05-12 |
ITMI20020986A1 (it) | 2003-11-10 |
DK1503747T3 (da) | 2006-11-27 |
CA2477773A1 (en) | 2003-11-20 |
GEP20063822B (en) | 2006-05-10 |
IL163871A0 (en) | 2005-12-18 |
PL371426A1 (en) | 2005-06-13 |
ATE333872T1 (de) | 2006-08-15 |
WO2003094905A1 (en) | 2003-11-20 |
DE60307086T2 (de) | 2007-02-01 |
UA79110C2 (en) | 2007-05-25 |
AR039977A1 (es) | 2005-03-09 |
EP1503747B1 (en) | 2006-07-26 |
ES2268402T3 (es) | 2007-03-16 |
HK1071312A1 (en) | 2005-07-15 |
EP1503747A1 (en) | 2005-02-09 |
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