TWI361693B - Novel use of peptide compounds for treating essential tremor and other tremor syndromes - Google Patents
Novel use of peptide compounds for treating essential tremor and other tremor syndromes Download PDFInfo
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- TWI361693B TWI361693B TW094121028A TW94121028A TWI361693B TW I361693 B TWI361693 B TW I361693B TW 094121028 A TW094121028 A TW 094121028A TW 94121028 A TW94121028 A TW 94121028A TW I361693 B TWI361693 B TW I361693B
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- tremor
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- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 239000007886 soft shell capsule Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000000542 thalamic effect Effects 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000005309 thioalkoxy group Chemical group 0.000 description 1
- 125000005296 thioaryloxy group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 229960004394 topiramate Drugs 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 229940102566 valproate Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| US58208404P | 2004-06-24 | 2004-06-24 |
Publications (2)
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| TWI361693B true TWI361693B (en) | 2012-04-11 |
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| TW094121028A TWI361693B (en) | 2004-06-24 | 2005-06-23 | Novel use of peptide compounds for treating essential tremor and other tremor syndromes |
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| BR (1) | BRPI0512622A (enExample) |
| CA (1) | CA2566301C (enExample) |
| EA (1) | EA013592B1 (enExample) |
| IL (1) | IL179732A0 (enExample) |
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| NO (1) | NO20070423L (enExample) |
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| TW (1) | TWI361693B (enExample) |
| UA (1) | UA88166C2 (enExample) |
| WO (1) | WO2006000397A1 (enExample) |
| ZA (1) | ZA200609021B (enExample) |
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| PT1243262E (pt) * | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| ES2185606T3 (es) * | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| ATE428413T1 (de) * | 2003-12-02 | 2009-05-15 | Sanol Arznei Schwarz Gmbh | Neue verwendung von peptidverbindungen zur behandlung ovn zentralen neuropathischen schmerzen |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| EP1579858A1 (en) * | 2004-03-26 | 2005-09-28 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in painful diabetic neuropathy |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| CN1950101B (zh) | 2004-04-16 | 2011-03-30 | 舒沃茨药物股份公司 | 肽化合物用于预防和治疗慢性头痛的用途 |
| EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EP1781276B1 (en) * | 2004-08-27 | 2010-06-23 | UCB Pharma GmbH | Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| US7902401B2 (en) * | 2006-12-14 | 2011-03-08 | Nps Pharmaceuticals, Inc. | Fluorinated compounds |
| PT2462990E (pt) | 2006-06-15 | 2014-04-02 | Ucb Pharma Gmbh | Composição farmacêutica com efeito anticonvulsivo sinergístico |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| US8450336B2 (en) * | 2006-12-14 | 2013-05-28 | Nps Pharmaceuticals, Inc | Use of D-serine derivatives for the treatment of anxiety disorders |
| US7747551B2 (en) * | 2007-02-21 | 2010-06-29 | Neurovista Corporation | Reduction of classification error rates and monitoring system using an artificial class |
| US8933065B2 (en) * | 2008-04-01 | 2015-01-13 | The University Of North Carolina At Chapel Hill | N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents |
| US20110281808A1 (en) * | 2010-05-14 | 2011-11-17 | Allmax Nutrition Inc. | Composition and Method for Increasing Pre Workout Thermogenics |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| EP2646001A2 (en) | 2010-12-02 | 2013-10-09 | UCB Pharma GmbH | Formulation of lacosamide |
| WO2018031748A1 (en) * | 2016-08-11 | 2018-02-15 | Ovid Therapeutics Inc. | Methods and compositions for treatment of epileptic disorders |
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| US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
| US5773475A (en) * | 1997-03-17 | 1998-06-30 | Research Corporation Technologies, Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| US6277825B1 (en) * | 1996-07-22 | 2001-08-21 | University Of Utah Research Foundation | Use of conantokins for treating pain |
| US6589994B1 (en) | 1996-08-30 | 2003-07-08 | Nps Pharmaceuticals, Inc. | Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound |
| US5866585A (en) * | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US6197764B1 (en) * | 1997-11-26 | 2001-03-06 | Protarga, Inc. | Clozapine compositions and uses thereof |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| ATE301995T1 (de) * | 2000-08-17 | 2005-09-15 | Teva Pharma | Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzen |
| DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| DE60127459T2 (de) * | 2000-08-25 | 2007-07-12 | Research Corp. Technologies, Inc., Tucson | Verwendung von aminosäurehaltigen Antikonvulsiva zur Behandlung von Schmerz |
| ES2307671T3 (es) | 2000-11-21 | 2008-12-01 | Ucb Pharma, S.A. | Compuestos de gaba n-alquilados, procedimientos para su preparacion y su uso como medicamentos. |
| US20040116505A1 (en) * | 2001-02-23 | 2004-06-17 | Gregory Krauss | Treatment of tics, tremors and related disorders |
| PT1243262E (pt) | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| ES2185606T3 (es) | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| TWI312285B (en) * | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US6828462B2 (en) * | 2001-11-07 | 2004-12-07 | Merz Pharma Gmbh & Co. Kgaa | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| US6559293B1 (en) * | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
| EP1539145A2 (en) * | 2002-09-13 | 2005-06-15 | Eisai Co., Ltd. | Method of treating tremors |
| AU2003283160A1 (en) | 2002-11-18 | 2004-06-15 | Bradley J. Steeves | Shrew paralytic peptide for use in neuromuscular therapy |
| US20050227961A1 (en) * | 2004-04-08 | 2005-10-13 | Vela Pharmaceuticals, Inc. | Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome |
| EP1604654A1 (en) * | 2004-05-18 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating dyskinesia |
| EP1604656A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
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2005
- 2005-06-10 US US11/149,181 patent/US7427601B2/en not_active Expired - Fee Related
- 2005-06-22 EA EA200700108A patent/EA013592B1/ru not_active IP Right Cessation
- 2005-06-22 KR KR1020067025264A patent/KR20070034477A/ko not_active Abandoned
- 2005-06-22 CA CA2566301A patent/CA2566301C/en not_active Expired - Fee Related
- 2005-06-22 WO PCT/EP2005/006750 patent/WO2006000397A1/en not_active Ceased
- 2005-06-22 BR BRPI0512622-3A patent/BRPI0512622A/pt not_active IP Right Cessation
- 2005-06-22 UA UAA200613472A patent/UA88166C2/ru unknown
- 2005-06-22 NZ NZ551207A patent/NZ551207A/en not_active IP Right Cessation
- 2005-06-22 CN CN2005800185331A patent/CN1964733B/zh not_active Expired - Fee Related
- 2005-06-22 AU AU2005256468A patent/AU2005256468B2/en not_active Ceased
- 2005-06-22 JP JP2007517196A patent/JP5038892B2/ja not_active Expired - Fee Related
- 2005-06-22 EP EP05753740A patent/EP1758606A1/en not_active Withdrawn
- 2005-06-22 MX MXPA06015010A patent/MXPA06015010A/es active IP Right Grant
- 2005-06-23 TW TW094121028A patent/TWI361693B/zh not_active IP Right Cessation
- 2005-06-24 MY MYPI20052909A patent/MY146509A/en unknown
- 2005-06-24 AR ARP050102604A patent/AR049940A1/es not_active Application Discontinuation
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2006
- 2006-10-30 ZA ZA200609021A patent/ZA200609021B/xx unknown
- 2006-11-30 IL IL179732A patent/IL179732A0/en unknown
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2007
- 2007-01-23 NO NO20070423A patent/NO20070423L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MY146509A (en) | 2012-08-15 |
| CN1964733B (zh) | 2012-05-23 |
| NZ551207A (en) | 2010-07-30 |
| JP2008503533A (ja) | 2008-02-07 |
| AU2005256468A1 (en) | 2006-01-05 |
| AR049940A1 (es) | 2006-09-13 |
| IL179732A0 (en) | 2007-05-15 |
| CA2566301A1 (en) | 2006-01-05 |
| CN1964733A (zh) | 2007-05-16 |
| EA200700108A1 (ru) | 2007-06-29 |
| EA013592B1 (ru) | 2010-06-30 |
| US7427601B2 (en) | 2008-09-23 |
| JP5038892B2 (ja) | 2012-10-03 |
| EP1758606A1 (en) | 2007-03-07 |
| KR20070034477A (ko) | 2007-03-28 |
| AU2005256468B2 (en) | 2010-12-09 |
| US20050288234A1 (en) | 2005-12-29 |
| UA88166C2 (ru) | 2009-09-25 |
| BRPI0512622A (pt) | 2008-03-25 |
| TW200603823A (en) | 2006-02-01 |
| WO2006000397A1 (en) | 2006-01-05 |
| NO20070423L (no) | 2007-03-22 |
| MXPA06015010A (es) | 2007-03-26 |
| ZA200609021B (en) | 2008-04-30 |
| CA2566301C (en) | 2011-06-14 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |