TWI343255B - - Google Patents
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- TWI343255B TWI343255B TW093130596A TW93130596A TWI343255B TW I343255 B TWI343255 B TW I343255B TW 093130596 A TW093130596 A TW 093130596A TW 93130596 A TW93130596 A TW 93130596A TW I343255 B TWI343255 B TW I343255B
- Authority
- TW
- Taiwan
- Prior art keywords
- fatty acid
- liquid composition
- acid ester
- fat
- liquid
- Prior art date
Links
- 239000007788 liquid Substances 0.000 claims abstract description 75
- -1 sucrose fatty acid ester Chemical class 0.000 claims abstract description 75
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 57
- 229930195729 fatty acid Natural products 0.000 claims abstract description 57
- 239000000194 fatty acid Substances 0.000 claims abstract description 57
- 229930006000 Sucrose Natural products 0.000 claims abstract description 30
- 239000005720 sucrose Substances 0.000 claims abstract description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 19
- 239000004359 castor oil Substances 0.000 claims abstract description 19
- 235000019438 castor oil Nutrition 0.000 claims abstract description 19
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 19
- 235000013305 food Nutrition 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002537 cosmetic Substances 0.000 claims abstract description 17
- 229920005862 polyol Polymers 0.000 claims abstract description 13
- 150000003077 polyols Chemical class 0.000 claims abstract description 13
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 7
- 239000011709 vitamin E Substances 0.000 claims abstract description 7
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940046009 vitamin E Drugs 0.000 claims abstract description 6
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- 239000000126 substance Substances 0.000 claims description 28
- 238000001556 precipitation Methods 0.000 claims description 18
- 150000004665 fatty acids Chemical class 0.000 claims description 12
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- 238000004519 manufacturing process Methods 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229940127557 pharmaceutical product Drugs 0.000 claims description 2
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- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 claims 1
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- 239000002244 precipitate Substances 0.000 abstract description 9
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 46
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- 239000011732 tocopherol Substances 0.000 description 15
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 15
- 239000002253 acid Substances 0.000 description 14
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 9
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 3
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
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- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 3
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- 238000002347 injection Methods 0.000 description 3
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- 238000000034 method Methods 0.000 description 3
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
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- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
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- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 2
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- AFSHUZFNMVJNKX-CLFAGFIQSA-N 1,2-dioleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC\C=C/CCCCCCCC AFSHUZFNMVJNKX-CLFAGFIQSA-N 0.000 description 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
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- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
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- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Edible Oils And Fats (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003352491 | 2003-10-10 |
Publications (2)
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| TW200515908A TW200515908A (en) | 2005-05-16 |
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| TW093130596A TW200515908A (en) | 2003-10-10 | 2004-10-08 | Novel liquid preparation composition |
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| Country | Link |
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| US (1) | US8557259B2 (enExample) |
| EP (1) | EP1679063B1 (enExample) |
| JP (1) | JP4787019B2 (enExample) |
| KR (1) | KR100953241B1 (enExample) |
| CN (1) | CN1863505A (enExample) |
| AT (1) | ATE556598T1 (enExample) |
| AU (1) | AU2004279225B2 (enExample) |
| TW (1) | TW200515908A (enExample) |
| WO (1) | WO2005034913A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070044805A (ko) | 2004-04-15 | 2007-04-30 | 키아스마, 인코포레이티드 | 생물학적 장벽 투과를 촉진시킬 수 있는 조성물 |
| US8158136B2 (en) * | 2004-08-18 | 2012-04-17 | L'oréal | Emulsification system for use in cosmetics |
| PL2034853T3 (pl) | 2006-06-27 | 2013-02-28 | Akzo Nobel Chemicals Int Bv | Preparaty zawierające witaminę oraz ich zastosowanie do wytwarzania wzbogaconej paszy i środków do pielęgnacji ciała |
| ES2629131T3 (es) | 2008-09-17 | 2017-08-07 | Chiasma Inc. | Composiciones farmacéuticas y métodos de suministro relacionados. |
| FR2942135B1 (fr) * | 2009-02-13 | 2012-06-15 | Oreal | Composition comprenant un ester de sucrose et un ester de polyglycerol |
| US9272165B2 (en) | 2009-02-20 | 2016-03-01 | L'oreal | Composition comprising a sucrose ester and a polyglycerol ester |
| FR2955490B1 (fr) * | 2010-01-25 | 2012-06-15 | Sicaf | Composition cosmetique et/ou dermatologique sous forme de gel, pour application topique |
| US8933134B2 (en) | 2010-06-09 | 2015-01-13 | L'oreal | Compositions containing agar and a softening agent |
| RS66942B1 (sr) | 2015-02-03 | 2025-07-31 | Amryt Endo Inc | Lečenje akromegalije oralnim oktreotidom |
| JP7070136B2 (ja) * | 2017-06-20 | 2022-05-18 | 三菱ケミカル株式会社 | 乳化組成物及び飲料 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| FR3125418B1 (fr) * | 2021-07-21 | 2023-06-16 | Clarins Lab | Composition cosmétique sous la forme d’émulsion huile-dans-eau à forte teneur en ingrédients d’origine naturelle |
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| JPS58103325A (ja) * | 1981-12-10 | 1983-06-20 | Sumitomo Chem Co Ltd | 酸性溶液に易分散性の着色製剤の製法 |
| JPS615011A (ja) | 1984-06-18 | 1986-01-10 | Ss Pharmaceut Co Ltd | 安定なビタミンｅの可溶化液 |
| JPH0636862B2 (ja) | 1985-04-08 | 1994-05-18 | 理研ビタミン株式会社 | 油溶性物質の可溶化組成物 |
| JPS61260860A (ja) * | 1985-05-15 | 1986-11-19 | T Hasegawa Co Ltd | 酸性飲料に配合するための乳化組成物 |
| JP2551755B2 (ja) | 1986-04-23 | 1996-11-06 | 太陽化学株式会社 | 可溶化液の製造法 |
| JPH05219885A (ja) * | 1992-02-14 | 1993-08-31 | Mitsubishi Kasei Corp | クリームリカー組成物 |
| JPH0636862A (ja) | 1992-07-14 | 1994-02-10 | Kurabe Ind Co Ltd | 加熱装置の製造方法 |
| JP3566739B2 (ja) * | 1993-09-30 | 2004-09-15 | 三省製薬株式会社 | 皮膚外用剤の安定化方法 |
| JP3880265B2 (ja) * | 1998-11-16 | 2007-02-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 脂溶性物質の水性液剤 |
| IL138616A0 (en) * | 2000-09-21 | 2001-10-31 | J P M E D Ltd | Oil in glycerin emulsion |
| JP4117119B2 (ja) * | 2000-07-05 | 2008-07-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 脂溶性物質の可溶化液剤 |
| KR100722326B1 (ko) | 2000-07-05 | 2007-05-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 지용성 물질의 가용화 액제 |
| JP4982913B2 (ja) | 2000-09-04 | 2012-07-25 | 大正製薬株式会社 | 鉄化合物配合内服液剤 |
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2006
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Also Published As
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| ATE556598T1 (de) | 2012-05-15 |
| TW200515908A (en) | 2005-05-16 |
| US8557259B2 (en) | 2013-10-15 |
| AU2004279225B2 (en) | 2009-10-29 |
| WO2005034913A1 (ja) | 2005-04-21 |
| KR100953241B1 (ko) | 2010-04-16 |
| JPWO2005034913A1 (ja) | 2006-12-21 |
| EP1679063A4 (en) | 2007-02-28 |
| KR20060123736A (ko) | 2006-12-04 |
| EP1679063B1 (en) | 2012-05-09 |
| CN1863505A (zh) | 2006-11-15 |
| US20060189662A1 (en) | 2006-08-24 |
| EP1679063A1 (en) | 2006-07-12 |
| AU2004279225A1 (en) | 2005-04-21 |
| JP4787019B2 (ja) | 2011-10-05 |
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