TWI341311B - - Google Patents

Info

Publication number
TWI341311B
TWI341311B TW093120267A TW93120267A TWI341311B TW I341311 B TWI341311 B TW I341311B TW 093120267 A TW093120267 A TW 093120267A TW 93120267 A TW93120267 A TW 93120267A TW I341311 B TWI341311 B TW I341311B
Authority
TW
Taiwan
Application number
TW093120267A
Other versions
TW200505894A (en
Inventor
Toru Kontani
Junji Miyata
Wataru Hamaguchi
Tomoaki Kawano
Akio Kamikawa
Hiroshi Suzuki
Kenji Sudo
Original Assignee
Astellas Pharma Inc
Rational Drug Design Lavoratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Rational Drug Design Lavoratories filed Critical Astellas Pharma Inc
Publication of TW200505894A publication Critical patent/TW200505894A/zh
Application granted granted Critical
Publication of TWI341311B publication Critical patent/TWI341311B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
TW093120267A 2003-08-08 2004-07-06 Tetrahydro-2H-thiopyran-4-carboxamide derivative TW200505894A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003290850 2003-08-08

Publications (2)

Publication Number Publication Date
TW200505894A TW200505894A (en) 2005-02-16
TWI341311B true TWI341311B (zh) 2011-05-01

Family

ID=34114142

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093120267A TW200505894A (en) 2003-08-08 2004-07-06 Tetrahydro-2H-thiopyran-4-carboxamide derivative

Country Status (19)

Country Link
US (2) US7465748B2 (zh)
EP (1) EP1652843B1 (zh)
JP (1) JP4549974B2 (zh)
KR (1) KR101157074B1 (zh)
CN (1) CN100445271C (zh)
AU (1) AU2004263448B2 (zh)
BR (1) BRPI0413430B8 (zh)
CA (1) CA2535199C (zh)
CY (1) CY1115461T1 (zh)
DK (1) DK1652843T3 (zh)
ES (1) ES2462292T3 (zh)
MX (1) MXPA06001526A (zh)
NO (1) NO335467B1 (zh)
PL (1) PL1652843T3 (zh)
PT (1) PT1652843E (zh)
RU (1) RU2336273C2 (zh)
SI (1) SI1652843T1 (zh)
TW (1) TW200505894A (zh)
WO (1) WO2005014559A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518391A (ja) * 2001-12-21 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ Ｇｋ活性化剤としてのアミド誘導体
CA2744893A1 (en) * 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as glucokinase activators
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
CA2551324C (en) * 2004-01-06 2012-11-27 Novo Nordisk A/S Heteroaryl-ureas and their use as glucokinase activators
KR20070100833A (ko) * 2005-02-02 2007-10-11 아스텔라스세이야쿠 가부시키가이샤 포진 바이러스가 관여하는 질환의 예방 또는 치료제
WO2006082820A1 (ja) * 2005-02-02 2006-08-10 Astellas Pharma Inc. 性器ヘルペス治療剤
US20090048310A1 (en) * 2005-02-02 2009-02-19 Astellas Pharma Inc. Agent for prevention/treatment of disease caused by acyclovir-resistant herpesvirus
JP5011739B2 (ja) * 2005-02-03 2012-08-29 アステラス製薬株式会社 テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体を含有する医薬組成物
US7999114B2 (en) * 2005-07-08 2011-08-16 Novo Nordisk A/S Dicycloalkylcarbamoyl ureas as glucokinase activators
US7582769B2 (en) * 2005-07-08 2009-09-01 Novo Nordisk A/S Dicycloalkyl urea glucokinase activators
AU2006268589B2 (en) 2005-07-14 2011-09-29 Vtv Therapeutics Llc Urea glucokinase activators
EP2118083A1 (en) * 2007-01-09 2009-11-18 Novo Nordisk A/S Urea glucokinase activators
EP2099777B1 (en) * 2007-01-11 2015-08-12 Novo Nordisk A/S Urea glucokinase activators
DE102008014523A1 (de) * 2008-03-15 2009-09-17 Robert Bosch Gmbh Heizgerät
JP5381978B2 (ja) * 2008-04-02 2014-01-08 アステラス製薬株式会社 アミド誘導体含有医薬組成物
KR101612971B1 (ko) * 2008-05-14 2016-04-15 아스테라스 세이야쿠 가부시키가이샤 아미드 화합물
EP2351565A1 (en) * 2008-10-20 2011-08-03 Astellas Pharma Inc. Medicine for preventing or treating pain related to herpes zoster
CN108623577B (zh) * 2018-05-08 2020-09-25 山东百诺医药股份有限公司 阿莫奈韦及其中间体的制备方法
AU2019287437A1 (en) 2018-06-12 2020-09-10 Vtv Therapeutics Llc Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
WO2020038812A1 (en) * 2018-08-20 2020-02-27 Rijksuniversiteit Groningen New process for the preparation of amenamevir
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288091B1 (en) * 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
HUP9902341A2 (hu) 1995-12-29 1999-10-28 Boehringer Ingelheim (Canada) Ltd. Herpeszvírus elleni hatású fenil-tiazol-származékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyszerkészítmények
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6500817B1 (en) * 1999-03-08 2002-12-31 Bayer Aktiengesellschaft Thiazolyl urea derivatives and their utilization as antiviral agents
EP1185508A2 (en) 1999-05-24 2002-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
WO2000071507A2 (en) 1999-05-24 2000-11-30 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
ATE302197T1 (de) 2000-11-10 2005-09-15 Yamanouchi Pharma Co Ltd Amidderivate
DE10139060A1 (de) 2001-08-08 2003-02-20 Merck Patent Gmbh Phenylderivate
WO2003095435A1 (fr) 2002-05-09 2003-11-20 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amides
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative

Also Published As

Publication number Publication date
SI1652843T1 (sl) 2014-06-30
NO20061100L (no) 2006-03-07
BRPI0413430A (pt) 2006-10-17
EP1652843B1 (en) 2014-04-02
DK1652843T3 (da) 2014-05-05
US7465748B2 (en) 2008-12-16
BRPI0413430B1 (pt) 2019-04-30
ES2462292T3 (es) 2014-05-22
PT1652843E (pt) 2014-06-02
CN100445271C (zh) 2008-12-24
MXPA06001526A (es) 2006-05-25
KR101157074B1 (ko) 2012-06-22
JP4549974B2 (ja) 2010-09-22
CY1115461T1 (el) 2017-01-04
AU2004263448A1 (en) 2005-02-17
EP1652843A1 (en) 2006-05-03
US20060229295A1 (en) 2006-10-12
US6903125B2 (en) 2005-06-07
PL1652843T3 (pl) 2014-09-30
WO2005014559A1 (ja) 2005-02-17
CA2535199C (en) 2010-12-14
BRPI0413430B8 (pt) 2021-05-25
KR20060073928A (ko) 2006-06-29
RU2336273C2 (ru) 2008-10-20
NO335467B1 (no) 2014-12-15
US20050032855A1 (en) 2005-02-10
AU2004263448B2 (en) 2009-02-05
CA2535199A1 (en) 2005-02-17
JPWO2005014559A1 (ja) 2006-10-05
EP1652843A4 (en) 2010-07-28
RU2006106922A (ru) 2006-08-27
TW200505894A (en) 2005-02-16
CN1832930A (zh) 2006-09-13

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