TWI334869B - - Google Patents
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- TWI334869B TWI334869B TW93130845A TW93130845A TWI334869B TW I334869 B TWI334869 B TW I334869B TW 93130845 A TW93130845 A TW 93130845A TW 93130845 A TW93130845 A TW 93130845A TW I334869 B TWI334869 B TW I334869B
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- noble metal
- compound
- metal compound
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- 150000001875 compounds Chemical class 0.000 claims description 48
- 229910000510 noble metal Inorganic materials 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 33
- 150000002736 metal compounds Chemical class 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 14
- 238000001069 Raman spectroscopy Methods 0.000 claims description 9
- 125000005647 linker group Chemical group 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- 239000002243 precursor Substances 0.000 claims description 7
- 239000010970 precious metal Substances 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 description 20
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- 229910052751 metal Inorganic materials 0.000 description 20
- 239000002184 metal Substances 0.000 description 20
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- -1 carboxypentyl Chemical group 0.000 description 15
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 12
- 230000008859 change Effects 0.000 description 11
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- LTXFOYBHWPNWIT-UHFFFAOYSA-N prop-1-ene-1,1-dithiol Chemical compound CC=C(S)S LTXFOYBHWPNWIT-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- ZNZJJSYHZBXQSM-UHFFFAOYSA-N propane-2,2-diamine Chemical compound CC(C)(N)N ZNZJJSYHZBXQSM-UHFFFAOYSA-N 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 238000009774 resonance method Methods 0.000 description 1
- 238000000790 scattering method Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- CSRCBLMBBOJYEX-UHFFFAOYSA-M sodium;2-morpholin-4-ylethanesulfonic acid;hydroxide Chemical compound [OH-].[Na+].OS(=O)(=O)CCN1CCOCC1 CSRCBLMBBOJYEX-UHFFFAOYSA-M 0.000 description 1
- PWEBUXCTKOWPCW-UHFFFAOYSA-N squaric acid Chemical compound OC1=C(O)C(=O)C1=O PWEBUXCTKOWPCW-UHFFFAOYSA-N 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003356934 | 2003-10-16 | ||
| JP2004044035 | 2004-02-20 | ||
| JP2004094160 | 2004-03-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200517397A TW200517397A (en) | 2005-06-01 |
| TWI334869B true TWI334869B (enExample) | 2010-12-21 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093130845A TW200517397A (en) | 2003-10-16 | 2004-10-12 | Method of measuring surface plasma resonance and noble metal compound for use in the method |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1674857B1 (enExample) |
| JP (2) | JP4616176B2 (enExample) |
| CN (1) | CN100595573C (enExample) |
| AU (1) | AU2004282761A1 (enExample) |
| CA (1) | CA2542742C (enExample) |
| TW (1) | TW200517397A (enExample) |
| WO (1) | WO2005038442A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP4616194B2 (ja) * | 2003-10-16 | 2011-01-19 | 株式会社ナード研究所 | ビオチン化合物 |
| US7804592B2 (en) | 2003-10-16 | 2010-09-28 | Nard Institute, Ltd. | Method for measuring a surface plasmon resonance and noble metal compound used for the same |
| EP1785489B1 (en) * | 2004-07-13 | 2010-03-03 | Toyo Boseki Kabushiki Kasisha | Method for detection of phosphorylation by spr with zinc chelate |
| DE602005018689D1 (de) * | 2005-08-01 | 2010-02-11 | Nard Institute Ltd | Polyacrylamidgel für die elektrophorese, polyacrylamidgelelektrophoreseverfahren damit, herstellungsverfahren dafür und acrylamidverbindung |
| WO2007018225A1 (ja) * | 2005-08-09 | 2007-02-15 | Manac Inc. | リン酸基を有する物質の染色方法 |
| CN101341409B (zh) * | 2005-10-27 | 2012-11-28 | 生物辐射海法有限公司 | 结合层及其制备方法和用途 |
| JP4979609B2 (ja) * | 2008-02-01 | 2012-07-18 | 富士フイルム株式会社 | 測定装置 |
| ES2773778T3 (es) * | 2015-11-10 | 2020-07-14 | Lacrisciences Llc | Sistemas y procedimientos para determinar la osmolaridad de una muestra |
| TWI596331B (zh) * | 2016-09-20 | 2017-08-21 | Jing- Chen | Quasi-radial polarized surface plasmon excitation device and imaging method thereof |
| CN109799220B (zh) * | 2018-12-21 | 2021-03-26 | 中国科学院合肥物质科学研究院 | 基于金属螯合物拉曼标签技术检测组织液中组胺的方法 |
| CN115808241A (zh) * | 2021-09-13 | 2023-03-17 | 暨南大学 | 一种微型光谱仪及光谱测试方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376556A (en) * | 1989-10-27 | 1994-12-27 | Abbott Laboratories | Surface-enhanced Raman spectroscopy immunoassay |
| DE69110032T2 (de) * | 1991-06-08 | 1995-12-21 | Hewlett Packard Gmbh | Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen. |
| DE4433980C2 (de) * | 1994-09-23 | 1996-08-22 | Boehringer Ingelheim Int | Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz |
| SE9503028D0 (sv) * | 1995-09-01 | 1995-09-01 | Pharmacia Biosensor Ab | Method of analysing chemical and physical interactions at a sensor surface |
| JP3778248B2 (ja) * | 1999-07-30 | 2006-05-24 | 独立行政法人科学技術振興機構 | 偏光を用いたｓｐｒ装置及びｓｐｒ測定方法 |
| JP3689724B2 (ja) * | 1999-09-10 | 2005-08-31 | 独立行政法人産業技術総合研究所 | 除草剤検出のための光合成反応中心タンパク質固定化チップ |
| DE10297577B4 (de) * | 2001-12-21 | 2007-11-22 | Tohru Koike | Zinkkomplexe, die fähig sind, Substanzen, die anionische Substituenten haben, abzufangen |
| JP3972194B2 (ja) * | 2002-09-11 | 2007-09-05 | 東洋紡績株式会社 | 電気泳動用試薬、電気泳動用組成物及び核酸の分離方法 |
| US7202093B2 (en) * | 2003-03-03 | 2007-04-10 | Kabushiki Kaisha Nard Kenkyusho | Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds |
| JP4109621B2 (ja) * | 2003-03-07 | 2008-07-02 | 株式会社ナード研究所 | リン酸モノエステル化合物の分子量を求める方法、およびマススペクトル測定用添加剤 |
| JP2004305024A (ja) * | 2003-04-02 | 2004-11-04 | Toyobo Co Ltd | 酵素活性の調節方法および試薬 |
| JP2004309303A (ja) * | 2003-04-07 | 2004-11-04 | Toyobo Co Ltd | プロテインキナーゼ活性の解析方法 |
-
2004
- 2004-10-12 JP JP2005514810A patent/JP4616176B2/ja not_active Expired - Lifetime
- 2004-10-12 AU AU2004282761A patent/AU2004282761A1/en not_active Abandoned
- 2004-10-12 CN CN200480029990A patent/CN100595573C/zh not_active Expired - Fee Related
- 2004-10-12 TW TW093130845A patent/TW200517397A/zh not_active IP Right Cessation
- 2004-10-12 WO PCT/JP2004/015347 patent/WO2005038442A1/ja not_active Ceased
- 2004-10-12 EP EP04773797.8A patent/EP1674857B1/en not_active Expired - Lifetime
- 2004-10-12 CA CA 2542742 patent/CA2542742C/en not_active Expired - Fee Related
-
2010
- 2010-04-16 JP JP2010095483A patent/JP2010210630A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2542742A1 (en) | 2005-04-28 |
| JPWO2005038442A1 (ja) | 2007-01-18 |
| JP2010210630A (ja) | 2010-09-24 |
| EP1674857B1 (en) | 2014-04-02 |
| EP1674857A1 (en) | 2006-06-28 |
| CN1867823A (zh) | 2006-11-22 |
| AU2004282761A1 (en) | 2005-04-28 |
| TW200517397A (en) | 2005-06-01 |
| JP4616176B2 (ja) | 2011-01-19 |
| EP1674857A4 (en) | 2007-08-08 |
| WO2005038442A1 (ja) | 2005-04-28 |
| CA2542742C (en) | 2015-04-21 |
| CN100595573C (zh) | 2010-03-24 |
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