TWI322017B - Drive mechanisms for use in drug delivery devices,assembly and drug delivery device including the same,method of assembling and use of the drug delivery devices - Google Patents
Drive mechanisms for use in drug delivery devices,assembly and drug delivery device including the same,method of assembling and use of the drug delivery devices Download PDFInfo
- Publication number
- TWI322017B TWI322017B TW093109829A TW93109829A TWI322017B TW I322017 B TWI322017 B TW I322017B TW 093109829 A TW093109829 A TW 093109829A TW 93109829 A TW93109829 A TW 93109829A TW I322017 B TWI322017 B TW I322017B
- Authority
- TW
- Taiwan
- Prior art keywords
- sleeve
- drive
- housing
- drug delivery
- dose indicating
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title claims description 29
- 230000007246 mechanism Effects 0.000 title claims description 25
- 238000000034 method Methods 0.000 title claims description 3
- 239000003814 drug Substances 0.000 claims description 11
- 230000005540 biological transmission Effects 0.000 claims description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 102000018997 Growth Hormone Human genes 0.000 claims description 3
- 108010051696 Growth Hormone Proteins 0.000 claims description 3
- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 239000000122 growth hormone Substances 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 229940127557 pharmaceutical product Drugs 0.000 claims description 3
- 229940127554 medical product Drugs 0.000 claims 2
- 230000002440 hepatic effect Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000007306 turnover Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 8
- 229940126601 medicinal product Drugs 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000002079 cooperative effect Effects 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 241000345998 Calamus manan Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 241001164374 Calyx Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229940025708 injectable product Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0308267.4A GB0308267D0 (en) | 2003-04-10 | 2003-04-10 | Improvements in and relating to a pen-type injector |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200507898A TW200507898A (en) | 2005-03-01 |
| TWI322017B true TWI322017B (en) | 2010-03-21 |
Family
ID=9956535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093109829A TWI322017B (en) | 2003-04-10 | 2004-04-09 | Drive mechanisms for use in drug delivery devices,assembly and drug delivery device including the same,method of assembling and use of the drug delivery devices |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7918832B2 (https=) |
| EP (1) | EP1615686A1 (https=) |
| JP (1) | JP4847858B2 (https=) |
| AR (1) | AR043842A1 (https=) |
| AU (1) | AU2004228940B2 (https=) |
| CA (1) | CA2521634C (https=) |
| GB (1) | GB0308267D0 (https=) |
| IL (1) | IL171247A (https=) |
| MX (1) | MXPA05010623A (https=) |
| TW (1) | TWI322017B (https=) |
| WO (1) | WO2004089450A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10117998B2 (en) | 2013-03-11 | 2018-11-06 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE197408T1 (de) | 1998-01-30 | 2000-11-11 | Novo Nordisk As | Eine injektionsspritze |
| TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
| US6663602B2 (en) * | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| CA2475573C (en) | 2002-02-11 | 2013-03-26 | Antares Pharma, Inc. | Intradermal injector |
| US9205197B2 (en) | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
| GB0304822D0 (en) * | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| WO2005018721A1 (en) | 2003-08-12 | 2005-03-03 | Eli Lilly And Company | Medication dispensing apparatus with triple screw threads for mechanical advantage |
| ES2555125T3 (es) * | 2004-02-18 | 2015-12-29 | Ares Trading S.A. | Dispositivo manual de inyección controlada electrónicamente para inyectar medicamentos líquidos |
| EP1799287B1 (en) * | 2004-10-04 | 2013-06-19 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device |
| EP1804865B1 (en) | 2004-10-21 | 2009-09-30 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
| US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
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| EP1855744A1 (en) * | 2005-02-28 | 2007-11-21 | Novo Nordisk A/S | A dose setting mechanism for an injection device |
| US20080221530A1 (en) * | 2005-04-24 | 2008-09-11 | Novo Nordisk A/S | Injection Device With A GearBox |
| US20090043264A1 (en) * | 2005-04-24 | 2009-02-12 | Novo Nordisk A/S | Injection Device |
| US8361036B2 (en) | 2006-03-10 | 2013-01-29 | Novo Nordisk A/S | Injection device having a gearing arrangement |
| WO2007104636A1 (en) | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device and a method of changing a cartridge in the device |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
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| TW201121600A (en) * | 2009-09-29 | 2011-07-01 | Sanofi Aventis Deutschland | Assembly for a drug delivery device |
| US9555192B2 (en) * | 2009-09-30 | 2017-01-31 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2109690B (en) | 1981-02-12 | 1985-02-20 | Robert Charles Turner | Dose metering plunger devices for use with syringes |
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-
2003
- 2003-04-10 GB GBGB0308267.4A patent/GB0308267D0/en not_active Ceased
-
2004
- 2004-04-07 AR ARP040101203A patent/AR043842A1/es active IP Right Grant
- 2004-04-08 WO PCT/EP2004/003782 patent/WO2004089450A1/en not_active Ceased
- 2004-04-08 AU AU2004228940A patent/AU2004228940B2/en not_active Ceased
- 2004-04-08 CA CA2521634A patent/CA2521634C/en not_active Expired - Fee Related
- 2004-04-08 JP JP2006505074A patent/JP4847858B2/ja not_active Expired - Fee Related
- 2004-04-08 EP EP04726460A patent/EP1615686A1/en not_active Withdrawn
- 2004-04-08 US US10/820,047 patent/US7918832B2/en not_active Expired - Fee Related
- 2004-04-08 MX MXPA05010623A patent/MXPA05010623A/es active IP Right Grant
- 2004-04-09 TW TW093109829A patent/TWI322017B/zh not_active IP Right Cessation
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10117998B2 (en) | 2013-03-11 | 2018-11-06 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05010623A (es) | 2005-12-12 |
| AR043842A1 (es) | 2005-08-17 |
| JP2006522630A (ja) | 2006-10-05 |
| TW200507898A (en) | 2005-03-01 |
| JP4847858B2 (ja) | 2011-12-28 |
| IL171247A (en) | 2012-08-30 |
| CA2521634A1 (en) | 2004-10-21 |
| WO2004089450A1 (en) | 2004-10-21 |
| EP1615686A1 (en) | 2006-01-18 |
| AU2004228940B2 (en) | 2010-09-30 |
| US20050004529A1 (en) | 2005-01-06 |
| GB0308267D0 (en) | 2003-05-14 |
| CA2521634C (en) | 2011-11-22 |
| US7918832B2 (en) | 2011-04-05 |
| AU2004228940A1 (en) | 2004-10-21 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |