JP4847858B2 - 医薬品送達装置において使用されるのに適切な駆動機構 - Google Patents
医薬品送達装置において使用されるのに適切な駆動機構 Download PDFInfo
- Publication number
- JP4847858B2 JP4847858B2 JP2006505074A JP2006505074A JP4847858B2 JP 4847858 B2 JP4847858 B2 JP 4847858B2 JP 2006505074 A JP2006505074 A JP 2006505074A JP 2006505074 A JP2006505074 A JP 2006505074A JP 4847858 B2 JP4847858 B2 JP 4847858B2
- Authority
- JP
- Japan
- Prior art keywords
- sleeve
- dose dial
- drive
- dial sleeve
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000007246 mechanism Effects 0.000 title claims description 26
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 102000018997 Growth Hormone Human genes 0.000 claims description 3
- 108010051696 Growth Hormone Proteins 0.000 claims description 3
- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 239000000122 growth hormone Substances 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 239000003055 low molecular weight heparin Substances 0.000 claims description 3
- 229940127215 low-molecular weight heparin Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000006073 displacement reaction Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 description 8
- 238000012377 drug delivery Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229940127557 pharmaceutical product Drugs 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0308267.4 | 2003-04-10 | ||
| GBGB0308267.4A GB0308267D0 (en) | 2003-04-10 | 2003-04-10 | Improvements in and relating to a pen-type injector |
| PCT/EP2004/003782 WO2004089450A1 (en) | 2003-04-10 | 2004-04-08 | Drive mechanisms suitable for use in drug delivery devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522630A JP2006522630A (ja) | 2006-10-05 |
| JP2006522630A5 JP2006522630A5 (https=) | 2007-05-31 |
| JP4847858B2 true JP4847858B2 (ja) | 2011-12-28 |
Family
ID=9956535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505074A Expired - Fee Related JP4847858B2 (ja) | 2003-04-10 | 2004-04-08 | 医薬品送達装置において使用されるのに適切な駆動機構 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7918832B2 (https=) |
| EP (1) | EP1615686A1 (https=) |
| JP (1) | JP4847858B2 (https=) |
| AR (1) | AR043842A1 (https=) |
| AU (1) | AU2004228940B2 (https=) |
| CA (1) | CA2521634C (https=) |
| GB (1) | GB0308267D0 (https=) |
| IL (1) | IL171247A (https=) |
| MX (1) | MXPA05010623A (https=) |
| TW (1) | TWI322017B (https=) |
| WO (1) | WO2004089450A1 (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69900026T2 (de) | 1998-01-30 | 2001-05-10 | Novo Nordisk As | Eine injektionsspritze |
| TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
| US6663602B2 (en) * | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| JP3993169B2 (ja) | 2002-02-11 | 2007-10-17 | アンタレス・ファーマ・インコーポレーテッド | 皮内注射器 |
| GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| EP2210634A1 (en) | 2009-01-22 | 2010-07-28 | Sanofi-Aventis Deutschland GmbH | Drug delivery device dose setting mechanism |
| AU2004266131C1 (en) | 2003-08-12 | 2010-12-16 | Eli Lilly And Company | Medication dispensing apparatus with triple screw threads for mechanical advantage |
| CN100569307C (zh) | 2004-02-18 | 2009-12-16 | 阿瑞斯贸易股份公司 | 用于注射液态药物的手持式电控注射装置 |
| NZ554384A (en) | 2004-10-04 | 2010-04-30 | Sanofi Aventis Deutschland | Drive mechanism for drug delivery device |
| US7686786B2 (en) | 2004-10-21 | 2010-03-30 | Novo Nordiks A/S | Dial-down mechanism for wind-up pen |
| CA3015269A1 (en) | 2004-11-22 | 2006-06-01 | Kaleo, Inc. | Devices, systems, and methods for medicament delivery |
| WO2006083876A2 (en) | 2005-02-01 | 2006-08-10 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
| US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
| DE102004063664A1 (de) * | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Echtzeitanzeige für eine Vorrichtung zur dosierten Verabreichung eines Produkts |
| JP4903160B2 (ja) * | 2005-01-18 | 2012-03-28 | ウォックハート アメリカズ インコーポレイテッド | ペン型薬物注入デバイス |
| JP5216328B2 (ja) | 2005-01-24 | 2013-06-19 | アンタレス ファーマ インコーポレイテッド | あらかじめ充填された針補助シリンジジェット式注射器 |
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| EP1855744A1 (en) * | 2005-02-28 | 2007-11-21 | Novo Nordisk A/S | A dose setting mechanism for an injection device |
| WO2006114395A1 (en) * | 2005-04-24 | 2006-11-02 | Novo Nordisk A/S | An injection device with a gearbox |
| CN101163514B (zh) * | 2005-04-24 | 2012-01-25 | 诺和诺德公司 | 注射装置 |
| WO2007104636A1 (en) | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device and a method of changing a cartridge in the device |
| WO2007104697A2 (en) | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device having a gearing arrangement |
| WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
| ATE458517T1 (de) | 2006-05-16 | 2010-03-15 | Novo Nordisk As | Getriebemechanismus für ein injektionsgerät |
| PL2023982T3 (pl) * | 2006-05-18 | 2012-11-30 | Novo Nordisk As | Urządzenie wstrzykujące ze środkami blokującymi |
| HUE060243T2 (hu) | 2006-09-15 | 2023-02-28 | Ypsomed Ag | Injekciós eszköz továbbfejlesztett továbbítóelemmel |
| DE602008002896D1 (de) | 2007-02-05 | 2010-11-18 | Novo Nordisk As | Injektionsknopf |
| CA2681023C (en) * | 2007-03-23 | 2015-11-03 | Novo Nordisk A/S | An injection device comprising a locking nut |
| US8771237B2 (en) | 2007-12-20 | 2014-07-08 | Novo Nordisk A/S | Injection device for delivering a fixed dose of liquid drug |
| EP2268342B1 (en) | 2008-03-10 | 2015-09-16 | Antares Pharma, Inc. | Injector safety device |
| USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
| EP3581224A1 (en) | 2008-08-05 | 2019-12-18 | Antares Pharma, Inc. | Multiple dosage injector |
| CN102612381B (zh) | 2009-03-20 | 2015-09-09 | 安塔瑞斯制药公司 | 危险试剂注入系统 |
| SE0900371A1 (sv) * | 2009-03-24 | 2010-09-25 | Istvan Bartha | Anordning för distribution av flytande läkemedel |
| US8672896B2 (en) | 2009-06-01 | 2014-03-18 | Sanofi-Aventis Deutschland Gmbh | Inner housing for a drug delivery device |
| US8257319B2 (en) * | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
| CA2763737A1 (en) * | 2009-06-30 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism and drug delivery device |
| TW201121600A (en) * | 2009-09-29 | 2011-07-01 | Sanofi Aventis Deutschland | Assembly for a drug delivery device |
| EP2482879B1 (en) * | 2009-09-30 | 2016-11-09 | Sanofi-Aventis Deutschland GmbH | Method and assembly for a drug delivery device |
| WO2011039219A2 (en) * | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device |
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| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
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| WO2013127876A1 (de) * | 2012-02-29 | 2013-09-06 | Tecpharma Licensing Ag | Injektionsvorrichtung mit verbessertem kolbenstangenantrieb |
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| ES2969984T3 (es) | 2013-02-11 | 2024-05-23 | Antares Pharma Inc | Dispositivo de inyección por chorro asistido por aguja que tiene fuerza de disparo reducida |
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| US10173016B2 (en) | 2013-04-10 | 2019-01-08 | Sanofi | Dispensing speed control mechanism and injection device |
| US10350349B2 (en) | 2014-05-20 | 2019-07-16 | Cequr Sa | Medicine delivery device with restricted access filling port |
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| JP6830067B2 (ja) | 2015-06-30 | 2021-02-17 | カレオ,インコーポレイテッド | プレフィルドシリンジ内の医薬を投与する自動注射器 |
| WO2018119218A1 (en) | 2016-12-23 | 2018-06-28 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
| HRP20240485T1 (hr) | 2017-08-24 | 2024-07-05 | Novo Nordisk A/S | Pripravci glp-1 i njihova upotreba |
| EP3603703A1 (en) | 2018-07-30 | 2020-02-05 | Tecpharma Licensing AG | Alternative device for adjusting a dosage with a limiting mechanism for a device for administering a product |
| WO2020102781A1 (en) * | 2018-11-16 | 2020-05-22 | Tync, Llc | Device for dispensing essential oil or tincture |
| US12478739B2 (en) | 2018-12-29 | 2025-11-25 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| WO2021030210A1 (en) | 2019-08-09 | 2021-02-18 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| USD1011914S1 (en) | 2019-11-15 | 2024-01-23 | Tync, Llc | Dispenser for essential oil |
| PE20230819A1 (es) | 2020-02-18 | 2023-05-19 | Novo Nordisk As | Composiciones y usos de glp-1 |
| US12268847B1 (en) | 2021-02-10 | 2025-04-08 | Kaleo, Inc. | Devices and methods for delivery of substances within a medicament container |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH067445A (ja) * | 1992-06-25 | 1994-01-18 | Matsushita Electric Works Ltd | ペン型注射装置 |
| JP3130939B2 (ja) * | 1991-10-18 | 2001-01-31 | ノボ ノルディスク アクティーゼルスカブ | ペン形状のシリンジ |
| JP2004503303A (ja) * | 2000-06-16 | 2004-02-05 | ノボ ノルディスク アクティーゼルスカブ | ギアボックスを備えた注射装置 |
| JP2004533869A (ja) * | 2001-03-27 | 2004-11-11 | ディーシーエー デザイン インターナショナル リミテッド | 注入装置の改良および注入装置に関連する改良 |
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2003
- 2003-04-10 GB GBGB0308267.4A patent/GB0308267D0/en not_active Ceased
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2004
- 2004-04-07 AR ARP040101203A patent/AR043842A1/es active IP Right Grant
- 2004-04-08 EP EP04726460A patent/EP1615686A1/en not_active Withdrawn
- 2004-04-08 US US10/820,047 patent/US7918832B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2004089450A1 (en) | 2004-10-21 |
| CA2521634A1 (en) | 2004-10-21 |
| AU2004228940A1 (en) | 2004-10-21 |
| CA2521634C (en) | 2011-11-22 |
| TWI322017B (en) | 2010-03-21 |
| JP2006522630A (ja) | 2006-10-05 |
| US7918832B2 (en) | 2011-04-05 |
| IL171247A (en) | 2012-08-30 |
| TW200507898A (en) | 2005-03-01 |
| GB0308267D0 (en) | 2003-05-14 |
| US20050004529A1 (en) | 2005-01-06 |
| EP1615686A1 (en) | 2006-01-18 |
| AR043842A1 (es) | 2005-08-17 |
| MXPA05010623A (es) | 2005-12-12 |
| AU2004228940B2 (en) | 2010-09-30 |
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