TWI319326B - Stable high -concentration injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one - Google Patents

Stable high -concentration injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one

Info

Publication number
TWI319326B
TWI319326B TW091109816A TW91109816A TWI319326B TW I319326 B TWI319326 B TW I319326B TW 091109816 A TW091109816 A TW 091109816A TW 91109816 A TW91109816 A TW 91109816A TW I319326 B TWI319326 B TW I319326B
Authority
TW
Taiwan
Prior art keywords
pyrazolin
phenyl
methyl
stable high
injection containing
Prior art date
Application number
TW091109816A
Other languages
English (en)
Inventor
Hiroshi Yoshida
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Application granted granted Critical
Publication of TWI319326B publication Critical patent/TWI319326B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
TW091109816A 2001-05-11 2002-05-10 Stable high -concentration injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one TWI319326B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001141683 2001-05-11

Publications (1)

Publication Number Publication Date
TWI319326B true TWI319326B (en) 2010-01-11

Family

ID=18988098

Family Applications (1)

Application Number Title Priority Date Filing Date
TW091109816A TWI319326B (en) 2001-05-11 2002-05-10 Stable high -concentration injection containing 3-methyl-1-phenyl-2-pyrazolin-5-one

Country Status (8)

Country Link
US (1) US7211596B2 (zh)
EP (1) EP1386606B1 (zh)
JP (1) JP4302990B2 (zh)
KR (1) KR100921199B1 (zh)
CN (1) CN1525856A (zh)
CA (1) CA2446837C (zh)
TW (1) TWI319326B (zh)
WO (1) WO2002092082A1 (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005535642A (ja) * 2002-06-28 2005-11-24 ニトロメッド インコーポレーティッド オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
US7312239B2 (en) * 2002-09-04 2007-12-25 Mitsubishi Pharma Corporation Medicament for prevention and/or therapy of arterial wall disorder
JO2735B1 (en) 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
JP4746856B2 (ja) * 2004-08-12 2011-08-10 三笠製薬株式会社 ピラゾロン系製剤
JP4850426B2 (ja) * 2005-03-17 2012-01-11 東和薬品株式会社 安定な高濃度エダラボン注射液
CA2611917A1 (en) * 2005-06-13 2006-12-21 Takeda Pharmaceutical Company Limited Injection
WO2007055312A1 (ja) * 2005-11-10 2007-05-18 Mitsubishi Tanabe Pharma Corporation ピラゾロン化合物含有水溶液が充填されたプラスチック容器
JP2008001605A (ja) * 2006-06-20 2008-01-10 Mitsubishi Pharma Corp ピラゾロン化合物を含有する水溶液剤
JP2008001606A (ja) * 2006-06-20 2008-01-10 Mitsubishi Pharma Corp ピラゾロン化合物を含有する水溶液剤
BRPI0815597A2 (pt) * 2007-11-21 2014-09-30 Teikoku Pharma Usa Inc Formulações de emulsões com derivado de pirazolona
JP2009143902A (ja) * 2007-11-21 2009-07-02 Kowa Co エダラボンを含有する安定な水溶性製剤
CN101524352A (zh) * 2008-03-04 2009-09-09 江苏先声药物研究有限公司 一种含有3-甲基-1-苯基-2-吡唑啉-5-酮的组合物
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
US20100034752A1 (en) * 2008-08-11 2010-02-11 Toru Hibi Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
CA2734284C (en) * 2008-11-20 2014-01-21 Techno Guard Co., Ltd. Pyrazolone derivative formulations
WO2010068717A2 (en) * 2008-12-10 2010-06-17 Auspex Pharmaceutical, Inc Pyrazolinone scavengers of free radicals
AU2010218424B2 (en) 2009-02-26 2014-02-13 Techno Guard Co., Ltd. Narcotic emulsion formulations for treatment of cancer pain
CN101732247B (zh) * 2010-01-06 2012-04-25 长沙易睿医药科技有限公司 一种含有依达拉奉的注射液
AU2017223706A1 (en) 2016-02-23 2018-09-20 Indiana University Research & Technology Corporation Combination therapies for treatment of spinal muscular atrophy
WO2019055540A1 (en) * 2017-09-13 2019-03-21 D.E. Shaw Research, Llc COMPOUNDS AS INHIBITORS OF RAS AND THEIR USE
WO2019167178A1 (ja) * 2018-02-28 2019-09-06 田辺三菱製薬株式会社 ３－メチル－１－フェニル－２－ピラゾリン－５－オン原薬の分析方法、筋萎縮性側索硬化症の治療および筋萎縮性側索硬化症の進行抑制、ならびに、３－メチル－１－フェニル－２－ピラゾリン－５－オン原薬を含む薬剤の製造方法
KR102261931B1 (ko) 2018-09-17 2021-06-07 제이투에이치바이오텍 (주) 에다라본 전구체 약물 화합물 및 이들의 신경퇴행성 또는 운동신경 질환의 치료 또는 개선을 위한 의약 용도

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231820A (en) 1975-09-02 1977-03-10 Meiji Seika Kaisha Ltd Preparation of injections
DE2914869A1 (de) * 1979-04-12 1980-10-30 Hoechst Ag Elektrolyseapparat
DE3115651A1 (de) * 1981-04-18 1982-11-04 Bayer Ag, 5090 Leverkusen Russpraeparationen
DK169672B1 (da) 1985-05-20 1995-01-09 Mitsubishi Chem Ind Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater
DE3789754T2 (de) * 1986-11-20 1994-12-15 Mitsubishi Chem Ind Die Bildung von Lipid-peroxiden hemmende Zusammenstzung und dafür geeignete Verbindungen.
JPH07121861B2 (ja) 1986-11-25 1995-12-25 三菱化学株式会社 ３−メチル−１−フエニル−２−ピラゾロン−５−オンを含有する安定な注射剤
ES2082023T3 (es) * 1986-12-05 1996-03-16 Pharmacia Spa Soluciones inyectables listas para su utilizacion que contienen un agente antitumoral del tipo antraciclina glucosido.
JPH0725765A (ja) 1993-07-07 1995-01-27 Mitsubishi Chem Corp 眼疾患用薬剤
GB9405593D0 (en) 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
JPH10279480A (ja) * 1997-04-07 1998-10-20 Mitsubishi Chem Corp 皮膚組織障害の予防・治療剤
WO2002000260A1 (fr) 2000-06-29 2002-01-03 Mitsubishi Pharma Corporation Jp0105585atif contre des maladies du nerf optique et analogue
JP3758164B2 (ja) * 2000-10-24 2006-03-22 三菱ウェルファーマ株式会社 筋萎縮性側索硬化症（ａｌｓ）治療剤

Also Published As

Publication number Publication date
EP1386606B1 (en) 2015-08-19
JPWO2002092082A1 (ja) 2004-08-26
JP4302990B2 (ja) 2009-07-29
CN1525856A (zh) 2004-09-01
KR20030096377A (ko) 2003-12-24
CA2446837A1 (en) 2002-11-21
EP1386606A1 (en) 2004-02-04
WO2002092082A1 (en) 2002-11-21
US7211596B2 (en) 2007-05-01
US20040162330A1 (en) 2004-08-19
KR100921199B1 (ko) 2009-10-13
CA2446837C (en) 2012-01-03
EP1386606A4 (en) 2007-12-12

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