TWI296931B - Use of perfluoroalkyl-containing metal complexes as contrast media in mr-imaging for visualization of plaque, tumors and necroses - Google Patents

Use of perfluoroalkyl-containing metal complexes as contrast media in mr-imaging for visualization of plaque, tumors and necroses Download PDF

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Publication number
TWI296931B
TWI296931B TW090119643A TW90119643A TWI296931B TW I296931 B TWI296931 B TW I296931B TW 090119643 A TW090119643 A TW 090119643A TW 90119643 A TW90119643 A TW 90119643A TW I296931 B TWI296931 B TW I296931B
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TW
Taiwan
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group
formula
groups
patent application
cns
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Application number
TW090119643A
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English (en)
Chinese (zh)
Inventor
Platzek Johannes
Mareski Peter
Niedballa Ulrich
Raduchel Bernd
Weinmann Hanns-Joachim
Misselwitz Bernd
Original Assignee
Schering Ag
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Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of TWI296931B publication Critical patent/TWI296931B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW090119643A 2000-08-11 2001-08-10 Use of perfluoroalkyl-containing metal complexes as contrast media in mr-imaging for visualization of plaque, tumors and necroses TWI296931B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Publications (1)

Publication Number Publication Date
TWI296931B true TWI296931B (en) 2008-05-21

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
TW090119643A TWI296931B (en) 2000-08-11 2001-08-10 Use of perfluoroalkyl-containing metal complexes as contrast media in mr-imaging for visualization of plaque, tumors and necroses

Country Status (26)

Country Link
EP (1) EP1307236A2 (de)
JP (1) JP2004506025A (de)
KR (1) KR20030022387A (de)
CN (1) CN1469757A (de)
AR (1) AR034139A1 (de)
AU (2) AU2001277549B2 (de)
BG (1) BG107542A (de)
BR (1) BR0113188A (de)
CA (1) CA2419223A1 (de)
CZ (1) CZ2003392A3 (de)
DE (1) DE10066210B4 (de)
EE (1) EE200300061A (de)
HR (1) HRP20030173A2 (de)
HU (1) HUP0300736A3 (de)
IL (1) IL154385A0 (de)
MX (1) MXPA03001287A (de)
NO (1) NO20030604L (de)
NZ (1) NZ523932A (de)
PL (1) PL365596A1 (de)
RU (1) RU2290206C2 (de)
SK (1) SK1572003A3 (de)
TW (1) TWI296931B (de)
UA (1) UA82642C2 (de)
WO (1) WO2002013874A2 (de)
YU (1) YU10603A (de)
ZA (1) ZA200301949B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102006049821A1 (de) * 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
CN109715597A (zh) 2016-09-14 2019-05-03 大金工业株式会社 含支链含氟化合物
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CA3120665A1 (en) 2018-11-23 2020-05-28 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Also Published As

Publication number Publication date
AU7754901A (en) 2002-02-25
ZA200301949B (en) 2004-12-14
BR0113188A (pt) 2003-06-24
EE200300061A (et) 2004-12-15
WO2002013874A8 (de) 2002-06-13
SK1572003A3 (en) 2003-10-07
YU10603A (sh) 2006-05-25
HUP0300736A3 (en) 2010-01-28
EP1307236A2 (de) 2003-05-07
IL154385A0 (en) 2003-09-17
WO2002013874A2 (de) 2002-02-21
JP2004506025A (ja) 2004-02-26
NZ523932A (en) 2007-07-27
MXPA03001287A (es) 2003-10-06
BG107542A (bg) 2003-09-30
NO20030604D0 (no) 2003-02-07
CN1469757A (zh) 2004-01-21
CA2419223A1 (en) 2003-02-11
UA82642C2 (uk) 2008-05-12
RU2290206C2 (ru) 2006-12-27
DE10066210B4 (de) 2008-02-28
HRP20030173A2 (en) 2005-04-30
AU2001277549B2 (en) 2007-02-08
KR20030022387A (ko) 2003-03-15
AR034139A1 (es) 2004-02-04
NO20030604L (no) 2003-04-11
CZ2003392A3 (cs) 2003-09-17
HUP0300736A2 (hu) 2003-09-29
PL365596A1 (en) 2005-01-10

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