TW546152B - A storage-stable self-emulsifying preconcentrate of an anticancer drug such as taxane, pharmaceutical composition thereof and a method of enhancing the oral bioavailability of a taxane - Google Patents
A storage-stable self-emulsifying preconcentrate of an anticancer drug such as taxane, pharmaceutical composition thereof and a method of enhancing the oral bioavailability of a taxane Download PDFInfo
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- TW546152B TW546152B TW088105111A TW88105111A TW546152B TW 546152 B TW546152 B TW 546152B TW 088105111 A TW088105111 A TW 088105111A TW 88105111 A TW88105111 A TW 88105111A TW 546152 B TW546152 B TW 546152B
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- Prior art keywords
- concentrate
- preconcentrate
- component
- fatty acid
- ethanol
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- 229940123237 Taxane Drugs 0.000 title claims abstract description 6
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
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- 238000000034 method Methods 0.000 title description 12
- 230000002708 enhancing effect Effects 0.000 title 1
- 239000004094 surface-active agent Substances 0.000 claims abstract description 33
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- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims abstract description 9
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
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| US8027398P | 1998-04-01 | 1998-04-01 | |
| US8027298P | 1998-04-01 | 1998-04-01 |
Publications (1)
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| TW546152B true TW546152B (en) | 2003-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| TW088105111A TW546152B (en) | 1998-04-01 | 1999-05-14 | A storage-stable self-emulsifying preconcentrate of an anticancer drug such as taxane, pharmaceutical composition thereof and a method of enhancing the oral bioavailability of a taxane |
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| EP (1) | EP1067908B9 (https=) |
| JP (1) | JP4695260B2 (https=) |
| KR (1) | KR100661879B1 (https=) |
| CN (1) | CN100341485C (https=) |
| AT (1) | ATE327735T1 (https=) |
| AU (1) | AU756752B2 (https=) |
| CA (1) | CA2326485C (https=) |
| DE (1) | DE69931617T2 (https=) |
| IL (2) | IL138767A0 (https=) |
| SE (1) | SE0003449L (https=) |
| TW (1) | TW546152B (https=) |
| WO (1) | WO1999049848A1 (https=) |
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| US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
| US7255877B2 (en) | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| KR100615783B1 (ko) * | 1997-05-27 | 2006-08-25 | 아이박스 리서치 인코포레이티드 | 탁산 치료를 받고 있는 인체를 제외한 포유동물의 과민증 또는 알러지 반응을 경감시키기 위한 방법 및 약학적 키트 |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| EP1479382A1 (en) * | 1999-06-18 | 2004-11-24 | IVAX Research, Inc. | Oral pharmaceutical compositions containing taxanes and methods for treatment employing the same |
| AU2006201100B2 (en) * | 1999-09-21 | 2009-09-24 | Jagotec Ag | Surface modified particulate compositions of biologically active substances |
| ATE296091T1 (de) * | 1999-09-21 | 2005-06-15 | Skyepharma Canada Inc | Oberflächenmodifizierte teilchenförmige zusammensetzungen biologisch aktiver stoffe |
| AU7638300A (en) * | 1999-10-20 | 2001-04-30 | Vesifact Ag | Microemulsion preconcentrates and microemulsions |
| IL149360A0 (en) * | 1999-10-27 | 2002-11-10 | Baker Norton Pharma | Method and compositions for administering taxanes orally to human patients |
| EP1118333A1 (en) * | 2000-01-18 | 2001-07-25 | Eurand International S.P.A. | Compositions with enhanced oral bioavailability |
| DE10030378A1 (de) * | 2000-06-21 | 2002-03-14 | Audit Inst For Medical Service | Neue pharmazeutische Zusammensetzung zur topischen Anwendung von wasserunlöslichen und/oder schwer wasserlöslichen Wirkstoffen |
| ATE290372T1 (de) * | 2000-07-24 | 2005-03-15 | Upjohn Co | Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln |
| JP2004536026A (ja) | 2000-11-28 | 2004-12-02 | トランスフォーム ファーマシューティカルズ，インコーポレーティッド． | パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤 |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| PT1249231E (pt) * | 2001-04-12 | 2004-06-30 | Vesifact Ag | Formulacoes farmaceuticas contendo substancias activas anti-inflamatorias e sua utilizacao |
| KR100774366B1 (ko) * | 2001-09-10 | 2007-11-08 | 주식회사 중외제약 | 파클리탁셀 주사제 조성물 |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| US20040092428A1 (en) * | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
| EP1460992B1 (en) * | 2001-12-03 | 2009-03-11 | Dor Biopharma, Inc. | Stabilized reverse micelle compositions and uses thereof |
| JP4526120B2 (ja) * | 2002-05-22 | 2010-08-18 | 日本製薬株式会社 | Ｌ−メントール水中油型乳剤 |
| KR20040008816A (ko) * | 2002-07-19 | 2004-01-31 | 한미약품 주식회사 | 파클리탁셀 또는 그의 유도체와 ｐ-당단백질 저해제를함유하는 혈관재협착 방지를 위한 경구투여용 약학 조성물 |
| KR100573289B1 (ko) * | 2002-07-20 | 2006-04-24 | 대화제약 주식회사 | 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법 |
| DE10247399A1 (de) * | 2002-10-08 | 2004-04-29 | Schering Ag | Pharmazeutische Zubereitungen, Verwendung dieser Zubereitung und Verfahren zur Erhöhung der Bioverfügbarkeit von peroral zu applizierenden Arzneistoffen |
| EP1498143A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids |
| EP1498120A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid formulations for the oral administration of taxoids |
| WO2005037251A1 (en) * | 2003-10-17 | 2005-04-28 | Amylin Pharmaceuticals, Inc. | Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds |
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| NZ549016A (en) | 2004-02-13 | 2012-03-30 | Bioavailability Inc | A microemulsion preparation of high concentration propofol for anesthetic uses |
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| MX2007011250A (es) * | 2005-03-21 | 2007-11-14 | Ivax Pharmaceuticals Sro | Inhibidor de la cristalizacion y su uso en capsulas de gelatina. |
| WO2008058366A1 (en) * | 2006-09-28 | 2008-05-22 | Université de Montréal | Oil-in-water emulsions, methods of use thereof, methods of preparation thereof and kits thereof |
| US20090088393A1 (en) * | 2007-09-28 | 2009-04-02 | Zomanex, Llc | Methods and formulations for converting intravenous and injectable drugs into oral dosage forms |
| EP2204167A1 (en) | 2009-01-05 | 2010-07-07 | Azad Pharma AG | Pharmaceutical microemulsion for preventing supramolecular aggregation of amphiphilic molecules |
| CN101785757B (zh) * | 2009-01-22 | 2012-02-22 | 美迪思生物科技(北京)有限公司 | 一种紫杉醇自乳化制剂及其制备方法和用途 |
| EP2301523A1 (de) | 2009-09-22 | 2011-03-30 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Galenische Formulierung in kolloidaler Form |
| CA2781529C (en) | 2009-09-23 | 2017-10-24 | Indu Javeri | Methods for the preparation of liposomes comprising docetaxel |
| US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| CN102228431A (zh) * | 2010-03-16 | 2011-11-02 | 王国强 | 紫杉烷类化合物的自乳化药物组合物 |
| EA027666B1 (ru) * | 2010-05-03 | 2017-08-31 | ТЕИКОКУ ФАРМА ЮСЭй, ИНК. | Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования |
| US20120095098A1 (en) * | 2010-10-18 | 2012-04-19 | Bhiku Patel | Bioavailability Enhancement Delivery System |
| JO3685B1 (ar) * | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| EP2878311A1 (en) * | 2013-11-27 | 2015-06-03 | Freund Pharmatec Ltd. | Solubility Enhancement for Hydrophobic Drugs |
| EP3086777A1 (en) * | 2013-12-23 | 2016-11-02 | Johnson & Johnson Consumer Inc. | Racecadotril compositions |
| DE102014015625A1 (de) | 2014-10-16 | 2016-04-21 | Gonzalo Urrutia Desmaison | Lösungsvermittelnde Zusammenssetzungen |
| KR101542364B1 (ko) * | 2014-10-31 | 2015-08-07 | 대화제약 주식회사 | 탁산을 포함하는 경구 투여용 약학 조성물 |
| EP3326652B1 (en) * | 2015-07-30 | 2021-10-06 | Dae Hwa Pharma. Co., Ltd | Pharmaceutical composition for oral administration comprising high concentration taxane |
| TWI838700B (zh) * | 2015-09-30 | 2024-04-11 | 香港商慧源香港創新有限公司 | 口服紫杉烷組合物及方法 |
| CN109589305B (zh) * | 2018-12-03 | 2021-03-19 | 昆明积大制药股份有限公司 | 多西他赛-环孢素a共包载自乳化制剂及其制备方法 |
| US20220096376A1 (en) * | 2019-01-07 | 2022-03-31 | Pusan National University Industry-University Cooperation Foundation | Drug delivery platform using w/o/w-type triolein emulsion promotive of blood-brain barrier opening |
| PL241264B1 (pl) * | 2020-02-19 | 2022-08-29 | Inventionbio Spółka Akcyjna | Samoemulsyfikująca kompozycja, przeznaczona do podawania naskórnego, zawierająca biosurfaktant, ko-surfaktant oraz fazę olejową |
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| AU680441B2 (en) * | 1992-09-22 | 1997-07-31 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Use of taxol for treating lymphomas and breast cancer |
| US5567592A (en) * | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
| US5560931A (en) * | 1995-02-14 | 1996-10-01 | Nawosystems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
| GB9509321D0 (en) * | 1995-05-09 | 1995-06-28 | Zylepsis Ltd | Methods of and substances for inhibiting oxidative enzymes |
| TW527186B (en) * | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| US6060518A (en) * | 1996-08-16 | 2000-05-09 | Supratek Pharma Inc. | Polymer compositions for chemotherapy and methods of treatment using the same |
| PL335891A1 (en) * | 1997-03-27 | 2000-05-22 | Baker Norton Pharma | Methods of and compositions for treating ovarian carcinoma |
-
1999
- 1999-03-30 KR KR1020007010507A patent/KR100661879B1/ko not_active Expired - Fee Related
- 1999-03-30 WO PCT/US1999/007162 patent/WO1999049848A1/en not_active Ceased
- 1999-03-30 CN CNB998065986A patent/CN100341485C/zh not_active Expired - Fee Related
- 1999-03-30 AT AT99915190T patent/ATE327735T1/de not_active IP Right Cessation
- 1999-03-30 EP EP99915190A patent/EP1067908B9/en not_active Expired - Lifetime
- 1999-03-30 JP JP2000540814A patent/JP4695260B2/ja not_active Expired - Fee Related
- 1999-03-30 AU AU33770/99A patent/AU756752B2/en not_active Ceased
- 1999-03-30 CA CA002326485A patent/CA2326485C/en not_active Expired - Fee Related
- 1999-03-30 IL IL13876799A patent/IL138767A0/xx active IP Right Grant
- 1999-03-30 DE DE69931617T patent/DE69931617T2/de not_active Expired - Lifetime
- 1999-05-14 TW TW088105111A patent/TW546152B/zh not_active IP Right Cessation
-
2000
- 2000-09-27 SE SE0003449A patent/SE0003449L/xx not_active Application Discontinuation
- 2000-09-28 IL IL138767A patent/IL138767A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1067908B9 (en) | 2007-01-24 |
| WO1999049848A1 (en) | 1999-10-07 |
| ATE327735T1 (de) | 2006-06-15 |
| JP4695260B2 (ja) | 2011-06-08 |
| DE69931617D1 (de) | 2006-07-06 |
| SE0003449L (sv) | 2000-11-23 |
| EP1067908A1 (en) | 2001-01-17 |
| AU756752B2 (en) | 2003-01-23 |
| JP2002509877A (ja) | 2002-04-02 |
| KR20010034622A (ko) | 2001-04-25 |
| SE0003449D0 (sv) | 2000-09-27 |
| CN100341485C (zh) | 2007-10-10 |
| DE69931617T2 (de) | 2007-05-24 |
| IL138767A0 (en) | 2001-10-31 |
| AU3377099A (en) | 1999-10-18 |
| KR100661879B1 (ko) | 2006-12-27 |
| CN1303269A (zh) | 2001-07-11 |
| CA2326485C (en) | 2008-12-09 |
| EP1067908B1 (en) | 2006-05-31 |
| IL138767A (en) | 2007-06-03 |
| CA2326485A1 (en) | 1999-10-07 |
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