TW217383B - - Google Patents

Info

Publication number
TW217383B
TW217383B TW078106510A TW78106510A TW217383B TW 217383 B TW217383 B TW 217383B TW 078106510 A TW078106510 A TW 078106510A TW 78106510 A TW78106510 A TW 78106510A TW 217383 B TW217383 B TW 217383B
Authority
TW
Taiwan
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
TW078106510A
Other languages
English (en)
Chinese (zh)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of TW217383B publication Critical patent/TW217383B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Artificial Filaments (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Amplifiers (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
  • Television Systems (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW078106510A 1988-09-12 1989-08-23 TW217383B (cg-RX-API-DMAC7.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12

Publications (1)

Publication Number Publication Date
TW217383B true TW217383B (cg-RX-API-DMAC7.html) 1993-12-11

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
TW078106510A TW217383B (cg-RX-API-DMAC7.html) 1988-09-12 1989-08-23

Country Status (14)

Country Link
US (1) US5541339A (cg-RX-API-DMAC7.html)
JP (1) JP3380237B2 (cg-RX-API-DMAC7.html)
KR (1) KR0137959B1 (cg-RX-API-DMAC7.html)
AT (1) ATE198335T1 (cg-RX-API-DMAC7.html)
AU (1) AU632288B2 (cg-RX-API-DMAC7.html)
CA (1) CA1340215C (cg-RX-API-DMAC7.html)
DE (1) DE68929275T2 (cg-RX-API-DMAC7.html)
DK (1) DK175458B1 (cg-RX-API-DMAC7.html)
FI (1) FI103668B1 (cg-RX-API-DMAC7.html)
GR (1) GR3035589T3 (cg-RX-API-DMAC7.html)
LV (1) LV12806B (cg-RX-API-DMAC7.html)
NO (1) NO303498B1 (cg-RX-API-DMAC7.html)
TW (1) TW217383B (cg-RX-API-DMAC7.html)
WO (1) WO1990002746A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0563475T3 (da) * 1992-03-25 2000-09-18 Immunogen Inc Konjugater af cellebindende midler og derivater af CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
ATE446317T1 (de) 2001-05-11 2009-11-15 Ludwig Inst For Cancer Res Ltd Spezifische bindungsproteine und ihre verwendung
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
NZ533310A (en) 2001-11-09 2004-12-24 Boehringer Ingelheim Pharma Benzimidazoles useful as protein kinase inhibitors
CA2494942A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
CA2501547A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
CA2531485C (en) * 2003-07-07 2013-03-26 Merck Patent Gmbh Malonamide derivatives
US20050209284A1 (en) * 2004-02-12 2005-09-22 Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors
US7446195B2 (en) * 2005-08-17 2008-11-04 Schering Corporation High affinity thiophene-based and furan-based kinase ligands
CN101711284A (zh) 2007-01-25 2010-05-19 达娜-法勃肿瘤研究所 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
ES2542152T3 (es) 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
WO2009023265A1 (en) 2007-08-14 2009-02-19 Ludwig Institute For Cancer Research Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
PT2344478T (pt) 2008-11-03 2017-11-28 Syntarga Bv Análogos de cc-1065 e seus conjugados
DK3108886T3 (da) 2010-04-21 2020-08-10 Syntarga Bv Konjugater af CC-1065-analoger og bifunktionelle linkere
EP3388060A1 (en) 2012-10-22 2018-10-17 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
KR102323301B1 (ko) 2014-01-10 2021-11-09 비온디스 비.브이. Cys 연결된 항체-약물 접합체의 정제 방법
MY180257A (en) * 2014-01-27 2020-11-26 Pfizer Bifunctional cytotoxic agents
CA2954934C (en) 2014-06-30 2023-09-26 Glykos Finland Oy Drug derivative and conjugates
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
CA2923862C (en) * 2015-03-20 2024-02-13 Pfizer Inc. Bifunctional cytotoxic agents containing the cti pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
JP2598819B2 (ja) * 1986-12-19 1997-04-09 ジ・アップジョン・カンパニー 新規なｃｃ‐１０６５同族体

Also Published As

Publication number Publication date
NO303498B1 (no) 1998-07-20
NO910958L (no) 1991-05-10
DK41791D0 (da) 1991-03-08
CA1340215C (en) 1998-12-15
FI103668B (fi) 1999-08-13
LV12806B (lv) 2002-05-20
NO910958D0 (no) 1991-03-11
LV12806A (en) 2002-03-20
FI103668B1 (fi) 1999-08-13
DK175458B1 (da) 2004-11-01
KR900701801A (ko) 1990-12-04
DE68929275D1 (de) 2001-02-01
ATE198335T1 (de) 2001-01-15
DE68929275T2 (de) 2001-05-23
FI911193A0 (fi) 1991-03-11
DK41791A (da) 1991-03-08
GR3035589T3 (en) 2001-06-29
AU4192289A (en) 1990-04-02
KR0137959B1 (ko) 1998-05-15
US5541339A (en) 1996-07-30
JP3380237B2 (ja) 2003-02-24
JPH04500664A (ja) 1992-02-06
WO1990002746A1 (en) 1990-03-22
AU632288B2 (en) 1992-12-24

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