TW202409059A - 抑制由二酮哌嗪形成之缺陷的胜肽合成方法 - Google Patents

抑制由二酮哌嗪形成之缺陷的胜肽合成方法 Download PDF

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Publication number
TW202409059A
TW202409059A TW112116267A TW112116267A TW202409059A TW 202409059 A TW202409059 A TW 202409059A TW 112116267 A TW112116267 A TW 112116267A TW 112116267 A TW112116267 A TW 112116267A TW 202409059 A TW202409059 A TW 202409059A
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TW
Taiwan
Prior art keywords
group
peptide
solvent
compound
fmoc
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TW112116267A
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English (en)
Chinese (zh)
Inventor
陰未来
田宮実
金澤純一朗
野村研一
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日商中外製藥股份有限公司
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Publication of TW202409059A publication Critical patent/TW202409059A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW112116267A 2022-05-02 2023-05-02 抑制由二酮哌嗪形成之缺陷的胜肽合成方法 TW202409059A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022-075743 2022-05-02
JP2022075743 2022-05-02

Publications (1)

Publication Number Publication Date
TW202409059A true TW202409059A (zh) 2024-03-01

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ID=88646535

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112116267A TW202409059A (zh) 2022-05-02 2023-05-02 抑制由二酮哌嗪形成之缺陷的胜肽合成方法

Country Status (7)

Country Link
US (1) US20250353875A1 (https=)
EP (1) EP4509517A1 (https=)
JP (1) JPWO2023214577A1 (https=)
KR (1) KR20250006193A (https=)
CN (1) CN119213009A (https=)
TW (1) TW202409059A (https=)
WO (1) WO2023214577A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
US12312379B2 (en) 2021-05-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Methods for producing cyclic compounds comprising N-substituted amino acid residues
JP7823181B2 (ja) 2022-05-06 2026-03-03 中外製薬株式会社 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6112011B2 (ja) * 2011-05-31 2017-04-12 味の素株式会社 ペプチドの製造方法
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
WO2018021233A1 (ja) * 2016-07-25 2018-02-01 積水メディカル株式会社 新規キサンテン保護剤
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
EP3730497B1 (en) * 2017-12-19 2022-11-16 Sekisui Medical Co., Ltd. Novel alkyl diphenylmethane protection agent
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
KR20230097018A (ko) 2020-11-05 2023-06-30 추가이 세이야쿠 가부시키가이샤 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법
JP7063409B1 (ja) * 2021-07-02 2022-05-09 ペプチスター株式会社 Ｆｍоｃ基を除去する方法
JP7063408B1 (ja) * 2021-07-02 2022-05-09 ペプチスター株式会社 液相ペプチド製造方法

Also Published As

Publication number Publication date
CN119213009A (zh) 2024-12-27
US20250353875A1 (en) 2025-11-20
EP4509517A1 (en) 2025-02-19
KR20250006193A (ko) 2025-01-10
WO2023214577A1 (ja) 2023-11-09
JPWO2023214577A1 (https=) 2023-11-09

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