CN119213009A - 抑制由二酮哌嗪形成引起的缺陷的肽合成方法 - Google Patents

抑制由二酮哌嗪形成引起的缺陷的肽合成方法 Download PDF

Info

Publication number
CN119213009A
CN119213009A CN202380036194.8A CN202380036194A CN119213009A CN 119213009 A CN119213009 A CN 119213009A CN 202380036194 A CN202380036194 A CN 202380036194A CN 119213009 A CN119213009 A CN 119213009A
Authority
CN
China
Prior art keywords
peptide
compound
solvent
group
fmoc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380036194.8A
Other languages
English (en)
Chinese (zh)
Inventor
阴未来
田宫实
金泽纯一朗
野村研一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CN119213009A publication Critical patent/CN119213009A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202380036194.8A 2022-05-02 2023-05-02 抑制由二酮哌嗪形成引起的缺陷的肽合成方法 Pending CN119213009A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-075743 2022-05-02
JP2022075743 2022-05-02
PCT/JP2023/017114 WO2023214577A1 (ja) 2022-05-02 2023-05-02 ジケトピペラジン形成による欠損を抑制するペプチド合成方法

Publications (1)

Publication Number Publication Date
CN119213009A true CN119213009A (zh) 2024-12-27

Family

ID=88646535

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380036194.8A Pending CN119213009A (zh) 2022-05-02 2023-05-02 抑制由二酮哌嗪形成引起的缺陷的肽合成方法

Country Status (7)

Country Link
US (1) US20250353875A1 (https=)
EP (1) EP4509517A1 (https=)
JP (1) JPWO2023214577A1 (https=)
KR (1) KR20250006193A (https=)
CN (1) CN119213009A (https=)
TW (1) TW202409059A (https=)
WO (1) WO2023214577A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
US12312379B2 (en) 2021-05-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Methods for producing cyclic compounds comprising N-substituted amino acid residues
JP7823181B2 (ja) 2022-05-06 2026-03-03 中外製薬株式会社 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6112011B2 (ja) * 2011-05-31 2017-04-12 味の素株式会社 ペプチドの製造方法
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
WO2018021233A1 (ja) * 2016-07-25 2018-02-01 積水メディカル株式会社 新規キサンテン保護剤
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
EP3730497B1 (en) * 2017-12-19 2022-11-16 Sekisui Medical Co., Ltd. Novel alkyl diphenylmethane protection agent
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
KR20230097018A (ko) 2020-11-05 2023-06-30 추가이 세이야쿠 가부시키가이샤 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법
JP7063409B1 (ja) * 2021-07-02 2022-05-09 ペプチスター株式会社 Ｆｍоｃ基を除去する方法
JP7063408B1 (ja) * 2021-07-02 2022-05-09 ペプチスター株式会社 液相ペプチド製造方法

Also Published As

Publication number Publication date
US20250353875A1 (en) 2025-11-20
TW202409059A (zh) 2024-03-01
EP4509517A1 (en) 2025-02-19
KR20250006193A (ko) 2025-01-10
WO2023214577A1 (ja) 2023-11-09
JPWO2023214577A1 (https=) 2023-11-09

Similar Documents

Publication Publication Date Title
JP7808554B2 (ja) ジケトピペラジン形成による欠損を抑制するペプチド合成方法
CN119213009A (zh) 抑制由二酮哌嗪形成引起的缺陷的肽合成方法
CN110799520B (zh) 用于合成含有n-取代氨基酸的肽的方法
EP4269422A1 (en) Method for producing peptide compound containing n-substituted-amino acid residue
CN114630835B (zh) 包含空间位阻大的氨基酸的肽化合物的制备方法
JP7766028B2 (ja) 高難度配列の効率的ペプチド縮合法
US20070249526A1 (en) Process for the preparation of cyclic peptides
JPWO2019117274A1 (ja) ペプチドの製造方法、及び塩基の処理方法
JP5515738B2 (ja) ジベンゾフルベン誘導体の淘汰方法
SA111320880B1 (ar) عملية لتصنيع دِجاريليكس ومركباته الوسطية
CN120051480A (zh) 用于生产含有n-取代氨基酸残基的环肽化合物的方法
HK40113203A (zh) 抑制由二酮呱嗪形成引起的缺陷的肽合成方法
KR20250148640A (ko) 리라글루타이드의 테트라펩타이드 단편의 제조 방법
US20210238230A1 (en) A method for production of high purity icatibant
HK40089629A (zh) 抑制由二酮哌嗪形成导致的缺损的肽合成方法
CN116615411A (zh) 包含n-取代氨基酸残基的肽化合物的制造方法
HK40109833A (zh) 用於合成含有n-取代氨基酸的肽的方法
US20250353810A1 (en) Process for the preparation of trofinetide
Vasanthakumar et al. Synthesis of Alkyl and Aryl Esters of N-Protected β-Homoamino Acids from N-Protected α-Aminodiazoketones
HK40120616A (zh) 用於生产含有n-取代氨基酸残基的环肽化合物的方法
EP4011902A1 (en) Method for producing peptide compound, reagent for forming protecting group, and hydrazine derivative
JPS634531B2 (https=)

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40113203

Country of ref document: HK