KR20250006193A - 디케토피페라진 형성에 의한 결손을 억제하는 펩티드 합성 방법 - Google Patents
디케토피페라진 형성에 의한 결손을 억제하는 펩티드 합성 방법 Download PDFInfo
- Publication number
- KR20250006193A KR20250006193A KR1020247038699A KR20247038699A KR20250006193A KR 20250006193 A KR20250006193 A KR 20250006193A KR 1020247038699 A KR1020247038699 A KR 1020247038699A KR 20247038699 A KR20247038699 A KR 20247038699A KR 20250006193 A KR20250006193 A KR 20250006193A
- Authority
- KR
- South Korea
- Prior art keywords
- peptide
- solvent
- compound
- solution
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP-P-2022-075743 | 2022-05-02 | ||
| JP2022075743 | 2022-05-02 | ||
| PCT/JP2023/017114 WO2023214577A1 (ja) | 2022-05-02 | 2023-05-02 | ジケトピペラジン形成による欠損を抑制するペプチド合成方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20250006193A true KR20250006193A (ko) | 2025-01-10 |
Family
ID=88646535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247038699A Pending KR20250006193A (ko) | 2022-05-02 | 2023-05-02 | 디케토피페라진 형성에 의한 결손을 억제하는 펩티드 합성 방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250353875A1 (https=) |
| EP (1) | EP4509517A1 (https=) |
| JP (1) | JPWO2023214577A1 (https=) |
| KR (1) | KR20250006193A (https=) |
| CN (1) | CN119213009A (https=) |
| TW (1) | TW202409059A (https=) |
| WO (1) | WO2023214577A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| US12312379B2 (en) | 2021-05-07 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing cyclic compounds comprising N-substituted amino acid residues |
| JP7823181B2 (ja) | 2022-05-06 | 2026-03-03 | 中外製薬株式会社 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018225851A1 (ja) | 2017-06-09 | 2018-12-13 | 中外製薬株式会社 | Ｎ－置換アミノ酸を含むペプチドの合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6112011B2 (ja) * | 2011-05-31 | 2017-04-12 | 味の素株式会社 | ペプチドの製造方法 |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| WO2018021233A1 (ja) * | 2016-07-25 | 2018-02-01 | 積水メディカル株式会社 | 新規キサンテン保護剤 |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| EP3730497B1 (en) * | 2017-12-19 | 2022-11-16 | Sekisui Medical Co., Ltd. | Novel alkyl diphenylmethane protection agent |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| KR20230097018A (ko) | 2020-11-05 | 2023-06-30 | 추가이 세이야쿠 가부시키가이샤 | 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법 |
| JP7063409B1 (ja) * | 2021-07-02 | 2022-05-09 | ペプチスター株式会社 | Ｆｍоｃ基を除去する方法 |
| JP7063408B1 (ja) * | 2021-07-02 | 2022-05-09 | ペプチスター株式会社 | 液相ペプチド製造方法 |
-
2023
- 2023-05-02 US US18/860,859 patent/US20250353875A1/en active Pending
- 2023-05-02 TW TW112116267A patent/TW202409059A/zh unknown
- 2023-05-02 EP EP23799506.3A patent/EP4509517A1/en active Pending
- 2023-05-02 KR KR1020247038699A patent/KR20250006193A/ko active Pending
- 2023-05-02 CN CN202380036194.8A patent/CN119213009A/zh active Pending
- 2023-05-02 JP JP2024519230A patent/JPWO2023214577A1/ja active Pending
- 2023-05-02 WO PCT/JP2023/017114 patent/WO2023214577A1/ja not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018225851A1 (ja) | 2017-06-09 | 2018-12-13 | 中外製薬株式会社 | Ｎ－置換アミノ酸を含むペプチドの合成方法 |
Non-Patent Citations (4)
| Title |
|---|
| Bachem에서 발행한 Solid Phase Peptide Synthesis(https://www.bachem.com/fileadmin/user_upload/pdf/Catalogs_Brochures/Solid_Phase_Peptide_Synthesis.pdf) |
| J. Peptide Res., 2005, 65, 153-166. |
| Org. Lett., 2008, 10, 3857-3860. |
| Org. Lett., 2012, 14, 612-615. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN119213009A (zh) | 2024-12-27 |
| US20250353875A1 (en) | 2025-11-20 |
| TW202409059A (zh) | 2024-03-01 |
| EP4509517A1 (en) | 2025-02-19 |
| WO2023214577A1 (ja) | 2023-11-09 |
| JPWO2023214577A1 (https=) | 2023-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20241121 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application |