TW202309062A - 抗體組成物之純化方法 - Google Patents

抗體組成物之純化方法 Download PDF

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Publication number
TW202309062A
TW202309062A TW111117152A TW111117152A TW202309062A TW 202309062 A TW202309062 A TW 202309062A TW 111117152 A TW111117152 A TW 111117152A TW 111117152 A TW111117152 A TW 111117152A TW 202309062 A TW202309062 A TW 202309062A
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TW
Taiwan
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gly
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TW111117152A
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English (en)
Chinese (zh)
Inventor
吉森孝行
斯蒂芬 愛魯梭
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日商凱依歐姆 生物科學股份有限公司
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Publication of TW202309062A publication Critical patent/TW202309062A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW111117152A 2021-05-10 2022-05-06 抗體組成物之純化方法 TW202309062A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021079977 2021-05-10
JP2021-079977 2021-05-10

Publications (1)

Publication Number Publication Date
TW202309062A true TW202309062A (zh) 2023-03-01

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ID=84029593

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111117152A TW202309062A (zh) 2021-05-10 2022-05-06 抗體組成物之純化方法

Country Status (10)

Country Link
US (1) US20240383945A1 (https=)
EP (1) EP4353734A4 (https=)
JP (1) JPWO2022239704A1 (https=)
KR (1) KR20240005771A (https=)
CN (1) CN117279929A (https=)
AU (1) AU2022271741A1 (https=)
CA (1) CA3219950A1 (https=)
IL (1) IL308169A (https=)
TW (1) TW202309062A (https=)
WO (1) WO2022239704A1 (https=)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS644947A (en) 1987-06-29 1989-01-10 Rohm Co Ltd Consecutive recording method for video tape recorder
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
EP1739089A4 (en) 2004-03-30 2007-05-02 Hiroshi Yanagisawa PROCESS FOR DISINTER SEPARATION
WO2008120801A1 (ja) 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法
US9249182B2 (en) * 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
ES2665341T3 (es) * 2012-10-03 2018-04-25 Chiome Bioscience Inc. Anticuerpo anti-DLK-1 humana con actividad antitumoral in vivo
WO2014145744A1 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
US20180327447A1 (en) * 2015-11-18 2018-11-15 Merck Patent Gmbh Improved protein separation in ion exchange chromatography
CA3127174A1 (en) * 2019-01-23 2020-07-30 Daiichi Sankyo Company, Limited Methods for purifying antibodies comprising of a process by using activated carbon materials
US20220177582A1 (en) * 2019-03-13 2022-06-09 Ichnos Sciences SA Non-consensus glycosylation of bispecific antibodies
JP2021079977A (ja) 2019-11-19 2021-05-27 凸版印刷株式会社 袋状容器の注出口ユニット

Also Published As

Publication number Publication date
CN117279929A (zh) 2023-12-22
CA3219950A1 (en) 2022-11-17
WO2022239704A1 (ja) 2022-11-17
EP4353734A1 (en) 2024-04-17
JPWO2022239704A1 (https=) 2022-11-17
AU2022271741A1 (en) 2023-11-23
EP4353734A4 (en) 2025-05-21
IL308169A (en) 2024-01-01
KR20240005771A (ko) 2024-01-12
US20240383945A1 (en) 2024-11-21

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