KR20240005771A - 항체 조성물의 정제 방법 - Google Patents

항체 조성물의 정제 방법 Download PDF

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Publication number
KR20240005771A
KR20240005771A KR1020237040492A KR20237040492A KR20240005771A KR 20240005771 A KR20240005771 A KR 20240005771A KR 1020237040492 A KR1020237040492 A KR 1020237040492A KR 20237040492 A KR20237040492 A KR 20237040492A KR 20240005771 A KR20240005771 A KR 20240005771A
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KR
South Korea
Prior art keywords
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val
thr
gly
lys
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Pending
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KR1020237040492A
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English (en)
Korean (ko)
Inventor
다카유키 요시모리
스테판 이아루소
Original Assignee
치오메 바이오사이언스 가부시키가이샤
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Publication of KR20240005771A publication Critical patent/KR20240005771A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020237040492A 2021-05-10 2022-05-06 항체 조성물의 정제 방법 Pending KR20240005771A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021079977 2021-05-10
JPJP-P-2021-079977 2021-05-10
PCT/JP2022/019548 WO2022239704A1 (ja) 2021-05-10 2022-05-06 抗体組成物の精製方法

Publications (1)

Publication Number Publication Date
KR20240005771A true KR20240005771A (ko) 2024-01-12

Family

ID=84029593

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237040492A Pending KR20240005771A (ko) 2021-05-10 2022-05-06 항체 조성물의 정제 방법

Country Status (10)

Country Link
US (1) US20240383945A1 (https=)
EP (1) EP4353734A4 (https=)
JP (1) JPWO2022239704A1 (https=)
KR (1) KR20240005771A (https=)
CN (1) CN117279929A (https=)
AU (1) AU2022271741A1 (https=)
CA (1) CA3219950A1 (https=)
IL (1) IL308169A (https=)
TW (1) TW202309062A (https=)
WO (1) WO2022239704A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001064300A (ja) 1999-07-02 2001-03-13 F Hoffmann La Roche Ag エリスロポエチン誘導体
WO2005100379A1 (ja) 2004-03-30 2005-10-27 Hiroshi Yanagisawa タンパク質の分離方法
WO2008120801A1 (ja) 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法
WO2014054820A1 (ja) 2012-10-03 2014-04-10 株式会社リブテック in vivoで抗腫瘍活性を有する抗ヒトDlk-1抗体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS644947A (en) 1987-06-29 1989-01-10 Rohm Co Ltd Consecutive recording method for video tape recorder
US9249182B2 (en) * 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
WO2014145744A1 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
US20180327447A1 (en) * 2015-11-18 2018-11-15 Merck Patent Gmbh Improved protein separation in ion exchange chromatography
CA3127174A1 (en) * 2019-01-23 2020-07-30 Daiichi Sankyo Company, Limited Methods for purifying antibodies comprising of a process by using activated carbon materials
US20220177582A1 (en) * 2019-03-13 2022-06-09 Ichnos Sciences SA Non-consensus glycosylation of bispecific antibodies
JP2021079977A (ja) 2019-11-19 2021-05-27 凸版印刷株式会社 袋状容器の注出口ユニット

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001064300A (ja) 1999-07-02 2001-03-13 F Hoffmann La Roche Ag エリスロポエチン誘導体
WO2005100379A1 (ja) 2004-03-30 2005-10-27 Hiroshi Yanagisawa タンパク質の分離方法
WO2008120801A1 (ja) 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法
WO2014054820A1 (ja) 2012-10-03 2014-04-10 株式会社リブテック in vivoで抗腫瘍活性を有する抗ヒトDlk-1抗体

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
Anal. Biochem., 349, 197-207 (2006)
Biochem. J., 338 (2), 529-538 (1999)
Bull. Natl. Inst. Health Sci., 132, 36-46 (2014)
CHROMATOGRAPHY, 34 (2), 83-88 (2013)
Embo J., 10, 2717-2723 (1991)
Front. Immunol., 8 (646), 1-8 (2017)
ICH Q6 B Guideline
J. Biol. Chem., 284 (47), 32493-32506 (2009)
J. Biol. Chem., 285 (21), 16012-22 (2010)
J. Immunol. Methods, 467, 58-62 (2019)
J. Immunol., 196, 1435-1441 (2016)
J. Pharm. Biomed. Anal., 130, 3-18 (2016)
mAbs, 6 (4), 852-858 (2014)
Nature Review | Immunology, published online, 04 Feb, (2019)
Oncotarget, 7 (21), 31166-76 (2016)
Protein Cell, 9, 63-73 (2018)
YAKUGAKU ZASSHI 137 (7), 815-816 (2017)

Also Published As

Publication number Publication date
CN117279929A (zh) 2023-12-22
CA3219950A1 (en) 2022-11-17
WO2022239704A1 (ja) 2022-11-17
TW202309062A (zh) 2023-03-01
EP4353734A1 (en) 2024-04-17
JPWO2022239704A1 (https=) 2022-11-17
AU2022271741A1 (en) 2023-11-23
EP4353734A4 (en) 2025-05-21
IL308169A (en) 2024-01-01
US20240383945A1 (en) 2024-11-21

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