TW202309026A - 雜環類衍生物抑制劑、其製備方法和應用 - Google Patents

雜環類衍生物抑制劑、其製備方法和應用 Download PDF

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TW202309026A
TW202309026A TW111115479A TW111115479A TW202309026A TW 202309026 A TW202309026 A TW 202309026A TW 111115479 A TW111115479 A TW 111115479A TW 111115479 A TW111115479 A TW 111115479A TW 202309026 A TW202309026 A TW 202309026A
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cycloalkyl
alkoxy
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TW111115479A
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高鵬
曾蜜
王少寶
俞文勝
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大陸商上海翰森生物醫藥科技有限公司
大陸商江蘇豪森藥業集團有限公司
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW111115479A 2021-04-23 2022-04-22 雜環類衍生物抑制劑、其製備方法和應用 TW202309026A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CN202110443582.0 2021-04-23
CN202110443582 2021-04-23
CN202110653169.7 2021-06-11
CN202110653169 2021-06-11
CN202110808316.3 2021-07-16
CN202110808316 2021-07-16
CN202110926676.3 2021-08-12
CN202110926676 2021-08-12
CN202210072358 2022-01-21
CN202210072358.X 2022-01-21

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US (1) US20240228490A1 (https=)
EP (1) EP4328225A4 (https=)
JP (1) JP2024514338A (https=)
KR (1) KR20240005756A (https=)
CN (2) CN115232154A (https=)
AU (1) AU2022261029A1 (https=)
BR (1) BR112023019797A2 (https=)
CA (1) CA3215823A1 (https=)
IL (1) IL307824A (https=)
MX (1) MX2023012054A (https=)
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WO2022222965A1 (zh) * 2021-04-23 2022-10-27 成都百裕制药股份有限公司 吡啶衍生物及其在医药上的应用
US20230159525A1 (en) 2021-10-01 2023-05-25 Xinthera, Inc. Azetidine and pyrrolidine parp1 inhibitors and uses thereof
JP7762306B2 (ja) * 2021-11-19 2025-10-29 康百達（四川）生物医薬科技有限公司 選択的ｐａｒｐ１阻害剤およびその用途
CN116143776A (zh) * 2021-11-22 2023-05-23 南京圣和药业股份有限公司 Parp1抑制剂及其应用
CA3241338A1 (en) * 2021-12-17 2023-06-22 Yongqi Deng Parp inhibitor, pharmaceutical composition comprising same, and use thereof
WO2023138541A1 (zh) * 2022-01-20 2023-07-27 微境生物医药科技(上海)有限公司 吡啶酰胺类parp抑制剂、及其制备方法和医药用途
AU2023209820B2 (en) 2022-01-21 2024-10-10 Xinthera, Inc. Parp1 inhibitors and uses thereof
US20260098024A1 (en) * 2022-01-27 2026-04-09 Xinthera, Inc. Parp1 inhibitors and uses thereof
KR20240161147A (ko) 2022-03-14 2024-11-12 슬랩 파마슈티컬스 엘엘씨 다중 사이클릭 화합물
FI4497438T3 (fi) 2022-04-28 2025-10-20 Xinthera Inc Trisyklisiä parp1:n estäjiä ja niiden käyttötapoja
WO2023207284A1 (en) * 2022-04-28 2023-11-02 Ningbo Newbay Technology Development Co., Ltd Piperazine derivatives as parp1 inhibitiors
CN115919859B (zh) * 2022-07-14 2024-01-05 四川海思科制药有限公司 一种杂芳基衍生物的药物组合物及其在医药上的应用
WO2024041608A1 (zh) * 2022-08-24 2024-02-29 四川海思科制药有限公司 一种杂芳基衍生物parp抑制剂的晶体形式及其用途
WO2024041605A1 (zh) * 2022-08-24 2024-02-29 四川海思科制药有限公司 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途
US20240132449A1 (en) * 2022-08-30 2024-04-25 1Cbio, Inc. Heterocyclic compounds and methods of use thereof
CN119365468A (zh) * 2022-08-31 2025-01-24 江苏恒瑞医药股份有限公司 稠合二环类化合物、其制备方法及其在医药上的应用
CN117658983A (zh) * 2022-09-01 2024-03-08 浙江文达医药科技有限公司 选择性parp1抑制剂
TW202415658A (zh) * 2022-09-30 2024-04-16 大陸商中國醫藥研究開發中心有限公司 含氮雜環類化合物及其醫藥用途
TW202416977A (zh) * 2022-09-30 2024-05-01 大陸商中國醫藥研究開發中心有限公司 含氮雜環類化合物及其醫藥用途
WO2024083218A1 (zh) * 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 取代四氢吡啶类化合物及其用途
CN117946074A (zh) * 2022-10-20 2024-04-30 上海海和药物研究开发股份有限公司 具有parp1抑制活性的化合物及其用途
WO2024083201A1 (zh) * 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 并杂环类化合物及其用途
JP2025535834A (ja) * 2022-11-02 2025-10-28 スアンズ バイオファーマシューティカル カンパニー，リミテッド 多環式ポリ（ａｄｐリボース）ポリメラーゼ選択的阻害剤
EP4615581A2 (en) * 2022-11-09 2025-09-17 Laekna Pharmaceutical Ningbo Co., Ltd. Fused multicyclic compounds and their use as parp1 inhibitors
CN117903159A (zh) * 2022-12-30 2024-04-19 成都硕德药业有限公司 一种内酰胺类衍生物、其制备方法及用途
CN116375700B (zh) * 2023-01-10 2024-12-17 中国科学院成都生物研究所 一种4-氮杂吲哚啉类化合物及其合成方法与应用
EP4669633A1 (en) * 2023-02-21 2025-12-31 1Cbio, Inc. HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THEM
WO2024178125A1 (en) * 2023-02-21 2024-08-29 1Cbio, Inc. Heterocyclic compounds and methods of use thereof
EP4673448A1 (en) * 2023-03-01 2026-01-07 Impact Therapeutics (Shanghai), Inc. Substituted nitrogen-containing tricyclic compounds as parp inhibitors and the use thereof
TW202502341A (zh) * 2023-03-13 2025-01-16 大陸商江蘇豪森藥業集團有限公司 哌啶烯類化合物在製備治療癌症的藥物中的應用
AU2024316921A1 (en) * 2023-07-28 2026-02-05 Sunshine Lake Pharma Co., Ltd. Substituted nitrogen-containing bicyclic compound and use thereof
CN119462669A (zh) * 2023-08-11 2025-02-18 上海海和药物研究开发股份有限公司 稠合三环类化合物、其药物组合物和用途
CN121335891A (zh) * 2023-08-17 2026-01-13 Dic株式会社 化合物和使用该化合物的液晶组合物、液晶显示装置、传感器、液晶透镜、光通信装置和天线
WO2025103407A1 (zh) * 2023-11-16 2025-05-22 江苏豪森药业集团有限公司 抗体药物偶联物和多腺苷二磷酸核糖聚合酶抑制剂的联合应用
WO2025168048A1 (zh) * 2024-02-08 2025-08-14 上海璎黎药业有限公司 一种三键结构化合物、其药物组合物及其应用
WO2025265123A1 (en) * 2024-06-21 2025-12-26 Protheragen Inc. Parp1 inhibitors for the treatment of diseases
WO2026002281A1 (zh) * 2024-06-28 2026-01-02 上海翰森生物医药科技有限公司 哌啶烯类化合物联合用药在制备治疗癌症的药物中的用途
CN119039301B (zh) * 2024-10-31 2025-09-02 江苏豪森药业集团有限公司 一种含氮杂环的多环化合物晶型ⅰ的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1190466B (de) * 1961-11-07 1965-04-08 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Piperazinderivaten
HUP9903758A3 (en) * 1996-05-29 2000-07-28 Warner Lambert Co Benzoxazinone dopamine d4 receptor antagonists and pharmaceutical compositions containing the same
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
EA010592B1 (ru) * 2003-12-10 2008-10-30 Янссен Фармацевтика Н.В. 6-замещённые циклогексилалкил 2-замещённые хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(adp-рибоза)полимеразы
RU2007101544A (ru) * 2004-06-17 2008-08-10 Уайт (Us) Антагонисты рецепторов высвобождающего гонадотропин гормона
US8404713B2 (en) * 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
WO2010111626A2 (en) * 2009-03-27 2010-09-30 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
EP3804336A4 (en) * 2018-07-11 2021-08-11 Huawei Technologies Co., Ltd. FILTERING PROCESS AND APPARATUS DEPENDING ON THE ASPECT RATIO FOR INTRA-PREDICTION
MX2022000711A (es) * 2019-07-19 2022-02-23 Astrazeneca Ab Inhibidores de parp1.
TW202309025A (zh) * 2021-04-19 2023-03-01 美商辛瑟拉股份有限公司 Parp1抑制劑及其用途

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