TW202241962A - 分裂抗體及使用方法 - Google Patents

分裂抗體及使用方法 Download PDF

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Publication number
TW202241962A
TW202241962A TW111101051A TW111101051A TW202241962A TW 202241962 A TW202241962 A TW 202241962A TW 111101051 A TW111101051 A TW 111101051A TW 111101051 A TW111101051 A TW 111101051A TW 202241962 A TW202241962 A TW 202241962A
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TW
Taiwan
Prior art keywords
seq
antibody
amino acid
acid sequence
antigen
Prior art date
Application number
TW111101051A
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English (en)
Chinese (zh)
Inventor
克里斯汀 克萊
亞歷山大 哈斯
俊 沙賓 因霍夫
蘇菲亞 佛洛斯特
Original Assignee
瑞士商赫孚孟拉羅股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 瑞士商赫孚孟拉羅股份公司 filed Critical 瑞士商赫孚孟拉羅股份公司
Publication of TW202241962A publication Critical patent/TW202241962A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW111101051A 2021-01-12 2022-01-11 分裂抗體及使用方法 TW202241962A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21151245.4 2021-01-12
EP21151245 2021-01-12

Publications (1)

Publication Number Publication Date
TW202241962A true TW202241962A (zh) 2022-11-01

Family

ID=74175694

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111101051A TW202241962A (zh) 2021-01-12 2022-01-11 分裂抗體及使用方法

Country Status (16)

Country Link
US (1) US20240082437A1 (enExample)
EP (1) EP4277705A1 (enExample)
JP (1) JP2024504931A (enExample)
KR (1) KR20230131204A (enExample)
CN (1) CN116829593A (enExample)
AR (1) AR124609A1 (enExample)
AU (1) AU2022207615A1 (enExample)
CA (1) CA3206466A1 (enExample)
CL (1) CL2023001989A1 (enExample)
CO (1) CO2023009153A2 (enExample)
CR (1) CR20230385A (enExample)
IL (1) IL304224A (enExample)
MX (1) MX2023008084A (enExample)
PE (1) PE20240690A1 (enExample)
TW (1) TW202241962A (enExample)
WO (1) WO2022152656A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025176614A1 (en) 2024-02-20 2025-08-28 F. Hoffmann-La Roche Ag Novel pre-targeting antibodies and uses thereof

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Also Published As

Publication number Publication date
CL2023001989A1 (es) 2024-02-02
CN116829593A (zh) 2023-09-29
MX2023008084A (es) 2023-07-13
AR124609A1 (es) 2023-04-12
US20240082437A1 (en) 2024-03-14
WO2022152656A1 (en) 2022-07-21
AU2022207615A1 (en) 2023-07-13
JP2024504931A (ja) 2024-02-02
IL304224A (en) 2023-09-01
CO2023009153A2 (es) 2023-07-21
CR20230385A (es) 2023-09-25
CA3206466A1 (en) 2022-07-21
PE20240690A1 (es) 2024-04-10
EP4277705A1 (en) 2023-11-22
KR20230131204A (ko) 2023-09-12

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