CA3206466A1 - Split antibodies which bind to cancer cells and target radionuclides to said cells - Google Patents

Split antibodies which bind to cancer cells and target radionuclides to said cells

Info

Publication number
CA3206466A1
CA3206466A1 CA3206466A CA3206466A CA3206466A1 CA 3206466 A1 CA3206466 A1 CA 3206466A1 CA 3206466 A CA3206466 A CA 3206466A CA 3206466 A CA3206466 A CA 3206466A CA 3206466 A1 CA3206466 A1 CA 3206466A1
Authority
CA
Canada
Prior art keywords
seq
amino acid
acid sequence
antibody
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3206466A
Other languages
English (en)
French (fr)
Inventor
Christian Klein
Alexander Haas
Sabine Imhof-Jung
Sofia FROST
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA3206466A1 publication Critical patent/CA3206466A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3206466A 2021-01-12 2022-01-10 Split antibodies which bind to cancer cells and target radionuclides to said cells Pending CA3206466A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21151245.4 2021-01-12
EP21151245 2021-01-12
PCT/EP2022/050359 WO2022152656A1 (en) 2021-01-12 2022-01-10 Split antibodies which bind to cancer cells and target radionuclides to said cells

Publications (1)

Publication Number Publication Date
CA3206466A1 true CA3206466A1 (en) 2022-07-21

Family

ID=74175694

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3206466A Pending CA3206466A1 (en) 2021-01-12 2022-01-10 Split antibodies which bind to cancer cells and target radionuclides to said cells

Country Status (16)

Country Link
US (1) US20240082437A1 (enExample)
EP (1) EP4277705A1 (enExample)
JP (1) JP2024504931A (enExample)
KR (1) KR20230131204A (enExample)
CN (1) CN116829593A (enExample)
AR (1) AR124609A1 (enExample)
AU (1) AU2022207615A1 (enExample)
CA (1) CA3206466A1 (enExample)
CL (1) CL2023001989A1 (enExample)
CO (1) CO2023009153A2 (enExample)
CR (1) CR20230385A (enExample)
IL (1) IL304224A (enExample)
MX (1) MX2023008084A (enExample)
PE (1) PE20240690A1 (enExample)
TW (1) TW202241962A (enExample)
WO (1) WO2022152656A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025176614A1 (en) 2024-02-20 2025-08-28 F. Hoffmann-La Roche Ag Novel pre-targeting antibodies and uses thereof

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Also Published As

Publication number Publication date
CL2023001989A1 (es) 2024-02-02
CN116829593A (zh) 2023-09-29
MX2023008084A (es) 2023-07-13
AR124609A1 (es) 2023-04-12
US20240082437A1 (en) 2024-03-14
WO2022152656A1 (en) 2022-07-21
AU2022207615A1 (en) 2023-07-13
JP2024504931A (ja) 2024-02-02
IL304224A (en) 2023-09-01
CO2023009153A2 (es) 2023-07-21
TW202241962A (zh) 2022-11-01
CR20230385A (es) 2023-09-25
PE20240690A1 (es) 2024-04-10
EP4277705A1 (en) 2023-11-22
KR20230131204A (ko) 2023-09-12

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