TW202216697A - 用於調節剪接之組成物 - Google Patents

用於調節剪接之組成物 Download PDF

Info

Publication number
TW202216697A
TW202216697A TW110128712A TW110128712A TW202216697A TW 202216697 A TW202216697 A TW 202216697A TW 110128712 A TW110128712 A TW 110128712A TW 110128712 A TW110128712 A TW 110128712A TW 202216697 A TW202216697 A TW 202216697A
Authority
TW
Taiwan
Prior art keywords
compound
formula
methyl
mmol
azabicyclo
Prior art date
Application number
TW110128712A
Other languages
English (en)
Chinese (zh)
Inventor
麥克 路茲歐
布萊恩 盧卡斯
天生 王
Original Assignee
美商史凱霍克醫療公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商史凱霍克醫療公司 filed Critical 美商史凱霍克醫療公司
Publication of TW202216697A publication Critical patent/TW202216697A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW110128712A 2020-08-05 2021-08-04 用於調節剪接之組成物 TW202216697A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063061742P 2020-08-05 2020-08-05
US63/061,742 2020-08-05

Publications (1)

Publication Number Publication Date
TW202216697A true TW202216697A (zh) 2022-05-01

Family

ID=80117649

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110128712A TW202216697A (zh) 2020-08-05 2021-08-04 用於調節剪接之組成物

Country Status (13)

Country Link
US (1) US20230331718A1 (https=)
EP (1) EP4192454B1 (https=)
JP (1) JP2023538524A (https=)
KR (1) KR20230048106A (https=)
CN (1) CN116171153B (https=)
AR (1) AR123150A1 (https=)
AU (1) AU2021320763A1 (https=)
CA (1) CA3188104A1 (https=)
IL (1) IL300352A (https=)
MX (1) MX2023001558A (https=)
TW (1) TW202216697A (https=)
UY (1) UY39368A (https=)
WO (1) WO2022031838A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020163248A1 (en) 2019-02-04 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
EP3920915A4 (en) * 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
CN114126613A (zh) 2019-02-05 2022-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
WO2020163544A1 (en) 2019-02-06 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN113661162A (zh) 2019-02-06 2021-11-16 斯基霍克疗法公司 用于调节剪接的方法和组合物
GB202106871D0 (en) * 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2579949T3 (es) 2010-02-05 2016-08-17 Heptares Therapeutics Limited Derivados de 1,2,4-triazin-4-amina
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
CN112272666A (zh) 2018-04-10 2021-01-26 斯基霍克疗法公司 用于治疗癌症的化合物
WO2020163248A1 (en) * 2019-02-04 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
EP3920915A4 (en) * 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
EP3920918A4 (en) * 2019-02-05 2022-11-16 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING
WO2022031998A2 (en) 2020-08-05 2022-02-10 Skyhawk Therapeutics, Inc. Process for the preparation of intermediates useful in the preparation of compounds that modulate splicing

Also Published As

Publication number Publication date
AR123150A1 (es) 2022-11-02
IL300352A (en) 2023-04-01
CN116171153A (zh) 2023-05-26
US20230331718A1 (en) 2023-10-19
WO2022031838A1 (en) 2022-02-10
CN116171153B (zh) 2025-11-21
EP4192454A4 (en) 2024-09-11
EP4192454A1 (en) 2023-06-14
CA3188104A1 (en) 2022-02-10
UY39368A (es) 2022-01-31
JP2023538524A (ja) 2023-09-08
KR20230048106A (ko) 2023-04-10
MX2023001558A (es) 2023-04-26
AU2021320763A1 (en) 2023-03-30
EP4192454B1 (en) 2026-04-22

Similar Documents

Publication Publication Date Title
TW202216697A (zh) 用於調節剪接之組成物
US10138249B2 (en) Triazolopyridines and triazolopyrazines as LSD1 inhibitors
EP3057586B1 (en) Bromodomain inhibitors
TW202400582A (zh) 驅動蛋白kif18a抑制劑及其應用
WO2022060951A1 (en) Compositions for modulating splicing
EP3287463A1 (en) Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
WO2022060943A1 (en) Compositions for modulating splicing
JP2018076285A (ja) 二環性イミダゾロ誘導体を含む医薬
US20200038402A1 (en) Substituted quinazoline sulfonamides as thioredoxin interacting protein (txnip) inhibitors
CN112088003A (zh) 制备嘧啶基-4-氨基吡唑化合物的工艺
KR20100103544A (ko) N-페닐-이미다조[1,2-a]피리딘-2-카르복스아미드 화합물, 그의 제법 및 그의 치료학적 용도
WO2022060944A1 (en) Compositions for modulating splicing
CN116249691B (zh) 双环类衍生物调节剂、其制备方法和应用
CN114163446B (zh) 一种喹啉酮骨架的pde4抑制剂及其制备方法与应用
HK40080347A (en) Bromodomain inhibitors
US20250179092A1 (en) Pyrido[1,2-a]pyrimidin-4-one derivatives
HK40017640A (en) Bromodomain inhibitors
HK40017640B (en) Bromodomain inhibitors
HK1226316B (en) Bromodomain inhibitors
HK1226316A1 (en) Bromodomain inhibitors
CZ367499A3 (cs) Sloučeniny